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        • KCI등재

          용성산인(龍城山人) 이창원(李昌遠)의 사상학설(四象學說)과 체질침(體質鍼)에 대한 고찰(考察)

          안창범,윤현민,허재영,권혜연,Ahn,,Chang-beohm,Youn,,Byuon-Min,Hea,,Jae-young,Kwon,,Hae-Yon 대한침구의학회 2002 대한침구의학회지 Vol.19 No.1

          Objective : This study was carried out to review Chang-Won Lee's theory of Sasangand acupuncture of constitution. Methods : We have investigated Chang-Won Lee's unknown literature "Medicine of sassang "(四象醫學). Results : Constitutional acupuncture is based on the diversity of human being and medically developed the response variation to disease and acupuncture. The diversity is due to the Organ's Congenital Formation Variation based on human nature and it is categorized as four from physiology, pathology, symptoms, to therapy. Chang-Won Lee's constitutional acupuncture discriminated constitution of comparison palpations of right and left both sides. He insisted that constitution only four type(Sasang), not exist man of To-Hyoung (土形人) in "young -chu"(靈樞) and his constitutional acupuncture all used Jung-kyuck (reinforcement acupuncture method) and Seong-kyuck(reducing acupuncture method) of Sa-am(舍岩)

        • KCI등재

          약침용 봉독성분 melittin의 영향에 의한 인체 폐암세포의 apoptosis 유도

          안창범,임춘우,윤현민,박수진,최영현,Ahn,,Chang-beohm,Im,,Chun-woo,Youn,,Hyoun-min,Park,,Su-jin,Choi,,Yung-hyun 대한침구의학회 2003 대한침구의학회지 Vol.20 No.5

          Objective : To investigate the possible molecular mechanism(s) of melittin as a candidate of anti-cancer drug, we examined the effects of the compound on the growth of human lung carcinoma cell line A549. Methods: MTT, morphological changes, DAPI staining, Western blot, RT-PCR and in vitro prostaglandin E2 (PGE2) accumulation assays were performed. Results: The anti-proliferative effect by melittin treatment in A549 cells was associated with morphological changes such as membrane shrinking and cell rounding up. Melittin induced apoptotic cell death in a concentration-dependent manner, which was associated with inhibition or degradation of apoptotic target proteins such as ${\beta}$-catenin, poly(ADP-ribose) polymerase(PARP) and phospholipase $C-{\gamma}1(PLC-{\gamma}1)$. Melittin treatment inhibited the expression of cyclooxygenase-2(COX-2) and accumulation of PGE2 in aconcentration-dependent fashion. In addition, Melittin treatment induced the down-regulation of telomerase reverse transcriptase(hTERT) and proto-oncogene c-myc expression of A549 cells. Conclusions: Taken together, these findings suggest that melittin-induced inhibition of human lung cancer cell proliferation is associated with the induction of apoptotic cell death via regulation of several major growth regulatory gene products, and melittin may have therapeutic potential in human lung cancer.

        • SCOPUSKCI등재

          오행침자법(五行鍼刺法) 원리 및 임상응용에 관한 연구 - II 임상응용에 관한 연구

          안창범,민영광,김정은,문혁철,송춘호,이장천,신상우,Ahn,,Chang-Beohm,Min,,Young-Kwang,Kim,,Jeong-Eun,Moon,,Hyuck-Chol,Song,,Chun-Ho,Lee,,Jang-Cheon,Shin,,Sang-Woo 대한약침학회 2008 Journal of pharmacopuncture Vol.11 No.3

          Objective: To review the clinical basis of the Sa-Ahm 5 Element acupuncture originated about 360 years ago, papers and books were researched. Methods: Total of 58 books and papers ranging from ancient Huang Di nei jing to modern Bio Medical Acupuncture for Pain Management were investigated to study the clinical practice of it. Results: It could be practiced differently depending upon the viewpoints of diagnosis. They are ranging from theories of the greater-less of Yin and Yang, 7 emotions, organs- visceras, 8 diagnostic criteria, and pulse diagnosis to meridian circulation. Conclusions: It needs to be set clinical guidelines by which to practice Sa-Ahm acupuncture though it is nowadays mostly-used method in accordance with practitioner's viewpoints.

        • KCI등재

          Bax의 발현증가 및 Caspase의 활성을 통한 봉독약침액 Melittin의 인체폐암세포 Apoptosis 유발에 관한 연구

          안창범,임춘우,김철홍,윤현민,장경전,송춘호,최영현,Ahn,,Chang-beohm,Im,,Chun-woo,Kim,,Cheol-hong,Youn,,Hyoun-min,Jang,,Kyung-jeon,Song,,Choon-ho,Choi,,Yung-hyun 대한침구의학회 2004 대한침구의학회지 Vol.21 No.2

          Objective : To investigate the possible molecular mechanism (s) of melittin as a candidate of anti-cancer drug, we examined the effects of the compound on the growth of human lung carcinoma cell line A549. Methods : Growth inhibitory study, flow cytometry analysis, SDS-polyacrylamide gel electrophoresis and Western blot analysis, RT-PCR and in vitro caspases activity assay were performed. Results : Melittin treatment declined the cell viability of A549 cells in a concentration-dependent manner, which was associated with induction of apoptotic cell death. Melittin treatment down-regulated the levels of Bcl-XS/L mRNA and protein expression of A549 cells, an anti-apoptotic gene, however, the those of Bax, a pro-apoptotic gene, were up-regulated. Melittin induced the proteolytic cleavage and activation of caspase-3 and caspase-9 protease in a dose-dependent manner without alteration of inhibitor of apoptosis proteins family and Akt expression. Western blot analysis and RT-PCR data revealed that the levels of tumor suppressor p53 and cyclin-dependent kinase inhibitor p21 were also remained unchanged. Conclusions : Taken together, these findings suggest that melittin-induced inhibition of human lung cancer cell growth is associated with the induction of apoptotic cell death via regulation of several major growth regulatory gene products, and melittin may have therapeutic potential in human lung cancer.

        • KCI등재

          현훈(眩暈)의 침구치료(鍼灸治療)에 대한 문헌적(文獻的) 고찰(考察)

          송춘호,안창범,장경전,윤현민,Song,Choon-Ho,Ahn,Chang-Beohm,Jang,Kyung-Jeon,Youn,Hyoun-Min 경락경혈학회 2003 Korean Journal of Acupuncture Vol.20 No.4

          Objectives & Methods : This study was to study acupuncture and moxibustion treatments for dizziness, I've got compared and analyzed 41 kinds of books since Nei Jing(內經). It seems that the meridians of Bladder, Gall bladder and Governing vessel were mostly used for them in connection with functions of each meridians. Results and Conclusion : 1. The symptoms of dizziness are illusion, nausea, vertigo, tinnitus and mild headache 2. The meridians of acupuncture points which was used much for dizziness were Bladder meridian, Gall bladder meridian and Governing Vessel 3. The frequency of using acupuncture points in this treatment were P'ung Ji(GB20)-27th, Chok-Samni(S36)-17th, Paek'oe(GV20)-15th, Pungnyung(S40)-9th, Shinmack (B62)-9th.

        • SCOPUSKCI등재

          『영추(靈樞)』, 『소문(素問)』, 『난경(難經)』에 나타난 오수혈(五輸穴)의 개념에 대한 고찰

          안철우,민영광,안창범,장경전,김철홍,송춘호,윤현민,Ahn,,Chul-Woo,Min,,Young-Kwang,Ahn,,Chang-Beohm,Jang,,Kyung-Jun,Kim,,Cheol-Hong,Song,,Choon-Ho,Yoon,,Hyun-Min 대한약침학회 2008 Journal of pharmacopuncture Vol.11 No.1

          In $\ulcorner$Yingshu(靈樞)$\lrcorner$, $\ulcorner$Sumun(素問)$\lrcorner$ and $\ulcorner$Najing(難經)$\lrcorner$, there are differences in viewing FiveSu-point(五輸穴) and its practical application in treatment. The following conclusions are induced from these different point of views. 1. Fundamental features of FiveSu-point are shown in$\ulcorner$Yingshu(靈樞)$\lrcorner$ 2. In $\ulcorner$Internal classic(內經)$\lrcorner$ and $\ulcorner$Najing(難經)$\lrcorner$, it seems attachment that FiveSu-point is identical to the Five Elements, but there are differences in using the Five Elements sangsyang-sangguk in treatment. 3. There are clear differences between $\ulcorner$Internal classic(內經)$\lrcorner$ and $\ulcorner$Najing(難經)$\lrcorner$ in attachment of FiveSu-point and Fourseasons. Differences are shown in each chapter of $\ulcorner$Yingshu(靈樞)$\lrcorner$. 4. Different application of FiveSu-point's various cases is shown in $\ulcorner$Yingshu(靈樞)$\lrcorner$, $\ulcorner$Sumun(素問)$\lrcorner$ and $\ulcorner$Najing(難經)$\lrcorner$. 5. Different application of FiveSu-point in $\ulcorner$Yingshu(靈樞)$\lrcorner$, $\ulcorner$Sumun(素問)$\lrcorner$ and $\ulcorner$Najing(難經)$\lrcorner$ is due to different historical background.

        • KCI등재

          Effect of Juglans sinensis Dode extract on chemical hypoxia-induced cell injury in human glioma cells

          윤현민,허재영,안창범,Youn,,Hyoun-min,Heo,,Jae-yeong,Ahn,,Chang-beohm The Korean Acupuncture Moxibustion Medicine Societ 2003 대한침구의학회지 Vol.20 No.2

          이 논문(論文)은 활성 산소(ROS)의 작용(作用)을 규명하고 호도약침액(胡桃藥鍼液)이 인간의 신경교종 세포인 A172에서 화학적(化學的) 저산소증(低酸素症)으로 유발된 세포 사멸에 대해 효능이 있는지를 연구(硏究)한 것이다. 화학적(化學的) 저산소증(低酸素症)은 세포내 미토콘드리아의 전자 수송을 방해하는 antimycin A를 가진 배양세포에 의해 유발(誘發)하였다. 화학적(化學的) 저산소증(低酸素症)에 노출된 세포(細胞)는 시간과 그 양에 따라서 세포 사멸의 결과(結果)가 다르게 나타난다. 화학적 저산소증에 의해서 ROS의 생산이 증가하는데 이것은 $H_2O_2$ 소거(消去) Catalase(과산화수소를 물과 산소로 분해하는 효소)에 의해 방지(防止)된다. Catalase는 화학적 저산소증에 의해 유발(誘發)된 세포 사멸을 방지하는데 비해 DMTU는 효과적이지 않다. 지질(脂質)에 녹는 산화방지제 DPPD와 물에 녹는 산화방지제 Trolox는 세포사멸을 방지하는데 효과(效果)가 없다. 호도약침액(胡桃藥鍼液)은 그 양(量)에 의존적으로 저산소증에 의해 유발된 세포 사멸을 방지하는 효과가 있다. 즉 화학적 저산소증으로 유도된 ROS의 발생을 막고, $H_2O_2$로 유도된 세포사멸을 방지하는데 이것은 화학적 저산소증과 $H_2O_2$의해 유도된 세포사멸에 대해 호도약침액(胡桃藥鍼液)이 방지효과(防止效果)가 있다는 것을 의미한다. 이러한 결과(結果)들은 $H_2O_2$가 지질 과산화와는 무관한 메카니즘으로 저산소증(低酸素症)으로 유발(誘發)된 세포사멸을 중재하고, 따라서 호도약침액(胡桃藥鍼液)은 지질막의 과산화를 방지하기 보다는 ROS를 직접적으로 소거(消去)함으로써 방지 효과가 있다는 것을 의미한다. 더구나 화학적(化學的) 저산소증(低酸素症)은 caspase와 무관한 메카니즘으로 apoptosis를 유발(誘發)한다.

        • SCOPUSKCI등재

          기능성 두통에 대한 황련해독탕약침(黃連解毒湯藥鍼)의 임상적 연구

          김홍기,윤현민,안창범,Kim,,Hong-Ki,Youn,,Hyoun-Min,Ahn,,Chang-Beohm 대한약침학회 2006 Journal of pharmacopuncture Vol.9 No.3

          Objective : The aim of this study was to investigate the effect of HHT(Hwangryunhaedoktang Herbal-Acupuncture) on functional headache. Methods : 26 clinical experiment participants who experienced functional headache were gathered. The qualified patients were classified in two group, Normal saline injection group and Hwangryunhaedoktang Herbal-Acupuncture group. NS group was injected normal saline and HHT group was injected HHT at GB20, GB21, LI4. Treatment was applied 4 times every second day. The effects of both groups were analyzed using VAS scores and BPI(Brief Pain Inventory). Result : The VAS pain scores improved in both groups. the BPI scores decreased only in HHT group. The decrease rate of VAS scores and BPI scores was larger in HHT group. Conclusion : These results provided that HHT group is more effective than NS group. For clearly comparing the Effect of Hwangryunhaedoktang Herbal-Acupuncture on functional headache, it is need more sample's number and more treatment's duration.

        • KCI등재

          Effect of Juglans sinensis Dode extract on chemical hypoxia-induced cell injury in human glioma cells

          Youn,,Hyoun-min,Heo,,Jae-yeong,Ahn,,Chang-beohm 대한침구학회 2003 대한침구의학회지 Vol.20 No.2

          이 論文은 활성 산소(ROS)의 作用을 규명하고 胡桃藥鍼液이 인간의 신경교종 세포인 A172에서 化學的 低酸素症으로 유발된 세포 사멸에 대해 효능이 있는지를 硏究한 것이다. 化學的 低酸素症은 세포내 미토콘드리아의 전자 수송을 방해하는 antimycin A를 가진 배양세포에 의해 誘發하였다. 化學的 低酸素症에 노출된 細胞는 시간과 그 양에 따라서 세포 사멸의 結果가 다르게 나타난다. 화학적 저산소증에 의해서 ROS의 생산이 증가하는데 이것은 H_2 O_2 消去 Catalase(과산화수소를 물과 산소로 분해하는 효소)에 의해 防止된다. Catalase는 화학적 저산소증에 의해 誘發된 세포 사명을 방지하는데 비해 DMTU는 효과적이지 않다. 脂質에 녹는 산화방지제 DPPD와 물에 녹는 산화방지제 Trolox는 세포사멸을 방지하는데 效果가 없다. 胡桃藥鍼液은 그 量에 의존적으로 저산소증에 의해 유발된 세포 사멸을 방지하는 효과가 있다. 즉 화학적 저산소증으로 유도된 ROS의 발생을 막고, H_2 O_2로 유도된 세포사멸을 방지하는데 이것은 화학적 저산소증과 H_2 O_2의해 유도된 세포사멸에 대해 胡桃藥鍼液이 防止效果가 있다는 것을 의미한다. 이러한 結果들은 H_2 O_2가 지질 과산화와는 무관한 메카니즘으로 低酸素症으로 誘發된 세포사멸을 중재하고, 따라서 胡桃藥鍼液은 지질막의 과산화를 방지하기 보다는 ROS를 직접적으로 消去함으로써 방지 효과가 있다는 것을 의미한다. 더구나 化學的 低酸素症은 caspase와 무관한 메카니즘으로 apoptosis를 誘發한다.

        • KCI등재

          만성요통환자에 대한 Bee Venom과 Sweet Bee Venom의 치료효능 비교 연구

          김재홍,장선희,윤현민,안창범,장경전,김철홍,송춘호,최하나,Kim,,Jae-Hong,Jang,,Sun-Hee,Yoon,,Hyun-Min,Jang,,Kyung-Jun,Ahn,,Chang-Beohm,Kim,,Cheol-Hong,Song,,Choon-Ho,Choi,,Han-Na 대한약침학회 2008 Journal of pharmacopuncture Vol.11 No.4

          Objective The aim of this study is to investigate if Sweet Bee Venom(SBV) Therapy has the equal effect in comparison with Bee Venom (BV) Therapy on Chronic Lower Back Pain. Methods Clinical studies were conducted to 39 patients who were treated Chronic Lower Back Pain in Dept. of Acupuncture and Moxibustion, Dongeui University from March 1 to June 30, 2008. Subjects were randomly devided into 2 groups : BV treated group(Group A, n=19), SBV treated group(Group B, n=20) In BV treated group(Group A), we treated patients with dry needle acupuncture and BV Therapy. In SBV treated group(Group B), we treated patients with dry needle acupuncture and SBV Therapy. All process of treatment were performed by double blinding method. 1. To estimate the efficacy of venom in controlling pain, we have checked Visual Analog Scale(VAS). 2. For evaluating functional changes of patients, we have checked Oswestry Lower Back Disability Questionnaire(ODI). 3. To estimate Itching which is the most prominent symptom of allergic reaction, we have checked Visual Analog Scale(VAS). Results 1. In controlling pain, the results of BV treated group(Group A) is more effective than that of SBV treated group(Group B). 2. In promoting function, the results of BV treated group (Group A) is more effective than that of SBV treated group(Group B). 3. In controlling itching, the results of SBV treated group(Group B) is more effective than that of BV treated group(Group A). Conclusions According to the study, SBV Therapy shows more effective result than BV Therapy in controlling itching. But BV Therapy is more effective than SBV Therapy in controlling pain and promoting function.

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