동의보감(東醫寶鑑)에 따른 편(偏), 담궐(痰厥) 몇 기궐두통(氣厥頭痛) 환자의 임상적 고찰

김지윤,홍현우,김재연,김기탁,허태율,박동일,감철우,Kim, Ji-Yun,Hong, Hyun-Woo,Kim, Jae-Yeon,Kim, Ki-Tak,Heo, Tae-Yool,Park, Dong-Il,Gam, Chul-Woo 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.4

Objective : The purpose of this study is to investigate clinical characteristics and remedial value oriental medical therapy for sufferers of severe headache. Methods : On the authority of DongEuiBoCam, patients were classified into three groups: migraine, qi-syncope headache and phlegm-headache. All patients wert treated with acupuncture therapy and herb medicines. After that inquiry was made into the extent of improvement of headache. Results : 1. In accordance with the statistics, 56 cases(50.5%) had phlegm-syncope headache, 28 cases(25.2%) had qi-syncope headache and 27 cases(24.3%) had migraine. 2. The ratio between males and females was about 1:4. Most patients were in their forties. 3. 12 cases(31.6%) with migraine had pain only on the right side of the head, 20 cases(26.3%) with phlegm-syncope and 17 cases(45.6%) with qi-syncope headache suffered from the frontal lobe headache. 4. 8 cases(29.6%) with migraine had been suffering for a week or less, 12 cases(21.4%) with phlegm-syncope headache had been suffering for over six months and under one year and 6 cases(21.4%) with qi-syncupe headache had suffered over one year and under five. 5. Overwork and stress was deemed the main cause of migraine. Phlegm-syncope headache was also attributed to stress and tense situations. Qi-syncope headache was believed to be variously caused by traffic accident, noise, blood pressure and other reasons. 6. 46 cases(30%) felt dull headache and 32 cases(20.9%) felt dizzy. The common associated symptoms of migraine and qi-syncope headache included back, neck and shoulder pain and other pains. Dizziness was an especially prevalent symptom of phlegm-syncope headache. 7. After the oriental medical therapy, 12 cases(10.8%) almost entirely recovered, 50 cases(45%) were in about half as much pain, 45 cases(40.5%) improved little and 4 cases(3.6%) felt no improvement. Conclusions : The results support a role for oriental medical therapy in treatment of headache.

수생태계 종적 연결성 평가를 위한 국내외 연구 현황 및 어류기반 종적 연속성 평가모델 적용성 분석

김지윤,김재구,배대열,김혜진,김정은,이호성,임준영,안광국,Kim, Ji Yoon,Kim, Jai-Gu,Bae, Dae-Yeul,Kim, Hye-Jin,Kim, Jeong-Eun,Lee, Ho-Seong,Lim, Jun-Young,An, Kwang-Guk 한국환경생물학회 2020 환경생물 : 환경생물학회지 Vol.38 No.4

최근, 우리나라에서는 하천에 중소형 보(Weir) 및 각종 구조물(어도) 건설이 건설되면서 수생태계의 단절 및 훼손이 보고되고 있고, 이들은 수생태계 건강도에 직접적으로 영향을 주면서 수생태계의 종적 연결성 평가가 중요한 이슈가 되었다. 본 연구에서는 수생태 건강성 확보를 위한 일환으로 수생태계 종적 연결성 평가를 위한 국내외 연구 현황, 선진국의 어류 기반 종적 연속성 평가모델 개발 및 현장 적용성에 대한 분석을 실시하였다. 이를 위해, 우리나라에서 하천의 종적 연결성 현황 및 구조적 문제점, 어류 모니터링 기법 및 현황, 종적 측면의 어류 이동성 단절 및 종 다양성 영향에 대한 현황분석을 하였다. 또한, 물리적 서식지 적합도 평가, 환경생태유량 평가 및 어류 서식처 모의를 위한 생태-수리모델링의 기술적 한계 등에 대한 연구 현황을 분석하였다. 또한, 어류 유영력 기반 이동성 분석 및 행위자 기반(ABM) 어류행동예측 프로그램개발에 대한 현재 기술의 한계성도 제시하였다. 전 세계에서 적용된 하천 종적 연결성 평가모델 및 기법(프로토콜)에 대해 문헌, 자료 및 다양한 모델을 종합적으로 검토한 결과에 따르면, 첫째, 하천 구조물과 어류 유영속도, 점프력 등의 지표 기반 평가기법, 둘째, 직접 현장 어류조사 및 모니터링 기법, 셋째, 하천지형학적 접근방식 평가 기법 및 구조물 기반 DB 구축기법 및 넷째, 하천 연계성 지수 평가법 등으로 분석되었다. 종적 연결성 평가모델의 조사방법론 및 적용성 평가 결과에 따르면, 유럽권의 ICE 모델(Information sur la Continuite Ecologique)과 ICF 모델(Index de Connectivitat Fluvial)을 우리나라에 수정보완하여 적용할 경우 적절할 것으로 평가되었다. Recently, stream longitudinal connectivity has been a topic of investigation due to the frequent disconnections and the impact of aquatic ecosystems caused by the construction of small and medium-sized weirs and various artificial structures (fishways) directly influencing the stream ecosystem health. In this study, the international and domestic research trends of the longitudinal connectivity in aquatic ecosystems were evaluated and the applicability of fish-based longitudinal connectivity models used in developed countries was analyzed. For these purposes, we analyzed the current status of research on longitudinal connectivity and structural problems, fish monitoring methodology, monitoring approaches, longitudinal disconnectivity of fish movement, and biodiversity. In addition, we analyzed the current status and some technical limitations of physical habitat suitability evaluation, ecology-based water flow, eco-hydrological modeling for fish habitat connectivity, and the s/w program development for agent-based model. Numerous references, data, and various reports were examined to identify worldwide longitudinal stream connectivity evaluation models in European and non-European countries. The international approaches to longitudinal connectivity evaluations were categorized into five phases including 1) an approach integrating fish community and artificial structure surveys (two types input variables), 2) field monitoring approaches, 3) a stream geomorphological approach, 4) an artificial structure-based DB analytical approach, and 5) other approaches. the overall evaluation of survey methodologies and applicability for longitudinal stream connectivity suggested that the ICE model (Information sur la Continuite Ecologique) and the ICF model (Index de Connectivitat Fluvial), widely used in European countries, were appropriate for the application of longitudinal connectivity evaluations in Korean streams.

N-Screen 기반의 해양시설물용 모니터링 시스템 설계

김지윤,오진석,Kim, Ji-Yoon,Oh, Jin-Seok 한국정보통신학회 2015 한국정보통신학회논문지 Vol.19 No.3

급격하게 발전하는 IT 기술과 국내 해상에 넓게 분포된 해양시설물의 모니터링 시스템이 융합된 효율적인 모니터링 시스템은 필수적이다. 특히 스마트폰과 스마트패드의 보급 및 스마트 TV등의 등장은 다양한 기기 환경에서 편리하게 모니터링을 할 수 있는 환경을 제공하였고, 해양시설물의 관리자가 언제 어디서나 해양시설물을 모니터링 할 수 있게 하였다. 그러나 현재 이용되고 있는 스마트폰과 스마트패드 등은 제조사 및 적용되는 OS에 따라 다양한 환경내에서 모니터링 시스템의 서비스가 어렵다. 또한 각 디바이스별로 모니터링 시스템을 별도로 개발해야 하는 불편함이 있다. 이러한 문제점을 해결하기 위하여 NMMS(N-Screen Marine-facility Monitoring System)를 제안한다. NMMS는 효율적인 해양시설물의 모니터링 시스템을 위해 해양시설물의 전력 상태와 제어 상태를 실시간으로 확인 할 수 있는 실시간 모니터링 시스템과, 해양시설물의 고장진단을 확인할 수 있는 고장진단 시스템, 그리고 해양시설물의 모니터링 데이터를 장기간 저장 및 확인할 수 있는 데이터 저장 시스템으로 구성된다. NMMS는 최근 각광받는 웹 표준 언어인 HTML 5를 이용해 각종 디바이스에서 접근성을 용이하게 하였다. 본 논문에서 제안하는 NMMS를 이용하여 관리자 및 관리단체가 사용하고 있는 개인 PC, 노트북, 스마트폰, 스마트패드 등의 다양한 기기 및 다양한 OS의 종류에 제한받지 않고 해양시설물의 모니터링을 가능하게 하였다. The convergence of IT technology and marine facilities monitoring system is needed for effective monitoring systems to marine facilities. Especially the spread of smart device such as smart phone, smart pad, smart TV provide an environment that can check the status of the marine facility for marin facilities manager. However, smart phones and smart pads are used in a variety of OS used. Thus the monitoring system of the various service environments is difficult. In addition, There is inconvenience that must individually developed monitoring system for each device. In order to solve this problem NMMS (N-Screen Marine-facility Monitoring System) is proposed. NMMS is consist of Real-time monitoring system, Fault diagnosis system, Data storage system. To improve variety of smart devices accessibility, we use HTML 5. Through NMMS, marine facilities manager can use smart device such as PC, Notebook, smart phone, smart pad for marine facilities monitoring.

VR 기반 선원 안전교육용 콘텐츠 개발

김지윤,오진석,Kim, Ji-Yoon,Oh, Jin-Seok 한국정보통신학회 2022 한국정보통신학회논문지 Vol.26 No.12

Every year, many shipping companies provide seaman safety education programs periodically to reduce ocean-traffic accidents. However, undertaking the regular safety training for seaman has been difficult because of litimation of space and time. Recently, VR technolgy is received attentions to overcome previous problems. It can provide users educational interactions between a user and virtual environment and fulfill sustainable teaching. In this paper, VR-based safety education content for sailors has been developed, and it includes four programs. Also, survey was conducted with four questionnaires such as immersiveness, easy to experience, satisfaction of education contents, comparative evaluation between traditional education program and VR education contents. As the result, immersiveness questionnaire could be gain 53.83% positive assessment, and easy to experience could be gain 65.38% positive assessment, and satisfaction could be gain 69.23% positive assessment. Lastly, comparative evaluation between traditional education program and VR education contents could be gain about 46% positive and 34% neutral assessments.

A case of Bickerstaff's brainstem encephalitis in childhood

김지윤,김영옥,손영준,우영종,Kim, Ji-Youn,Kim, Young-Ok,Son, Young-Jun,Woo, Young-Jong The Korean Pediatric Society 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.4

Bickerstaff 뇌간 뇌염은(BBE) 4주 이내의 진행성이며, 비교적 대칭성으로 오는 안근 마비와 실조증, 의식 장애 또는 심부건 반사 항진 등의 임상적 특징을 가지며, 뇌간을 침범하는 타 질환을 배제하였을 때 진단할 수 있는 드문 질환이다. 혈청 또는 뇌척수액의 항 Ganglioside 항체(GM, GD and GQ) 는 때로 BBE의 진단에 도움이 되기도 하며, 뇌 자기 공명 영상, 뇌 척수액 검사, 신경 전도 검사 및 근 전도 검사 등은 진단에 크게 도움이 되지 않는다. 저자들은 안근 마비, 실조증, 언어 운동 장애, 연하 장애, 점진적 사지 마비, 의식 저하 등의 증상을 보이며 혈청과 뇌척수액에서 anti-GM1 항체의 증가를 보여 BBE로 진단하고 면역 글로불린과 스테로이드 치료 후 완치되었던 9세의 여아의 증례를 경험하였기에 문헌 고찰과 함께 이를 보고하는 바이다. Bickerstaff's brainstem encephalitis (BBE) is a rare disease diagnosed by specific clinical features such as 'progressive, relatively symmetric external ophthalmoplegia and ataxia by 4 weeks' and 'disturbance of consciousness or hyperreflexia' after the exclusion of other diseases involving the brain stem. Anti-ganglioside antibodies (GM, GD and GQ) in the serum or cerebrospinal fluid (CSF) are sometimes informative for the diagnosis of BBE because of the rarity of positive findings in other diagnositic methods: brain magnetic resonance imaging (MRI), routine CSF examination, motor nerve conduction study, and needle electromyography. We report a rare case of childhood BBE with elevated anti-GM1 antibodies in the serum, who had specific clinical symptoms such as a cranial polyneuropathy presenting as ophthalmoplegia, dysarthria, dysphagia, and facial weakness; progressive motor weakness; altered mental status; and ataxia. However, the brain MRI, routine CSF examination, nerve conduction studies, electromyography, somatosensory evoked potentials, and brainstem auditory evoked potentials were normal. BBE was suspected and the patient was successfully treated with intravenous immunoglobulins.

보건소의 방문보건재활업무 수행정도와 관련요인에 관한 연구

김지윤,Kim, Ji-Yun 한국지역사회간호학회 1999 지역사회간호학회지 Vol.10 No.1

Persons with disabilities have increased and among others, number of them in the community is at the high proportion. But they have a difficulty in physical, psychological adjusting and they don't be offered appropriate, sufficient rehabilitation services. Therefore, Community-Based Rehabilitation Services in Health Center be needed. With these backgrounds, this study was conducted to examine factors in relation to job performance of community-based rehabilitation program in Health Centers, and the factors are characteristics of district nurses, internal factors, external-environmental factors. This study provides guidelines for effective management for rehabilitation program. Subject in this study were 122 Health Centers randomly chosen. Data were collected from September, 16, 1998 to October, 9, 1998, and the data for analyses were ones of 105 respondents. The instrument of this study was job performance of community-based rehabilitation program is modified WHO guidelines. Credibility of instruments was 0.73-0.95 in main study. The summary of results was as follows. First, the mean of job performance of com munity-based rehabilitation program was 2.33 of full score 4.00. Significant differences were not obtained on the job performance among areas. Second, stepwise multiple regression analysis revealed that the most powerful predictor to job performance was community-based health program. The number of volunteer workers, the score of cooperation with other institution, the number of visiting nurse, the number of facilities for person with disabilities are accountable factor to the job performance of community-based rehabilitation program. In conclusions, for all the people with disabilities, Health Centers are necessary to promote community-based rehabilitation program and to increase participation of community residents and to cooperate with other institution.

단호박을 첨가하여 제조한 막걸리의 품질특성 및 항산화 활성

김지윤,송민규,전은비,박신영,Kim, Ji Yoon,Song, Min Gyu,Jeon, Eun Bi,Park, Shin Young 한국식품위생안전성학회 2021 한국식품위생안전성학회지 Vol.36 No.3

본 연구에서는 항산화 효능과 관능적 특성이 강화된 막걸리 제조를 위해 통단호박을 직접 찐 후 비율별로 첨가하여 막걸리를 제조하였다. 단호박 막걸리 제조를 위해 단호박을 쌀 중량의 5%, 10%, 20% 및 30%를 첨가하였으며 발효 및 담금 후 9일간 단호박 막걸리의 이화학적(pH, 총산 및 알코올), 미생물학적(유산균 및 효모수) 및 항산화 활성을 조사하였다. pH의 경우 모든 실험군에서 발효 및 저장기간이 늘어날수록 점차 낮아졌으며 9일차에는 단호박 무첨가군인 대조군(3.27)에 비해 단호박 첨가군(3.28-3.52)이 다소 높은 결과를 보였다. 총산도는 1일차(0.09-0.55) 및 3일차(0.81-0.86)에 급격히 증가하였으며, 그 후 서서히 증가하여 9일차에는 단호박 첨가군에서 1.16-1.32의 결과를 보였다. 알코올 함량은 9일차에 대조군 0%가 4.59로 가장 낮았고 단호박 5-30% 첨가군에서 5.20-5.77%로 단호박 첨가량이 많아질수록 알코올 함량이 높았다. 유산균수 측정의 경우 발효초반에 증가하는 양상을 보이다가 5일차부터 다소 감소하거나 유사하여 9일차에는 단호박 첨가 0-30% 첨가군에서 7.95-8.09 log CFU/g로 나타났으며, 효모수의 경우 발효가 진행될수록 증가와 감소를 다소 반복하였으며 9일차에는 7.68-7.99 log CFU/g으로 측정되었다. DPPH 및 ABTS 라디칼 소거능은 단호박 30% 첨가군에서 85.96 및 78.97%로 각각 측정되어 단호박 무첨가군의 DPPH (48.29%) 및 ABTS (62.12%) 결과와 비교 시 높은 항산화 활성도를 보였다. 따라서 추후 단호박 첨가에 따른 각종 비타민류, 무기질 및 β-carotene 등의 영양·기능성 성분의 분석과 더불어 소비자의 관능평가 등을 통해 항산화 기능이 강화된 단호박 막걸리의 실용화를 위한 구체적인 연구개발의 확대가 필요할 것으로 사료된다. Sweet pumpkin is rich in minerals such as calcium, phosphorus and fiber, and also contains a large amount of β-carotene, which has antioxidant effects. In this study, Makgeolli containing steaming sweet pumpkin (SP) was manufactured to enhance the antioxidant activity. To prepare the Makgeolli, SP was added in amounts of 5, 10, 20, and 30% (w/w), and the chemical (pH, total acidity, alcohol), microbiological (lactic acid bacteria, yeast) properties, and antioxidant activities (DPPH, ABTS) were examined during fermentation and storage for 9 days. The pH of SP Makgeolli was 4.00-4.23 at day 1 of fermentation, and then the pH gradually decreased as fermentation progressed, showing the lowest results at day 9 (3.28-3.52). At day 1, the total acidity was significantly increased (P<0.05) as the amount of SP (0-30%; 0.09-0.55%) and the total acidity in SP Makgeolli (1.01-1.20) was also rapidly increased by 5 days of fermentation. Alcohol content was significantly increased (P<0.05) as the amount of SP (0-30%; 4.59-5.77%) increased at day 9. The counts of lactic acid bacteria and yeast in SP Makgeolli were 8.0-8.1 and 7.9-7.8.0 CFU/mL, respectively, which was higher than SP 0% at day 9. DPPH and ABTS radical scavenging activities were significantly increased (P<0.05) as the amount of SP (0-30%; 48.29-78.97% for DPPH, 62.12-86.68% for ABTS) increased at day 9. This study suggests that Makgeolli added with SP could be potentially and commercially developed due to its superior microbiological and chemical properties, including high antioxidant activities.

소실모형이 탄소강 및 회주철 주물의 표면층 조직에 미치는 영향

김지윤,조남돈 ( Ji Youn Kim,Nam Don Cho ) 한국주조공학회 1992 한국주조공학회지 Vol.12 No.4

N/A Steel and iron castings made with expandable polystylene (referred to hereafter as EPS) patterns are often affected by distinctive defects associated with incomplete decomposition of the EPS as the molds are filled with metal. The effects of practical factors on carbon pick-up were investigated on the specimens, by taking successive layers of swarf and analysis, whereas the lustrous carbon is determined by using combustion analysis. The quality of the castings, with particular reference to carbon pick-up in low carbon steel and lustrous carbon on gray iron, is further influenced to a significant extent by such practical factors as reduced pressure, the pouring temperature, the density of EPS pattern, the additive in coating and in pattern and the casting thickness. The rate at which carbon pick-up and lustrous carbon deposites are formed can be reduced by reducing the density of the pattern and also reducing pressure, especially by adding Na₂CO₃in coating and in pattern to promote CO₂evolution. The upper parts of castings obtained using EPS patterns are slightly higher in carbon pick-up and in lustrous carbon than other parts.

Development of High Intensity Focused Ultrasound (HIFU) Mediated AuNP-liposomal Nanomedicine and Evaluation with PET Imaging

김지윤,신운철,박지용,유란지,Soeku Bae,Tae Hyeon Choi,Kyuwan Kim,Young Chan Ann,Jin Sil Kim,Yu Jin Shin,이호규,이용진,이교철,김성욱,이윤상 대한방사성의약품학회 2023 Journal of radiopharmaceuticals and molecular prob Vol.9 No.1

Liposomes as drug delivery system have proved useful carrier for various disease, including cancer. In addition, perfluorocarbon cored microbubbles are utilized in conjunction with high-intensity focused-ultrasound (HIFU) to enable simultaneous diagnosis and treatment. However, microbubbles generally exhibit lower drug loading efficiency, so the need for the development of a novel liposome-based drug delivery material that can efficiently load and deliver drugs to targeted areas via HIFU. This study aims to develop a liposome-based drug delivery material by introducing a substance that can burst liposomes using ultrasound energy and confirm the ability to target tumors using PET imaging. Liposomes (Lipo-DOX, Lipo-DOX-Au, Lipo-DOX-Au-RGD) were synthesized with gold nanoparticles using an avidin-biotin bond, and doxorubicin was mounted inside by pH gradient method. The size distribution was measured by DLS, and encapsulation efficiency of doxorubicin was analyzed by UV-vis spectrometer. The target specificity and cytotoxicity of liposomes were assessed in vitro by glioblastoma U87mg cells to HIFU treatment and analyzed using CCK-8 assay, and fluorescence microscopy at 6-hour intervals for up to 24 hours. For the in vivo study, U87mg model mouse were injected intravenously with 1.48 MBq of 64Cu-labeled Lipo-DOX-Au and Lipo-DOX-Au-RGD, and PET images were taken at 0, 2, 4, 8, and 24 hours. As a result, the size of liposomes was 108.3 ± 5.0 nm at Lipo-DOX-Au and 94.1 ± 12.2 nm at Lipo-DOX-Au-RGD, and it was observed that doxorubicin was mounted inside the liposome up to 52%. After 6 hours of HIFU treatment, the viability of U87mg cells treated with Lipo-DOX-Au decreased by around 20% compared to Lipo-DOX, and Lipo-DOX-Au-RGD had a higher uptake rate than Lipo-DOX. In vivo study using PET images, it was confirmed that 64Cu-Lipo-DOX-Au-RGD was taken up into the tumor immediately after injection and maintained for up to 4 hours. In this study, drugs released from liposomes-gold nanoparticles via ultrasound and RGD targeting were confirmed by non-invasive imaging. In cell-level experiments, HIFU treatment of gold nanoparticle-coupled liposomes significantly decreased tumor survival, while RGD-liposomes exhibited high tumor targeting and rapid release in vivo imaging. It is expected that the combination of these models with ultrasound is served as an effective drug delivery material with therapeutic outcomes.

소실모형 주조법에서 도형제가 오스테나이트 스테인레스강 주물의 표면층조직에 미치는 영향

김지윤,조남돈 ( Ji Youn Kim,Nam Don Cho ) 한국주조공학회 1995 한국주조공학회지 Vol.15 No.6

N/A Austenitic stainless steel castings using expandable polystylene(referred to hereafter as EPS) patterns are often affected by distinctive defects associated with incomplete decomposition of the EPS as the molds are filled with metal. The quality of the castings, with particular reference to carbon pick-up in austenitic stainless steel is further influenced to a significant extent by such factors as reduced pressure, the additive by adding Na₂CO₃in coating. The steel composition and microstructure were examined at the surface layer of castings, at depths of 1mm, by taking successive layers of swarf and analysis. In experiments, the carburizing atmosphere was neutralized, showing that the coating performed efficiently by decomposing almost instantly on heating and liberating CO₂. The upper parts of castings obtained using EPS patterns were slightly higher in carbon pick-up than other parts. Comparing the 316L and 304 stainless steel castings, qualitative and quantative differences could be found between the carbon pick-up behaviours as influence of the carbon content and alloying elements. Carbide former such as Cr makes carbon more soluble in the steel. This must make carbon pick-up in the surface layer but at the same time richer in carbon especially in the 304 stainless steel castings.