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Yi Seop Song,Yonghee Lee,Tae-Rin Kwon,Young Heui Kim,김범준 한국생물공학회 2014 Biotechnology and Bioprocess Engineering Vol.19 No.3
The present study was designed to investigatethe anti-inflammatory effects of Picrasma quassioides(P. quassioides) in lipopolysaccharide (LPS)- and interferon(IFN)-γ-stimulated RAW 264.7 cells. P. quassioides hasbeen used as a traditional medicine for the treatment ofgastro-enteritis, eczema, and snakebite. P. quassioidessignificantly decreased LPS- and IFN-γ-stimulated nitricoxide (NO) production in a concentration-dependent manner. Real-time PCR or Western blotting confirmed that theexpression of the extra-cellular signal-regulated kinase(ERK), p42 and, p38 mitogen-activated protein kinases(MAPKs), c-Jun N-terminal kinase, inducible nitric oxidesynthase (iNOS), and cyclooxygenase-2 (COX-2) mediatedMAPK signaling pathways in LPS- and IFN-γ-stimulatedRAW264.7 cells. Mechanistic studies revealed the activitiesof nuclear factor kappa B (NF-κB). As P. quassioidesregulated the gene expression of iNOS and COX-2 inRAW264.7 cells, it might be a promising agent for theprevention and/or treatment of various inflammatory diseases.
송이섭 ( Yi Seop Song ),김형미 ( Hyeong Mi Kim ),이용희 ( Yonghee Lee ),손인평 ( In Pyeong Son ),박귀영 ( Kui Young Park ),이갑석 ( Kapsok Li ),김범준 ( Beom Joon Kim ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.1
Background: Hyaluronic acid (HA) is a carbohydrate, occurring naturally throughout the human body. With linear polysaccharide structure, it is (HA) found in soft connective tissues, cartilage and joinfluids. Hyaluronic acid filler is used for treatment of depth of the fold or volume of filler needed and performed for wrinkle improvement and cosmetic. We did property of matter for the Perfecthaⓡ fillers. Objective: Our purpose is to describe and comment on our experiences with two kinds of Perfecthaⓡ fillers. Methods: We obtained image of the shape of fillers using a folliscope, VC98 and particle size using the Scanning electron microscope (SEM). We tested to make sure that affinity both fillers with water. We mixed the fillers and distilled water. We the PARKER ink added to the mixture. Viscosity and elasticity were measured using a Results: The test revealed that a particle sized Perfecthaⓡ derm deep is bigger than a Perfecthaⓡ derm. We were confirmed as hydrophile. While Perfecthaⓡ derm deep filler has high viscosity and elasticity, Perfecthaⓡ derm filler Conclusion: Two kinds of Perfecthaⓡ fillers act as space filler by binding to water and thus keeping the skin wrinkle-free. (Korean J Dermatol 2014;52(1):7∼12)
송이섭 ( Yi Seop Song ),이용희 ( Yong Hee Lee ),김형미 ( Hyeong Mi Kim ),손인평 ( In Pyeong Son ),정봉열 ( Bong Youl Chung ),이종오 ( Jong Oh Lee ),임채영 ( Chae Young Lim ),박귀영 ( Kui Young Park ),이갑석 ( Kap Sok Li ),김범준 ( 대한피부과학회 2014 대한피부과학회지 Vol.52 No.2
Background: Hyaluronic acid (HA) is a mucopolysaccharide that occurs naturally throughout the human body, where it attaches to collagen and elastin to form cartilage, and also helps maintain the strength and flexibility of the cartilage that cushions joints. A decline in HA synthesis may lead to a variety of symptoms, ranging from joint discomfort, to wrinkles. Cross-linked HA is a viscoelastic solid that resists in vivo degradation by hyaluronidase for much longer than endogenous HA, and which is also a key ingredient in various cosmetics. Objective: To describe our experience with three kinds of Elravieⓡ fillers. Methods: We obtained images of filler shape using a folliscope. Scanning electron microscopy (SEM) was used to compare particle sizes. Hydrophilic filler is a hydroxyl, and for this reason, we mixed the filler with water. Next, PARKER ink was added to the mixture, and viscosity and elasticity were measured using a rheometer. Results: Among the tested fillers, particle size was largest in the Restylaneⓡ SubQ. Elravieⓡ ultra volume filler was greater in volume than Elravieⓡ deep line, and Elravieⓡ light fillers. We confirmed Elravieⓡ fillers to be hydrophilic. Elravieⓡ ultra volume filler was found to have the highest viscosity and elasticity, whilst Elravieⓡ light filler had the lowest. Conclusion: All three kinds of Elravieⓡ fillers were found to be suitable for human cosmetic use.
The risk factors for herpes zoster in bortezomib treatment in patients with multiple myeloma
Yi, Yang-Seon,Chung, Joo-Seop,Song, Moo-Kon,Shin, Ho-Jin,Seol, Young-Mi,Choi, Young-Jin,Cho, Goon-Jae,Lee, Gyeong-Won,Moon, Joon-Ho,Hwang, In-Hye,Ahn, Kang-Hee,Lee, Hee-Sun,Shin, Kyung-Hwa,Hwang, Jong Korean Society of Hematology; Korean Society of Bl 2010 Blood Research Vol.45 No.3
<P><B>Background</B></P><P>Bortezomib has significant activity in treating multiple myeloma (MM). The risk of herpes zoster (HZ) has been reported to increase significantly with bortezomib treatment, but the predisposing factors for HZ are not clear. This study is a retrospective analysis of the relevant risk factors for HZ in Korean MM patients treated with bortezomib.</P><P><B>Methods</B></P><P>Sixty-six patients with refractory or relapsed MM who underwent chemotherapy with bortezomib were included in the study. Prophylactic antiviral drugs were not used for treatment. The following parameters were reviewed: age, gender, stage and type of MM, extent of previous treatment, history of HZ, duration from the time of diagnosis to the time of bortezomib treatment initiation, and absolute lymphocyte counts (ALC) at the time of bortezomib treatment initiation.</P><P><B>Results</B></P><P>The incidence of HZ was 16.7%. There were no intergroup differences between the HZ-positive and the HZ-negative groups with regard to a history of HZ, number of previous treatments, and exposure to steroids before bortezomib treatment. The median duration from the time of MM diagnosis to the time of bortezomib treatment initiation in the HZ-positive group was significantly shorter than that in the HZ-negative group. The median ALC at the time of bortezomib initiation in the HZ-positive group was significantly lower than that in the HZ-negative group.</P><P><B>Conclusion</B></P><P>Bortezomib itself might act as a risk factor for HZ by inhibiting cell-mediated immunity, and patients with low ALC at the time of bortezomib treatment initiation were at greater risk of HZ during bortezomib treatment.</P>
( Song Yeon Yi ),( Young Ju Kim ),( Dong Yeop Lee ),( Jae Ho Yu ),( Jin Seop Kim ),( Soung Gil Kim ),( Ji Heon Hong ) 대한물리치료학회 2021 대한물리치료학회지 Vol.33 No.6
Purpose: This study investigated the effects of open kinetic chain (OKC) exercise for the gastrocnemius (GCM) and tibialis anterior (TA) muscles on static and dynamic balance and muscle strength. Methods: We recruited 21 healthy participants, dividing them into 3 groups (GCM, TA, and non-exercise). Each group contains 7 participants. Two exercise groups (GCM and TA) performed OKC exercise with elastic bands twice per week for 4 weeks, while non-exercise group did nothing. We obtained the data for static and dynamic balance and muscle strength before and after the intervention. We used the Kruskal-Wallis test to compare and analyze the pre-post-intervention differences among the groups. Results: For static balance, the stability index of the TA group was the lowest for the dynamic platform (p<0.05). The dynamic balance of the TA group increased for the anterior and posteromedial directions (p<0.05). The peak torque increased in the TA group for dorsiflexion (D/F) movement and in the GCM group for plantar flexion movement compared with the other groups, except for the left direction during D/F (p<0.05). Conclusion: OKC exercises with elastic bands were effective for selectively increasing muscle strength. It is clinically thought that strength training for TA muscles will be effective among the muscles of the ankle.
HT-29 대장암세포에서 Akt 활성 저해에 따른 셀레늄의 세포 증식억제 효과
Song Yi Park(박송이),In-Seop Kim(김인섭),Se Hee Lee(이세희),Sol Hwa Lee(이솔화),Da Woon Jung(정다운),Ock Jin Park(박옥진),Young Min Kim(김영민) 한국생명과학회 2012 생명과학회지 Vol.22 No.1
Akt는 세포의 증식과 분화에 관여하며 많은 암종에서 과발현되어 있다는 것이 보고되었다. 본 연구에서는 Akt의 조절을 통한 셀레늄의 HT-29 세포의 세포증식억제 시너지효과를 확인하였다. 셀레늄을 농도별과 시간별로 처리하였을 때 HT-29 세포의 증식이 억제되었고, apoptosis가 일어남을 확인하였다. 셀레늄을 농도별로 처리하여 Western blotting 및 immunofluorescence를 실시한 결과 Akt의 인산화가 저해되었고 COX-2의 발현도 저해되었다. 또한 Akt 저해제인 LY294002를 처리한 결과, HT-29 대장암세포의 증식이 억제되었으며, LY294002를 셀레늄과 병행처리하였을 때 셀레늄에 의한 세포증식억제 효과가 더 강하게 나타나는 것을 확인하였다. Akt siRNA에 의한 Akt의 불활성화는 non-transfected 세포에 비하여 HT-29 세포의 성장을 더 강하게 억제하였으며, Akt가 불활성화 되었을 때 COX-2의 발현 역시 non-transfected 세포에 비하여 감소된 것을 확인하였다. 따라서 HT-29 세포에서 셀레늄의 세포증식억제 효과는 Akt와 COX-2 신호분자의 조절을 통해 일어나며, Akt 의 저해는 셀레늄의 대장암세포증식 억제에 시너지 효과를 나타냄을 확인하였다. Akt is known to play an important role in cell proliferation and differentiation, and is also over-expressed in several types of cancer cells. In this study, we explored the anti-proliferative effects of selenium in HT-29 colon cancer cells, mediated through effects on Akt and COX-2. Selenium treatments at different concentrations and for different durations inhibited proliferation of HT-29 colon cancer cells and increased apoptotic cell death. Selenium treatment decreased Akt phosphorylation and COX-2 expression. Treatment with LY294002 (an Akt inhibitor) decreased proliferation of HT-29 cells, while a combined treatment with LY294002 and selenium resulted in even further decreases in cell proliferation. Inactivation of Akt by Akt siRNA treatment abolished these inhibitory effects on cell growth. COX-2 expression decreased in Akt transfected cells compared to non-transfected cells. These results suggest that selenium induced both anti-proliferative and apoptotic effects by inhibiting Akt phosphorylation and COX-2 expression. Selenium treatment also appeared to induce synergistic anti-proliferative effects by inhibition of Akt in HT-29 colon cancer cells.
DC 마그네트론 스퍼터링에 의해 증착한 AZO 박막의 특성
박이섭(Yi Seop Park),이승호(Seung Ho Lee),송풍근(Pung Keun Song) 한국표면공학회 2007 한국표면공학회지 Vol.40 No.3
Aluminum doped zinc oxide (AZO) films were deposited on non-alkali glass substrate by DC magnetron sputtering with 3 types of AZO targets (doped with 1.0 wt%, 2.0 wt%, 3.0 wt% Al₂O₃). Electrical, optical properties and microstructure of AZO films have been investigated by Hall effect measurements, UV/VIS/ NIR spectrophotometer, and XRD, respectively. Crystallinity of AZO films increased with increasing substrate temperature (Ts) and doping ratio of Al. Resistivity and optical transmittance in visible light were 8.8×10 ?⁴ Ω㎝ and above 85%, respectively, for the AZO film deposited using AZO target (doped with 3.0 wt% Al₂O₃) at Ts of 300℃. On the other hand, transmittance of AZO films in near-infrared region decreased with increasing Ts and doping ratio of Al, which could be attributed to the increase of carrier density.