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천명이 있는 소아의 CD8+ T 세포의 IL-5, IL-13, IFN-γ 생산
이문희 ( Moon Hee Lee ),문세나 ( Se Na Moon ),장지현 ( Ji Hyun Jang ),정명숙 ( Myung Sook Chung ),김유진 ( Eu Gene Kim ),윤종서 ( Jong Seo Yoon ),김현희 ( Hyun Hee Kim ),이준성 ( Joon Sung Lee ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2008 소아알레르기 및 호흡기학회지 Vol.18 No.3
목적: 소아 천명 환자에서 CD8+ T 세포의 IL-5, IL-13, 그리고 IFN-γ의 생산을 비교하여 천명성 질환의 병인에 있어서 CD8+ T 세포의 역할에 대한 이해의 폭을 넓히고자 하였다. 방법: 천명을 주소로 입원한 소아 환자를 대상으로 하여 알레르겐 특이 IgE의 양성여부를 기준으로 아토피성 천명군과 비아토피성 천명군으로 분류하였다. 반복적인 하기도 감염의 병력이 있으나 천명의 병력은 없었던 소아환자를 질병 대조군으로 하고, 비감염성 비염증성 질환으로 입원한 비아토피 소아 환자를 건강 대조군으로 하였다. 말초혈액에서 CD8+ T 세포를 분리하여 phytohemagglutinin (PHA)과 함께 또는 PHA 없이 72시간 동안 시험관에서 배양하였다. 배양 상층액에서 IL-5, IL-13과 IFN-γ의 농도를 측정하였다. 결과: 아토피성 천명군에서 PHA와 함께 배양된 CD8+ T 세포로부터의 IL-5의 생산이 PHA없이 배양된 경우보다 높았다. 비아토피성 천명군, 질병 대조군, 건강 대조군에서는 CD8+ T 세포의 IL-5 생산이 PHA 자극 유무에 따라 다르지 않았다. IL-13의 농도는 모든 CD8+ T 세포 배양 상층액에서 측정되지 않았다. 모든 군에서 CD8+ T 세포로부터 IFN-γ의 생산은 PHA 자극 유무에 따라 유의한 차이가 없었다. 결론: CD8+ T 세포는 IL-5의 생산을 통하여 아토피 소인을 가진 소아의 천명 발생에 기여할 가능성이 있다. Purpose: Our objective was to investigate the role of CD8+ T cells in pathogenesis of wheezing in children with atopic nature. Methods: Twelve atopic wheezers, 8 nonatopic wheezers, 8 disease controls and 8 healthy controls were enrolled in the study. We isolated CD8+ T cells from peripheral blood samples, incubated them for 72 hours either in the absence or presence of phytohemagglutinin (PHA) and compared the concentrations of interleukin (IL)-5, IL-13, and interferon (IFN)-γ in the cell culture supernatants. Results: In the atopic wheezer group, the IL-5 concentration was significantly higher after PHA stimulation than after non-stimulated incubation. This difference was not observed in the nonatopic wheezer, disease control and healthy control groups. IL-13 was undetectable in all of the cell culture supernatants. There was no significant difference in the IFN-γ concentration between the PHA-stimulated and non-stimulated conditions in all 4 groups. Conclusion: The results of this study suggest that CD8+ T cells may play a role in the pathogenesis of wheezing in children with atopic nature through the production of IL-5. [Pediatr Allergy Respir Dis(Korea) 2008;18: 228-235]
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엉덩 관절 벌림 운동 시 압력 생체 되먹임 장치와 골반 벨트의 사용이 엉덩 벌림근의 선택적 근 활성도에 미치는 영향
이동규 ( Dong Kyu Lee ),문세나 ( Se Na Moon ),노경희 ( Kyung Hee Noh ),박경희 ( Kyung Hee Park ),김태호 ( Tae Ho Kim ),오재섭 ( Jae Seop Oh ) 대한물리의학회 2011 대한물리의학회지 Vol.6 No.3
Purpose:The purpose of this study was to examine the effects of using a pressure bio-feedback unit (PBFU) and a pelvic belt (PB) on the electromyographic (EMG) signal amplitude of the gluteus medius (Gmed) and the quadratus lumborum (QL) during hip abduction exercise when lying on the side. Methods:Twenty able-bodied volunteers (10 male, 10 female) were recruited for this study. The EMG signal amplitude was randomly measured during hip abduction with preferred hip abduction (PHA), with PBFU, and with PB. The surface EMG signal was recorded from the Gmed and the QL. Data were analyzed using a one-way repeated ANOVA. Results:Muscle activity of Gmed was significantly higher in PBFU and in PB than in PHA (p<05). There were no significant difference between PBFU and PB (p>.05). Muscle activity of the QL was significantly lower in PB than in PHA (p<.05). The Gmed/QL muscle activity ratio was also significantly higher in PBFU and in PB than in PHA (p<.05), with no significant difference between PBFU and PB (p>.05). Conclusion:Based on these findings, using a PBFU and a PB is an effective method to disassociate QL use from Gmed use during hip abduction exercises when lying on the side.
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엎드려 누운 자세에서 엉덩관절 폄시 내적, 외적 안정화 방법이 큰 볼기근의 선택적 근활성에 미치는 영향
노경희 ( Kyung Hee Noh ),문세나 ( Se Na Moon ),이동규,윤지연,김태호 ( Tae Ho Kim ),오재섭 ( Jae Seop Oh ) 한국전문물리치료학회 2011 한국전문물리치료학회지 Vol.18 No.3
The effects of an abdominal drawing-in maneuver (ADIM) using a pressure bio-feedback unit (PBFU) were compared to the effects of a pelvic belt (PB) on the muscle activities of the hip and back extensor muscles during hip extension in the prone position. Fifteen healthy male participants all performed prone hip extensions under three conditions: 1) prefened hip extension (PIlE), 2) performing an ADIM, and 3) using a PB. The muscle activities of the erector spinae, the gluteus maximus, and the medial hamstring on the right side were recorded by surface electromyography. The muscle activity of the erector spinae was significantly lower while performing an ADIM during prone hip extension than during PHE or with a PB (p<.05). Gluteus maximus muscle activity was significantly higher while performing an ADIM (p<.05). No significant dlifference was found for the medial hamstring muscle among the three conditions (p>.05). We concluded that the internal stabilization of the pelvis and lumbar spine afforded by the ADIM using a PBFU could be more effective than the external stabilization provided by a PB in terms of in-creasing selectively gluteus maximus activation during prone hip extension.
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