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원발성 세균성 복막염 진단에 있어서 혈액 배양 배지를 이용한 복수 배양법의 유용성
이명래(Myung Rae Lee),전재윤(Jae Yoon Chon),문영명(Young Myoung Moon),박인서(In Suh Park),이경원(Kyung Won Lee) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.6
N/A Background/Aims: Spontaneous bacterial peritonitis(SBP) is a serious and frequently fata1 compli- cation in cirrhotics, therefore earlier detection and earlier institution of appropriate treatment is crucial for good result. However, the conventional method of ascitic tluid culture has a low sensitivity in detecting causative organism of SBP. Methods: We have compared the sensitivity of the conventional method to the bedside inoculation of ascites into blood culture media. Two kinds of ascites culture methods were compared in cirrhotic patients with spontaneous bacterial peritoni- tis: 1) conventional(on blood agar, MacConkey agar, thioglycolate broth, and phenylethanol blood agar) and 2) blood culture media method(inoculation of each S mL of ascites into one 30-mL tryptic soy broth bottle and one30-mL thioglycolate broth bottle at the patients bedside. Results: In a 55-month period, 67 episodes of SBP in 61 cirrhotic patients were examined using simultane- ous both culture methods. The conventional method grew bacteria in 22 episodes(32.8%), whereas the blood culture media method grew in 55 episodes(82.1%), which showed a significantly higher sensitivity(p0.005). The organisms most frequently isolated in ascitic fluids in this study were aerobic gram-negative bacteria(88.37o), among them E. coli was the most most common pathogen comprising 55.0% of total isolates. The conventional method grew five species of organism whereas the b]ood culture media did eleven species. Most of E. coli were susceptible to amino- glycosides, third generation cephalosporins, aztreonam, and ofloxacin, but resistant to ampicil]in. Conclusions: It is suggested that the inoculation of ascitic fluid to a blood culture media is more sensitive than the conventional method and shou]d be routinely used for ascitic fluid culture in cirrhotic patients. (Korean J Gastroenterol 1995;27: 659 - 672)
Desferoxamine 이 시험관내 인체 간암세포 성장에 미치는 영향
송시영(Si Young Song),김원호(Won Ho Kim),전미연(Mi Yun Chon),한광협(Kwang Hyub Han),정재복(Jae Bock Chung),전재윤(Chae Yoon Chon),문영명(Young Myung Moon),강진경(Jin Kyung Kang),박인서(In Suh Park),최흥재(Heung Jai Choi),윤정구(Jung 대한내과학회 1994 대한내과학회지 Vol.47 No.3
N/A Objectives: It has been known that excessive iron promote the growth of cancer cells aad suggested that iron oversupply in cancer patients may enhance tumor growth and adversely affect cancer therapy and that desferoxamine (DFO) as a iron chelating agent may have a place in anticancer agents, which acts as a potent inhibitor of DNA synthesis via inhibition of the ribonucleotide reductase. However there have been no reports on the combined effect of DFO with other chemotherapeutics in vitro, This study was done to answer the questions: Does DFO inhibit the growth of cultured hepatoma cells? and Does the combination of DFO and chemotherapeutic agents have a synergistic effect on inhibition of tumor growth? Methods: Using PLC/PRF/5 and Hep G2 cells as hepatoma cells and normal diploid cells of WI-38 as control, the MTT assay was performed for evaluation of the cytotoxicity and an isobologram method to analyze the combined effects of DFO and other chemotherapeutic agents. Results: 1) The hepatoma cells grew faster in an iron-enriched medium than in the medium without additional iron supplementation but the normal diploid cells of WI-38 did not. 2) The 50% inhibitory concentrations (IC50) on PLC/ PRF/5 and Hep 62 cells were 75.1 and 29.1 ㎍/ml, respectively. But the growth of WI-38 was not inhibited below 74.4% with even 200 ㎍/ml of DFO. 3) On both hepatoma cells, the growth inhibitory effects of DFO were reversed with simultaneous administration of stoichiometric doses of ferric citrate. 4) Adriamycin (ADR), 5-fluorouracil (5-FU) and cisplatin (DDP) inhibited the growth of all 3 cell lines, but larger doses were required to inhibit the WI-38 to obtain the same effect. 5) When DFO was combined with chemotherapeutic agents, a marked synergistic effect was observed with the combination of DFO and 5-FU on PLC/PRF/5 cells. The synergistic effect was also noted in Hep G2 cells with all three combinations of DFO-ADR, DFO-5-FU and DFO-DDP. Conclusion: Iron oversupply may enhance the hepatoma growth and this should be taken into consideration treating patients with hepatoma. And the antitumor effect of DFO and its synergistic effect with other chemotherapeutic agents may suggest that iron chelator like the DFO may be a useful treatment for patients with hepatoma in conjuction with other anticancer drugs.
권태정,김정숙,문영명,Kwon Tae-Jung,Kim Chung-Soak,Moon Young-Myung 한국현미경학회 1981 Applied microscopy Vol.11 No.1
Gastric xanthoma which is not a true neoplasm and clinically insignificant consists of the small yellowish lesion of the gastric mucosa, frequently of multiple occurrence. Histologically the lesion shows chronic superficial gastritis with intestinal metaplasia and occasional collections of foam cells within the lamina propria. Electron microscopically. the xanthoma, cells are composed of. lipid-laden histiocytes with. many autophagocytic Iysosomes surrounding the cytoplasmic lipid vacuoles. Many residual bodies are also noted. The pathogenesis of the gastric xanthoma is obscure, however it is thought that a previous focal lesion of the gastric mucosa may have been a factor. One case of gastric xanthoma is reported here and a brief review of literature is also made.
간장 ( 肝腸 ) 및 담도 ( 膽道 ) : Thallium - 201의 경직장 신티그라피를 이용한 문맥순환의 평가
최흥재(Heung Jae Choi),문영명(Young Myung Moon),김경희(Kyung Hee Kim),이관식(Kwan Sik Lee),김병철(Byung Chul Kim),김경철(Kyung Chul Kim),오제덕(Jae Duk Oh) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3
N/A A new method for evaluating portal systemic circulation by administration of Thallium-201 per rectum was performed in 8 control subjects and in 32 patients with various liver diseases. The heart-to-liver uptake ratio at 20 min after administration (H/L ratio) was used as an index of portal systemic shunting. Also H/L ratios were compared with the results of ICG R15 test and some liver function tests. The results obtained were as follows: 1) The thallium distribution and time-activity curve observed in patients with portal hypertension were clearly distinctive from those in normal control subjects. 2) The H/L ratios obtatined in each group were as, 0.29 +- 0.06 in normal controls, 0.34 +- 0.04 in asymptomatic HBsAg carrier, 0.44 +- 0.10 in patients with CPH, 0.50 +- 0.23 in patients with CAH, and 0.70 +- 0.43 in patients with ]iver cirrhosis. 3) There was a relatively good correlation between the H/L ratio and ICG R15 (indocyanine green retention rate at 15 min) test (r=0.79, p<0.001). 4) No correlation was observed between H/L ratio values and albumin, bilirubin, SGOT, SGPT, but correlations were observed between H/L ratio and prothrombin time (r=-0.70, p<0.001), and platelet counts (r= -0.45, p<0.01). The above results suggest that this noninvasive method seems to be useful in evaluating portal-to- systemic shunting in various liver diseases with portal hypertension.
위암의 병기판정에 있어서 위에 물을 채운후 시행하는 복부초음파검사의 의의
홍성표(Sung Pyo Hong),송시영(Si Young Song),김원호(Won Ho Kim),정재복(Jae Bock Chung),문영명(Young Myung Moon),강진경(Jin Kyung Kang),박인서(In Suh Park),이종태(Jong Tae lee) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.1
N/A The accurate prediction of the stage is essential in the treatment of gastric cancer. Recently endoscopic ultrasonography(EUS) is introduced and that was known to be very effective in the assessment of depth of invasion in gastric cancer. Although the endoscopic ultrasono- graphy can be successfully employed for the selective evaluation of regional wall changes, a systematic study of the entire stomach and upper abdominal structures such as liver is not possible. The recent advances of ultrasonographic equipments made it possible to visualize precisely and the transabdominal ultrasound of stomach after fluid ingestion made it also pos- sible to visualize all layers of gastric wall with high degree of image resolution without any difficulty. To assess the accuracy of transabdominal ultrasound of fluid-filled stomach for staging of stomach cancer, we performed ultrasonographic examinations in sixty-two patients with gas- tric cancer immediately after 600cc water ingestion prior to surgery and the image findings were compared with histologic or surgical findings. The overall accuracy for the depth of invasion was 75.8%. The depth of invasion was overes- timated in 5 cases(8.1%) and underestimated in 10 cases(16.1%). The diagnostic accuracy for the depth of invasion increased with the progression of T stages(Tl, T2, T3 and T4: 33.3%, 68. 8%, 83.3% and 90.0%, respectively). The diagnostic accuracy for the depth of invasion in 39 pa- tients with ulceration was 69.2% and 10 patients without ulceration 80/. There was no statis- tical differences in the accuracy for the depth of invasion according to the location and direc- tion of the lesion. Lymph node metastasis was correctly diagnosed in 42 of 62 cases(67.7%). According to N stage, the accuracy in NO is 94.7%, Nl 58.3% and NZ 52.6%. Distant metastasis was correctly diagnosed in 59 of 62 cases(95.2%). In 3 cases a false-negative diagnosis was made who had tiny tumor nodules at the surface of right hepatic dome or mesentery. The ac- curacy for the overall stage was 55.1%. In conclusion, transabdominal ultrasonography of fluid-filled stomach is considered to be very simple and useful method in the staging of gastric cancer such as endoscopic ultrasono- graphy. (Korean J Gastroenterol 1994; 26: 63 72)
심장이식후 발생한 대장기종 ( Pneumatosis Cystoides Intestinalis )
이천균(Chun Kyun Lee),송시영(Si Young Song),이용찬(Yong Chan Lee),장병철(Byung Chul Chang),문영명(Young Myung Moon),강진경(Jin Kyung Kang),박인서(In Suh Park) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.5
Pneumatosis cystoides intestinalis(PCl) is a rare disease of undetermined etiology which is characterized by multiple gas-filled cysts in the wall of the small or large intestine or both. It is associated with various medicosurgical conditions including organ transplantation. Fewer than 50 cases of PCI occurring after organ transplantation including 4 cases of cardiac transplantation have been reported in the world literatures. We report a 47-year-old man of PCI who suffered from right lower quadrant abdomina) pain for 1 week. He was taken heart transplantation due to acute myocardiac infarction and ischemic cardiomyopathy 1 year ago. On plain abdominal X-ray revealed the multiple clustered localized collections of gas in the ascending and hepatic flexure of colon. Co]onoscopy showed the typical finding of PCI, which was multiple variable size protruding masses which apperared as round, soft, and somewhat bluish colored cysts. After the puncture of the above cystic mass using endoscopic injection needle, we can observe the deflation of the above ass. This is the first case in Korea. (Korean J Gastroenterol 1995;27: 732 - 737)