비글개에서 신우황청심원의 급성 및 아급성독성시험

권오경,성하정,곽형일,방명주,신대희,이진영,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Single and 4 weeks oral administration of New Woohwangchungsimwon (NWCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs(3 males and 3 females) in acute experiments were administered orally with single dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NWCH, 160 ㎎/㎏/day(low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NWCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NWCH in beagle dogs is considered to be safe.

Refractory Ceramic Fiber와 Rock Wool로 자극한 폐포대식 세포에서 Reactive Oxygen Species 분비와 관련된 세포내 신호변환계

이권행,임영,양경숙,오현숙,김은경,김경아 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4

Objectives : It is known that the high fibrogenecity of particles is connected with their cytotoxicity for macrophages. Although the molecular mechanism leading to fiber-induced fiber-induced cytotoxicity is still not clear, several mechanism have been suggested. The release of reactive oxygen species(ROS) from activated alveolar macrophages(AM) by dust have been suggested as a possible mechanism of particle-induced cell damage. But the mechanism which man-made vitreous fiber(MMVF) induces the production of ROS in AM is still not clear. In this study, we evaluated the relationship between ROS production and lactate dehydrogenase(LDH) release from alveolar treated with refractory ceramic fiber(RF2) or rock wool(RWI) and signal transduction path-way of ROS production in RF2 or RW1 exposed AM. Methods : We investigated LDH release from MMVF-stimulated AM for index of cytotoxicity. To determine what kind of signal transduction pathways are involved in MMVF-stimulated ROS generation, we used some drugs which have an effect on the signal transduction pathway. Results : RF2 and RW1 induced increase of LDH release with dose-dependent manner with RF2 having greater effect than RW1. There was a dose-dependent increase in the production of ROS by RF2 or RW1. At all level of concentration, RF2 induced more ROS production than RW1. Inhibitors of PKC(bisindolylmaleimide), PLC(U73122 and neomycine) and PTK(genistein and erbstatin) suppressed RF2 or RW1-induced ROS production. Conclusion : There was significant correlation between LDH release and ROS production from AM treated with RF2 or RW1. RF2 and RW1 induced ROS generation through protein kinase C(PKC), phospholipase C(PLC) and protein tyrosin kinase(PTK) pathways.

갑상선 초음파검진의 유용성

배오근,김재권,강명순,조영익,김임봉,신유진,임성규,서민호 한국건강관리협회 2000 건협 Report Vol.3 No.-

생산성 향상을 위한 생산 관리 시스템

김영진,오삼권,임기욱 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

기업 내 관련 업무 및 조직의 유기적 연결을 통한 원활한 정보의 흐름은 생산성의 중대에 많은 영향을 주며 기업의 경쟁력과도 밀접한 관계가 있다.이러한 이유로 연구개발에서부터 설계, 제조, 판매에 이르기까지 컴퓨터와 통신기술을 활용하여 기업의 업무 흐름을 통합적으로 관리할 수 있는 컴퓨팅 시스템이 필요하다.그러나 기업 내 업무의 성격 및 규모, 어플리케이션 튜닝 등의 충분한 검토가 수행되지 않은 컴퓨팅 시스템은 개발비용의 부담과 더불어 시스템의 성능을 오히려 저하시킬 수 있다.본 논문은 생산 제조 업체의 업무의 성격과 환경에 적합하고 업무의 흐름을 유기적으로 통합 관리할 수 있는 클라이언트/서버 기반 생산 관리 시스템을 설계 및 구현하였다.

粘性土의 反復壓密特性에 關한 硏究

鄭哲源,權俊五,鄭永同 朝鮮大學校 工科大學 1974 論文集 Vol.3 No.-

Up until today, there are not a few problems to be applied in the course of the analysis of consolidation characteristics of cohesive soil under repeated loads. As this consolidation is belived to occur on road subgrades as well as on railway bases when the latters are under traffic loads, in the ground under periodic stresses of oil tanks, docks, and occur on clay layers under fluctuating condition through ground -water-level, the consolidation sinkage is not the same as that of static stress. This consolidation sinkage is understood to be designed in the light of repeated stress.

만성 간질환 환자에서 Phospholipase A₂활성도

이종면,권영오,김능수 경북대학교 의학연구소 1999 경북대학교병원의학연구소논문집 Vol.3 No.1

Background/Purpose : Phospholipase A2 (PLA2) is an rate-limiting enzyme hydrolyzing arachidon-ic acid from the sn-2 position of membrane phospholipids. In vitro studies demonstrated that the enzyme could be secreted into extracellular mileu by pro-inflammatory cytokines and endotoxin which were reported to have important roles in chronic liver diseases. This study was performed to know whether the enzyme is involved in the pathophysiology of the diseases. Methods : The subjects were cumposed of 24 patients with chronic hepatitis B, 26 patients with liver cirrhosis and 14 healthy individuals. The PLA2 activities were measured in the sera of the subjects by detecting radioactivity of 14C-fatty acid hydrolyzed from 14C-labeled phosphotadylethanolamine by the enzy-me. Results : The activities of PLA2 were increased in the patients with chronic liver diseases, especially in the chronic hepatitis B patients with acute exacerbation and in the decompensated cirrhoses patients. Furthermore, their activities were closely realted with the levels of transam-inase in hepatitis group and with the levels of serum albumin in cirrhosis group, respectively. Conclusions : These results suggest that extracellular PLA2 might be involved in the exacerbation and progression of the chronic liver diseases.

위내시경에 의한 칫솔제거

최성곤,권영오,김성국,최용환,정준모 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.1

최근 내시경술의 발전으로 진단적인 측면 뿐 아니라 그 치료적인 면에서도 많이 이용되고 있는 실정이다. 저자들은 오심을 해결하기 위해 칫솔로 설근부를 자극하여 구토를 유발하던 중 우발적으로 연하되어 식도·위 접합부 및 위내에 있다가 내시경으로 제거된 칫솔 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. With the improvement of the technique and instrument, the gastroduodenal endoscope has been used not only in diagnostic purpose but in therapeutic approach. In this case, we removed a swallowed toothbrush in esophagus and stomach with gastroduodenal endoscope and snare without complication.

비글개에서 신원방우황청심원의 급성 및 아급성독성시험

성하정,권오경,방명주,곽형일,이진영,신대희,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Single and 4 weeks oral administration of New wonbangwoohwangchungsimwon (NSCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs (3 males and 3 females) in acute experiments were administered orally with sinlge dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NSCH, 160 ㎎/㎏/day (low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NSCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NSCH in beagle dogs is considered to be safe.

골프 스코어 관리 시스템

윤경현,서태연,민용식,오삼권 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

본 연구는 골프 수행 능력(핸디캡)을 향상시키기 위한 도구 개발로서, 자신의 스코어를 통계적인 측면에서 관리를 보다 과학적으로 하고자 하는데 도움을 주는 소프트웨어를 개발하는데 그 주된 목적이 있다.

Long Term Success Rate of Abstinence in the Elderly After Admission to Intensive Smoking Cessation Camp

( Jaekyeong Lee ),( Yu-il Kim ),( Ha-young Park ),( In-jae Oh ),( Tae-ok Kim ),( Hong-joon Shin ),( Yong-soo Kwon ),( Sung-chul Lim ),( Sun-seog Kweon ),( Hyungjoo Oh ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Backgrounds Cigarette smoking is a major cause of lung cancer and COPD. Smoking cessation should be recommended at any age to prevent disease. But a question can be raised if recommendation to stop smoking in elderly is equally effective compared with non-elderly people. Because myth like stereotype exists about elderly people that they are prone to think they have lived long enough so that they don't try to put any effort to change their old habit. In this study, we will find if the abstinence rates are significantly different between non-elderly(< 65) and elderly( >=65) age group. Methods Current smokers had participated in intensive smoking cessation camp at Chonnam national university hospital between 2015 and 2017. We performed a retrospective study to figure out the differences of abstinence success rate between elderly and non-elderly groups. We followed up patients at 6 months from start of abstinence and 2019 year for long term follow-up. Logistic regression analysis was done to figure out which factors were associated with long term success rate of smoking cessation including age group, comorbidities, CO value, regular exercise which were statistically significant in chi-square test or standard t-test. Results Total 351 patients were enrolled. 51 of 81 (62.9%) patients in elderly and 74 of 181 (40.8%) in non-elderly were successful in maintaining abstinence at the time of long term follow up. Age group was not statistically significant in logistic regression analysis (p = 0.07, 95% CI = 0.956 - 3.205). 6 month abstinence was statistically significant in long-term success of abstinence (p = 0.003, 95% CI = 1.311 - 3.910). Conclusion There was no inferior result of abstinence success in the elderly. We can suggest elderly smokers quit their old habit because they are as eager as young-aged people to change.