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      • SCOPUSKCI등재

        유자의 항 Influenza 바이러스 A형 활성에 관한 연구

        김호경,고병섭,전원경,Kim, Ho-Kyoung,Ko, Byoung-Seob,Jeon, Won-Kyung 한국생약학회 2000 생약학회지 Vol.31 No.1

        To evaluate anti-influenza virus activity of 113 specimens of Korean traditional medicine both water and methanol extracts were examined using haemagglutination inhibition test. The water extract from Citrus junos was found to inhibit influenza virus A/Taiwan/l/86(H1N1). The survival rates of virus were determined by in situ cellular enzyme-linked immunosorbent assay. The water extract of Citrus junos was fractionated by chromatographic separating using Amberlite XAD-4, 40% MeOH and 60% MeOH layer had antiviral activity. The half inhibition concentration $(IC_{50})$ of 40% MeOH layer on survival of influenza virus was $MIC>361.5{\mu}g/ml$ and $IC_{50}$ value of fr. 40-4 fractionated from 40% MeOH layer was $677.19{\mu}g/ml$. These results suggested that the fractions of Citus junos have potent anti-influenza A virus activity.

      • KCI등재

        A comparative electrical transport study on Cu/n-type InP Schottky diode measured at 300 and 100 K

        김호경,Chan Yeong Jung,Se Hyun Kim,Yunae Cho,김동욱 한국물리학회 2016 Current Applied Physics Vol.16 No.1

        Two oxygen plasma treated InP samples with different plasma powers of 100 and 250 W were prepared and a comparative study on the electrical properties of Cu/n-type InP Schottky diode measured at 300 and 100 K was performed to investigate the current transport mechanism in detail. The forward and reverse bias currentevoltage (IeV) characteristics were analyzed with considering various transport models. The fitting to the forward bias IeV characteristics revealed that relatively high ideality factor at 300 K for untreated sample were related with the generation-recombination (GR) current and the large E00 value at 100 K for 100 W plasma treated sample were associated with more significant tunneling effect. The analyses on the reverse bias current characteristics showed the suitable current transport model has changed from thermionic emission (TE) to TE combined with barrier lowering for both untreated and 250 W treated samples and from TE þ BL to thermionic field emission for 100 W treated sample with increasing temperature from 100 to 300 K.

      • KCI우수등재

        시공중 자정식 현수교의 행거 장력변화

        김호경,서정인,Kim, Ho Kyung,Suh, Jeong In 대한토목학회 1994 대한토목학회논문집 Vol.14 No.6

        앵커리지 (Anchorage)가 주케이블을 지지하는 전형적인 현수교에서는 행거를 가설한 후에 보강형을 순차적으로 가설하기 때문에 시공시 행거에 별도의 긴장력이 필요없다. 이와는 달리 자정식 현수교는 가교각으로 보강형을 지지한 후 행거를 설치하게 된다. 따라서 행거 가설시 초기 긴장력을 가할 필요가 있으며 이 후 계속되는 시공과정에 의해 장력이 지속적으로 변화하게 된다. 따라서 행거의 가설방법을 변화시켜가며 이에 따른 행거장력의 변화 양상을 파악하여 가장 효율적으로 행거를 가설할 수 있는 방법을 결정할 필요가 있다. 이를 위하여 본 연구에서는 해석적인 방법을 제시하였다. 현수교 시공의 진행에 따라 단계적으로 변화하는 구조계를 모사할 수 있는 사공단계해석 알고리즘을 제시하였다. 또한 자정식 현수교에서 발생할 수 있는 기하비선형 해석모델을 제시하였다. 실물 교량을 대상으로 제시된 해석방법에 따라 가장 효과적이라고 생각되는 시공방법을 제시하였다. Because the stiffening girders are constructed after the installation of hangers for typical suspension bridge, no additional tensioning to hangers in construction is necessary for this bridge type in which main cable is earth-anchored. However, for self-anchored suspension bridge, hangers are installed after temporarily supporting stiffening girders constructed in previous stage. Therefore, initial tension is required on installing hangers. Tension of hangers varies as the construction proceeds. Hence, it is necessary to determine the most efficient method of installing hangers among several methods. This study presents finite element procedures and the algorithms of construction stage analysis to simulate construction processes. Geometric nonlinear analysis scheme is also included. The most effective method regarding the installation of hangers is presented through the examples of actual bridge model.

      • 유통한약 품질규격 모니터링 연구

        김호경,천진미,이아영,이혜원,최지현,장설,고병섭,Kim, Ho-Kyoung,Chun, Jin-Mi,Lee, A-Young,Lee, Hye-Won,Choi, Ji-Hyun,Jang, Seol,Ko, Byoung-Seob 한국한의학연구원 2005 한국한의학연구원논문집 Vol.11 No.2

        This study was investigated to determine the quality control of Oriental medicine from stores dealing in Oriental medicine around Seoul and Daegu. We tested total 120 samples that widely used 15 species in herbal medicine (Lycii Fructus, Platycodi Radix, Angelicae Gigantis Radix and 12 others) being collected from Oriental medicine clinic, pharmacy, Oriental pharmacy, Oriental medical hospital and Oriental drug store. We have estimated Oriental medicine by K.P. (Korean Pharmacopoeia), K.H.P(Korean Herbal Pharmacopoeia) and announcement of KFDA. The items of examination were identification, purity, loss on drying, ash, acid insoluble ash, extract content, essential oil content, assay, heavy metal limit, and pesticides residue(BHC, DDT, Aldrin, Endrin, Dieldrin). As a result, 20 samples in total 120 samples were not satisfied with the standard and 7 species in total 15 species were not satisfied with the standard. Identification test, extract content test and pesticides residue(BHC, DDT, Aldrin, Endrin, Dieldrin) were satisfied with the standard. The result will be the basic data for the quality control of Oriental medicine.

      • SCOPUSKCI등재

        알루미늄 고용체 합금의 고온변형 거동에 관한 연구

        김호경,Kim, Ho-Gyeong 대한기계학회 1997 大韓機械學會論文集A Vol.21 No.2

        The creep characteristics of an Al-5wt.% Ag alloy including the stress exponent, the activation energy for creep and the shape of the creep curve were investigated at a normalized shear stress extending from $ 10^{-5}{\;}to{\;}3{\times}10^{-4}$ and in the temperature range of 640-873 K, where silver is in solid solution. The experimental results shows that the stress exponent is 4.6, the activation energy is 141 kJ/mole, and the stacking fault energy is $180{\;}mJ/m^2$, suggesting that the creep behavior of Al-5 wt.% Ag is similiar to that reported for pure aluminum, and that under the current experimental conditions, the alloy behaves as a class II(metal class). The above creep characteristics obtained for Al-5 wt.% Ag are discussed in the light of prediction regarding deformation mechanisms in solid solution alloys.

      • SCOPUSKCI등재

        다축응력상태에서의 304 스테인리스강의 고온 파괴수명에 관한 연구

        김호경,정강,정진성,Kim, Ho-Kyung,Chung, Kang,Chung, Chin-Sung 대한기계학회 1998 大韓機械學會論文集A Vol.22 No.3

        Specimens of 304 stainless steel were tested to failure at elevated temperatures under multiaxial stress states, uniaxial tension using smooth bar specimens, biaxial shearing using double shear bar specimens, and triaxial tension using notched bar specimens. Rupture times are compared for uniaxial, biaxial, and triaxial stress states with respect to the maximum principal stress, the von Mises effective stress, and the principal facet stress. The results indicate that the principal facet stress gives the best correlation for the material investigated, and this parameter can predict creep life data under multiaxial stress states with rupture data obtained with specimens under uniaxial stresses. The results also suggest that grain boundary cavitation, coupled with localized deformation processes such as grain boudary sliding, controls the lifetimes of the specimens.

      • KCI등재

        디지털 래디오그라피의 신호 및 잡음 특성에 대한 방사선 영향에 관한 연구

        김호경,조민국,Kim, Ho-Kyung,Cho, Min-Kook,Graeve, Thorsten 대한의용생체공학회 2007 의공학회지 Vol.28 No.6

        For the combination of phosphor screens having various thicknesses and a photodiode array manufactured by complementary metal-oxide-semiconductor (CMOS) process, we report the observation of image-quality degradation under the irradiation of 45-kVp spectrum x rays. The image quality was assessed in terms of dark pixel signal, dynamic range, modulation-transfer function (MTF), noise-power spectrum (NPS), and detective quantum efficiency (DQE). For the accumulation of the absorbed dose, the radiation-induced increase both in dark signal and noise resulted in the gradual reduction in dynamic range. While the MTF was only slightly affected by the total ionizing dose, the noise power in the case of $Min-R^{TM}$ screen, which is the thinnest one among the considered screens in this study, became larger as the total dose was increased. This is caused by incomplete correction of the dark current fixed-pattern noise. In addition, the increase tendency in NPS was independent of the spatial frequency. For the cascaded model analysis, the additional noise source is from direct absorption of x-ray photons. The change in NPS with respect to the total dose degrades the DQE. However, with carefully updated and applied correction, we can overcome the detrimental effects of increased dark current on NPS and DQE. This study gives an initial motivation that the periodic monitoring of the image-quality degradation is an important issue for the long-term and healthy use of digital x-ray imaging detectors.

      • KCI등재

        Ethanol Extract of Inonotus obliquus Inhibits Lipopolysaccharide-Induced Inflammation in RAW 264.7 Macrophage Cells

        김호경,김태웅,Deok-Hyo Yoon,Chun-Hoi Kim,Bhushan Shrestha,장우철,So-yeon Lim,Won-Ho Lee,Je-O Lee,Mi-Hee Lim,Geun-Young Kim,최성아,송원옥,Jae-Mo Sung,황기철,Sang-Guk Han 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.1

        Inonotus obliquus(Pers.:Fr.) Pil. is a white rot fungus that belongs to the family Hymenochaetaceae of Ba-sidiomycetes. Extracts and fractions of this fungus have been known to have biological activities, including antimutagenic,anticancer, antioxidative, and immunostimulating effects. Recently, there have been reports that the anti-inflammatory and an-tinociceptive properties of the methanol extract of I. obliquusmay be due to the inhibition of inducible nitric oxide (NO) syn-thase (iNOS) and cyclooxygenase-2 (COX-2) expression via the down-regulation of nuclear factor .B (NF-.B) binding ac-tivity. However, the effects of I. obliquusmediator production have not yet been elucidated. In the present study, a 70% ethanol extract of I. obliquus(IOE70) showedantioxidative effects. We also tested the ability of the I. obliquusextract to inhibit the inflammatory cascades in lipopolysac-charide (LPS)-induced RAW 264.7 macrophage cells. The NO inhibition of IOE70 was better than that of other ethanol ex-tracts from I. obliquus. To investigate the mechanism by which IOE 70 inhibits NO production and iNOS and COX-2 ex-pression, we examined the activations of I.B., Akt, and c-Jun NH2-terminal kinase (JNK) in LPS-activated macrophages.IOE70 markedly inhibited the phosphorylation of I.B.macrophages. Taken together, these experiments demonstrated that IOE70 inhibition of LPS-induced expression of iNOS andCOX-2 protein is mediated by Akt and JNK. Based on our findings, the most likely mechanism that can account for this bi-ological effect of IOE70 involves the inhibition of NF-.B through the phosphatidylinositol 3-kinase/Akt/I.B pathway and theinhibition of JNK activation. Thus, IOE70 might have useful clinical applications in the management of inflammatory dis-eases and may also be useful as a medicinal food.

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