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Case Report : Autosomal Translocation Patient Who Experienced Premature Menopause: A Case Report
( Tae-hee Kim ),( Yesol Kim ),( Do-won Jeong ),( Eun-gyeong Lee ),( Dong-su Jeon ),( Jun-mo Kim3 ) 대한폐경학회 2015 대한폐경학회지 Vol.21 No.2
Premature ovarian failure (POF) is a condition in which the ovarian functions of hormone production and oocyte development become impaired before the typical age for menopause. POF and early menopause are present in a broad spectrum of gonad dysgenesis, from a complete cessation of ovarian function to an intermittent follicle maturation failure. Actually POF has been identified as a genetic entity (especially chromosome X), but data on genetic factors of premature menopause are limited. Until now, several cases revealed that inactivation of X chromosomes has an effect on ages of premature menopause and females with balanced or unbalanced X-autosome translocations can have several reproductive problems. On the other hand, there have been a few data that was caused by autosome-autosome translocation can lead. Therefore we report a relevant case of POF with translocation between chromosomes 1 and 4. She had her first menstrual period at the age of 12, and after 7 years she stopped menstruation. Chromosomal analysis showed 46, XX, t (1;4) (p22.3;q31.3). While evaluating this rare case, we could review various causes (especially genetic factors) of POF. To remind clinicians about this disease, we report a case of POF caused by autosomeautosome translocation with a literature review. (J Menopausal Med 2015;21:112-114)
폐암 환자의 우울에 대한 비약물적 중재의 효과: 체계적 문헌고찰 및 메타분석
김예솔(Kim, Yesol),김보라(Kim, Bora),김희정(Kim, Heejung) 대한종양간호학회 2021 Asian Oncology Nursing Vol.21 No.3
Purpose: The purpose of this study was to examine the effects of non-pharmacological interventions (NPIs) on depression among patients with lung cancer. Methods: A systematic review and meta-analysis were conducted focusing on randomized controlled trials (RCTs) and quasi-experimental studies. A literature search was performed through PubMed, EMBASE, CINAHL, PsycINFO, Cochrane Library, and five Korean databases in November 2020. Data were analyzed using the Comprehensive Meta-Analysis Ver. 3.0 and Review Manager Ver. 5.4 programs. Results: A total of 37 studies, including 25 RCTs and 12 quasi-experimental studies, were identified; 27 studies reported data suitable for meta-analysis. In meta-analysis, the overall effect sizes for NPIs of RCTs and quasi-experimental studies were -0.61 (95% confidence interval (CI): -0.90, -0.31) and -0.40 (95% CI: -0.59, -0.21), respectively. Among the types of NPI in RCTs, the effect size of psychological therapy was the largest with -0.68 (95% CI: -1.13, -0.23). In addition, information & communication technology (ICT) had a larger effect size of -0.68 (95% CI: -1.13, -0.23), compared to face-to-face intervention. Conclusion: NPIs may have a significant effect in reducing depressive symptoms in patients with lung cancer. It is suggested that further studies develop and apply structured NPIs considering intervention components such as type and mode of ICT delivery.
Jung-Hee Kim,Heejong Kim,Yesol Bak,Jeong-Woo Kang,Dong Hun Lee,Man Sub Kim,박연선,Eun-Jin Kim,정강연,YOONGHO LIM,Jin-TaeHong,윤도영 한국응용생명화학회 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.1
Anti-cancer effects of naringenin derivative diethyl (5,4'-dihydroxy flavanone-7-yl) phosphate were evaluated in human lung cancer cells. The effect of diethyl (5,4'-dihydroxy flavanone-7-yl) phosphate (dEdHF-7-p) on A549 cell viability was measured using MTS assay and cell counting. Morphological changes were detected using phase-contrast microscopy. Apoptosis was analyzed using Hoechst staining. The influence of dEdHF-7-p on cell cycle distribution was determined using propidium iodide (PI) staining, and protein expression was determined by Western blot analysis. A newly synthesized naringenin derivative dEdHF-7-p suppressed cell growth of A549though mechanisms including inhibition of cell cycle and increased apoptosis. Apoptotic and cell cycle modulators were changed by dEdHF-7-p in A549 cells; cyclins, ppRB, and antiapoptotic factor Bcl-2 were down-regulated, whereas apoptotic factor Bax and cyclin-dependent kinase inhibitors p21 and p53were enhanced, thereby releasing cytochrome c into the cytosol of dEdHF-7-p -treated-A549 cells. dEdHF-7-p treatment processed caspases-3/-8/-9 and cleavage of poly ADP-ribose polymerase. The dEdHF-7-p treatment enhanced Fas expression and decreased expression of cell survival factors such as PI3K and p-Akt in a dose-dependent manner. Taken together, dEdHF-7-p induces apoptosis by inhibiting the PI3K/Akt survival signaling pathway and modulating mitochondria-emanated intrinsic and Fas extrinsic pathways in A549 cells.
Kim, Yesol,Shukla, Shruti,Ahmed, Maruf,Son, Seokmin,Kim, Myunghee,Oh, Sejong Korean Society for Food Science of Animal Resource 2012 한국축산식품학회지 Vol.32 No.6
The present study was aimed to produce a chicken polyclonal antibody against Cronobacter muytjensii and to develop an immunoassay for its detection. Purification of anti-C. muytjensii IgY from egg yolk was accomplished using various methods such as water dilution and salt precipitation. As a result, sodium dodecyl sulfate-polyacrylamide gel electrophoresis produced two bands around 30 and 66 kDa, corresponding to a light and a heavy chain, respectively. Indirect competitive enzyme-linked immunosorbent assay (IC-ELISA) was performed to determine the effectiveness of the chicken IgY against C. muytjensii. The optimum conditions for detecting C. muytjensii by indirect ELISA and checkerboard titration of the antigen revealed an optimum average absorbance at the concentration of 18 ${\mu}g/mL$, having ca. $10^8$ coated cells per well. The anti-C. muytjensii IgY antibody had high specificity for C. muytjensii and low cross-reactivity with other tested pathogens. In this assay, no cross-reactivity was observed with the other genera of pathogenic bacteria including Escherichia coli O157:H7, Salmonella Typhimurium, Staphylococcus aureus, Bacillus cereus, Enterobacter aerogenes, Salmonella Enteritidis and Listeria monocytogenes. In addition, detection of C. muytjensii in infant formula powder showed a low matrix effect on the detection curve of IC-ELISA for C. muytjensii, with similar detection limit of $10^5$ CFU/mL as shown in standard curve. These findings demonstrate that the developed method is able to detect C. muytjensii in infant formula powder. Due to the stable antibody supply without sacrificing animals, this IgY can have wide applications for the rapid and accurate detection of C. muytjensii in dairy foods samples.
Yesol Kim,Seho Cho,Sungho Lee,Young-Seak Lee 한국탄소학회 2012 Carbon Letters Vol.13 No.4
Nanoporous non-woven carbon fibers for a gas sensor were prepared from a pitch/polyacrylonitrile (PAN) mixed solution through an electrospinning process and their gas-sensing properties were investigated. In order to create nanoscale pores, magnesium oxide (MgO) powders were added as a pore-forming agent during the mixing of these carbon precursors. The prepared nanoporous carbon fibers derived from the MgO pore-forming agent were characterized by scanning electron microscopy (SEM), N2-adsorption isotherms, and a gas-sensing analysis. The SEM images showed that the MgO powders affected the viscosity of the pitch/PAN solution, which led to the production of beaded fibers. The specific surface area of carbon fibers increased from 2.0 to 763.2m2/g when using this method. The template method therefore improved the porous structure, which allows for more efficient gas adsorption. The sensing ability and the response time for the NO gas adsorption were improved by the increased surface area and micropore fraction. In conclusion, the carbon fibers with high micropore fractions created through the use of MgO as a pore-forming agent exhibited improved NO gas sensitivity.