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김재준(Jae Jun Kim),고광철(Kwang Cheol Koh),김태호(Tae Ho Kim),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한내과학회 1994 대한내과학회지 Vol.46 No.3
N/A Objectives: The effect of continued supplementation of diet with 10gp sucrose, lactose or glucose solution on rat intestinal disaccharidase specific activity was investigated. Methods: Adult rats were fed a diet with 10% sucrose, lactose or glucose solution supplementation. After 6 weeks, small intestines were removed and disaccharidase specific activities and sucrose mRNA levels were measured. Results: Adult rats when fed a diet with 10% sucrose, lactose or glucose solution supplementation for 6 weeks showed increased intestinal sucrose sperific activity. However, there was no increase of lactase specific activity. Slot blot analysis with radiolabeled rat intestinal sucrase cDNA revealed that mRNA levels of sucrase increased after 10% sucrose, lactose or glucose solution supplementation, and these changes in mRNA levels correlated with the corresponding enzyme specific activity (r=0.36, p<0.05). Conclusion: The results demonstrate that the induction of sucrase activity is directly associated with an increase in sucrase mRNA levels. In conclusion, substrate feeding induces an increase of transcription of rat intestinal sucrase gene.
한국인 태아 및 성인에서 유당분해효소 mRNA 의 발현양상
김재준(Jae Jun Kim),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한내과학회 1997 대한내과학회지 Vol.52 No.5
N/A Objective: The specific activity of lactase-phlorizin hydrolase (LPH) is very high at birth and sharply declines after weaning, producing lactose intolerance. The prevalence of lactose intolerance is up to 85% in Korean adults. Molecular basis of the regulatory mechanisms responsible for the decline of LPH specific activity is still unknown. In order to elucidate the molecular mechanisms regulating the LPH expression during development, LPH specific activity and mI4NA level of Korean fetal and adult intestines were compared. Methods: 20 fetal small intestines (16-27 weeks) were obtained during therapeutic abortion and were divided into 3 equal length. 20 adult jejunal tissues were obtained from patients without small intestinal disease during laparotomy. Mucosal homogenates were prepared for dissacharidases specific activities measurement and total RNA was extracted for northern and slot hvbridization. LPH mRNA level was measured by laser densitometer. Results: LPH specific activities of proximal, middle and distal portion of fetal intestines (n=20) were 36.2±22.5, 38.6±23.2 and 23.2±19.9 mu/mg protein, respectively. LPH specific activity of adult jejunum (n=8) was 5.9±1.8 mu/mg protein and significantly (p<0.05) lower than those of fetal intestines. However, there was no significant difference in sucrase and trehalase specific activities between fetal intestines and adult jejunum. Although LPH specific activity of adult jejunum was lower than those of fetal intestines, LPH mBNA level of adult jejunum was as high as those of fetal intestines. Conclusion: These results show that LPH specific activity and mRNA level do not parallel, indicating the posttranscriptional control of fetal development of LPH expression.
김재준(Jae Jun Kim),정성일(Sung Il Jung),김정은(Jung Eun Kim),윤서영(Seo Young Yoon),김준원(Jun Won Kim),최태영(Tae Young Choi),이종훈(Jong Hun Lee) 대한생물치료정신의학회 2017 생물치료정신의학 Vol.23 No.3
Objectives:The aim of this study was to examine the physical, psychological and social factors influencing quality of life of the elderly living alone in Daegu. Methods:A stratified random cluster sample of 625 community-dwelling old people living alone in Daegu completed a questionnaire through face-to-face interview. Quality of life was evaluated using the World Health Organization quality of life-brief(WHOQOL-BREF) questionnaire. Depression was measured using the geriatric depression scale short form-Korea(GDSSF-K). The other data including sociodemographic characteristics, emotional and economical support, perceived health status and activity of daily living were collected. The data were analyzed using independent t-test, ANOVA, multiple regression analysis to evaluate the relationship between quality of life and other variables. Results:Subjects were composed of 107 male(17.1%) and 518 female(82.9%) and their mean age was 75.5 (SD= 5.8). Multiple regression analysis showed that quality of life was significantly associated with depression, psychiatric illness, educational level, income level, presence of caregiver, and whether living alone was a voluntary decision. Depression was the most influential factor affecting quality of life. Participants suffering more severe depression had lower quality of life. Conclusion:Present study suggested that the quality of life in the elderly living alone should be recognized in a multiple perspective ways considering psychosocial approach as well as clinical symptoms. We also would like to emphasize the comprehensive multidisciplinary team approach for improvement of the quality of life in elderly people who live alone.
Trinitrobenzene Sulfonic Acid에 의해 유발된 백서의 대장염에서 항염증제제의 치료효과
김재준(Jae Jun Kim),류지곤(Ji Kon Ryu),이동호(Dong Ho Lee),송인성(In Sung Song),김정룡(Chung Yong Kim),김용일(Yong Il Kim) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.2
N/A Background/Aims: The causes and pathogenesis of inflammatory bowel disease remain unknown and no definite therapy exists until now. In order to clarify the effect of Artemisia capillaris, colitis was induced by trinitrobenzene sulfonic acid(TNBS) in rats, and the effect of anti-inflammatory drugs and Artemisia capillaris was compared. Methods: Wel]-grown Sprague-Dawley rats were divided into 7 groups and colitis was induced by TNBS except the control group. Each group was treated with 1% methyl ce]lulose, prednisolone l mg/kg, sulfasalazine 100 mg/kg, prednisolone and sulfasalazine, A.capillaris 1 mg/kg and 10 mg/kg per oral route from the next day. After 2 weeks, rats were sacrificed and gross morphologic features of colons were examined. Resullts: Ulceration, adhesion, thickening and dilatation were noticed in the colonic mucosa after TNHS insti]lation. Adhesion, thickening and di]atation were significantly improved in all the treated groups, but the ulceration was significantly improved only in groups treated by prednisolone and A.capillaris 10mg/kg. Conclusions: The colitis induced by TNBS is sirnilar to the human inflammatory bowel disease and the prednisolone and A.capillaris have a healing effect on rat colitis induced by TNBS. (Korean J Gastroenterol 1996; 2S:224 - 231)