Flavonoid 35 Hydroxylase 유전자가 도입된 동양계 백합 형질전환체의 유전분석 및 다종 바이러스 저항성 백합 형질전환체 개발

김선(Sun Kim),박교원(Kyo Won Park),유영숙(Yung Sook Ryu),안병준(Byung Joon Ahn) 한국원예학회 2012 한국원예학회 학술발표요지 Vol.2012 No.10

도시화로 인한 지하수 함양 변화 및 대수층의 수리적 특성

정찬호 ( Chan Ho Jeong ),서병민 ( Byong Min Seo ),김희섭 ( Hee Seop Kim ),김교원 ( Kyo Won Kim ) 대한지질공학회 2006 대한지질공학회 학술발표회논문집 Vol.2006 No.-

운동부하심전도검사에서 있어서 ST / HR Slope 의 진단적 의의

이태일(Tae Il Lee),권준영(Jun Young Kwen),최교원(Kyo Won Choi),김영진(Young Jin Kim),신동구(Dong Gu Sin),김영조(Young Jin Kim),심봉섭(Bong Sup Shim),이현우(Hyun Woo Lee) 대한내과학회 1995 대한내과학회지 Vol.48 No.3

N/A closely related to changes in myocardial oxygen demand during higher exercise workloads, the ST/HR slope should more accurately reflect the balance of myocardial oxygen supply demand than does simple mearsurement of the amount, of exercise induced ST segment depression, For improvement the accuracy of exercise stress electrocardiogram for the identification of coronary artery disease, exercise stress test and coronary angiograpty were performed. Methods: Exercise stress test and coronary angiography were performed in 213 patients who visit Yeuneg-nam Universit.y Hospital due to chest pain. Results: 112 patints had normal coronary artery and 101 patients had coronary artery stenoses. Among 101 patients 64 patients had 1 vessel disease, 33 patients had 2 vessel disease, 4 patients had 3 vessel disease. The sensitivity of ST segment. change criteria was 60.4%, specificity 68.8%,. At cutpoint 1.1, 2.4, 3.0 and 6.0 μV/beat/min the sensitivity of ST/HR slope were 60.4%, 48.5%, 42.6%, and 20.8%, the specificity were 60.7%, 88.4%, 96.4%, 100%, and overall test accuracy were 60.7%, 69.5%, 70.9 % and 62.4%, respectively. The mean ST/HR slope was significant higher in coronary artery disease group than normal coronary artery group(0.9±l.l vs 3.2±4.0μV/beat/min, p< 0.05). Conclusion: In conclusion, ST/HR slope did not improve the diagnostic accuracy of the exercise test to identify the presence of coronary arytery disease but was useful for the identification of severity of coronary artery disease.

경피적 관상동맥 성형술의 성공율에 영향을 미치는 인자에 대한 고찰

최교원,권준영,김영진,이태일,신동구,김영조,심봉섭,이현우,이삼범 영남대학교 의과대학 1994 Yeungnam University Journal of Medicine Vol.11 No.2

경피적 관상동맥 성형술의 성공률과 그에 영향을 주는 인자들을 알아보기 위하여 1992년 9월부터 1993년 8월까지 영남대학교 의과대학 부속병원에 입원하여 급성 심근경색증, 불안정형 협심증, 안정형 협심증, 경색후 협심증으로 진단된 172개소의 협착병소를 대상으로 하여 경피적 관상동맥 조영술 및 성형술을 시행하였다. 임상적 변수들로 나이, 성별, 협심증기간, 심혈관 위험인자, 임상적 진단명으로 구분하였고, 협착병변의 특징 및 술기적 변수들로는 American Heart Association/American College of Cardiology에 따른 분류, 병변혈관의 위치, 협착병소의 길이, 석회화유무 그리고 팽창압력과 팽창시간들로 구분하였고 성공군과 실패군에서 각각의 혈관탄성반도를 구하였다. 관상동맥 성형술의 전체성공율은 87.2%이고 성별로는 여성이 93.5%로 남성보다 높았으며 임상적 진단에 따라서는 안정형 협심증이 93.7%로 가장 높았고 경색후 협심증이 77.7%로 가장 낮았다. 협착부위의 소견중 45도 이상 굴곡된 병변과 혈전이 있는 병변에서 성공률이 낮았고 성공군과 실패군의 비교에서 관상동맥 성형술 전의 지름 협착율, 혈관탄성반도, 그리고 병변의 길이가 실패군에서 유의하게 크게 나왔다(p〈0.05). American Heart Association/American College of Cardiology 분류에서는 C형에서, 단일 혈관 질환보다는 다혈관 질환에서 성공률이 낮았고 그외 관상동맥 성형술전에 혈전용해 요법을 시행했을 때가 관상동맥 성형술만을 시행했을 때보다 성공율이 높았다. 결론적으로 관상동맥 성형술의 성공율에 영향을 미치는 인자로는 다혈관 질환, 45도 이상 굴곡된 병소, 혈전이 동반된 병소, Type C인 병소(p〈0.05), 협착정도(p〈0.05), 혈관탄성반도(p〈0.05), 협착길이(p〈0.05)로 보이며 앞으로 더 많은 례에서의 연구, 검토가 필요할 것으로 사료된다. In order to evaluate determinants of successful of percutaneous transluminal coronary angioplasty (PTCA), PTCA was performed for 172 coronary arterial lesions in 120 patients (89 male, 31 female) at Yeungnam university hospital from Sep. 1992 to Aug 1993. The corinary artery luminal diameter at the site of the original stenosis was eveluated from end-diastolic frames of identecal projections of the preangioplasty and immediate post angioplasty. The coronary luminal and balloon diameters were measured with using of computer and immediate post angioplasty. The coronary luminal and balloon diameters were measured with using of computer measuring system. Overall success rate of 172 attempted lesions was 87.2%. Success rate of female patients was 93.5% and higher than those of post myocardial infarction angina, unstable angina and acute myocardial infarcrion. Success rate of American Heart Association type C lesion was 65.5% and lower those of type A (95.7%), type B (89.5%). There was signfifcantly difference in preangioplasty luminal stenosis, elastic recoil and length of lesion between successful PTCA group and failed PTCA group. Success rate of lesion location at a bend〉45° and presence of intracoronary thrombus were lower than than those of other angiographic findings. In coclusion, primary angioplasty success was affected by specific angiographic factors. Stenosis severity, thrombus, lesion location at a bend 〉45°, elastic recoil, and length of lesion were the principle of determinants of coronary angioplasty success rate.

승모판 협착증과 동반된 자유롭게 부유하는 좌심방 구형혈전 1례

이정철,김영조,김영진,한승세,이태일,이동협,홍은표,최교원,심봉섭,강승호,신동구,이현우 영남대학교 의과대학 1993 Yeungnam University Journal of Medicine Vol.10 No.1

저자들은 승모판 협착증과 동반된 자유롭고 부유하는 좌심방내의 구형혈전은 1례를 치험하였기에 그 희귀성에 비추어 문헌 고찰과 함께 보고하는바이다. A free-floating ball thrombus in the left atrium is a rare complication of the mitral valvular disease. A 53-year-old man was admitted for pain and paresthesia on both legs. On admission he had auscultatory sign of mitral stenosis and mitral regurgitation, and the roentgenogram of his chest revealed a slight pulmonary venous congestion, enlargement of the pulmonary conus and cardiomegaly. Laboratory findings including complete blood counts, coagulation studies and blood chemistry were normal. An echocardiographic examination revealed a mitral stenosis and a free-floating ball thrombus in the left atrium. We performed the emergent open heat surgery for removal of the ball thrombus and mitral replacement successfully with Duromedics 29 mm valve. The size of thrombus was 39 X 32 X 30 mm.

간세포암에서 방사선 치료의 역할

이헌주,최교원,김명세,은종렬 영남대학교 의과대학 2000 Yeungnam University Journal of Medicine Vol.17 No.2

간세포암에 대한 방사선 치료의 효과를 평가하고자 1984년 1월부터 2000년 1월까지 영남대학교 의과대학 부속병원에서 간세포암으로 진단된 환자들 중에서 방사선 치료 단독 혹은 간동맥 색전술과 병합요법을 한 18명의 환자들의 의무기록과 방사선 사진을 검토하여 다음과 같은 결과를 얻었다. 남자가 15명, 여자가 3명이었으며 평균 나이는 51세였다. 복수가 4명(22.2%)에서 있었으며 간경변이 11명(61.1%)에서 있었다. 간기능은 Child-Pugh class A, B, C가 각각 6명, 3명, 2명이었다. 14명(77.8%)에서 HBs 항원 양성이었으며 anti-HCV 양성은 없었다. 사망원인은 간성혼수를 포함한 간부전이 2명(11.1%), 위장관출혈이 1명(5.6%), 암사망이 1명(5.6%), 현재 생존이 4명(22.2%)였으며 10명(55.6%)은 불명이었다. 종양의 위치는 간우엽이 10례 좌엽이 3례 양쪽 모두가 5례였으며, 종양의 형태는 결절형이 4례, 괴상형이 7례, 미만형이 7례였다. 8례(44.4%)에서 동정맥우회(shunt)가 있었으며 간문맥혈전증이 4례(22.2%)에서 있었다. 병기는 Ⅰ기, Ⅱ기, Ⅲ기, Ⅳ기 각각 0례, 5례, 4례, 9례였다. 종양의 크기(volume percentage)는 4025%(5-96)였다. 치료에 대한 반응은 partial response가 2례(11.1%), minimal response가 4례(22.2%), no change가 11례(61.1%), progressive disease가 1례(5.6%)였다. 평균 생존률은 97개월(2-25)로 반응률(response rate)은 33.3%였다. 3개월, 6개월, 12개월, 24개월 생존률은 각각 81.3%, 43.8%, 18.8%, 6.3%였다. 결론적으로, 간세포암에 있어서 방사선 치료는 생존률을 향상시키지는 못하더라도 종양의 크기를 줄이는데 효과가 있었다. 간동맥 색전술과의 병합치료가 치료효과를 강화하는 것으로 생각되나 방사선 단독 치료의 효과를 알기 위해서는 더 많은 연구가 필요할 것으로 생각된다. Background : Hepatocellular carcinoma(HCC) has been considered to be relatively radioresistant. The role of radiotherapy(RT) in the treatment of HCC is controversial. But RT has a role in the treatment of hepatocellular carcinoma as a single or combination modalities. The effect of radiotherapy on HCC was evaluated. Material and Methods : From January 1984 through January 2000, a total of 18 patients with unresectable HCC underwent radiotherapy alone or in conjunction with transarterial imbolization(TAE). We reviewed the medical records of patients with RT and measured the tumor size using planimetry method. The Kaplan-Meier method was used to calculate the survival rate. Results : The RT patients were 15 men and 2 women. The mean age was 51 years. Four(22.2%) of them were accompanied with ascites. Eleven(61.1%) of them were accompanied with liver cirrhosis and their functions were 6, 3, 2 in each Child-Pugh A, B, C, respectively. A partial response(PR) was observed in 1 patients(11.1%), minimal response(MR) in 4 patients(22.2%) and no change(NC), in 11 patients(61.1%), whereas progressive disease(PD) was seen in 1 patients(6%). The survival rate determined at 3, 6, 12, and 24 months were 81.3%, 43.8%, 18.8%, and 6.3%, respectively. Conclusions : Although the radiotherapy in HCC did not improve the survival rate, it decreased the tumor size. Radiotherapy strengthens the therapeutic efficacy when compbined with TAE, but more studies are needed.

완전방실블록 환자에서 쌍극의 영구박동기를 이식후 반복 발생된 증상이 단극으로 전환후 증상이 소실된 예

이현우,심봉섭,최교원,김영조,신동구,권준영 영남대학교 의과대학 1994 Yeungnam University Journal of Medicine Vol.11 No.1

저자들은 완전방실블록 환자에서 쌍극의 영구심장박동기를 이식후에도 계속되는 실신발작을 보여 단극의 영구심장박동기로 바꾼 후 그 증상이 소실된 예를 경험하였기에 이를 보고하는 바이다. Pacemaker malfunctions are secondary to alterations of the preset pacing rate, irregular pacing failure of sensing, failure of cardiac capture or depolarization, and various combinations of these events. A 76 years old male patient was admitted due to pacemaker malfunction. 2 years age, he was diagnosed as complete atrioventricular block. And then bipolar permanent pacemaker was implanted. Since then syncopal attack developed repetitivly. 12 lead ECG and 24 hour holter moniter monitoring, revealed pacing and sensing failure, thus we converted bipolar system into unipolar system. Since then syncopal attack did not developed again.

영남대학교 의과대학 부속병원에서의 이차성 고혈압의 유병율

이형우,이현우,윤경우,권준영,심봉섭,김영조,신동구,최교원 영남대학교 의과대학 1994 Yeungnam University Journal of Medicine Vol.11 No.1

이차성 고혈압은 일차성 고혈압에 비해 빈도가 매우 적지만 그 원인 인자를 교정했을때 정상 혈압으로 완치가 되거나 증상의 완화를 보일 수 있기 때문에 이차성 고혈압을 시사하는 소견들이 있을 때에는 원인을 조사하여 그에 맞는 적절한 치료를 하는 것이 매우 중요하다. We studied the incidence and results of treatment of secondary hypertension in Yeungnam University Hospital. Nineteen hundred fifty patients with hypertension were included from march 1990 to march 1994. We analysed the prevalence of secondary hypertension and results of treatment. The incidence of secondary hypertension in Yeungnam University Hospital was six percent. The most common underlying causes of secondary hypertension was renal parenchymal disease. Patients with three forms of potentially reversible secondary hypertension, namely, renovascular hypertension, endocrine disease, exogenous hormone, were assed to determine whether surgery or withdrawal of the exogenous hormane had led to an improvement in blood pressure control. The incidence of secondary hypertension in Yeungnam University Hospital was low(6%), but some of these are curable. Thus it is very inportant that evaluate the secondary hypertension.