지난 4년간 학회지 "신경정신의학" 심사 평가보고

오병훈,권준수,남궁기,김승현,지익성,김창윤,하규섭,박원명,김성곤,오강섭,김정범,이수정,정한용,이창욱,박용천,이영문,김세주,이병욱 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.5

Four Years Reports of "Journal of Korean Neuropsychiatric Association" during 2001 to 2005 were evaluated by 18 Editorial Board of Korean Neuropsychiatric Association. We investigated the articles to specific fields and rejection rate etc. by different section chiefs. Although several problems concerning review time duration and rejection guideline issues indicated but generally all reviewer processes proved relatively clear and concise criteria. Through these objective and systematic evaluation Processes, "Journal of Korean Neuropsychiatric Association" will develop a good journal.

MR Angio영상의 Ray Casting 가속화 Algorithm에 관한 연구

정용규,권영만,김욱동 凡石學術奬學財團 2001 凡石學術論文集 Vol.5 No.1

Volume render is to visualize 3D (3 Dimension) information, which is used in diverse applications, such as medical imaging, fluid dynamics, meteorology, failure analysis, and molecular modeling. Medical applications are mainly diagnosis. virtual surgery. image guided surgery and others. Most widely used 3D method in MR and CT Images is Ray Casting, It has some shortcomings of the slow rendering speed. In this reason, many 3D volume visualization methods have been developed. General methods are surface and volume rendering. This paper intends to, show that the job related 3D volume visualization let' us be capable of displaying more realistic images than surface rendering. Proposed method is Ray Casting witch Octree algorithm, Which follows as bellow steps. First of all, depth information is made by threshold segmentation. Secondly, depth range is adjusted. Finally, area within specified depth range is processed to produce the result image. In this step, sampling point which is acquired by interpolating voxel is blended as. semitransparent material. Using blending operation, overlapped objects can be displayed correctly. It accelerates the job more than general Ray Casting.

허혈성 흰쥐 대뇌에서 NMDA 수용체 아단위2A와 중간세사섬유들의 변화

정용욱,문일수,고복현 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

대뇌피질의 지연성 신경손상과 NMDA수용체 아단위2A, NF200K, GFAP의 표현 변화와의 관계를 알아보기 위해 전반적 저산소증(92% N2/8% O2)과 불완전 국소허혈(왼온목동맥 결찰)을 시행하였으며 허혈성 손상이 후 대뇌 피질에서의 NR2A,NF200K,GFAP의 변화는 immuno blot방법과 면역조직화학법을 이용하여 관찰하여 다음과 같은 결과를 얻었다. 1)허혈 손상 3일 후 대뇌 피질 PSD에서의 NR2A항체에 대한 면역 반응성은 정상에 비해 증가하였 으며 NF200K의 면역 반응성은 감소하였다. 2) 허혈 손상 6일 후 대뇌 피질 PSD에서의 NR2A, NF200K항체에 대한 면역 반응성은 함께 감소 하였다. 3) 면역조직화학법에서 NF200K,GFAP에 대한 중간세사섬유들의 표현은 3일 후 정상에 비해 함께 감소 하였다가 6일 후 허혈의 정도에 따라 증가군과 감소군으로 나누어졌다. 이상의 결과를 볼 때 대뇌 피질 PSD에서 NF200K는 3일 이전에는 NR2A의 양에 의해 조절되며 6일 이후에는 NR2A, NF200K 모두 손상되는 과정을 거치는 것으로 생각된다. 또한 별아교세포의 증식은 신경세포 손상을 방지 하기위해 보상적으로 증가하는 것으로 생각 된다. Ischemic brain cortex has been developed to understand the relationship between delayed neuronal damage at the cerebral cortex regions and the expression of NMDA receptor subunit (NR2A), NF200K and GFAP in the conditions of global hypoxia and focal left common carotid artery ligation. Changes of NR2A, NF200K and GFAP in rat brain after ischemic injury were investigated through immunoblot analyses and immunohistochemistry. We found that immunoreactivity to NR2A antibody in the cerebral cortex PSD was up-regulated and recovered to normal by 3 and 6 days while NF200K was down-regulated by 3 and 6 days. Immunoreactivity to anti-NF200K and GFAP antibody was decreased at the third day but by sixth day they were varied on the degree of ischemic damage. These resulys imply that the amount of NR2A and NF200K in cerebral cortex PSD at the third day were reversely changed but by the sixth day all of them were decreased in the process of delayed neuronal damage and that, neuroprotective proliferation of astrocytes may be compensated by the elevation of neuronal cell damage.

위암의 세포유전학적 분석

정용욱,장성익 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

In order to find out the specific chromosomal abnormalities of the gastric adenocarcinoma in Korea, author investigated one primary and two cell lines of gastric cancer with G-banding technique. All tumor cells had clonal chromosomal abnormalities : total 101 numerical and 25 structural karyotypic abnomalies were identified. The most prominent and recurring numerical abnonormalities were trisomy 1, 2, 3, 6, 9, 10, 16, X and tetrasomy 1, 7, 9, 18, 20, 21 and recurrent structural abnormalities were del(1) (q32 →qter), del(1)(p34 →qter), del(3)(p25 →qter), der(4)(4 : 1)(q32 : qter), del(10)(p13 →pter) del(X)(p22). The above results of wide variety of karyotyping in stomach cancer cells indicate that these are general due to secondary changes rather than primary changes specific to stomach cancer cells and also the break at bands 1p34, 2p24, 3p25, 4p14, 5q34, 6p11, 8q24, 11p15, 11q23 give rise to the deletion of cellular oncogenes fgr, src-2, N-myc, rafl, raf2, fms, K-rasl, myc, abl, H-ras1.

SELDI-TOF MS를 이용한 유방암 환자 진단을 위한 새로운 혈청 표지자의 개발

정용식,김호승,윤태일,전미선,윤용달,이용성,이기환,김혜진,김명욱,박희붕 한국유방암학회 2004 한국유방암학회지 Vol.7 No.1

발열을 동반한 호중구감소증에서 Cefepime 단독투여와 Ceftazidime 및 Tobramycin 병합투여의 효능비교

정현욱,채제욱,강미라,양정채,문치숙,기현균,장현하,오원섭,김기현,백경란,이남용,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

목적 : 국내에서 발열을 동반한 호중구감소증이 있는 악성 종양환자에게 경험적 항생제로 베타락탐계 항생제와 아미노배당체의 병합요법의 사용이 일반적이다. Cefepime은 광범위 항균 작용을 가지고 있어, 그람 음성균 뿐만 아니라 그람 양성균에 대해서도 우수한 효과를 나타낸다. 재료 및 방법: 발열을 동반한 호중구감소증이 있는 악성 종양환자를 대상으로 무작위, 공개, 비교 연구를 시행하였다. 대상 환자를 무작위로 cefepime 단독요법군과 ceftazidime 및 tobramycin 병합요법군으로 나누어 투여하고 각각의 임상적 효능과 안전성을 비교하였다. 구강및 인후 점막염이 있는 환자에서 분리된 녹색 연쇄알 구균에 대한 항생제 내성 정도를 조사하였다. 결과 : 대상환자 89명 중 CA 투여군이 48예(53.9%), CT 투여군이 41예(46.1%)이었다. 발열의 유형별로 MDI는 18예(20.2%), CDI는 9예(10.1%), UF는 62예(69.7%)로 두 군 간에 차이가 없었다. CA 투여군과 CT 투여군의 임상적 호전률은 시험약 투여 후 2-4일째 각각 91.7%, 85.4% (P=0.31), 치료 종료 시 각각 91.7%, 100% (P=0.15)로 두 군간에 유의한 차이가 없었다. 치료 종료 시 CA 투여군과 CT 투여군의 세균학적 소실률은 모두 100%로 두 군간의 유의한 차이가 없었다(P=0.78). 점막염이 있는 환자로부터 녹색 연쇄알 구균이 분리된 경우는 25예(28.1%)이었으며, 분리된 녹색 연쇄알 구균은 penicillin, ceftriaxone, cefepime, vancomycin에 모두 감수성을 보였다. 약제 관련 이상 반응의 발생 빈도도 두 군간에 유의한 차이가 없었다. 결론 : 발열을 동반한 호중구감소증이 있는 악성 종양환자의 경험적 항생제로서 cefepime 단독요법은 ceftazidime 및 아미노배당체의 병합요법만큼 효과적이고 안전하였다. Background : Broad-spectrum antibiotic therapy has been recommended as an empirical regimen in cancer patients with febrile neutropenia. Cefepime is a fourth generation cephalosporin with good activity against both gram-positive cocci and gram-negative bacilli. Materials and Methods : To compare the efficacy and safety of cefepime alone with ceftazidime plus tobramycin as empirical regimen for adult cancer patients with febrile neutropenia, a randomized, open label, comparative trial was performed. If the patient showed clinical improvent 72 hours, antibiotic could be changed to oral ciprofloxacin. Clinical and microbiological responses were determined at 72 hours and at the end of therapy. To investigate the antimicrobial resistance of viridans streptococci, swab cultures were obtained from throat in all enrolled patients and antimicrobial susceptibility tests were performed by using microdilution method according to the NCCLS. Results : A total of 89 patients were enrolled. Forty-eight patients received cefepime alone (CA), and 41 patients received ceftazidime plus tobramycin (CT). Demographic and baseline clinical characteristics were similar in both groups (P>0.05). The initial clinical success rate at day 2-4 in group CA (91.7%) was similar with that in CT group (85.4%) (P=0.31). At the end of therapy, the final clinical success rate in CA group (91.7%) was similar to that in CT group (100%) (P=0.15). In 18 patients, with microbiologically defined infections, the eradication rate was 100% in both groups. Adverse events including liver dysfunction (21.3%) and renal dysfunction (2.2%), were similar in both groups (P=0.87). Viridans streptococci were isolated from the throat cultures in 25 cases, and all of these strains were susceptible to penicillin (MIC_(90) 0.12 ㎍/mL), cefepime (1 ㎍/mL), and vancomycin (0.12 ㎍/mL). Conclusion : Efficacy and safety of cefepime monotherapy was comparable to the combination of ceftazidime and tobramycin. It could be used as an alternative empirical regimen for treating cancer patients with febrile neutropenia.

간호사의 병원감염관리에 대한 인지도, 수행도와 심리적 임파워먼트의 관계

정연욱,이용환,유병철 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Background : High degree of awareness and performance for nosocomial infection control are very significant prevention factor of nosocomial infection which is increasing alarmingly in recent years and one of the common cause of opportunistic infection. The aim of this study was to find out the relation between degree of nurse's awareness and performance for nosocomial infection control and their psychological empowerment as a measurement tool for feeling of achievement in their hospitals. Method : We conducted a questionnaire survey during the period from August 2006 to April 2007. Investigation subjects were 262 nurses in 4 medical centers which is located in Busan. We measured nurse's awareness, performance for nosocomial infection control and psychological empowerment with questionnaire. Data analysis was performed with descriptive analysis, t-test, ANOVA and multiple regression analysis using SPSS Win(ver 12.0k) program. Result : The mean score of nurse's awareness, performance for nosocomial infection control and psychological empowerment were 4.76 ± 0.36, 4.32 ± 0.47 and 3.54 ± 0.58, respectively. The mean scores of nurse's awareness were lower than nurse's performance in total score and all subcategories. The correlation of nurse's awareness, performance for nosocomial infection control and psychological empowerment were statistically significant. The nurse's performance of nosocomial infection control was important influential factor of their psychological empowerment. Conclusion : From the result, we can concluded that nurse's awareness level was lower than nurse's performance level and nurse's performance of nosocomial infection control was important influential factor of their psychological empowerment. Therefore, methods for improving nurse's performance level are required for effective prevention of nosocomial infection and increase their psychological empowerment level.

제놈 분석용 계산 Web 서버의 구성

박기정,이병욱,박용하 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

국내 제놈 프로젝트와 생물학 연구자들을 지원하기 위한 GINet 서버에서 분석 프로그램들을 Web을 통해 사용할 수 있도록 GINet 분석계산용 Web 서버를 구성하였다. 각 분석 프로그램의 구조를 분석하여 필요한 데이타와 옵션의 종류 및 사용 형태를 정리한 후, 사용자가 이들을 입력할 수 있는 입력 form을 HTML로 작성하였다. 입력된 옵션과 데이터는 Web 서버에 전송되는데, 이들을 분석하여 해당 실행 프로그램을 실행한 후 분석 결과를 Web 사용자에게 전송해 주도록 CGI 프로그램들을 작성하였다. 특히 분석 프로그램의 형태를 2가지로 나눠 각 경우 CGI 프로그램을 구현하는 공통적인 절차를 구성하였고, 여기에 각 분석 프로그램마다 개별적으로 다른 부분은 개별적으로 보완하는 방식으로 각 CGI 프로그램을 구현하였다. 현재 이 서버에서 직접 지원하는 분석 프로그램은 사용 빈도가 가장 높은 프로그램들과 자체 개발한 프로그램들을 포함한 것이고, 추후 설치되거나 자체 개발되는 프로그램들의 대부분도 이 계산 Web 서버에서 제공될 수 있도록 시스템이 구성될 것이다. A computation server is needed to provide analysis programs to Korean biologists, especially genome researchers, on GINet. For each analysis program, we implmented an input form with HTML and a CGI program of interface between an input form and an analysis program with C language on GINet computation Web server. We made two construction methods of CGI programs for analysis programs, and implemented all CGI programs based on the methods followd by modifying each CGI program for specific processing of each analysis program. On the server ten programs are available now, which include most frequently used ones and those developed by our team, and most programs which will be ported or developed by our team will be available on the Web server.

수직적 안모형태와 치아성숙도의 상관관계에 대한 연구

구용한,현홍근,김정욱,장기택,이상훈,한세현,김종철 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

본 연구는 수직적 안모형태와 치아성숙도의 관계를 평가하고 이러한 연관성에 대한 사춘기 성장의 영향을 평가하기 위한 것이다. 이번 연구를 위해 7세에서 9세, 13세에서 15세 환자 1306명을 Ricketts의 VERT index를 이용하여 수직적 안모 형태를 분류하였고 환자들의 치령을 Demirjian법으로 평가하여 다음과 같은 결과를 얻었다. 1. 모든 군에서 치령이 역령과 비교 시 통계적으로 유의한 수준에서 크게 측정되었다. 2. 사춘기 연령군에서 brachyfacial type의 경우가 dolichofacial type 보다 치아성숙도가 크게 나타나는 경향을 보였다. 여성의 경우는 통계적으로 유의성있게 차이가 나타났으며, 남성의 경우는 통계적 유의성은 보이지 않았다. 3. Brachyfacial type의 경우 사춘기전 군들과 비교 시 사춘기 군들에서 치아성숙도가 유의성있게 높게 나타났으며, dolichofacial type의 경우는 연령층간 치아성숙도의 차이를 보이지 않았다. The purpose of this investigation was to study the relationship between vertical facial pattern and dental maturation in children in pubertal and pre-pubertal periods. The material consisted of lateral head films and panoramic radiographs of 1306 patients. The subjects were selected according to Ricketts's VERT index and other including criteria. These subjects were divided by VERT index to brachyfacial group and dolichofacial group. In each selected subject, dental age was determined according to Demirjian's dental maturity score. All subjects were distributed according to age, vertical facial type and sex, mean and standard deviation of chronological age, dental age and age difference were determined in each group. And the data were analysed to find the difference of tooth maturation by facial pattern. Findings of this study include: 1. In all groups, dental age was determined higher than chronological age in statistically significant level. 2. Compared by vertical facial pattern, in pubertal age groups, it seems that subjects with brachyfacial type presented the tendency to have an advanced dental maturation, only in female group. 3. Compared by pubertal period, brachyfacial groups presented more advanced dental maturation in pubertal groups than pre-pubertal groups.

경북 최초의 신장이식 1례

이중현,김용섭,이정호,이창우,김상욱,이문섭,오민구,하달봉,이경섭 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

신장이식은 환자의 삶의 질을 높이고 거의 정상적인 사회생활을 가능하게 함으로써 말기신부전 환자의 3가지 신대체 요법(혈액투석, 복막투석, 신장이식) 중에 가장 효과적이고 각광받는 치료법이라 할 수 있다. 최근 들어 의료기술과 의학의 발달로 신장이식의 성공률은 과거에 비해 비약적으로 높아지고 있으며 국내에서도 점차 신장이식수술을 받는 환자가 증가하고 있으나 서울이나 다른 대도시에 비해 의료환경이 열악한 중소도시나 지방의 병원에서는 아직도 시행하지 못하고 있는 형편이다. 이에 저자들은 경북 최초로 자체 의료진에 의해 고혈압과 말기 신부전으로 동국대 포항병원에서 혈액투석을 받고 있던 32세의 남자환자에게 부인으로부터 신장을 제공받아 신장이식을 성공적으로 시행하였기에 문헌고찰과 함께 보고하고자 한다. Kidney transplantation is the preferred treatment modality for many patients with end-stage renal disease (ESRD), because it offers improved quality of life over both hemodialysis and peritoneal dialysis. Patients who do well after transplantation generally report improvement in vitality and freedom to return to the style of life that they experienced before their progression to ESRD. Recently, the success rate of kidney transplantation is greatly being increased as the surgical technique and immunosuppressive drugs are developed. Kidney transplantation is also popular in Korea which has good result. But, until now the general hospitals which are located at small city can't try the kidney transplantation because they don't have proper facilities and experts. We firstly experienced a case of kidney transplantation in a 32 years old man with hypertension and chronic renal failure at KyoungBuk province. So we report this case with references.