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충청지역에서 발생한 쭈쭈가무시병의 임상상, 원인균의 혈청형 및 혈청역학적 연구
김선영,김윤성,박장규,윤태영,강재승,송인숙,최명식,최인학,차창룡,이우곤,박종우,이증훈,장우현,유영해,윤광혁,송계용 대한감염학회 1989 감염 Vol.21 No.2
From September to december 1987, eighty-six cases of tsutsugamushi disease were diagnosed by indirect immunofluorecent test or by isolating the causative agent in Chungcheung area. Their clinical features and patterns of antibody response to R. tsutsugamushi were analyzed. For the indenfication of prevalent antigenic types of R. tsutsugamushi in Chungcheung area, twenty-seven strains isolated were tested by indirect immunofluorescent test. To assess the extent of exposure to R.tsutsugamushi of a general population in Korea, the prevalence of antibody was investigated in 6,572 sera obtained from the residents of Chungcheung area by indirect immunofluorescent test. The female patients slightly outnumbered the male patients. More cases (68%) were older than 40 years of age. The epidemic peaked in October. The mean incubation period estimated was about 8 days. The major clinical features were fever and chill, headache, rash, eschar, and lymphadenopathy. Increased serm transaminase was the most singificant laboratory findings. Abnormalities in the chest roentgenography were often observed. The antibody titer rose rapidly 5 days after the onset, reached its peak at 20 days (1:640), and then declined agradually until 7 months(1:20). The seroype of 23 out of the 27 isolates wase found to be karp, one was Gilliam, and 3 isolates could not be classified by using polyclonal mouse hyperimmune sera. The prevalence of antibody to R.tsutsugamushi in the residents of Chungcheung area was 4.8%. The prevalence of antibody was higher in the female than in the male. The prevalence was higher in the residents of age above 40 years than below 40 years, and was the lowest in the children less than 10 years of age. Of the 318 positive sera from normal residents, only 2 sera showed the titers higher than 1:80.
한국 농촌거주 정상인의 Leptospira Interrogans에 대한 항체보유율 현황
최강원,최성배,국윤호,장우현,우준희,박경희,강재승,차창룡,김양수,김석용,윤종구,김익상,이우곤,최명식,송영욱 대한감염학회 1988 감염 Vol.20 No.3
It has been well known that leptospiroisis is a one of the prevailing acute febrile diseases in Korea. In order to find out the incidence of past infection of L. interrogans among normal population, a total of 1,171 sera obtained from rural residents and tested by microscopic agglutination test. All of normal resident's sera were collected during July in 1987, just before epidemic season, at Keochang county(248 sera), at Wanju county(145 sera), at Wonseoung county(255 sera), at Cholwon county(411 sera) and at Kongju county(112 sera). Seropositive rate against L. interrogans among rural residents was 12.0% and ranged from 2.7% in Kongju county to 18.5% in Cholwon county. There was a higher seropositive rate in males and the majority of seropositives occurred in the age group over 30 yesrs. Icterohaemorrhagiae was a most commonly reacting serotype of L. interrogans and followed by CH-48 and Canicola. The sera reacted with Cynopteri, Ballum, Australis, and Pyrogenes were present also.
새로 국내에서 밝혀진 균주(R19)와 전통적 균주를 이용하여 혈청학적으로 진단된 쯔쯔가무시병의 임상상 및 항체반응 양상
이수기,이은경,허충,임병욱,김용림,강재승,이진관,조준탁,박동철,박경현 대한감염학회 1991 감염 Vol.23 No.1
From September to December 1989, eighteen cases of tsutsugamushi disease were diagnosed by indirect immunofluorescent antibody test in Ulsan-Ulchu area. Their clinical features and patterns of antibody response to R. tsutsugamuschi were analyzed. It was most prevailing in female over 30 years old. Most of patients (16 patients) were rural inhabitants. Two patients in urban area had reaped the rice in the rice field at several days before onset of the disease. It occurred between September and November with a peak in October. Chief complaints of patients were febrile sensation with or without chills or headache. All patients had fever and chills. Headache and myalgia were common. In one patient, delirium with visual hallucination was seen. The major physical findings were skin rash (83%), eschr (78%), lymphadenopathy (11%). The skin rash appeared on whole body or on the trunk. The eschar appeared on the chest or abdomen or in the genial region. The antobody titer to R 19 that had been newly isolated strain in Korea was universally high. There often were anemia (31%), leukocytosis (23%). Microscopic hematuria and pyuria were also seen in routine urinalysis. Liver function tests showed eleveted aminotransferases and LDH. There were erythrophagocytic histiocytes in the bone marrows of six patients among the ten patients whose bone marrow had been aspirated. Chloramphenicol had been used in all patients. The mean time to alleviation of fever was 2.5 days. All patients were cured.