제 2 형 당뇨병에서 미세혈관 합병증과 대혈관 합병증의 대비

강문호,이기영,정연실,김홍규,서찬종,송광식,박혜영,이원기 대한당뇨병학회 2001 Diabetes and Metabolism Journal Vol.25 No.2

Background: Type 2 diabetes is a heterogeneous disease. As to its complications, microangiopathy predominantly develop in some patients while macroangiopathy is more predominant in others. Therefore, this study was performed to identify the factors associated with such dissociation. Methods: Type 2 diabetic patients were classified into the macro and microangiopathy groups by carotid intima-medial thickness (IMT) and the presence of severe diabetic retinopathy. Patients with IMT ≤ 0.83 mm and severe NPDR or PDR were assigned to microangiopathy group; those with IMT 0.84 mm and no diabetic retinopathy were assigned to macroangiopathy group. Of 95 patients studied, 14 were classified as microangiopathy group and 20 as macroangiopathy group. Results: When the microangiopathy and macroangiopathy groups were compared, the microangiopathy group were significantly younger at the time of examination and at the onset of diabetes, and had longer duration of diabetes. Percentage of patients receiving insulin treatment was significantly higher and plasma C-peptide significantly lower in the microangiopathy group. However, HDL-cholesterol levels were significantly lower in the macroangiopathy group. Furthermore, the multiple logistic regression analyses revealed that younger onset of type 2 diabetes was an independent factor that was associated with the acceleration of microangiopathy. Conclusion: This study suggests that the age at onset of diabetes is an important independent risk factor that is associated with predominant development of microangiopathy in type 2 diabetic patients.

배양된 혈관내피세포에서 uncoupling protein 2 유전자 과발현이 세포내 산화스트레스 및 endothelin - 1 mRNA 발현에 미치는 영향

강효경,한정희,홍성관,김하영,남궁일성,박기영,박혜선,이재담,박중열,이인규,이기업 한국지질학회 2001 韓國脂質學會誌 Vol.11 No.2

급성 골수성 백혈병(M6)에 합병된 중추성 요붕증 1 예

김성연,조보연,이홍규,고창순,민헌기,김병국,김노경,신찬수,이명식,강덕현,조종태 대한내과학회 1989 대한내과학회지 Vol.37 No.2

Leukemia is known to be an extremely rare cause of diabetes insipidus. We report a case of diabetes insipidus as a complication of leukemia. An 18 year-old man was admitted because of polyuria polydipsia and fever. Bone marrow aspiration and biopsy revealed the diagnosis of acute erythroleukemia (AML, M6). On the water deprivation test, the diabetes insipidus was confirmed to be of the central type. He was managed with intranasal vasopressin for diabetes insipidus with good response. Induction chemotherapy was administered without response, and the patient died of septicemia and respiratory failure 2 months after initial diagnosis. A short review of the literature related to this subject is also presented.

운동후 측복통과 함께 발생한 급성 신부전 1 예

김종순,박영주,조종태,이정임,신민호,구천희,박태용,한승수,강진화 대한내과학회 1996 대한내과학회지 Vol.50 No.6

We report a case of acute renal failure with severe loin pain and patchy renal vasoconstriction after exercise. An immediate postcontrast computed tomogram of this case shows multiple patchy areas of poor contrast enhancement in the cortex of the both kidneys. A 24-hours delayed scan without further injection of contrast dye shows multiple wedge-shaped contrast enhancement in the coincident areas of poor enhancement in the immediate scan. The 2 and 5 days delayed scans show that wedge-shaped contrast enhancement becomes disappeared gradually to the renal cortex, and the 8 days delayed scan shows complete disappearance of contrast enhancement. The renal scintigrams with technetium-99m-methylene diphosphonate and dimercaptosuccinic acid show diffuse increased uptakes and multiple patchy photon deficient areas in the both kidneys respectively. The follow-up renal scintigrams show nearly normal findings, This patient had an uneventful hospital course and recovered completely without dialysis.

발전플렌트용 9Cr 페라이트 내열강의 미세조직과 강도특성

강창룡,성장현,이종문,이규현,이문용 한국열처리공학회 2000 熱處理工學會誌 Vol.13 No.1

This present study were investigated effect of Ni contents on the microstructure and strength characteristic in 9Cr ferritic heat-resistant steel added 1.7%W in place of Mo in order to restrain laves phase formation. The result obtained from this study are as follow. Volume fraction, number of particles per unite area and particle size of carbide decreased with increase of Ni contents. Other side, carbides of M_(23)C_6 type was mainly precipitated in this steel, but laves phases could not precipitated in spite of increasing of aging time. With increase of tempering temperature, hardness was increased, and maximum value was showed around 873k by secondary hardening due to precipitation of W₂C type carbide and then, was decreased. Tensile and yield strength due to decrease precipitation amount of carbide and number of particles per unite area was decreased, but elongation and impact value was increased. In case of aged specimen after tempering than tempered specimen, strength was higher and elongation was lower due to increasing of precipitated amount of carbide and number of particles per unite area

시간응답특성을 고려한 2 광원 1 센서 방식의 capnograph 시스템용 NDIR 식 CO2 가스 챔버 설계 및 측정 회로의 구현

강신원,이성기,조진호,박일용,이인기,강경목 한국센서학회 2001 센서학회지 Vol.10 No.5

The capnograph system for determining the partial pressure of carbon dioxide in the blood of a patient was developed based on the NDIR(non-dispersive infrared) absrnption technology. NDIR gas analyzing method requires an optical absorption chamber and signal processing hardware. In this paper, we have designed and implemented NDIR type CO₂ gas chamber in consideration of the time response characteristics and lamp chopping frequency. And we have implemented signal processing hardware using two infrared sources to reduce the thermal background effect. The implemented gas chamber and signal processing hardware were tested in the temperature variation experiment and human expiratory experiment. The results showed that the system could produce a stable output signal and a good CO₂ gas concentration curve like a typical capnogram.

Cu 함유 TRIP 형 고장력 강판의 잔류오스테나이트 및 인장특성에 관한 연구

강창룡,성장현,김한군,문원진,김효정 한국열처리공학회 1999 熱處理工學會誌 Vol.12 No.3

Volume fraction and morphology of retained austenite, tensile peoperties of TRIP type high strength steel sheet with Fe-C-Si-Mn-Cu chemical composition have been investigated. The retained austenite of granular, bar and film type existing in specimen was obtained after intercritical annealing and austempering. The granular type retained austenite increased with increase of intercritical annealing and austempering temperature. With increase of intercritical annealing temperature, retained austenite and carbon contents increased. Maximum contents of retained austenite was obtained by austempering at 400℃. The maximum tensile strength was obtained by austempering at 450℃ and maximum elongation was obtained at 400℃. T.S×E.L value increased with increase of retained austenite contents due to the elongation strongly controlled by contents of retained austenite, but tensile strength was affected with various factors such as bainitic structure etc.

13%Cr 스테인리스강의 표면 질소침투처리에 미치는 Al 첨가의 영향

강창룡,성장현,이해우,김기돈,윤삼석 한국열처리공학회 1999 熱處理工學會誌 Vol.12 No.3

The surface nitrogen permeation of Al alloyed 0.14%C-13%Cr stainless steels was investigated after heat treating at 1050℃∼1150℃ in the nitrogen gas atmosphere. The strong affinity between Al and nitrogen permeates the nitrogen through the interior of the steels. Two precipitates of round type and needle type are observed at the surface layer. These precipitates mainly consist of AlN containing plenty of aluminum. The surface layer of 0.53%Al alloyed specimen shows ferrite phase, while the surface layers of 1.65%Al and 2.27%Al alloyed specimens appear γ plus α phases. The depth of nitrogen permeation depends upon the Al content and microstructure of the matrix. The 1.65%Al alloyed specimen representing α+γ matrix phases at the nitrogen permeation temperature shows the maximum case depth in this experiment. Although the surface hardness increases by raising the Al content of the specimen owing to the increase of nitride precipitation density, the nitride precipitation deteriorates the corrosion resistance in the solution of HCl, H₂SO₄, and FeCl₃.

Cu-Al-Ni-Ti-Mn 합금의 변태특성 및 기계적 성질에 미치는 가공열처리의 영향

강조원,장우양,양권승,이영수,곽사호,김춘동,백승남 한국열처리공학회 1999 熱處理工學會誌 Vol.12 No.2

The distribution of the second phase, the change of transformation temperature and mechanical properties with thermomechanical treatment conditions were investigated by metallography, calorimetry, EDS, tensile test and fractography in a Cu-Al-Ni-Ti-Mn alloy. The cast structure revealed Ti-rich precipitates(X_L phase) between dendrite arms, which have been identified as (Cu,Ni)₂TiAl intermetallic compounds. By homogenizing above 900℃, the X_L phase was melted in the matrix, while the X_s phase was precipitated in matrix and the volume fraction of it was increased. When hot-rolled specimen was betatized below 750℃, recrystallization could not be observed. However, the specimen betatized above 800℃ was recrystallized and the grain size was about 50㎛, while X_s phase was precipitated in matrix. With raising betatizing temperature, M_s and A_s temperatures were fallen and transformation hysteresis became larger. The strain of the specimen betatized at 800℃ was 8.2% as maximum value. The maximum shape recovery rate could be obtained in the specimen betatized at 800℃ but it was decreased due to the presence of X_s phase with increasing betatizing temperature.

Trip 형 고장력강판의 인장성질 및 점용접성

강창룡,김태일,김효정,김창규,이병우,이규현,이문용 한국열처리공학회 1998 熱處理工學會誌 Vol.11 No.4

The effects of retained austenite and carbon content in the retained austenite on the tensile strength-elongation balance and spot weldability of TRIP high strength steel sheet have been investigated. The retained austenite of granular type increased with increasing intercritical annealing and austempering temperature, and film type was increased with the increase of austempering time. The volume fraction of retained austenite increased with 'decreasing intereritical annealing temperature, and the maximum value was obtained at austempering temperature of 400℃. The values of tensile strength-elongation balance increased with decreasing intercritical annealing temperature and maximum value was obtained at austempering temperature of 400℃. The maximum value of tensile strength-elongation balance was obtained at a retained austenite content of about 12%. Tensile shear strength of the specimens with retained austenite was higher than that of the normalizing specimens. With increasing welding current and time, the tensile shear strengh and nugget diameter increased, while nugget thickness showed the peak value and then decreased. The optimum range of welding condition at the given welding pressure of 350kgf was 7-11㎄ and 10∼15 cycles.