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다양한 피부 종양에서 c-Jun과 JunB 발현에 관한 연구
고범준 ( Bum Joon Ko ),조문균 ( Moon Kyun Cho ),박영립 ( Young Lip Park ),이종석 ( Jong Suk Lee ),이증훈 ( Jeung Hoon Lee ),황규왕 ( Kyu Uang Whang ) 대한피부과학회 2014 大韓皮膚科學會誌 Vol.52 No.4
Background: c-Jun along with JunB, JunD, and the Fos group proteins comprise the core members of the activatorprotein 1 (AP1) family of transcription factors. Recently, many studies have demonstrated the key roles of AP1 inregulating a wide spectrum of biological processes, including tumorigenesis. We therefore hypothesized that c-Junand JunB influence the differentiation and malignant change of various skin tumors. Objective: We measured the expression levels of c-Jun and JunB in different skin tumors. Methods: The expressions of c-Jun and JunB were examined by performing the immunohistochemical staining of 55specimens of skin tumors, including 13 cases of seborrheic keratosis, 4 cases of keratoacanthoma, 9 cases of actinickeratosis, 4 cases of Bowen’s disease, 4 cases of basal cell carcinoma, 16 cases of squamous cell carcinoma, and5 cases of malignant melanoma. Results: Immunohistochemical analysis of the skin tumor tissue samples revealed a significantly higher expressionof c-Jun in malignant skin tumors (basal cell carcinoma, squamous cell carcinoma, malignant melanoma) than inbenign (seborrheic keratosis, keratoacanthoma) or premalignant skin tumors (actinic keratosis, Bowen``s disease). Theexpression of JunB, however, was significantly lower in malignant skin tumors than in benign skin tumors. Conclusion: These findings showed that c-Jun has a positive association with skin malignancies, while JunB has anegative association with skin malignancies. The role of AP1 as key regulators of cell proliferation and epidermaltumor progression is suggested.
베냉 여행 후 입국한 외국인에서 발생한 종기성 피부 구더기증
고범준 ( Bum Joon Ko ),조홍기 ( Hong Ki Cho ),이인용 ( In Yong Lee ),용태순 ( Tai Soon Yong ),황규왕 ( Kyu Uang Whang ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.5
Myiasis is the infestation of any part of the body by Diptera larvae. It is the fourth most common travel-associated skin disease and cutaneous myiasis is the most frequently encountered clinical form. Furuncular lesions may result when the skin is affected. Cutaneous myiasis caused by Cordylobia anthropophaga has been endemic in the sub-Saharan African region for more than 135 years. There have been some reported cases from non-endemic regions, and yet C. anthropophaga infestations are rarely acquired outside of Africa. We report here a rare case of furuncular cutaneous myaisis by C. anthropophaga in a German patient who came to Korea after a three-week trip to Benin.
다양한 진단도구와 반복적인 피부조직검사를 통해 확진한 원발성 전신성 유전분증
고범준 ( Bum Joon Ko ),이강모 ( Gang Mo Lee ),최인호 ( In Ho Choi ),박영림 ( Young Lip Park ),이성열 ( Sung Yul Lee ),황규왕 ( Kyu Uang Whang ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.9
Amyloidosis is a group of disorders resulting from the extracellular deposition of amyloid fibrils in tissues and organs. Primary systemic amyloidosis may be myeloma-associated or idiopathic. It involves the kidney, heart, liver,peripheral nerves, autonomic nervous system and skin. We report a case of a 76 year-old woman with primary systemic amyloidosis who suffered from ecchymotic purpura on the periorbital, flexural area with hemorrhagic bulla,and macroglossia for two years. She showed typical symptoms of AL amyloidosis, and while primary systemic amyloidosis was suspected from electrophoresis results, no amyloid was found in the skin, tongue, and bone marrow. Upon her admission due to panperitonitis from diverticulitis, she was diagnosed with primary systemic amyloidosis after amyloid deposition was confirmed in the skin and colon biopsy. She had been treated with bortezomib, but she expired from methicillin-resistant Staphylococcus aureus septic shock.
Blaschko선을 따라 발생한 선상의 Grover병 1예
안제민 ( Je Min An ),고범준 ( Bum Joon Ko ),조문균 ( Moon Kyun Cho ),황규왕 ( Kyu Uang Whang ) 대한피부과학회 2016 大韓皮膚科學會誌 Vol.54 No.7
Grover disease (also known as transient or persistent acantholytic dermatosis) is a pruritic polymorphic papulovesicular eruption that is histologically characterized by the presence of epidermal acantholysis. It primarily occurs in middle-aged individuals and manifests as scattered erythematous or brown papules as well as papulovesicles on the sun-exposed skin of the trunk. A 52-year-old man had erythematous papules and patches linearly arranged on the left thigh and leg with mild pruritus. The skin lesions were successfully treated with a topical corticosteroid. However, 2 months later, the lesions recurred. The histological examination of a punch biopsy revealed focal acantholytic clefts with dyskeratotic cells, hyperkeratosis, and the infiltration of perivascular lymphocytes and eosinophils. Taken together with the late onset and lack of family history, we diagnosed this condition as Grover disease distributed along the Blaschko line, a condition presented here for the first time. (Korean J Dermatol 2016;54(7):544∼547)