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      • 소아에서 발생한 일광 두드러기 1례

        강훈,조상현,김의한,강훈 대한알레르기학회 1999 천식 및 알레르기 Vol.19 No.3

        Solar urticaria is a rare disorder in which immediate erythema and wheals are induced by ultraviolet or visible irradiation. This condition usually occurs in the third and fifth decades of life and is very rare in childhood. A 3-year-old girl presented with a history of an erythematous rash which had occurred on the face and neck, immediately after exposure to sunlight for one month. A diagnosis of solar urtiacria was made on the clinical reviews and phototest. Other photosensitive disorders could be excluded by the clinical and laboratory findings. She was treated with ketotifen and sun protection showing good early results.

      • KCI등재

        시뮬라크르 사유를 표출하는 ‘흐름의 건축'에 관한 연구

        강훈(Kang Hoon) 대한건축학회 2011 대한건축학회논문집 Vol.27 No.3

        'Flux architecture' is the trial expressing Deleuze?Gattari's 'the virtual' through process of 'becoming' constantly. It will be born as 'an abundant body without organs'. As doing so, it would suggest the direction to which contemporary architecture should go. Further more, the lasting creation and processing to 'an abundant body without organs' means 'flux architecture'. So, this paper studies the concept of Deleuze?Gattari's 'the virtual' and 'the simulacre' for 'Flux architecture', and it takes interest in the form and space generated from that. And examined architectural digitally designed works instance that base simulacre's thought to express 'the virtual' to architectural space. In conclusion, this paper shows degital form and space creation technique that suitable method for 'Flux architecture' based on simulacre's thought.

      • KCI등재
      • Regulation of hair growth and cycles: dermal papilla approach

        강훈 ( Hoon Kang ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

        The dermal papilla (DP) cells of the hair follicle are permanent repository for epithelial progenitor cells that regenerate the hair follicle and generate the hair shaft. In this session, I will review experiments that revealed the importance of the DP cells (DPCs) in regulating the hair follicle regeneration and the hair growth cycles. I. DPCs in hair morphogenesis · Epidermal placode recruits cells from the underlying dermis · Dermal condensate: a local increase in dermal cell density beneath the epidermal placode · Active signaling between dermal condensate and placode stabilizes both populations and drives further development of the hair peg · Dermal condensate becomes the DP as it further compacts and is engulfed by the growing hair peg · DP act as the progenitor population that produces the inner root sheath (IRS) and hair shaft · At the end of the growth phase, the progenitor population adjacent the DPCs either differentiate or die · The hair shaft and IRS are drawn upward to the permanent portion of the follicle · Secondary germ: compact ball shaped DPCs which located at the base of resting follicle · Start of a new anagen phase: DPCs becomes less compact and the subsequent regeneration of the lower follicle is quite similar to initial morphogenesis · Throughout the hair cycle, the DP is well positioned to provide inductive signals that guide the activity of the cells that generate and regenerate the follicle · DPCs serve as the physical niche for progenitor cells II. DPCs as a regulator of hair growth environment · DPCs are dynamic regulator of hair follicle · Various types of gene expression of DPCs indicate that DPCs are source of diffusible signals that influence follicular epithelium · Implantation of DP was sufficient to restore regeneration · The role of the mesenchyme in directing morphology of the hair produced is maintained in the mature DPCs III. Anagen initiation · DPCs send signals to the stem cells of the follicular bulge to initiate a new anagen phase · Activation of the keratinocytes adjacent the DPCs is the first step of anagen initiation · DPCs expresse Wnts, FGFs, Noggin and R-spondins all of which can promote follicle growth and contribute to initiating follicular regeneration · Regeneration of the follicle accompany initial activation of signaling between mesenchyme and epithelium · β-catenin gene in DPCs is essential for the initiation of anagen -β-catenin gene lacking in the DP enter the telogen phase, fail to reenter anagen · Reduced cell number of DP induce delayed anagen initiation · Importance of macroenvironmental factor - signals from adjacent follicles - signals from other cell types in the skin - hormonal signals generated outside the skin IV. Maintenance of DP size · DPCs population in a follicle is not fixed - decrease number during telogen phase, but restore at anagen · Healthy and normal-sized epithelial compartment can either recruit new cells or sustain the proliferation of existing DPCs to regenerate its niche · The source of additional DPCs during regeneration after damage has not been characterized

      • SCOPUSKCI등재

        개에서 폐내진동환기법이 심폐혈역학 및 산소운반능에 미치는 영향

        강훈,김성덕,백희정 대한마취과학회 1989 Korean Journal of Anesthesiology Vol.22 No.2

        To evaluate effects of IPV (Intrapulmonary Percussive Ventilation) on cardiopulmonary hemodynamics and oxygenation, we compared IPV with conventional IPPV (Intermittent Positive Pressure Ventilation} in eight mongrel dogs. After Swan-Ganz catheterization and femoral arterial cannulation, we applied IPPU and IPV for 30 minutes respectively at random order. There were no significant differences in cardiac output (CO), heart rate (HR), mean arterial pressure (MAP), vascular resistance (VR), pulmonary capillary wedge pressure (PCWP), rate pressure product (RPP), coronary perfusion pressure (CPP) and oxygenation-reflecting parameters such as AaDO₂, oxygen flux and oxygen consumption (VO₂) between IPPV and IPV. A slight increase of diastolic pulmonary arterial pressure (PAP) resulted in increase of pulmonary perfusion pressure (PPP). IPV increases left and right ventricular stroke work index which might be related to slight metabolic acidosis and a little deficient ventilation during IPV. We can conclude that IPV is safe and good in cardiopulmonary hemodynamics and tissue oxygena-tion in dogs, but its better to be cautious in ventilation during IPV.

      • 생장점배양에서 유래된 Freesia, 구근 Iris 및 Amaryllis의 소자구 증식과 비대를 위한 수경재배법 개발

        소인섭,강훈 濟州大學校 亞熱帶農業硏究所 1995 亞熱帶農業硏究 Vol.12 No.-

        생장점배양에서 유래된 소자구의 증식과 비대를 위한 수경재배 매질과 배양액의 효과를 실험한 결과는 다음과 같다. 가. 공시한 3종의 식물에 대한 수경매질의 효과로 볼 때 공시 품종간에 차이는 없었고 생육, 구근증식률과 구근비대에서는 송이+peatmoss처리구에서 가장 좋은 결과를 보였다. 나. 수경액의 종류에 따른 생육, 구근증식률, 및 구근비대에서는 공시 품종간의 차이는 없었고 프리지아의 경우 원더그로 용액이, 구근아이리스의 경우 한국원시액 A가, 그리고 아마릴리스의 경우에는 한국원시액 B가 적합한 결과를 보였다. 다. 구근아이리스의 경우 생육중 부패률이 60% 이상 발생한 결과를 나타내었는데 이는 수경재배 자체의 수분과다가 원인으로 나타나 구근아이리스는 다소 건조상태에서 양구해야할 사항으로 지적된다. This experiment was carried out according to kinds of nutrient solutions and medium for bulb multiplication and enlargement in virus-free bulblet of Freesia. Dutch Iris and Amaryllis obtained by apical meristem culture in vitro. a. The best medium for water culture was soil mixture consisted of one part scoria and one part peatmoss. In this medium, highest ratio of growth and propagation was acquired from the bulblet produced by meristem-tip culture. b. No difference in the bulb growth and the bulblet propagation was obsered between cultivars tested. The best results for bulb growth and bulblet propagation of Freesia, Dutch Iris, and Amaryllis were obtained in Wondergrow, Korean standard nutrient Solution A, and Korean standard nutrient solution B respectively. c. During the nutrient solution cultivation Dutch Iris, over 60% of bulbs decay was observed. Because the over watering may cause the bulb decay, wettable soil condition has to be avoided for the good growth of the Dutch Iris.

      • KCI등재
      • SCOPUSKCI등재

        국소마취에 의한 성형외과 수술에서 보조적으로 사용된 정맥 마취의 효과

        이태섭,방사익,강훈 大韓成形外科學會 1998 Archives of Plastic Surgery Vol.25 No.1

        When operations in the field of plastic surgery are performed under local anesthesia, the degree of pain suffering the patients becomes different depending on the kind, dosage effective duration of anesthetic agent and the technique of the operator. Patients suffer from pain physically and psychologically when skin infiltration is carried out. Recently, out-patient surgery has increased in number, so the necessity of more complete analgesia for the patient undergoing surgery is required. Patients were operated under the local infiltrative anesthesia, and the supplemental intravenous anesthesia to kill pain. Patients were randomly divided into four groups differing in combinations of intravenous anesthetic agents, such as ketamine, midazolam, fentanyl that have potent analgesic sedative and amnesic effects. By random allocation patients received ketamine and midazolam(Group Ⅰ), ketamine and fentanyl(Group Ⅱ), midazolam and fentanyl(Group Ⅲ), ketamine, fentanyl arts midazolam(Group Ⅳ). The purpose of this study is to focus on the results obtained in four groups for finding out a more safe and less complicated combination of intravenous anesthetic agents and for standardization of dosage. In conclusion the group I (ketamine and midazolam) showed better results than other groups for the following reasons; no significant change in vital signs, no hypoxia no complication such as nausea, headache unpleasant dream, and hallucination, potent analgesia effects, amnesia. We have found this combination to be a highly satisfactory anesthesia and analgesia technique for outpatient plastic surgery from the standpoints of the surgeon and the patient.

      • KCI등재후보

        도파 반응성 근육긴장이상, Segawa병 1례

        강훈철(Hoon Chul Kang), 이현숙(Hyeon Sook Lee), 김흥동(Heung Dong Kim) 대한소아신경학회 2004 대한소아신경학회지 Vol.12 No.1

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        도파 반응성 근육 긴장이상으로서, Segawa병은 10대에 발병하며 현저한 주간 변동을 보이는 유전성 진행형 근육 긴장이상 증상을 보이며 GCH I 유전자의 결함에 의한 dopamine 합성의 장애로 발생한다. 저용량 levodopa로도 부작용 없이 정상생활을 유지할 수 있고 혹 Segawa병과 관련된 저신장 또한 levodopa의 조기 투여로 정상 신장으로 회복 될 수 있는 바, 조기 발견에 의한 치료가 중요하며, 국내에서도 Segawa병과 관련된 근육 긴장 이상 질환들에 대한 임상적, 분자 생물학적 연구와 관심이 필요하다. 저자들은 전형적인 Segawa병의 임상 증상과 뇌척수액 neopterin 감소로 확진되어 저용량 levodopa로 정상 생활을 유지하는 여자 환아 1례를 경험하였기에 보고한다. Segawa disease, hereditary progressive dystonia with marked diurnal fluctuations or defined dopa-responsive dystonia has age-dependent clinical courses, which are characterized with marked progression in the first one and half decades, its subsiding in the third decade and almost stationary courses after the fourth decade. Also, it has characteristic diurnally fluctuating symptoms, aggravated towards the evening and alleviated after sleep. This autosomally dominantly inherited dystonia is caused by abnormalities of the gene of GTP cyclohydrolase I. The heterozygotic gene´s abnormality induces partial decrement of tetrahydrobiopterin and affects synthesis of tyrosine hydroxylase(TH) rather selectively. The reduction of TH induces decrement of dopamine and disfacilitates the Dl receptor-striatal direct pathway. The pathognomonic finding in biochemical examination is the decrease of neopterin in the cerebrospinal fluid(CSF). Levodopa, by replacing dopamine contents at the terminal, alleviates motor symptoms completely and the effects sustain without any side effects. We experienced a girl diagnosed as Segawa disease with typical clinical courses and a decrease of neopterin in the CSF.

      • SCOPUSKCI등재

        부적절한 헤파린화로 인한 인공심폐기 관류 실패

        강훈,임승운,박희평 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.32 No.5

        Resistance to heparin therapy during cadiopulmonary bypass(CPB) is infrequent but can result in potentially life-threatening event. The precise etiology of the heparin resistance remains unknown. Clearly, the most predictive risk factor is a history of previous heparin exposure. Assessment of the clinical heparin effect, by determination of the activated clotting time(ACT), identifies those patients with heparin resistance. The potential risk of suboptimal anticoagulation is circumvented by the administration of additional heparin. High dose aprotinin suppress the activation of intrinsic coagulation pathway through surface activators inhibition, as documented by increases in the ACTs during CPB. Such effect of aprotinin on ACT, which can allow heparin-resistant patients to overestimate heparinization. We report a case of pump failure due to inappropriate heparinization in heparin-resistant patient. (Korean J Anesthesiol 1997; 32: 839∼844)

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