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타액선 다형성 선종에서 Glycosaminoglycan의 발현
김성주,김철환,김경욱,Kim, Seong-Joo,Kim, Chul-Hwan,Kim, Kyung-Wook 대한악안면성형재건외과학회 2006 Maxillofacial Plastic Reconstructive Surgery Vol.28 No.1
Pleomorphic adenoma is the most common benign tumor in salivary glands, and occurred in frequency of 60% in parotid gland tumors, and 50% in submandibular gland tumors, and 25% in sublingual gland tumors. Histopathologically, pleomorphic adenoma is composed of epithelial cells and mesenchymal tissues, and called 'mixed tumor' because of morphological divergency. The cell structures of luminal area are composed of polyhedral and cuboidal secretory epithelial cells and modified myoepithelial cells around it, and mesenchymal tissue is composed of some myoepithelial cells and stromal tissue. In stromal tissue, myxoid change, chondroid change, or hyalinization can be seen even if bone tissue. In many studies, tumor cells of pleomorphic adenoma containing modified myoepithelial cell participate in synthesis of glycosaminoglycans. In this study, tissue sample of pleomorphic adenoma of human salivary gland were obtained from 20 surgical specimens, and all specimens were routinely fixed in 10% formalin and embedded. Serial 4-8${\mu}m$ thick sections were cut from paraffin blocks. The histopathologic evaluation was done with light microscopy. And, with immunohistochemical staining, characteristics of glycosaminoglycan were observed. And, for biochemical analysis of glycosaminoglycan, isolation of crude glycosaminoglycan from tumor tissue and immuno-blot analysis were carried out. With transmission electromicroscopy, tumor cells and biologic behavior of pleomorphic adenoma were observed with distribution and expression of glycosaminoglycan in tumor cells, The results were obtained as follows: 1. In immunohistochemical study, chondroitin 4-sulfate is highly postively stained in myxoid stromal tissue, and chondroitin 6-sulfate is highly positively stained in chondroid mesenchymal tissue, both glycosaminoglycans are positively stained in non-luminal cell of ductal area. 2. Dermatan sulfate and keratan sulfate is positively stained in periductal non-luminal tumor cells. 3. In immunohistochemical study, heparan sulfate is weakly stained in luminal cells and non-luminal cells around duct, and chondroid mesenchymal tissue. 4. In transmission electromicroscopic view, the tumor cells are composed of modified myoepithelial cells, and contain many microfilaments and well developed rough endoplasmic reticulum. 5. In Immuno-Blot analysis, the expression of glycosaminoglycans is expressed mostly in chondroitin 6-sulfate and chondroitin 4-sulfate. From the results obtained in this study, tumor cells of pleomorphic adenoma are composed of modified myoepithelial cells, and glycosaminoglycans of chondroitin 4-sulfate and chondroitin 6-sulfate mostly participate in the development of pleomorphic adenoma, but dermatan sulfate, keratan sulfate and heparan sulfate glycosaminoglycans were expressed variably.
타액선 다형성 선종에서 Glycosaminoglycan의 발현
김성주,김철환,김경욱,Kim, Seong-Joo,Kim, Chul-Hwan,Kim, Kyung-Wook 대한악안면성형재건외과학회 2006 Maxillofacial Plastic Reconstructive Surgery Vol.28 No.2
Pleomorphic adenoma is the most common benign tumor in salivary glands, and occurred in frequency of 60% in parotid gland tumors, and 50% in submandibular gland tumors, and 25% in sublingual gland tumors. Histopathologically, pleomorphic adenoma is composed of epithelial cells and mesenchymal tissues, and called 'mixed tumor' because of morphological divergency. The cell structures of luminal area are composed of polyhedral and cuboidal secretory epithelial cells and modified myoepithelial cells around it, and mesenchymal tissue is composed of some myoepithelial cells and stromal tissue. In stromal tissue, myxoid change, chondroid change, or hyalinization can be seen even if bone tissue. In many studies, tumor cells of pleomorphic adenoma containing modified myoepithelial cell participate in synthesis of glycosaminoglycans. In this study, tissue sample of pleomorphic adenoma of human salivary gland were obtained from 20 surgical specimens, and all specimens were routinely fixed in 10% formalin and embedded. Serial 4-8${\mu}m$ thick sections were cut from paraffin blocks. The histopathologic evaluation was done with light microscopy. And, with immunohistochemical staining, characteristics of glycosaminoglycan were observed. And, for biochemical analysis of glycosaminoglycan, isolation of crude glycosaminoglycan from tumor tissue and immuno-blot analysis were carried out. With transmission electromicroscopy, tumor cells and biologic behavior of pleomorphic adenoma were observed with distribution and expression of glycosaminoglycan in tumor cells, The results were obtained as follows: 1. In immunohistochemical study, chondroitin 4-sulfate is highly postively stained in myxoid stromal tissue, and chondroitin 6-sulfate is highly positively stained in chondroid mesenchymal tissue, both glycosaminoglycans are positively stained in non-luminal cell of ductal area. 2. Dermatan sulfate and keratan sulfate is positively stained in periductal non-luminal tumor cells. 3. In immunohistochemical study, heparan sulfate is weakly stained in luminal cells and non-luminal cells around duct, and chondroid mesenchymal tissue. 4. In transmission electromicroscopic view, the tumor cells are composed of modified myoepithelial cells, and contain many microfilaments and well developed rough endoplasmic reticulum. 5. In Immuno-Blot analysis, the expression of glycosaminoglycans is expressed mostly in chondroitin 6-sulfate and chondroitin 4-sulfate. From the results obtained in this study, tumor cells of pleomorphic adenoma are composed of modified myoepithelial cells, and glycosaminoglycans of chondroitin 4-sulfate and chondroitin 6-sulfate mostly participate in the development of pleomorphic adenoma, but dermatan sulfate, keratan sulfate and heparan sulfate glycosaminoglycans were expressed variably.
김성주,서재용,조현찬,김성현,김홍태,Kim, Seong-Joo,Seo, Jae-Yong,Cho, Hyun-Chan,Kim, Seong-Hyun,Kim, Hong-Tae 대한전자공학회 2002 電子工學會論文誌-CI (Computer and Information) Vol.39 No.6
웨이블릿 함수의 경우 스케일링 함수에서 비롯되었으며, 스케일과 중심을 결정함으로써 신경회로망의 노드로 구성된다. 본 논문에서는 웨이블릿 함수를 이용하여 망을 구성하는 과정에 스케일링 함수를 은닉층의 노드로 복합 구성한 구조를 제안하고자 한다. 제안한 구조의 특징은 스케일링 함수를 이용하여 대강 근사(rough approximation)를 행한 다음, 웨이블릿 함수를 이용하여 미세 근사(fine approximation)를 행하도록 신경회로망의 은닉층을 복합 구성하는 데 있다. 또한, 복합 신경회로망을 구성하는 과정에서 미세 근사에 필요한 웨이블릿 함수의 개수를 유전 알고리즘을 이용하여 결정하는 초기 구조의 최적화를 도모하고자 한다. The wavelet functions are originated from scaling functions and can be used as activation function in the hidden node of the network by deciding two parameters such as scale and center. In this paper, we would like to propose the mixed structure. When we compose the WNN using wavelet functions, we propose to set a single scale function as a node function together. The properties of the proposed structure is that while one scale function approximates the target function roughly, the other wavelet functions approximate it finely. During the determination of the parameters, the wavelet functions can be determined by the global search algorithm such as genetic algorithm to be suitable for the suggested problem. Finally, we use the back-propagation algorithm in the learning of the weights.
성인에서 눈꺼풀속말림과 눈꺼풀겉말림 환자에서 발생원인과 치료방법에 대한 분석
강선아,박태성,이정혜,장재우,김성주,최혜선,Sunah Kang,MD,Tae Seong Park,MD,Jung Hye Lee,MD,Jae Woo Jang,MD,Sung Joo Kim,MD,Hye Sun Choi,MD 대한안과학회 2014 대한안과학회지 Vol.55 No.7
<b>Purpose:</b> To evaluate the causes and treatments of entropion and ectropion in adults. <b>Methods:</b> A retrospective review was performed of 397 patients (490 eyes) with entropion and 109 patients (138 eyes) with ectropion who underwent corrective surgery at Kim's Eye Hospital from January 2009 to December 2012. <b>Results:</b> The surgical correction of entropion was 3.5 times greater than that of ectropion. The causes of entropion were classified as senile (98.4%), cicatricial (1.4%) and spastic (0.2%). The causes of ectropion were classified as cicatricial (60.1%), paralytic (23.2%) and senile (16.7%). <b>Conclusions:</b> The main causes of entropion and ectropion were senile and cicatricial, respectively. Specifically, senile entropion was more common than senile ectropion, which is considered to be related to the lid anatomy of Asian patients. J Korean Ophthalmol Soc 2014;55(7):953-957
김성주(Seong-Joo Kim) 한국지능시스템학회 2006 한국지능시스템학회 학술발표 논문집 Vol.16 No.1
The system that can generate biological brain information processing mechanism more precisely may have several abilities such as exact cognition, situation decision, learning and inference, and output decision. In this paper, to implement high level information processing and thinking ability in a complex system, the information processing layer based on the biological brain is introduced. The biological brain information processing mechanism, which is analyzed in this paper, provides fundamental information about intelligent engineering system, and the design of the layer that can mimic the functions of a brain through engineering definitions can efficiently introduce an intelligent information processing method having a consistent flow in various engineering systems. The applications proposed in this paper are expected to take several roles as a unified model that generates information process in various areas, such as engineering and medical field, with a dream of implementing humanoid artificial intelligent system.
김성주(Seong-Joo Kim),김종수(Jong-Soo Kim),전홍태(Hong-Tae Jeon) 한국지능시스템학회 2004 한국지능시스템학회 학술발표 논문집 Vol.14 No.2
인간의 뇌와 같이 다양한 정보들을 구분하고 처리하며 기억할 수 있는 능력을 지닌 시스템은 현재 지능 기법이 적용되고 있는 제어, 통신, 인터넷 응용 기술, 경영 분야, 분석 및 예측 등의 분야에 응용될 수 있으며 그 성능을 효과적으로 향상시킬 것이다. 이러한 다양한 분야에 활용될 수 있는 통합 모델을 제시하고 점차 발전시켜나감으로써 미래에 기대되는 다양한 인간형 시스템, 친환경적 시스템, 인간보조 시스템 등의 공학적 시스템 측면과 인간을 대신할 수 있으면서 인간과 유사한 능력을 지닌 학습 시스템, 추론 시스템, 판단 시스템 등의 지능형 시스템 측면에서 활용 가능한 모델로 성장시켜 나갈 수 있다. 이에, 본 논문에서는 생물학적인 두뇌의 정보처리 메커니즘을 해석하고 공학적인 개념의 정립과 정보처리 흐름을 규명하고 정의함으로써 출력에 반영할 수 있는 모듈을 설계하고 최종적으로, 뇌 정보처리 메커니즘에 기반한 레이어를 설계하여 범용으로 사용될 수 있도록 하고자 한다. 본 논문에서 설명되는 레이어 구조는 공학적인 분야는 물론 생물학적 뇌 연구에도 활용될 수 있을 것으로 기대된다.