3.0T MRI에서 온도변화가 T1 및 T2 이완시간에 미치는 영향

김호현,권순용,임우택,강충환,김경수,김순배,백문영,Kim, Ho-Hyun,Kwon, Soon-Yong,Lim, Woo-Teak,Kang, Chung-Hwan,Kim, Kyung-Soo,Kim, Soon-Bae,Baek, Moon-Young 대한디지털의료영상학회 2013 대한디지털의료영상학회논문지 Vol.15 No.2

Purpose : The relaxation times of tissue in MRI depend on strength of magnetic field, morphology of nuclear, viscosity, size of molecules and temperature. This study intended to analyze quantitatively that materials' temperatures have effects on T1 and T2 relaxation times without changing of other conditions. Materials and Methods : The equipment was used MAGNETOM SKYRA of 3.0T(SIEMENS, Erlagen, Germany), 32 channel spine coil and Gd-DTPA water concentration phantom. To find out T1 relaxation time, Inversion Recovery Spin Echo sequences were used at 50, 400, 1100, 2500 ms of TI. To find out T2 relaxation time, Multi Echo Spin Echo sequences were used at 30, 60, 90, 120, 150, 180, 210, 240, 270 ms of TE. This experiment was scanned with 5 steps from 25 to $45^{\circ}C$. next, using MRmap(Messroghli, BMC Medical Imaging, 2012) T1 and T2 relaxation times were mapped. on the Piview STAR v5.0(Infinitt, Seoul, Korea) 5 steps were measured as the same ROI, and then mean values were calculated. Correlation between the temperatures and relaxation times were analyzed by SPSS(version 17.0, Chicago, IL, USA). Results : According to increase of temperatures, T1 relaxation times were $214.39{\pm}0.25$, $236.02{\pm}0.87$, $267.47{\pm}0.48$, $299.44{\pm}0.64$, $330.19{\pm}1.72$ ms. T2 relaxation times were $180.17{\pm}0.27$, $197.17{\pm}0.44$, $217.92{\pm}0.39$, $239.89{\pm}0.53$, $257.40{\pm}1.77$ ms. With the correlation analysis, the correlation coefficients of T1 and T2 relaxation times were statistically significant at 0.998 and 0.999 (p< 0.05). Conclusion : T1 and T2 relaxation times are increased as temperature of tissue goes up. In conclusion, we suggest to recognize errors of relaxation time caused local temperature's differences, and consider external factors as well in the quantitative analysis of relaxation time or clinical tests.

혈부축어탕이 Triton WR-1339에 의한 고지혈증 유발 생쥐 간조직내 지질 축적 억제에 미치는 영향

김호현,방혜정,강윤호,박인식,안상현,김진택,이해풍,Kim, Ho-Hyun,Bang, Hyui-Jeng,Gang, Yun-Ho,Park, In-Sick,Ahn, Sang-Hyun,Kim, Jin-Tack,Lee, Hai-Poong 대한동의생리학회 1999 동의생리학회지 Vol.14 No.2

After Triton WR-1339 (TX; 600mg/kg) intraperitoneal injection, hepatic tissues of ICR mice were intragastric injected with Hyulboochucketang extract(HCE; 3.3ml/kg/day) were observed to investigate the suppressive effect of lipid accumulation that evoke by the antihyperlipidemic effect of HCE. These hepatic tissues were fixed in fromol-calcium solution and were cryocut. These tissues stained by H&E for general morphology, sudan black B for lipid and perchloric acid-naphthoquinone(PAN) method for cholesterol. After TX treatment, the increase of hepatocyte having meshlike cytoplasm(HHMC) were shown in all hepatic lobules and the hepatic plates were disappeared in the aggregative region of HHMC. The number of blue black colored lipid drop and dark green colored asterisk shaped cholesterol particle in hepatic cytoplasm were increased and the size of lipid drop and cholesterol particle were enlarged. But, in HCE-treated mice, the HHCM were disappeared and hapatic plate were rearranged. The number of lipid drop and cholesterol particle were decreased than TX-treated mice and the size of lipid drop and cholesterol particle were diminished. As results indicated that the HCE work on the suppression of lipid accumulation in hepatic tissue of hyperlipidemic mice caused by disturbance of lipid metabolism.

사립유치원 경력 교사의 사직에 담긴 살아가는 이야기에 관한 내러티브 탐구

김호현(Kim, Ho-Hyun) 한국영유아교원교육학회 2020 유아교육학논집 Vol.24 No.1

이 연구는 10년의 유치원 경력을 가진 한 선생님의 사직 전과 후의 정체성 변화 과정과 사직의 의미를 내러티브 탐구의 살아가는 이야기와 개인적·전문적 지식 전경의 틀로 들여다보았다. 이를 위해 10년 동안 몸담았던 유치원을 그만두고 대학원에 진학한 김선생님과 아홉 차례 대화를 나누었고, 내러티브 탐구 방식으로 현장, 중간, 연구텍스트를 구성하였다. 김선생님은 교사 시절 개인적 전경과 전문적 전경이 충돌하는 과정에서 좌절과 허탈함을 겪었으나 이 충돌은 김선생님에게 교사가 되기 전 상상했던 유아를 변화시키는 좋은 교사가 될 기회가 되었고, 부모교육 강사의 꿈을 가지고 사직을 한 뒤 대학원에 진학하였다. 가르치는 자에서 배우는 자로, 유치원에서 대학원으로 역할과 장소가 바뀌고, 새로운 관계가 만들어지고, 경제적 어려움과 차별의 벽에 좌절하면서 정체성에도 변화가 생겼지만 유아를 변화시키는 좋은 교사가 될 것이라는 중추의 정체성을 유지함으로써 교사 시절부터 지금껏 전문적 전경의 삶을 살고 있다. 그의 사직에 담긴 살아가는 이야기는 더 큰 꿈을 향해 여행하는 성장에 관한 이야기이고, 유아를 위해 무엇을 할 것인가에 관한 답을 찾는 과정이었다. The study looked inside the changing identity of a former kindergarten teacher with 10 years of career experience before and after her resignation and the meaning of her resignation within the frames of stories to live by and personal-professional knowledge landscapes. Nine deep dialogues with the teacher, Kim, were conducted and a constructed field, interim, and final search text were made. Kim went through frustration and letdowns in the middle of conflicts between the personal and professional landscapes but this conflict was a good chance for her to be a good teacher who changed the children for the better, a story imagined before she became a teacher. She chose to resign and attend graduate school. Her identity changed as her role, place, and relationships shifted from teacher to learner, from the kindergarten to the tertiary-level classroom and being frustrated due to financial difficulties and barriers of discrimination. However sustaining her core identity as a good teacher who changed children for the better, she has been living on the professional landscape linked from the rookie teacher. Stories to live by embedded in Kim’s resignation stories are about the story of one teacher’s travelling for a better dream and a course of answering what to do for the children.

삼음삼양(三陰三陽)의 종화규율(從化規律)에 관한 연구(硏究)

김호현,Kim, Ho-Hyun 대한동의생리학회 1999 동의생리학회지 Vol.14 No.2

This study was undertaken to define the expression rule of six vital substances for human life(六氣) in Meridians and the rule of following of three ${\breve{U}}m$ and three Yan. In order to investigate the expression rule of six vital substances for human life(六氣), incident(標)-fundamental(本) and Ki of middle energizer(中氣) of three ${\breve{U}}m$ and three Yang(三陰三陽) were reviewed. 1, The rule of following is formed centering around fundamental Ki(本氣) between incident(標) and fundamental(本). And in case the ${\breve{U}}m$ and Yang (陰陽) disposition of incident(標) and fundamental(本) is different, whether the ${\breve{U}}m$ and Yang(陰陽) disposition of incident(標) and fundamental(本) is same as those of Ki of middle energizer(中氣), is the key point in following fundamental and activating of the vital energy(氣化). 2. As twelve channels(十二經脈) have not only fundamental Ki(本氣) but also Ki of middle energizer(中氣) at the same time, in expression of six vital substances for human life(六氣), if the fundamental Ki(本氣) is stronger, fundamental Ki(本氣) can be expressed or if the fundamental Ki(本氣) is weaker, Ki of middle energizer(中氣) can be expressed. 3. Twelve channels which is connected with each other through the relation of the interior and the exterior can be regarded as a system, in which Wind(風) and Fire(火), Dryness(燥) and Dampness(濕), Cold(寒) and Heat(熱) maintain balance through mutual control. 4. We can see that in the disease caused by the unbalance of six vital substances for human life(六氣), expression of six pathogenic factor and controlment of six vital substances for human life(六氣) are made up after the following one in the rule of following(從化規律).

어린이 주요활동공간의 휘발성유기화합물류 노출로 인한 건강위해성 평가 : 초등학교 및 학원을 중심으로

김호현(Ho-Hyun Kim),임영욱(Young-Wook Lim),이청수(Chung-Soo Lee),김태훈(Tae-Hoon Kim),박주희(Ju-Hee Park),전준민(Jun-Min Jeon),신동천(Dong-Chun Shin),양지연(Ji-Yeon Yang) 한국실내환경학회 2011 한국실내환경학회지 Vol.8 No.4

This study was to assess the lifetime cancer and non-cancer risk on exposure to volatile organic compounds This study was assessed the lifetime cancer and non-cancer risk of volatile organic compounds (VOCs) exposure in young children at elementary-schools and academies in Korea. The samples were collected at children's facilities (50 elementary-schools and 42 academies) in summer (Aug ~ Sept, 2008), winter (Dec 2008 ~ Feb, 2009) and Spring (Mar ~ Apr, 2009) periods, and analyzed by GC-MSD. We estimated the lifetime excess cancer risks (ECRs) of benzene and the hazard quotients (HQs) of non-carcinogens toluene, ethylbenzene, xylene and styrene. In addition, for carcinogens, the excess cancer risk (ECR) was calculated by considering the process of deciding cancer potency factor (CPF) and age dependent adjust Factor (ADAF) from the data in adults. The average ECRs of benzene for young children were 1×10⁻⁷~1×10⁻⁹ level in all facilities. HQs of four non-carcinogens did not exceed 1.0 for all subjects in all facilities.

외상성 다발성 골절 후 발생한 뇌 지방 색전증 1예

김호현 ( Ho Hyun Kim ),박윤철 ( Yun Chul Park ),이동규 ( Dong Kyu Lee ),박찬용 ( Chan Yong Park ),김재훈 ( Jae Hun Kim ),김영대 ( Yeong Dae Kim ),김정철 ( Jung Chul Kim ) 대한외상학회 2013 大韓外傷學會誌 Vol.26 No.2

A cerebral fat embolism is an uncommon but serious complication of long bone fracture. It can be fatal, and early detection is not easy. Neurologic symptoms are variable, and the clinical diagnosis is difficult. The pathogenesis remains controversial, and several theories have been proposed. Magnetic resonance imaging can detect a cerebral fat embolism with a higher sensitivity than cerebral computed tomography. We report a case of a posttraumatic cerebral fat embolism without pulmonary involvement and review the existing literature.

정삭에 발생한 다발성 원격전이를 동반한 점액성 지방육종

김호현(Ho Hyun Kim),허영회(Young Hoe Hur),박찬용(Chan Yong Park),김정철(Jung Chul Kim),김신곤(Shin Kon Kim) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.5

Myxoid liposarcoma of the spermatic cord (MLSC) is a rare variant of spermatic sarcoma. Typically, it presents during the sixth decade of life as a painless scrotal or inguinal mass. Although local recurrences are not uncommon, prognosis following complete tumor removal is good because metastases are rare. Although myxoid liposarcoma is common elsewhere in the body, less than 20 cases have been described in the spermatic cord. Distant metastasis with MLSC (e.g., bone, liver, lung) is extremely rare, and no cases have been reported in the English literature. We report one case of MLSC with multiple bone, liver and peritoneal metastasis, incidentally found during inguinal hernia repair.

원발성 비장 혈관육종의 자발성 파열

김호현(Ho Hyun Kim),허영회(Young Hoe Hur),박찬용(Chan Yong Park),김정철(Jung Chul Kim),김신곤(Shin Kon Kim) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.4

Primary angiosarcoma of the spleen is an extremely rare malignancy, the pathogenesis of which is not completely understood, with high metastatic potential and an exceedingly poor prognosis, regardless of treatment regimen. The major complication is splenic rupture, which often leads to fatal hemoperitoneum. Overall, since 1879 when Langerhans described the first case of angiosarcoma of the spleen, there have been approximately 200 cases reported in the literature. Moreover, to the best of our knowledge, spontaneous rupture of primary splenic angiosarcoma and spontaneous rupture of remnant or recurred angiosarcoma is extremely rare, and no cases were reported in English literature. We report a case of spontaneous splenic rupture due to angiosarcoma in a 68-year-old man, and also review the existing literature.

단일 기관에서 시행한 복강경 간 절제술의 경험

김호현(Ho Hyun Kim),성진식(Jin Sik Sung),허영회(Young Hoe Hur),고양석(Yang Seok Koh),김정철(Jong Chul Kim),조철균(Chol Kyoon Cho),김현종(Hyun Jong Kim) 한국간담췌외과학회 2009 한국간담췌외과학회지 Vol.13 No.3

Background : An increasing number of small prospective studies have been published, since the first report of laparoscopic liver resection by Gagner et al. in 1992. They have shown encouraging results for the feasibility and safety of the procedure. This paper provides a retrospective analysis of a single center"s experience with elective laparoscopic liver resections. Methods : We did a retrospective study on laparoscopic liver resections performed from July 2005 to April 2009, undertaken in 34 patients with preoperative diagnosis of a benign lesion(7 cases, 20.6%), hepatocellular carcinoma in absence of complicated cirrhosis (18 cases, 52.9%), or liver metastasis (9 cases, 26.4%). The mean tumor size was 2.63±1.57 cm(range 0.55-7.5) Results : We carried out 15 wedge resections(44.1%), 3 right hemi-hepatectomies(8/8%), 4 left hemi-hepatectomies(11.8%), 5 liver segmentectomies(14.7%), 7 left lateral sectionectomies(20.6%). The average duration of an operation was 175.00±129.12 minutes. There were 6 patients (15%) in which a conversion to laparotomy was required none of the conversions occurred under emergency situations. Intraoperative transfusion was required for 5 patients(14.7%). Postoperative complications developed in 2 patients (5.8%)(1 intraabdominal abscess, 1 bile leakage). There were no deaths and no reoperations for complications. The mean postoperative hospital stay was 9.9 days. Conclusion : Our experience shows that laparoscopic liver resections, including major hepatectomies, are feasible and safe. Nonetheless, a prospective randomization study with a greater number of cases and longer follow-up is needed before laparoscopic liver resection can be regarded as the gold-standard approach for hepatic lesions.

비장 혈관종과 감별이 어려웠던 비장 해면상 림프관종

김호현(Ho Hyun Kim),허영회(Young Hoe Hur),박찬용(Chan Yong Park),고양석(Yang Seok Koh),김정철(Jung Chul Kim),조철균(Chol Kyoon Cho),김현종(Hyun Jong Kim) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.6

Lymphangioma of the spleen is a rare benign neoplasm with clinical manifestations ranging from insignificant incidental findings to large, symptomatic cystic masses requiring surgical intervention. We report a case of splenic cavernous lymphangioma mimicking splenic hemangioma. A 59-year-old woman presented with left upper quadrant pain and epigastric discomfort. Computed tomography showed a 9.5×8 ㎝ high attenuated mass with relatively homogenous enhancement in the spleen. The initial impression was a splenic hemangioma. The patient underwent splenectomy. Gross pathologic examination revealed a 9.5×6.8×9 ㎝-sized fairly well circumscribed soft mass. Histologically, the tumor was composed of dilated lymphatic vessels, which contained homogenous eosinophilic material. The Final diagnosis was cavernous lymphangioma of the spleen. Herein, we report a case of splenic cavernous lymphangioma mimicking splenic hemangioma and also review the existing literature.