멕켈 세포 암종 환자의 치험례: 전방 외측 대퇴부 천공지 유리 피판술을 이용한 재건

김규남,김태곤,김훈,강병수,홍준표,Kim, Kyu-Nam,Kim, Tae-Gon,Kim, Hoon,Kang, Byoung-Su,Hong, Joon-Pio 대한미세수술학회 2009 Archives of reconstructive microsurgery Vol.18 No.1

Purpose: Merkel cell carcinoma, also called neuroendocrine carcinoma, is a very rare type of skin cancer that develops as Merkel cells grow out of control. Merkel cell carcinoma is reported below 1% of whole skin neoplasms in the United States and is known that the 2-year survival rate is about 50~70%. The principles of treatment are wide excision of primary lesion with radiotherapy and/or chemotherapy that decrease the local recurrent rate. There has been no report of reconstruction with free flap after resection of Merkel cell carcinoma in Korea. Methods: We reconstructed the skin and soft tissue defect after wide excision of Merkel cell carcinoma with anterolateral thigh perforator free flap in two cases. No distant metastasis was found at the preoperative imaging work-up. In one case, preoperative chemotherapy was performed and the size of lesion was decreased. Results: There were no recurrence and significant complications. Functionally and aesthetically satisfactory results were obtained with reconstruction. Conclusion: Wide excision and reconstruction with anterolateral thigh perforator free flap for Merkel cell carcinoma patient is the first report in Korea. We regard this method as the treatment of choice in Merkel cell carcinoma.

횡복직근피판술을 이용한 즉시 유방재건과 동시 혹은 후에 시행한 복강 내 수술

김규남,이택종,Kim, Kyu-Nam,Lee, Taik-Jong 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.1

Purpose: As patients who take immediate breast reconstructions with TRAM flap have increased, concomitant or delayed other elective intra-abdominal operations in these patients also have increased. There are few reports of concomitant or delayed intra-abdominal operation in TRAM flap patients. We report our experiences and outcomes of these operations which is safe and feasible. Methods: We reviewed the charts and postoperative follow-up results of 11 patients among 471 consecutive patients who took immediate breast reconstruction with TRAM flap from December of 2002 to September of 2006. Four patients took concomitant intra-abdominal operation and 7 patients took delayed intra-abdominal operation between 1 to 52 months after TRAM flap Results: There were no significant postoperative abdominal and systemic complications. One patient who took concomitant intra-abdominal operation presented partial skin necrosis of abdomen, but recovered completely with conservative treatments. Two patients took transfusion in peri-operative periods. Conclusion: Concomitant or delayed intra-abdominal operation in immediate breast reconstruction with TRAM flap could be performed safely and feasibly when it is necessary. Furthermore, it could be helpful to patients and surgeons.

하지의 작거나 중등도의 결손 부위 재건을 위한 얕은엉덩휘돌이동맥 천공지 유리 피판술

김규남,정우식,홍준표,윤치선,Kim, Kyu Nam,Jeong, Woo Shik,Hong, Joon Pio,Yoon, Chi Seon 대한미세수술학회 2013 Archives of reconstructive microsurgery Vol.22 No.1

Purpose: For reconstruction of lower extremity defects, various flaps can be used and the appropriate flap must be selected and applied according to the size of the defect. In particular, in cases where the defect size is small to moderate, thinner or smaller volume flaps are useful. The authors performed reconstruction of small to moderate defects on the lower extremities using superficial circumflex iliac artery perforator free flaps and are reporting the results. Materials and Methods: Fifteen patients underwent reconstruction of defects on lower extremity areas using superficial circumflex iliac artery perforator free flaps from July 2011 to July 2012 at this hospital. The flaps were elevated from above the deep fat layer, and, in all cases, the vessel diameter of the flaps was less than 1mm, with the exception of superficial vein that accompanied it. Results: The mean follow up period was 4.46 months, and, despite a partial loss in the flap in two cases, there were no total losses. All donor sites were closed with primary closure, and there was no occurrence of complications, such as hematomas, seromas, or lymphorrheas. The patients were highly satisfied with the donor site scar since it could be masked by underwear. Conclusion: Compared to other flaps, superficial circumflex iliac artery perforator free flaps are thinner in thickness and smaller in volume, which results in a more natural contour of the recipient site after the operation. In addition, since the flap can be elevated from supra-deep fat layer, the operation time can be shortened, and lymphorrhea can be prevented, which in turn lessens donor-site morbidity.

정부기관 항공전문인력의 조직몰입특성과 직무만족에 대한 연구 : 해양경찰청 항공인력을 중심으로 Focused on Aviation Workers of The Korean Coast Guard

김규남 ( Kyu Nam Kim ),안영수 ( Young Soo Ann ) 한국항공경영학회 2008 한국항공경영학회지 Vol.6 No.2

프로바이오틱스(probiotics)에 대한 흔한 질문과 근거 중심 답변

김규남(Kyu-Nam Kim) 대한기능의학회 2022 Journal of Korean Institute for Functional Medicin Vol.5 No.1

Probiotics are living microorganisms that have beneficial effects on the human body. Food eaten by probiotics is called prebiotics, and the metabolites produced by probiotics are called postbiotics. The number of bacteria indicated on probiotic products means the guaranteed number of bacteria remaining until the expiration date. There seems to be no difference in the effects of probiotics depending on the material from which they are obtained. In general, the strains of probiotics consumed are diverse, and the greater the number of bacteria, the better the effect will be, but more research is needed. It is difficult to say that ingested probiotics must be excreted in the feces to be effective, but the higher the detection rate in feces, the better it seems to have settled in the intestinal mucosa. Finally, it seems that probiotics taken before meals have a higher rate of intestinal delivery than those taken after meals.

PP / MMT 복합체의 분산특성에 관한 연구

김규남(Kyu Nam Kim),김형수(Hyung Su Kim) 한국고분자학회 2000 폴리머 Vol.24 No.3

가치성향을 고려한 벤처기업 종업원의 인적자원관리방안에 대한 연구

김규남(Kyu Nam Kim) 한국국제통상학회 2002 국제통상연구 Vol.7 No.1

The purpose of this study is to find the HRM practices based on individual value orientation in employees of Korean Venture Businesses. We analyzed the characteristics of Organizational Commitment and the mediating effects of individual values in employees of Korean Venture Businesses. The results show that the level of individualism was increased but that of long-term orientation was decreased. And the individualism was negatively correlated with Affective Commitment(AC) but long-term orientation was positively correlated with Continuence Commitment(CC). Tenure was found to be positively correlated to AC. Formalization and centralization were found to be negatively correlated to AC and CC but negatively mediated to AC by individualism. These results would have two practical implications. First, the korean venture businesses need to emphasize individual motivation and economic incentives rather than forcing loyalty to individual employees to build a efficient HRM systems because the level of individualism was raised. It is also recommended that the firms should emphasize proper evaluating and compensating systems through fair rules and procedures, keeping individual autonomies and communications.

장내 세균 불균형과 비만

김규남(Kyu-Nam Kim) 대한기능의학회 2020 Journal of Korean Institute for Functional Medicin Vol.3 No.2

According to recent research results, approximately 40 trillion bacteria exist in the human gut, and this gut microbiota interact with our body from birth and contribute to maintaining our health. In order to maintain healthy gut microbiota, there are dietary habits such as a low fat and a high fiber diet. The preference of a high fat or a low fiber diet, and antibiotic ingestion is the cause of the gut dysbiosis. Gut dysbiosis leads to decreased production of secondary bile acids, decreased production of short-chain fatty acids, and inflammation, which contributing to the onset of obesity. Therapeutic strategy using beneficial bacteria and non-absorbable antibiotics has been studied as a clinical approach for the treatment of gut dysbiosis, but this application did not cause clinically significant weight change. However, since the metabolic indicators related to obesity have improved, it is necessary to develop a therapeutic approach to gut dysbiosis in the treatment of obesity. In addition, there are not many studies on the analysis of intestinal bacteria at the species level or strain level related to intestinal bacterial imbalance, so further studies are needed to be conducted. Herein, the author reviews studies linking gut microbiome to obesity, as well as studies analyzing their associated mechanisms and treatments. 최근 연구 결과에 의하면 사람의 장내에는 40조에 가까운 균이 존재하며 이러한 장내 세균은 사람이 태어나면서부터 우리 몸과 상호작용을 하며 우리의 건강을 유지하는데 기여한다. 건강한 장내 세균을 유지하기 위해서는 저지방 식이와 고섬유질 식이 등의 식습관이 있는데 고지방 식이나 저섬유질 식이의 선호는 문 수준에서의 Firmicutes/Bacteroidetes 비율 증가의 특징을 가지는 장내 세균 불균형의 원인이 된다. 장내 세균 불균형은 이차성 담즙산의 생성 감소 및 짧은 사슬 지방산 생성 감소, 염증 발생을 초래하여 비만의 발병에 기여하게 된다. 장내 세균 불균형 치료를 위한 임상적 접근법으로 유익균과 비흡수성 항생제 치료가 연구되어 왔으나 임상적으로 의미 있는 체중 변화를 일으키지는 않았다. 그러나 비만과 관련 있는 대사 지표의 호전을 보였기에 비만 치료에 있어 장내 세균 불균형에 대한 치료적 접근 전략을 세울 필요가 있다. 또한 아직까진 장내 세균 불균형과 관련된 종 수준이나 strain 수준에서의 장내 세균 분석 연구들은 많지 않아 이와 관련된 연구가 더 이루어져야 할 것으로 보이며 미래에는 비만과 관련 있는 특이 장내 세균을 확인하여 비만 치료에 이용될 것으로 보인다.

장내 세균 불균형과 뇌기능과의 관계

김규남(Kyu-Nam Kim) 대한기능의학회 2019 Journal of Korean Institute for Functional Medicin Vol.2 No.1

Based largely on results from preclinical studies, the concept of gut gut-brain interaction has been recognized, mediating bidirectional communication between the gut, its microbiome and the nervous system. Limited data obtained in humans suggests that alterations in these interactions may play a part in several brain gut disorders. Well characterized bidirectional communication channels, involving neural, endocrine and inflammatory mechanisms exist between the gut and the brain. Communication through these channels may be controlled by variations in the permeability of the intestinal wall and the blood brain barrier. Gut-brain interactions are programmed during the first 3 years of life, including the prenatal period, but can be modulated by diet, medications and stress throughout life. Based on correlational studies, alterations in these interactions have been implicated in the regulation of food intake, obesity and in irritable bowel syndrome, even though causality remains to be established. Targets within gut-brain interaction have the potential to become targets for novel drug development for gut dysbiosis-Brain disorders.

토끼의 하악골에서 β-TCP와 rhBMP-2의 골형성 효과에 대한 형태계측학적 연구

김규남(Kyu-Nam Kim),양정은(Jung-Eun Yang),장재원(Jea-Won Jang),사시카라 바라라만(Balaraman Sasikala),왕붕(Wang Beng),김일규(Il-Kyu Kim) 대한구강악안면외과학회 2010 대한구강악안면외과학회지 Vol.36 No.3

Introduction: This study was to assess the effectiveness of new bone formation and regeneration by using a rhBMP-2 and β-TCP as a carrier in rabbits’mandible. Materials and Methods: The mandibles of 36 rabbits were exposed and cortical bone was penetrated for this study. The experimental subjects were divided into 3 groups each 12 rabbits ; control group, experimental group 1, and experimental group 2. Control group had the defect itself without any treatment, in the experimental group 1, β-TCP only was grafted, and in the experimental group 2, rhBMP-2 soaked in β-TCP was grafted. The rabbits were sacrificed after 1, 2, 3, 4, 6, and 8weeks, and new bone formation area was examined and measured for bone quantitative and qualitative analysis with light, fluorescent and polarized microscopy. Results: In the experimental group 1, new bone formation from the adjacent host bone was made by osteoconduction, and in the experimental group 2, direct new bone formation by osteoinduction of rhBMP-2 as well as new bone formation by osteoconduction of β-TCP were observed. Conclusion: rhBMP-2 of experimental group 2 is very effective in the bone formation in early 2weeks and bone remodelling from 3weeks