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권명상,김영후,조정순,Kwon Myung-Sang,Kim Young-Hwu,Cho Jung-Soon 동아시아식생활학회 2005 동아시아식생활학회지 Vol.15 No.5
In recent years, propolis has attracted much attention as an useful substance in medicine and functional food, even if it is known as a natural remedy in folk medicine since ancient times. propolis was registered as natural food since 1995 on Korean Food Act by Korean Food and Drug Administration(KFDA). The present study demonstrated the optimization of isolation of crude propolis by ethanol, and tumoricidal effect of pro polis. The optimal concentration of ethanol to separate a high quantity of propolis was $60\%$. The cytotoxic effect of ethanol extracted propolis against various cancer cell lines including murine lymphoma (Sarcoma-180), murine T-lymphoma (YAC-1), human breast carcinoma (MCF-7), human gastric carcinoma (KATOIII) and human hepatocellular carcinoma (Hep3B) and human lung adenocarcinoma (A-549) was observed using SRB and MIT assay. In order to investigate the curative activity by oral administration of propolis on tumor, ICR mice was subcutaneously implanted Sarcoma 180. In 300mg/kg and 600mg/kg propolis administered group, development of implanted tumors was inhibited by $40.9\%\;and\;67.9\%$ at 16th day, respectively. In the same dose of propolis administered group, development of implanted tumors was inhibited more strongly with dose dependent manner. Therefore, these data suggested propolis may show tumoricidal effects. In conclusion, these results indicate that propolis, one of the few natural remedies, can be used as functional food with tumoricidal effects.
윤석주,권명상,Yoon, Seok-joo,Kwon, Myung-sang 대한수의학회 1995 大韓獸醫學會誌 Vol.35 No.2
The characterization of the MHC of domestic animals may constitute a first step towards increasing the efficiency of food production through improved disease resistance. In order to study the role of the MHC in regulating immune response it is first necessary to identify the different MHC alleles. In this research we try to investigate the possible associations between BoLA of Korean native cattles and infectious cattle disease. For this purpose we used one approach, serology. The results were summarized as follows : 1. Korean native cattle's lymphocyte reacted with alloantisera which recognized seven official BoLA allele. Korean native cattle's lymphocytes were reacted same as European breeds(especially with 673/3(W20)). 2. Korean native cattle's lymphocytes reacted with alloantisera 773/2, 673/3, 638/3, 773/3, 602/2, 639/2 and 639/3 at high reaction frequency. But alloantisera 642/1 was not expressed on Korean native cattle. If this allele, recognized by alloantisera(642/1), officially certificate In BoLA workshop it will be characterization factor of Korean native cattle. 3. According to cellular similarity index, we can presume on genetic relativity which has no family relationship.
아카바네 생바이러스 백신 접종에 의한 한우 백혈구 아군의 변화
박영남 ( Young Nam Park ),손승미 ( Sung Mi Son ),신명균 ( Myung Kyun Shin ),권명상 ( Myung Sang Kwon ) 한국가축위생학회 2006 韓國家畜衛生學會誌 Vol.29 No.3
To identify immune response of leukocytes in peripheral blood of cattle vaccinated with an attenuated live Akabane virus vaccine, leukocytes were reacted with monoclo-nal antibodies which are specific to bovine lymphocyte surface antigens and assayed by the flow cytometry. Serum neutralizing(SN) test was used to measure antibody titers after vaccination. SN antibody was appeared to 7 days post-vaccination(PV) and 2-8 antibody titers were observed in 14 days PV. Proportion of CD8-MHCclassⅡ+ expressing cells were rapidly increased at 3 days PV. CD8+MHCclassⅡ- cells were increased at 7 days PV. CD4+CD8-, WC+CD4-, CD4+CD8+, WC1-CD4+, WC1-CD8+, and CD4-CD8+ cells were highly increased at 3, 3, 7, 7, 14, 14 days PV, respectively.
김형춘(Hyoung Chun Kim),전완주(Wan Jhoo Chun),이현우(Hyun Woo Lee),권명상(Myung Sang Kwon),송계용(Kye Yong Song),주왕기(Wang Kee Jhoo) 대한약학회 1992 약학회지 Vol.36 No.2
This study investigated the hypothesis that carcinogen-induced elevation of oxyradical during the hepatocarcinogenesis in rat. The hepatic preneoplastic lesions in the Spraque-Dawley rats were induced by the carcinogen treatment such as diethylnitrosamine(DEN) and acetylaminofluorene(AAF) in combination with partial hepatectomy(PH). The liver sample was taken at 2,6,10 and 16 months after carcinogen treatments followed by PH. Carcinogen treatments initially increased the indices of oxidative damage(activities of xanthine oxidase and production rates of superoxide anion, microsomal hydrogen peroxide, hydroxyl radical ) in the liver compared to PH groups. However, cytosolic hydrogen peroxide did not change significantly throughout the full time period. Of hydrogen peroxide scavenger, the catalase was remained lower than PH groups, whereas the peroxidase was increased after carcinogen treatments. Morphologically, the immunohistochemical analysis with glutathione-S-transferase of a placenta form(GSTP) antibody was used to detect the induction of preneoplastic nodules. During the hepatocarcinogenesis, both production rate of hydroxyl radical and activity of glutathione-S-transferase(GST) markedly increased with the appearance of the preneoplastic nodule. These results indicated that the hydroxyl radical of reactive oxygen species seemed to have a major influence on the hepatocarcinogenesis and the effect of time after removal of the carcinogen also appeared to be highly critical in the hepatocarcinogenesis.