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- 저자 : 나흥식 ( Heung Sik Na ) (검색결과 21 건)
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신경병증성 통증이 유도된 척수에서 Protein Kinase C-γ mRNA 발현
유임주(Im Joo Rhyu),나흥식(Heung Sik Na),성백길(Backil Sung),강윤희(Yoon Hee Kang),김 현(Hyun Kim),서영석(Young-Suk Suh) 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.6
신경병증성 통증은 신경손상 후, 평상시에는 무해한 자극에도 비정상적으로 신경계가 과민하게 반응하여 나타나는 만성 병적 통증이다. 현재까지 알려져 있는 기전은 손상된 신경으로부터의 비정상적인 정보가 척수후각세포를 민감화시켜 통증이 나타난다는 것이다. 최근 PKC-γ가 척수후각세포의 민감화에 관여한다는 보고가 있어, 신경병증성통증 모델 흰쥐의 척수에서 PKC-γ mRNA 발현을 in situ 조직화학법을 이용하여 관찰하였다. 손상된 쪽과 건강한 쪽의 척수후각 모두에서 PKC-γ mRNA 발현을 관찰할 수 있었으나, 양쪽의 발현에서 통계적으로 유의한 차이는 보이지 않았다. 이러한 결과 신경병증성 통증 유발에 PKC-γ mRNA 자체 보다는 PKC-γ 단백이나, 그 기능적 활성화가 중요한 역할을 할 수 있음을 시사한다. Partial peripheral nerve injury occasionally results in neuropathic pain, including spontaneous burning pain and increased sensitivity to sensory stimuli such as hyperalgesia and allodynia. The pathophysiological mechanisms underlying this disease are poorly understood and the available treatments unsatisfactory. Presently, the neuropathic pain is believed to result from an increase in the excitability of the dorsal horn neurons (central sensitization), which is induced by abnormal signals from injured afferents. PKC-γ is known to play a pivotal role in central sensitization following peripheral nerve injury. In the present study, we examine the expression of PKC-γ mRNA of the spinal dorsal horn after neuropathic injury. There was no significant difference of PKC-γ mRNA between lesion and control sides. These results suggest that PKC-γ mRNA is not a key factor for the generation of neuropathic pain.
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고양이 허파에서 산소재유입 손상을 결정하는 저산소증의 정도
남현정,김유경,홍승길,나흥식,Nam, Hyun-Jung,Kim, Yoo-Kyung,Hong, Seung-Kil,Na, Heung-Sik 대한약리학회 1997 The Korean Journal of Physiology & Pharmacology Vol.1 No.6
Although reoxygenation is the best way to salvage hypoxic tissues, reduced oxygen species (ROS) generated during reoxygenation are blown to cause further tissue injuries and the induction of heat shock proteins (HSPs). The present study was undertaken to determine any causal relationship between the severity of hypoxia and the opposite outcomes, either beneficial or detrimental, of the subsequent reoxygenation by measuring the HSP72. To this aim, one group (6 male cats, $2.5{\sim}3.5\;kg$) was subjected to a 5-min episode of hypoventilation (H, ventilation rate: 5/min) for the induction of slight hypoxia and the other group (6 male cats, $2.4{\sim}3.7\;kg$) was subjected to a 5-min episode of apnea (A) for severe hypoxia. Each 3 animals from both groups received a 10-min episode of ventilation with $(95%\;O_2\;(0)$, whereas the remainder did not. After these procedures, all animals were allowed to be ventilated within physiological range for 1, 4, or 8 hours (1H, 1HO, 4H, 4HO, 8H, 8HO, 1A, 1AO, 4A, 4AO, 8A and 8AO groups). Control animals did not receive any manipulation. The arterial blood $pCO_2$ was significantly higher just after apnea than hypoventilation, while $pCO_2$ and pH were significantly lower just after apnea than hypoventilation. Western blot analysis revealed that the magnitude of HSP72 synthesis is larger in 1H, 4H and 8H groups than in 1HO, 4H and 8HO groups, respectively. In contrast, 1AO, 4AO and 8AO groups more induced HSP72 than 1A, 4A and 8A groups, respectively. These results suggest that the reoxygenation is beneficial after slight hypoxia but detrimental after severe hypoxia.
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구심성 미주신경과 구심성 하심장 신경에 대한 전기자극이 호흡과 혈압에 미치는 영향
나흥식 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.1
This experiment was performed to determine the influence on tachypnea evoked by coronary heart diseases with pain in itself or pulmonary congestion secondary to acute congestive heart failure in the anesthetized and vagotomized cats. The results are summarized as follows: 1. The impulse discharges of phrenic efferents resulted from electrical stimulation of the left inferior cardiac nerve were increased by the increment of rate of phrenic efferents during inspiration. These results indicate the hyperpnea that can be produced by excitation of afferent cardiac sympathetic nerve fibers. 2. Cardiac pain evoked by electrical stimulation increases the blood pressure. 3. Not only C fibers but also A delta fibers participated in the change of the respiration and blood pressure. 4. Activation of pulmonary stretch receptor produced apnea. 5. During cold nerve block, activation of J receptor and bronchial receptor caused tachypnea characterized by increased rate of respiration, increased expiratory reserve volume and decreased tidal volume.
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박금수,나흥식,남숙현 고려대학교 의과대학 1991 고려대 의대 잡지 Vol.28 No.1
To determine the cause of genesis of reperfusion arrhythmias, the left anterior descending coronary artery was cannulated and perfused by a carotid-coronary bypass wlth slde branch in 29 open-chest pentobarbital-anesthetized cats . Ischemia was produced by shunt occlusion during 20min. Thereafter the side branch was opened and the ischemic myocardium reperfused with unmodified arterial blood (13 cats). acidlc blood(pH 6.73-7.10, 8 cats), hypocalcemic blood(Ca^(++) 0.13-0.37mM, 3 cats), and venous blood(PO_2, 29.5-47.ImmHg, 3 cats). Each group was evaluated with respect to the incidence of ventricular premature beats, ventricular tachycardia, and ventricular fibrillation and the onset time of first arrhythmia of each arrhythmia in cats. The incidence of ventricular tachycardia was much lower in the acidic reperfusion group (three of 8 cats,38%) than in the unmodilfed reperfusion group(eleven of 13 cats. 85%), (p<0.O5) hypocalcemic reperfuslon group(three of 3 cats. 100%), and hypoxic reperfusion group(three of 3 cats, 100% ). And the incidence of ventricular fibrillation was much lower in the acidic reperfusion group(none of 8 cats, 0%) than in the unmodified reperfusion group(eleven of 13 cats, 85%),(p<0.O5) hypocalcemic reperfusion group(three of 3 cats, 100%), and hypoxic reperfusion group(two of 3 cats, 67%). The onset time of ventricular premature beat and ventricular tachycardia is later in acidic reperfusion group(158.9 ± 117.5sec., 70.8±54.70sec. (mean±S.E) than unmodified reperfusion group(6.78±1.29sec., 24.7±7.5sec. (mean±S.E.)). These results indicate that acidic reperfusion can prevent reperfusion-induced arrhythmias, presumably owing to a reduction of Ca^(++) influx into cells through Na^(++) -Ca^(++) exchange.
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Capsaicin 사전 투여에 의한 흰쥐의 공격성 감소 및 자율적 체온조절의 결손
박순권,홍승길,나흥식,김현택 한국심리학회 한국심리학회지 생물 및 생리 Vol.7 No.1
capsaicin 사전 처치가 흰쥐의 공격성과 체온조절에 미치는 영향을 알아보았다. 생후 6주경에 capsaicin을 피하주사하였고, 완전히 성숙한 후에 공격성 및 체온조절 기능을 검사하였다. 실험 1의 공격성 검사 결과 capsaicin 처치동물들의 공격성은 통제동물보다 낮았는데, 이것은 선행 연구의 결과와 상반된다. 체온조절 기능을 알아본 실험 2에서는 capsaicin 처치동물들이 37℃ 및 40℃ 조건에서 과체온과 빠른 체온증가를 보여주었다. 이것은 출생 직후 또는 성숙한 후에 약물을 투여한 선행연구들과 일치되는 결과이다. 따라서 capsaicin이 체온조절에 미치는 영향은 투여 시기와 무관한 것 같다. 논의에서는 본 연구의 두 가지 결과를 시상하부와 관련시켜 해석하였다. The present study was designed to examine effects of capsaicin administration on aggressive behaviors and autonomic thermoregulation in rats. In six-week-old rat, capsaicin was injected subcutaneously on 4 consecutive days in increasing doses(20㎎/㎏, 30㎎/㎏, 30㎎/㎏, 50㎎/㎏) to total of 150㎎/㎏ of the drug. The controls were treated in the same way with vehicle alone. Two experments began six or eight weeks after the treatment. In experiment 1, isolation-induced agressive behaviors, scored a 10-min session in the dyadic situation, were significantly decreased by capsaicin pretreatment. This result was not in accord with the previous findings. In experiment 2, body temperature of the capsaicin-treated rats increased more than the control's at two amibient temperatures studied(37℃ and 40℃). Our result concerning thermoregulation supports the preceding studies that applied to the capsaicin-treated animals as neonate or adult. Thus, it is likely that the effect of capsaicin treatment on thermoregulation has nothing to do with the age of capsaicin injection. The capsaicin effects from this study were compared with hypothalamic lesion effects in the discussion part.
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Capsaicin이 성숙한 흰쥐의 통각반응과 open-field 행동에 미치는 영향
박순권,김현택,나흥식,홍승길 한국심리학회 한국심리학회지 생물 및 생리 Vol.7 No.1
성숙한 흰쥐에게 전신계로 투여한 capsaicin(150㎎/㎏)이 개방장(open-field)행동과 통각반응의 역치 및 반응잠재기에 미치는 효과를 알아보았다. 첫째, open-field행동에는 capsaicin의 효과가 관찰되지 않았는데 이것은 capsaicin이 흰쥐의 정서반응성과 운동기능에는 영향을 미치지 않음을 의미하는 것이다. 둘째, capsaicin 투여에 의해 열자극에 대한 앞발 및 뒷발핥기의 역치는 변화되지 않았으나, 뛰어오르기의 역치는 증가되었다. 또한 역치 이상의 열자극에 대한 뒷발핥기 반응의 잠재기도 capsaicin 투여에 의해 증가되었다. 이 결과는 비교적 약한 열자극에 대한 적응반응에는 capsaicin이 영향을 미치지 않으나 강한 열자극에 대한 대처반응에는 영향을 미치는 것으로 해석된다. We investigated the effects of capsaicin(s.c. 150㎎/㎏) on the open-field behaviors and the thresholds and latency of nociceptive responses in adult rats. Results are as follows. 1) Capsaicin did not affect open-field behaviors. It hints that capsaicin did not alter the emotionality and motor function of rats. 2) Whereas the threshold of jumping was elevated, those of fore and hind paw licking were not in animals treated with capsaicin. Capsaicin also enhanced hind paw licking latency to thermal stimulus over thershold in hot plate test. These results suggest that capsaicin affects the coping reaction to strong thermal stimulus, but not adaptive reaction to mild stimulus, in adult rats.
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