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        • KCI등재

          Cyclosporine 저항성 만성 자발성 두드러기환자에서 Omalizumab 치료에 대한 단일기관 후향적 연구

          김학준 ( Hak-jun Kim ), 김우일 ( Woo-il Kim ), 신기혁 ( Kihyuk Shin ), 손진화 ( Jin-hwa Son ), 이원구 ( Won-ku Lee ), 김훈수 ( Hoon-soo Kim ), 김병수 ( Byungsoo Kim ), 김문범 ( Moon-bum Kim ), 고현창 ( Hyun-chang Ko ) 대한피부과학회 2021 大韓皮膚科學會誌 Vol.59 No.3

          Background: Cyclosporine is a recommended third-line treatment for chronic spontaneous urticaria (CSU) that is resistant to H1-antihistamines according to the EAACI/GA<sup>2</sup>LEN/EDF/WAO guidelines for management of urticaria. However, some patients with refractory urticaria do not respond to cyclosporine or antihistamines. Omalizumab, a humanized anti-immunoglobulin E antibody, has been shown to be effective and safe for antihistamine-resistant CSU. However, there are few reports on the efficacy of omalizumab in patients with CSU who are resistant to cyclosporine. Objective: To evaluate the efficacy of omalizumab in patients with cyclosporine-resistant CSU. Methods: Recalcitrant CSU patients who had symptoms (seven-day urticaria activity score, UAS7≥7) despite being administered cyclosporine (3∼5 mg/kg/day) and H1-antihistamine at up to a four-fold increased dose for 4 weeks were included in this study. Omalizumab was administered at 150 mg or 300 mg by subcutaneous injection every 4 weeks. Efficacy was assessed using UAS7 12 weeks after the initial administration of omalizumab. Results: A total of 28 patients (18 women, 10 men) with an average age of 43.8 years were included in the study. The mean duration of CSU was 40.0 (2∼288) months, and the mean UAS7 at baseline was 14.2 (9∼35) months. Overall, 22 patients (78.6%) showed a complete (UAS7=0) or partial response (0<UAS7≤6) at 12 weeks. Patients who were administered 300 mg of omalizumab had a more complete response (9/15, 60%) than those who were treated with 150 mg (3/13, 23.1%). Conclusion: Omalizumab is an effective therapy for CSU patients who do not respond to cyclosporine. (Korean J Dermatol 2021;59(3):175∼180)

        • KCI등재

          AHP를 활용한 국내 위탁급식사업의 KPI 우선순위 및 가중치개발에 관한 연구

          김학준(Hak Jun Kim), 김홍길(Hong Kil Kim), 김대관(Dae Kwan Kim) 한국관광연구학회 2011 관광연구저널 Vol.25 No.4

          The contracted foodservice business as an intangible service industry requires measurement in intangible values. By these measurements the limited capitals should be selected and invested to differentiate itself from competitors and secure competitiveness. Currently, there are items to evaluate the present, future, and past of the Contracted Foodservice Business, however no academically established priority of the items. The purpose of this research, a follow-up research of Kim, Hak-Jun & Kim, Ju-Yeon(2009) is development on significancy and priority of KPI in Korea. As a result of the study, customer perspective was understood to be most important, next financial perspective, internal process, and lastly the learning and growth perspective. KPI`s priority consists of customer satisfaction measurement in first place with a significant rate of 0.187. Next, following up was achieved profit targets and achieved sales goals. The results implicate that in the contracted foodservice business in Korea the business strategy should select and invest in limited capitals by investing in the increased customer satisfaction measurement and corresponding to the needs and wants of the customer to increase customer satisfaction measurement.

        • KCI등재
        • KCI등재

          국내 여행상품 기획을 위한 리조트 사업의 핵심성과지표(KPI)에 대한 우선순위 및 가중치 개발

          김학준(Hak Jun Kim) 한국관광연구학회 2011 관광연구저널 Vol.25 No.1

          To survive the competitive environment in and outside the country, the Resort Industry needs to measure the past financial recordings and future values. The Resort Industry being an Intangible Service Industry requires measurement in intangible values. By these measurements the limited capitals should be selected and invested to differentiate itself from competitors and secure competitiveness. Currently, there are items for evaluating the present, future, and past of the Resort Industry, however no academically established priority of the items. The purpose of this research, a follow-up research of Kim, Hak-Jun & Kim, Dea-Kwan(2007), “A study of suitability of the indicators for the Key Management Performance Evaluation in the resort industry”, is development on significancy and priority of Resort Industry KPI for domestic travel product planning. As a result of the study, Customer Perspective was understood to be most important, next Financial Perspective, Internal Process, and lastly the Learning and Growth Perspective. KPI`s priority consists of Operating Profit Rate in first place with a significant rate of 0.147. Next, following up was the Revisiting Intention Rate and Customer Satisfaction Rate. The results implicate that in the domestic Resort Industry the business strategy should select and invest in limited capitals by investing in the Customer Perspective and corresponding to the Needs and Wants of the customer to induce revisits.

        • KCI등재

          여행상품 기획을 위한 서울시내 특1급 호텔의 핵심성과지표(KPI)에 대한 우선순위 및 가중치 개발

          김학준(Hak Jun Kim) 한국관광연구학회 2011 관광연구저널 Vol.25 No.2

          The Hotel Business being an Intangible Service Industry requires measurement in intangible values. By these measurements the limited capitals should be selected and invested to differentiate itself from competitors and secure competitiveness. Currently, there are items for evaluating the present, future, and past of the Hotel Business, however no academically established priority of the items. The purpose of this research, a follow-up research of Kim, Dea-Kwan, Kim, Hak-Jun & Park, Yang-Woo(2009), "A Study on the Development of KPI in the Super Deluxe Hotel Business in Seoul Korea Using BSC", is development on significancy and priority of KPI in the Super Deluxe Hotel Business in Seoul Korea for travel product planning. As a result of the study, Financial Perspective was understood to be most important, next Customer Perspective, Internal Process, and lastly the Learning and Growth Perspective. KPI`s priority consists of customer satisfaction measurement in first place with a significant rate of 0.145. Next, following up was operating profit to sales ratio of sales and achievement ratio of operating profit. The results implicate that in the Super Deluxe Hotel Business in Seoul Korea the business strategy should select and invest in limited capitals by investing in the increased customer satisfaction measurement and corresponding to the Needs and Wants of the customer to increase customer satisfaction measurement.

        • KCI등재

          2017년 관광레저연구 연구트렌드 분석

          김학준(Kim, Hak-Jun), 박양우(Park, Yang-Woo) 한국관광레저학회 2018 관광레저연구 Vol.30 No.6

          The tourism & leisure research has the lowest integration power index among registered tourism journals even though the highest number of research papers are published in the tourism field. The reason might be the difference between the overall research trend of the tourismfield and the research trend of tourism& leisure research. To solve the problemwhat kinds of research should be done more for tourism & leisure research to catch up with the research trend of the tourismfield, this study compared and analyzed the research trend of the tourism & leisure research and registered tourism journals except for tourism & leisure research. The result shows that the major trends of the tourism& leisure research include such key words as "satisfaction", "service", "intention", "job satisfaction", "image", "behavior intention", "service quality", "customer satisfaction", "awareness" and "hotel". The key words of registered tourism journals except for tourism & leisure research are "service", "environment", "job satisfaction", "accomplishment", "corporation", "brand", "occupation", "airline", "values" and "image". The result of comparing the research trends shows that among the 10 top key words, which can be considered as research trend, "service", "job satisfaction" and "image" are common in both fields, but the rest 7 key words are not consistent. Especially the key words "environment", "accomplishment", "corporation" and "occupation" are not included in the top 38 frequent key words of tourism & leisure research. More research on "environment", "accomplishment" and "corporation" along with "occupation" related to the current job creation issue should be done.

        • KCI등재

          족근관 증후군

          김학준(Hak Jun Kim), 장규선(Gyu-Sun Jang), 이지호(Jiho Lee) 대한정형외과학회 2014 대한정형외과학회지 Vol.49 No.5

          족근관은 내과와 종골을 연결하는 굴건 지대 아래 쪽에 존재하는 터널로 후경골건, 장족지 굴곡건, 후경골 동정맥, 후경골 신경 및 장무지 굴곡건이 지나가는 구조물이다. 족근관 증후군은 족근관 내에서 후경골 신경 및 신경 분지가 압박되어 발생하는 일종의 압박성신경 증후군이다. 족근관 증후군을 발생시키는 원인으로는 공간 점유 병소, 비후된 굴건 지대, 골극, 족근골 결합증, 정맥류 및 외상 등으로 알려져 있으며 족부 내측의 통증이 가장 흔한 증상이며 압박되는 신경 분지에 따라서 감각 저하나 이상 감각이 나타날 수 있다. 진단은 자세한 병력 청취 및 내과 아래의 압박 검사 등의 신체 검사를 통해 진단할 수 있으며 결절종, 지방종 및 신경종 등과 같은 공간 점유 병소가 있는 경우는 초음파나 자기공명영상이 도움을 준다. 신경 근전도 검사가 이환된 신경 분지를 구분하는 데 도움을 주지만 신경 근전도 검사가 음성이라고 하여 족근관 증후군을 배제할 수 없으므로 병력 청취와 신체 검사가 가장 중요한 진단의 기준이 된다. 치료로는 물리 치료, 야간 부목 고정술, 스테로이드 주사 요법 등의 보존적인 치료가 우선 권장되나 증상의 완화가 관찰되지 않을 때에는 수술적인 감압술이 추천된다. 수술적인 치료 결과는 다양하게 보고되고 있으나 젊은 환자에서 종물에 의해 발생한 경우 조기에 수술적인 처치를 시행하면 만족할만한 결과를 얻을 수가 있다고 알려져 있다. The tarsal tunnel is located beneath the flexor retinaculum, which connects the medial malleolus and calacaneus. The tarsal tunnel contains the posterior tibialis tendon, flexor digitorum longus tendon, posterior tibial artery and vein, posterior tibial nerve, and flexor halluces longus tendon. Tarsal tunnel syndrome is a compressive neuropathy of posterior tibial nerve and its branches under the flexor retinaculum. The etiologies of tarsal tunnel syndrome are space-occupying lesion, hypertrophied flexor retinaculum, osteophytes, tarsal coalition, varicose vein, and trauma. The symptoms are foot pain and hypoesthesia or paresthesia at dermatome according to involving nerve branches. Clinical diagnosis can be obtained from a detailed history and physical examination such as compressive test at the tarsal tunnel area. Ultrasonography and magnetic resonance imaging can reveal the space-occupying lesion, such as ganglion, lipoma, and neuroma. The initial treatments of tarsal tunnel syndrome are conservative management, such as physical therapy, night splint, and steroid injection. Surgical decompression is indicated after failure of conservative managements. Variable results of surgical treatment have been reported. Favorable result after decompression could be obtained from young patients, early onset symptoms, and space-occupying lesion.

        • KCI등재

          족관절 염좌의 보존적 치료

          김학준(Hak Jun Kim) 대한정형외과학회 2014 대한정형외과학회지 Vol.49 No.1

          족관절 염좌는 족관절 스포츠 손상 중에서 가장 흔한 손상으로 알려져 있으며 외측 족관절 염좌가 족관절 전체 염좌 중 가장 많은 부분을 차지한다. 급성 외측 족관절 염좌의 치료는 단계적으로 시행하는 것이 좋다. 수상 후 처음 1-2주는 급성기로 통증 및 부종 감소를 위한 protection, rest, ice, compression, and elevation (PRICE) 요법을 이용하고, 두 번째 단계는 등자형 보조기를 이용하여 족관절 외측 인대의 고정을 하고 관절 운동을 시작하는 것이며, 세 번째 단계로는 관절의 운동 범위를 증가시키고 근력을 강화하는 운동을 시행한다. 이러한 적절한 방법으로 급성 외측 족관절 염좌를 치료하면 만성 외측 족관절 불안정성으로의 이행을 방지할 수 있다. 만성 외측 족관절 불안정성의 경우는 기능적 불안정성과 해부학적 불안정성으로 구분되는데 수술적인 치료를 이전에 고유수용감각 향상 및 비골건 강화를 위한 기능적 운동 치료를 통해 증상을 개선시킬 수 있다. 조기에 기능적인 운동 치료는 급성 족관절 외측 염좌 후에 족관절의 기능을 향상시키고 족관절 염좌의 반복을 예방할 수 있으며 만성 족관절 불안정성으로 인한 증상을 개선시킬 수 있다. Ankle sprains are the most common sports related lower extremity injuries. Lateral ankle sprains are most common in ankle sprains. The staged treatment is recommended for the acute lateral ankle sprain. First treatment for acute ankle sprains focuses on control of pain and swelling: protection, rest, ice, compression, and elevation (PRICE) is a well-established protocol for treatment of acute ankle injury. The second phase of treatment is allowed ankle range of motion (ROM) with stirrup brace and the third phase is the exercises which increase ROM and muscle strength around the ankle joint. Adequate treatment for acute lateral ankle sprain can prevent the occurrence of chronic lateral ankle instability. The chronic lateral ankle instabilities have two categories: function instability and anatomical instability. Functional exercise for improving proprioception and strength of peroneal muscle is the first line treatment for chronic lateral ankle instabilities instead of early surgery. Early functional exercises could improve the ankle function, protect the repeated ankle after acute lateral ankle sprain, and improve the symptoms of chronic lateral ankle instabilities.

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