http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
권영이(Y. E. Kwon),황규자(K. J. Whang),김안근(A. K. Kim),김국환(K. H. Kim),김원규(W. K. Kim),안동춘(D. C. Ahn) 대한약학회 2000 약학회지 Vol.44 No.2
Flavin mononucleotide (1,4-butanediamine) Pt(II) complex (7FMN) was synthesized and screened anticancer activity [J.Pharm.Soc.Korea 43(6), 762-770 (1999)]. 7FMN have good water solubility and moderate anticancer activity. In this paper, cell-cycle specificity and nephrotoxicity were studied. Interaction of DNA with cisplatin and synthesized 7FMN was analyzed by flow cytometry, and showed G2 arrest in L1210 cell fine. It means that cell-cycle on L1210 was inhibit in S phase by cisplatin and 7FMN. In order to biochemically analyze nephrotoxicity of cisplatin and 7FMN, after injecting each agent intrapenritoneary, blood was exsangumated after 6 hours, 1 day, 3 days and 7 days, respectively. Then, serum was separated from the blood. The serum level of BUN, creatinine and uric acid in cisplatin and 7FMN administrated mice (25-35g, ICR strain, a dose each 8, 12 and 16 times of the IC50 value, cisplatin; 7 times) were determined by autochemistry analyzer. In cisplatin-administered mice group, BUN level was elevated than normal control group at 3rd day and repaired at 7th day. In 7FMN administrated group was not elevated. Crea@e and uric acid level were no difference with the normal control group. Therefore synthesized 7FMN is less toxic than cisplatin in nephrotoxicity.