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우황청심원(牛黃淸心元)이 저산소증 유발 배양신경세포에 미치는 영향
조규선,신길조,문일수,이원철,정승현,Cho, Gyu-Seon,Shin, Gil-Cho,Moon, Il-Soo,Lee, Won-Chul,Chung, Sung-Hyun 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.2
Objectives : The purpose of this investigation is to evaluate the effects of Woohwangcheongsim-won on neuronal death of hypoxic E18 cortical neuroblast. Methods : To evaluate the effect of Woohwangcheongsim-won on neuronal death caused by hypoxia, the survival rate of E18 cortical neuroblast was measured with MTT assay and the changes of several synaptic proteins and enzymes were investigated with the immunoblot assays. Results : The E18 cortical neuroblasts were added 50, 100, 500, 1,000, and $5,000{\mu}g/ml$ Woohwangcheongsim-won. They showed neurotoxicity, when the concentration of Woohwangcheongsim-won was above $1,000{\mu}g/ml$. The E18 cortical neuroblasts, which were added 50, 100, and $500{\mu}g/ml$ Woohwangcheongsim-won, were exposed 98% $N_2/5%\;CO_2$ for 3 hours to induce hypoxia, 3 days later, the survival rate of $50{\mu}g/ml$ Woohwangcheongsim-won was 141.5% when compared to the control group. On the immuneblot assays, the expressions of ${\alpha}$CaMKII, NR2A, NR28, PDE2, PSD-95, and eEF-$1{\alpha}$ were increased in normoxia, but those of NR2A, NR2B were decreased in hypoxia when compared to the control group. Conclusions : The data shows that the effects of Woohwangcheongsim-won on neuronal death of hypoxic E18 cortical neuroblast is a significant result.
한국인 여성에서 인터루킨-1 수용체 안타고니스트 유전자 다형성과 비만 및체질과의 관련성 연구
문성원 ( Seong Won Moon ),박종하 ( Jong Ha Park ),염승룡 ( Seung Ryong Yeom ),이수경 ( Soo Kyung Lee ),신병철 ( Byung Cheul Shin ),권영달 ( Young Dal Kwon ),송용선 ( Yung Sun Song ),최현주 ( Hyun Joo Choi ) 한방재활의학과학회 2004 한방재활의학과학회지 Vol.14 No.4
목적: Interleukin-1 receptor antagonist(IL-1ra)의 혈장 농도는 비만에서 증가되며 강한 유전적 통제를 받는다. 이에 비만과 IL-1ra 유전자 다형성 및 사상체질과의 관계를 연구하고자 하였다. 방법: 67명의 정상군, 133명의 과체중군, 61명의 비만군 대상자에서 IL-1ra 유전자의 intron 2에서의 penta-allelic 86-bp tandem repeat 빈도를 조사하였으며, IL-1ra의 유전자형은 PCR을 통해 분석하였다. 체지방량과 체지방률은 체성분분석기를 이용하였으며, 사상체질 분석은 QSCC II 프로그램을 이용하였다. 결과: 정상체중군에 비하여 과체중과 비만군에서 A1A2 carrier의 빈도가 높았으며, 대립유전자 2형 보유자의 빈도가 정상체중군에 비하여 과체중과 비만군에서 2배정도 높게 나타났으나 통계학적인 유의성은 없었다. 태음인의 빈도는 정상체중군에 비하여 과체중과 비만군에서 높게 나타났으며, 특히 IL-1ra A2- carrier인 과체중과 비만군에서의 태음인의 빈도가 높게 나타났다.결론: IL-1ra 유전자 다형성은 BMI에 대하여 중요한 영향을 주는 인자는 아닌 것으로 보이나, 본 연구는 비만과 비만 후보유전자로서의 IL-1ra 유전자의 다형성 및 사상체질과의 관계를 규명하려고 하였다는 데에서 그 의의가 있다.
문원 ( Won Moon ) 대한소화기학회 2016 대한소화기학회지 Vol.67 No.2
Ulcerative colitis is a chronic inflammatory condition of the colon, characterized by diffuse mucosal inflammation and blood-mixed diarrhea. The main treatment has been 5-aminosalicylic acid, steroid, thiopurine, and anti-tumor necrosis factor alpha (TNF-α) antibodies including infliximab, adalimumab, and golimumab. Golimumab, a new anti-TNF-α agent has been recently approved for patients with moderate to severe ulcerative colitis. Its efficacy and safety has been demonstrated in line with infliximab and adalimumab in preclinical and clinical studies. This review will focus on golimumab therapy in ulcerative colitis.
K-IFRS 의무도입으로 인한 연결범위 변동과 관련기업 특성에 대한 연구
문해원(Moon, Hae Won),권경은(Kwon, Kyung Eun) 한국국제회계학회 2013 국제회계연구 Vol.0 No.52
본 연구는 2011년 K-IFRS을 의무도입한 상장기업을 대상으로 연결재무제표의 작성과 연결범위의 변동현황을 조사하였다. 그리고 연결범위 포함여부에 따라 관련기업의 재무적 특성을 파악함으로써 연결범위 결정요인을 알아보았다. 또한 지배력 판단 근거에 따라 관련기업을 재분류하여 재무적 특성을 살펴보고 판단기준의 차별적 특성 및 연결재무제표에 미치는 영향을 알아보았다. 표본은 K-IFRS를 의무도입한 유가증권 상장기업 666개와 코스닥 상장기업 897개, 총 1,563개의 상장기업과 이들이 보유한 7,661개의 관련기업이다. 연구결과, K-IFRS 도입 후 연결재무제표의 작성 비율이 약 26% 증가하였다. 종속기업 또한 증가하였는데, 유가증권 상장기업의 종속기업은 약 1.41배, 코스닥 상장기업의 종속기업은 약 3.11배 증가하였다. 연결범위를 결정하는 주된 판단근거는 지분율기준이었는데, 81.75%가 지분율기준을, 6.55%만이 실질지배력기준을 사용했다. 지배기업이 연결범위를 결정할 때 고려하는 주된 재무적 특성은 수익성으로 나타났으며 부채비율과 상대적 기업규모는 결정요인이 아닌 것으로 나타났다. 즉, 지배기업은 수익성을 고려하여 연결범위를 결정함으로써 연결실체의 수익성 향상을 도모하는 것으로 보인다. 또한 실질지배력기준은 지분율기준에 비해 수익성이 높고(낮고), 부채비율이 낮은(높은) 관련기업을 연결범위에 포함(제외)시키고 있었다. 따라서 실질지배력기준은 지분율기준에 비해 연결재무제표에 대한 긍정적 영향이 큰 경우에 사용되었다. 본 연구의 결과가 나타내듯이 연결범위의 주된 결정기준은 지분율이고 실질지배력의 사용빈도는 낮았다. 하지만 2013년부터 적용되는 「기준서 제1110호 ‘연결재무제표’」는 경제적 실질을 반영한 실질지배력기준을 더욱 강조하고 있다. 따라서 앞으로 실질지배력에 대한 전문가적 이해와 판단이 증진되어야 하고 실질지배력기준의 명확한 판단 근거 공시 및 일관된 적용이 요구된다. This paper investigates how many firms report consolidated financial statements and how firm’s consolidated coverage changes after the adoption of K-IFRS. We also investigate the financial characteristics of related firms which are included or excluded from consolidated entity. In addition, we compare the financial characteristics of firms that are included in consolidated financial statements based on the percentage ownership standards with those based on the de facto control standards. The sample is consisted of 666 KOSPI firms and 897 KOSDAQ firms in 2011. After the adoption of K-IFRS, the disclosure of consolidated financial statement has increased by 26%. The number of subsidiary companies is also increased by 1.41 times for KOSPI and 3.11 times for KOSDAQ respectively. Most firms use the percentage ownership as a standard to include subsidiaries in consolidated financial statements but they rarely employ the de facto control standard. 81.75% of the related firms are included based on the percentage ownership standard whereas 6.55% of them are included based on the de facto control standard. The findings also show that profitability of subsidiaries is the most important financial characteristics to be included in consolidated financial statements. Leverage ratio and relative firm size are not considered important. When the related firms induce favorable effect on consolidated entity, the de facto control is used as the consolidated coverage standard. Specifically, related firms that are included by the de facto standard are more profitable and have less leverage ratios, and larger relative size than other firms.
문원석(Moon Won-Suk) 한국문화산업학회 2006 문화산업연구 Vol.6 No.1
Jeju Provincial Government has recently implemented various legal and economic revisions to provide for Jeju Island's development into a free international island. But the main goal of these revisions, namely, to induce private investment, has not been achieved. The key reason for this failure to induce private investment is that policy markers have not cultivated the reliability necessary to develop confidence among international investors. Without this confidence it is not possible to create income through business activities in Jeju Island. To induce International investment, Jeju Island must promote a special emphasis on the specific advantage of local investment in order to attract firms based outside of Korea. To this effect, the purpose of this paper is to explore the existing weaknesses in policy regarding the inducement process for foreign investment in Jeju Island. In addition, this paper offers strategies for a more efficient inducement of international investment in Jeju Free International Island. Jeju Provincial Government has recently implemented various legal and economic revisions to provide for Jeju Island's development into a free international island. But the main goal of these revisions, namely, to induce private investment, has not been achieved. The key reason for this failure to induce private investment is that policy markers have not cultivated the reliability necessary to develop confidence among international investors. Without this confidence it is not possible to create income through business activities in Jeju Island. To induce International investment, Jeju Island must promote a special emphasis on the specific advantage of local investment in order to attract firms based outside of Korea. To this effect, the purpose of this paper is to explore the existing weaknesses in policy regarding the inducement process for foreign investment in Jeju Island. In addition, this paper offers strategies for a more efficient inducement of international investment in Jeju Free International Island.