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만성췌장염에서 췌석의 치료: 체외충격파 쇄석술 우선되어야 하나?
동석호 ( Seok Ho Dong ) 대한소화기학회 2014 대한소화기학회지 Vol.63 No.4
Safety and Effectiveness of Successive Extracorporeal Shock Wave Lithotripsy for Pancreatolithiasis under Intravenous Bolus Pethidine Administration Alone
동석호(Seok Ho Dong),오동환(Dong Hwan Oh),김성운(Sung Woon Kim),김영설(Young Seol Kim),최영길(Young Kil Choi),김진우(Jin Woo Kim),양인명(In Myung Yang) 대한내과학회 1988 대한내과학회지 Vol.35 No.4
N/A Serum lipid levels and lipoprotein profiles were studied in 64 normal Koreans and 73 Korean diabetics to observe the relationship among complications, serum lipid levels, lipoprotein patterns and clinical characteristics. The results are summarized as follows: 1) The concentrations of total lipid, cholesterol, trig-lyceride, lipoprotein, LDL and VLDL were significantly higher in diabetics than in the controls. 2) There were significant differences in the profiles of serum lipid and lipoprotein according to body weight, degree of glucose control and complication. 3) The frequency of neuropathy was 2.7 times higher in the group with hyperlipidemia, 2.5 times higher in hyperchole-sterolemia, 2.6 times higher in hypertrig-yceridemia, 2.9 times higher in high beta-lipoproteinemia and 2.8 times higher in high VLDL than in the control group. 4) The frequency of nephropathy was 4.2 times higher in the group with hyperlipidemia, 5.4 times higher in hyperchole-sterolemia, 3.4 times higher in high beta-lipoproteinemia and 2.6 times higher in high VLDL then in the control group. 5) The frequency of retinopathy was not significantly different among the above groups. We concluded that diabetic nephropathy had the closest relationship to a disorder in lipid metabolism, especially in cholesterol, and that the ratios of cholesterol,HDL and LDL.HDL could not predict the risk of diabetic complication.
B형 간염바이러스의 발현 및 증식에 있어서 X유전자의 역할
동석호(Seok Ho Dong),김효종(Hyo Jong Kim),김병호(Byung Ho Kim),이정일(Jung Il Lee),장린(Rin Chang) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.5
N/A Background/Aims: There are four open reading frames(ORF) in hepatitis B virus(HBV) genome, and three of them(S, P, C ORF) code proteins for essential functions for the viral life cyc1e. The smallest fourth open reading frame, termed X, is conserved in all mammalian hepadnavirus. X ORF encodes a 17-kDa protein which has been shown to transactivate the transcription of a wide range of viral and cellular genes in the cotransfection study. There have been still controversies whether X-gene is essential for viral life cycle. The aim of this study was to assess the role of X-gene for viral gene expression, replication and virion export. Methods: In-vitro transfection system for the wild-type HBV DNA and the X minus mutant was designed; the production of HBV DNA and RNA and the secretion of HBsAg and HBeAg were assessed in cultured hepatocellcelar carcinoma cell lines transfected with the wild-type HBV DNA and the X minus mutant. Results: Transfection analyses using Huh 9 cell line revealed no significant difference in viral proteins, replicative intermediates, and virion export between the wild type and the X minus mutant. But the level of viral replication was too low to assess in Hep G2 cell line. Conclusions: It is likely that HBV X-gene is not essential for viral replication in vitro, but further investigation about the fuction of HBV X-gene in vivo would be demanded. (Korean J Gastroenterol 1995;27: 546-554)
장린(Rin Chang),김병호(Byung Ho Kim),장영운(Young Woon Chang),이정일(Joung Il Lee),김효종(Hyo Jong Kim),김영관(Young Kwan Kim),동석호(Seok Ho Dong),이원호(Won Ho Lee),김석호(Seok Ho Kim) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.1
Inflammatory pseudotumor of the liver is rare acute benign lesion that is frequently misdiagnosed to be malignant tumor such as hepatocellular carcinoma or choiangiocellular carcinoma by imaging & gross morphologic characteristics during the hepatic resection. Its pathogenesis and etiology has not been elucidated exactly yet. We report a case of hepatic pseudotumor in 50 year old male who suffered from intrahepatic stones. E. coli was cultured from the pus of the abscess pocket complicated by stones within the pseudotumor. So the possibility of infection might be advocated once again as its cause.
김병호(Byung Ho Kim),정용희(Young Hee Joung),장영운(Young Woon Chang),민선기(Sun Kee Min),문주영(Ju Young Moon),한요셉(Yo Seb Han),이동근(Dong Keun Lee),동석호(Seok Ho Dong),김효종(Hyo Jong Kim),이정일(Jung Il Lee),장린(Rin Chang) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.4
Alendronate (Fosamax), an aminobisphosphonate and a selective inhibitor of osteoclast-mediated bone resorption, is used to treat postmenopausal osteoporosis and Paget's disease. In recent years, reports of severe esophageal injury in patients who took alendronate have evoked attention to the irritant effects of this drug on the mucosa of the upper gastrointestinal tract. We present a case of gastric ulcer caused by alendronate. The patient chiefly complainted of epigastric pain during 14 days. She had taken mefenamic acid for pain control for 3 years and she took once-weekly 70 mg of alendronate for 2 weeks for treatment of osteoporosis before the symptom started. Upper gastrointestinal endoscopy revealed two active gastric ulcers in the low body. The results of rapid urease test (CLO test) and modified Giemsa test for the detection of Helicobacter pylori infection were negative. After withdrawal of alendronate, the symptom resolved completely in one week. Six weeks later, follow-up endoscopy showed complete healing of the ulcer. (Korean J Gastroenterol 2001;38:284-287)
내시경적 정맥류 결찰요법의 단기 치료성적 및 안정성 - 내시경적 경화요법과의 비교 -
김병호 ( Byung Ho Kim ),김효종 ( Hyo Jong Kim ),김영관 ( Young Kwan Kim ),장린 ( Rin Chang ),이정일 ( Joung Il Lee ),동석호 ( Seok Ho Dong ),장영운 ( Young Woon Chang ) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.5
N/A Endoscopic sclerotherapy is an effective method for bleeding esophageal varices, however it is often associated with local and systemic complications which may limit its usefulness. A newly developed endoscopic treatment for bleeding esophageal varices, endoscopic variceal li- gation, which uses small rubber bands to occlude and eradicate the varices, may cause less damage to the esophagus and have no systemic complication theoretically. We compared the effectiveness and safty of the two techniques retrospectively. The patients had proved bleeding from esophageal varix and showed advanced liver cirrhosis. Nineteen patients were treated with ligation, and 20 patients with sclerotherpy. They were followed for a mean of 4 months. Acitve bleeding was controlled by ligation in 2 of 3 patients(67% ) and by sclerotherapy in 3 of 4 patients(75%). The eradication of varices was achieved by ligation in 6 of 14 patients(43 A ) and by sclerotherapy in 10 of 15 patients(67% ). But the mean number of treatments with ligation was lower than that with sclerotherapy(3.4 vs 4.2) ar J than other ligation treatment group(4-5). There was no significant difference in recurrent hernorrhage between two groups. There were one case of pleural effusion and one case of sepsis with acute renal failure in scle- rotherapy treated-patients, whereas none of these complications occurred in ligation treated patients. Two cases of treatment induced bleeding were developed in ligation group. Endoscop- ic variceal ligation has fewer local and/or systemic complications than sclerotherapy. To eradi- cate varices more completely and to achieve denudation of lower esophageal mucosa for pre- vention of recurrent hemorrhage, combination with sclerotherapy would be effective rather than ligation alone.(Korean J Gastroenterol 1994; 26: 765 770)
송종훈(Jong Hoon Song),동석호(Seok Ho Dong),김효종(Hyo Jong Kim),김병호(Byoung Ho Kim),장영운(Young Woon Chang),이정일(Jeong Il Lee),장린(Rin Chang),홍성화(Sung Wha Hong),이주희(Ju Hie Lee) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.4
Focal nodular hyperplasia is a benign epithelial tumor of the liver, occuring on noncirrhotic liver. It occurs usually in productive age women, but it is not associated with oral contraceptive use. We should differnentiate it from hepatocellular had not been reported in Korea. We experienced a case of focal nodular hyperplasia without liver cirrhosis of 23 years old woman, and it was confirmed by operation and histologic examination. (Korean J Gastroonterol 1994; 26 : 1034-1040)
Imatinib 치료 후 수술로 제거된 바터씨 팽대부의 악성 위장관간질종양
박정은 ( Jeung Eun Park ),동석호 ( Seok Ho Dong ),조근형 ( Kun Hyung Cho ),장재영 ( Jae Young Jang ),김효종 ( Hyo Jong Kim ),김병호 ( Byung Ho Kim ),장영운 ( Young Woon Chang ),장린 ( Rin Chang ) 대한소화기학회 2010 대한소화기학회지 Vol.56 No.1
Gastrointestinal stromal tumor (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract arising from Cajal`s cells, expressing CD 117. The standard treatment for primary GIST is complete surgical resection. Imatinib mesylate, a specific tyrosine kinase inhibitor, is effective against locally advanced and metastatic GIST. There are several reports of the effect of preoperative imatinib in patients with unresectable and locally advanced primary GIST. We report a case of unresectable primary GIST of the ampulla of Vater, which we were able to completely resect after treatment with a dosage of imatinib 400 mg daily for 5 months. Twelve months later, the patient was treated with imatinib and doing well with no evidence of recurrence. (Korean J Gastroenterol 2010;56:39-44)