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김태욱 ( Tae Wook Kim ), 문제호 ( Je Ho Mun ), 좌승욱 ( Seung Wook Jwa ), 송마가렛 ( Margaret Song ), 김훈수 ( Hoon Soo Kim ), 고현창 ( Hyun Chang Ko ), 김병수 ( Byung Soo Kim ), 김문범 ( Moon Bum Kim ) 대한피부과학회 2012 大韓皮膚科學會誌 Vol.50 No.10
Irritation fibroma, also known as traumatic fibroma or focal fibrous hyperplasia, is the most common soft tissue exophytic lesion occurring in the oral cavity. It is a reactive lesion, caused mostly by chronic trauma to the oral mucous membranes. There is no gender or racial predilection, and the most common sites for irritation fibromas are the buccal and labial mucosa and the lateral surface of the tongue. Typical lesion presents as smooth, dome-shaped or pedunculated nodule with color of surrounding mucosa. Histopathologically, irritation fibromas are characterized by their dome shape with a keratinized stratified squamous epithelium, dense bundles of collagen fibers, spindle- or fibroblast-like cells, relatively few blood vessels and inflammatory cells in the submucosa. Although dermatologist should have interest in irritation fibromas due to their higher prevalence, there have been few reports in dermatologic literatures. Herein, we report two cases of multiple irritation fibromas on the lower lip, following lip biting.
Cement is increasingly used in the construction industry. Cement handling has been found to be responsible for many cases of occupational dermatitis, but cement burns have rarely been reported. Alkalinity of wet cement, abrasion by sand particulates, and prolonged contact, due to wet clothes, are relevant factors for cement burns. Although cement burns can result in full thickness burn and severe sequelae, the prevalence and severity are underestimated, due to the unawareness of patients and physicians. Herein, we report two cases of cement burns in construction workers, who had contacted with wet cement on lower extremities from their occupational exposures. (Korean J Dermatol 2012;50(5):432∼435)
김태욱 ( Tae Wook Kim ), 문제호 ( Je Ho Mun ), 좌승욱 ( Seung Wook Jwa ), 송마가렛 ( Margaret Song ), 고현창 ( Hyun Chang Ko ), 김병수 ( Byung Soo Kim ), 김문범 ( Moon Bum Kim ), 김훈수 ( Hoon Soo Kim ) 대한피부과학회 2012 大韓皮膚科學會誌 Vol.50 No.6
Background: Cutaneous angiosarcoma (CAS) is occasionally difficult to differentiate with other benign dermatoses, clinically, because of various clinical manifestations. Objective: The aim of this study is to examine the clinical and histopathologic findings of CAS, and investigate specific clinicopathologic features to aid in the early diagnosis. Methods: We reviewed photographs, medical records and biopsy specimen of 10 cases diagnosed as CAS for 5 years at our clinic. Results: The male and female numbers were 7 and 3, and the mean onset age was 69.7 years old. The mean duration of disease was 5.7 months. The site of involvement was scalp or face in all patients. The most common clinical feature was erythematous or purpuric nodule, with surrounding erythematous or purpuric patch, without symptoms. Initial impressions based on clinical findings on the first visit of our clinic were CAS (n=6), squamous cell carcinoma (n=2), basal cell carcinoma (n=1), and erysipelas (n=1). Histopathologically, irregular vascular channels lined by atypical endothelial cell dissect between the collagen bundles were seen in 6 cases, malignant endothelial cells forming continuous sheets with epithelioid morphology in 3 cases, and mild vascular hyperplasia in 1 case. CD31 was positive on atypical endothelial cells in all patients. Conclusion: CAS should be included in differential diagnosis when cutaneous lesions show erythematous to purpuric nodule or patch with rapid progression on scalp or face of elderly patients. Histopathologically, CAS had wide spectrum from mild vascular hyperplasia to spindle cell tumors. As such, immunohistochemical stain, using endothelial markers, is valuable to diagnosis of CAS.
김태욱 ( Tae Wook Kim ), 송마가렛 ( Margaret Song ), 박현제 ( Hyun Je Park ), 김훈수 ( Hoon Soo Kim ), 김수한 ( Su Han Kim ), 고현창 ( Hyun Chang Ko ), 김병수 ( Byung Soo Kim ), 김문범 ( Moon Bum Kim ), 권경술 ( Kyung Sul Kwon ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.1
Churg-Strauss syndrome (CSS) is an uncommon disorder that is characterized by asthma or allergic rhinitis, fever, systemic vasculitis, extravascular granulomas and hypereosinophilia. Cutaneous manifestations of CSS are one of the most common extra-pulmonary findings, and they occur in approximately 60% of the cases. Other manifestations include pulmonary infiltrates and heart, kidney, gastrointestinal tract, peripheral and central nervous system involvement and the patients also complain of systemic symptoms, including malaise, fever, myalgia and weight loss. The diagnosis of CSS is difficult because the manifestations vary with the disease stage and delayed treatment can lead to fatal major organ damage. We report here on 3 cases of CSS that were first diagnosed by the dermatologic department and with consultation from other departments. So, we want to remind dermatologists that if the patients of asthma or other allergic diseases have purpuric skin lesion, then CSS should be included in the differential diagnosis. (Korean J Dermatol 2011;49(1):62~67)
The purpose of this research was to determine the effect of caffeine on alleviating muscular pain and immunological reaction in blood induced by repeated eccentric contraction. For this, 26 male and female college students with no prior exercise experience who do not habitually consume caffeine(<100 mg·day-1) classified control group(Con-G; male=6, female=6, age=23.17±1.99yrs, height=167.55±4.33 cm, body weight=61.71±6.67 kg, BMI=21.55±3.15 kg·m-2) and the experimental group with 3 mg·kg-1 caffeine ingestion(Caff-G; male=6, female=8, age=21.86±2.03 yrs, height=166.71±5.17 cm, weight=61.35±6.73 kg, BMI=21.68±2.96 kg·m-2). Both groups carried out backward walking at a 85-88 steps per minute rhythm on a treadmill with a ?15% elevation at a speed of 3 km·h-1 for 30 minutes under 32±0.3oC temperature and 33.93±0.53% humidity. The energy consumed by each of the subjects was approximately 5-7.9 kcal·min-1 varying by different physical traits. The results of the experiment showed no significant change in the level of whole body sweating volume in both groups(p=0.814). Although muscular pain in both groups increased significantly 5 minutes after the experiment, muscular pain was observed at a significantly lower rate in the Caff-G than in the Con- G(p=0.019). Furthermore, there was no significant change in RPE between the two groups(p=0.493). All the blood immunological reaction analyzed in this research, showed significant difference by Pre and Post backward walking for 30 min excluding basophil. However, when analyzing the groups, there were not significantly differences between groups. As a result, we derived the conclusion that while the consumption of 3mg·kg-1 of caffeine before exercise in high temperature environments is effective in reducing muscular pain, there are no side effects that deter blood immunological reaction. But a downside of this experiment is that the reason and process for the reduction of muscular pain in the experimental group is still unknown.