지하수 중 자연방사성물질의 위해성 관리에 대한 고찰

신동천,김예신,문지영,박화성,김진용,박선구 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.4

At present, the health risks associated with the natural radionuclides of ground water have become a concern as potential social problems. However, there are no regulatory actions or control strategies for such risks. Therefore, we have investigated and discussed the risks and associated management strategies for radionuclides in other countries. US EPA has proposed MCL (300 pCi/L) and AMCL (4,000 pCi/L) for radon, and 30 ppb for uranium, 15 pCi/L for gross-alpha and 5 pCi/L for radium as final MCLs. Also, Canada, WHO and European countries have their inherent management levels. Finally, we suggested several criteria for setting guidelines in our countries including exposure related criteria such as geological distribution, occurrence, exposure probability distribution, exposure population and multimedia exposure assessment, acceptable risk, and cost-benefit analysis. The national-scale exposure and risk assessment, and economic analysis should be conducted for producing and aggregating the representative information on these criteria.

서당과 소학의 전통교육이 현대 인성교육에 주는 함의

신창호 ( Shin Chang-ho ),예철해 ( Ye Cheol-hae ),윤영돈 ( Yoon Young-don ),임홍태 ( Lim Hong-tae ),지준호 ( Chi Chun-ho ) 안암교육학회 2017 한국교육학연구 Vol.23 No.1

본 연구는 조선시대 아동·청소년 교육의 중심이 된 서당과 소학교육을 검토하고, 그것이 현대 인성교육에 주는 함의를 살펴보는 작업이다. 이른바 전통교육을 현대 인성교육의 차원에서 모색하는 시도이다. 소학의 경우, 효(孝)와 경(敬)을 교육의 핵심내용으로 담고 있으며, 그것은 일상생활에서 실천할 수 있는 구체적 행위 지침을 제시하고 있다. 이에 소학의 기본인 쇄소응대진퇴(灑掃應對進退)와 예악사어서수(禮樂射御書數)의 의미를 구체적으로 분석하여 현대적 독해를 시도하였다. 소학에서 주의할 만한 함의는 교육내용의 습관화(習慣化)이다. 습관은 행위의 지속을 보장하기 때문에 인성을 강화하고 성장시킨다. 그것이 인성교육의 근본내용이자 방법으로 기능할 수 있다. 서당의 경우, 소학의 내용을 현실적으로 담보하며 실제로 가능케 하는 교육공간, 즉 학교라는 점에서 소학의 내용과 유기적으로 연결되는 동시에 실천하는 역할을 한다. 서당의 교육에서는 교육방법을 중심으로 고찰하였는데, 강독(講讀)과 제술(製述), 습자(習字)를 중심으로 교수-학습법을 구명하였다. 그 결과 소학과 서당의 전통 아동·청소년 교육은 현대 인성교육의 차원에서 몇 가지 시사점을 던져 준다. 첫째, 건전한 인성 형성을 위한 교육내용의 습관화, 둘째, 지식과 도덕의 융합과 통일화, 셋째, 인성확립을 위한 개별 수준의 학문과 깨달음의 전수이다. The purpose of this research is to examine So-Hak(小學) and Seodang(書堂) education, which were at the heart of child-adolescent education in Cho-Sun dynasty, and their implications on character education. In other words, this research is an attempt to review a traditional education from a modern character education perspective. So-Hak contains as major educational concepts Hyo(孝) and Kyeong(敬), guiding principles of daily lives. In this research, two basic concepts of So-Hak were reinterpreted from a modern perspective, namely, Soe-So-Eung-Dae-Jin-Tae(灑掃應對 進退) and Ye-Ak-Sa-Eu-Seo-Su(禮樂射御書數). One of major implications of So-Hak lies on the habituation of what is learned, for habit leads to continuation of action, out of which the development of character emerges. As such, the role of habituation in character education is twofold, namely, basic educational content and method. Seodang is a school in which the teachings of So-Hak is realized. From an educational method perspective, Seodang`s teaching-learning methods of reading, writing, and calligraphy methods were examined. As a result, three implications of So-Hak and Seodang were drawn, the habituation of what is learned, unification of knowledge and morality, and individualized learning based on one`s own level.

만성 견비통에 대한 동씨침 치료의 무작위 대조군의 임상 연구

김찬영,권나현,신예지,남동우,김건형,김종인,최도영,이윤호,이재동 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-

Objectives : To observe the effect of acupuncture treatment in chronic shoulder pain patients. Methods : 36 voluntary patients were randomly assigned to an acupuncture treatment group(E GrouP, n=18) and a control group(C GrouP, n=18). The E Group patients received acupuncture treatment on LI_(15), TE_(14), GB_(21) and Master Dong's acupuncture points, Shin-gwan and Gyun-joong, twice a week for four weeks. The C Group patients received no treatment. All patients in both groups were instructed to practise self exercise in their daily lives. Evaluations were made at baseline and after four weeks of study. The Constant Shoulder Assessment(CSA), Shoulder Pain and Disability Index(SPADI) and the patient's subjective pain was measured by Visual Analogue Scale(VAS). The obtained data was analyzed. Results '. The E Group showed significant(p<0.05) improvement in CSA, SPADI and VAS after four weeks of treatment. The C Group showed significant(p<0.05) improvement in CSA, but the change of SPADI and VAS was insignificant(P>0.05). CSA and SPADI of E Group significantly(p<0.05) improved compared to the C GrouP, but the difference of VAS change in the two groups was insignificant(p>0.05). Conclusions : Four weeks of acupuncture treatment significantly improved CSA, SPADI and VAS. The improvement of CSA and SPADI was significant(p<0.05) compared to untreated patients.

청소년의 물질남용 행위 변화를 위한 개념 모형

안성윤,송예헌,이문숙,신홍현,정영희 김천과학대학 2006 김천과학대학 논문집 Vol.32 No.-

The purpose of this study is to develop a new concept model to apply social networks and social support theory to drug abuse behaviors in adolescents group. As the result, this study can be provide fundamental data to develop intervention study in community setting with relating issues.

울산 지역에서 대기중 벤젠으로 인한 암 사망 손실비용 추정 모형에 관한 연구

이용진,김예신,신동천,신영철 한국환경경제학회 한국자원경제학회 2004 자원·환경경제연구 Vol.13 No.1

울산 지역에서 대기중 벤젠으로 인한 발암 인체영향에 대한 경제성 평가를 위해서, 건강 위해성 평가를 수행하여 대상 지역의 이론적 암 사망지수를 추정하고, 대상 지역 주민을 대상으로 가상 가치평가법을 통한 위해도 감소의 지불의사금액을 추정하여 1인의 통계적 생명가치액을 유도하여 이론적 암 사망지수에 대한 사망 손실비용을 유도하였다. 대상 지역의 대기중 벤젠의 평균 농도는 7.88㎍/㎥(min : 1.16∼max : 23.32㎍/㎥)로 조사되어 US EPA IRIS의 벤젠 단위 위해도 2.2×10^(-6)∼7.8∼10^(-6)을 사용하고, 30세 이상의 노출인구수 51만 6,641명에 대한 인구 집단 위해도를 추정한 결과 10년간 발생 가능한 발암 사망지수는 2.90명(5 percentile : 0.32명∼95 percentile : 9.11명)으로 조사되었다. 1인의 통계적 생명가치액을 추정하기 위하여, 공단 지역의 지불의사금약 모형을 추정한 결과, 응답자의 암 치료경험 유·무와 기대 여명, 가족수, 교육수즌이 유의한 영향 요인으로 조사되었고, 연간 1만 평당 5명의 위해도 감소에 대한 지불의사금액은 월1만 4,852원(95% C.I : 1만3,135원∼1만6,794)으로 산출되었으며, 위해도 감소치를 고려한 1인의 통계적 생명가치액은 약 3억6,000만원(95% C.I:3억2,000만원∼4억원)으로 추정되었다. 대기중 벤젠의 발암 영향으로 인한 건강 손실비용은 발암 위해성 평가로 추정된 이론적 사망지수에 1인의 통계적 생명가치액을 곱하여 추정하였다. 추정 결과, 현 수준의 벤젠의 발암 영향이 10년간 지속될 경우 약 10억원(5 percentile: 1억원∼95 percentile: 33억원)의 건강 손실이 있는 것으로 추정되었다. 본 연구 결과, 대기중 벤젠의 노출로 인한 위해도를 줄이기 위해서는 벤젠 단독물질에 대해서 이론적으로 10년간 약 10억원에 대응하는 감소 대책에 투자하여햐 한다. 그러나 벤젠 한 물질만을 감소시키기 위한 대안은 현실적이지 못하므로, 이 연구를 모델로 하여 차후 벤젠을 포함한 휘발성 유기오염물질에 대한 총합 적용이 필요하고, 손실비용을 재추정해야 할 것이다. This study aimed to evaluate cancer damage cost due to risk from benzene inhalation. We performed health risk assessment based on US EPA guideline to estimate annual population risk in Ulsan metropolitan city. Also, we estimated a willingness-to-pay amount for reducing a cancer mortality rate to evaluate a value of statistical life. We combined the annual population risk and the value of statistical life to calculate the cancer damage cost. In the health risk assessment, we applied the benzene unit risk (2.2×10^(-6)~7.8×10^(-6)) in the US EPA's Integrated Risk Information System to assess the annual population risk. Average concentration of benzene in ambient air is 7.88 ㎍/㎥(min: 1.16~ max: 23.32 ㎍/㎥). We targeted an exposure population of 516,641 persons who aged over 30 years old. Using a Monte-Carlo simulation for uncertainty analysis, we evaluated that the population risk of benzene during ten years in Ulsan city is 2.90 persons (5 percentile: 0.32 ~ 95 percentile: 9.11 persons). And the monthly averagc WTP for 5/1,000 cancer mortality reduction during ten years is 14,852 Won(95% C.I: 13,135 ~ 16,794 Won) and the implied VSL is 36 million Won(95% C.I: 32~40 million Won). Cancer damage cost due to risk from benzene inhalation during 10 years in Ulsan city is about 104 million Won(5 percentile: 13 ~95 percentile: 328 million Won). Health benefit cost to reduce a cancer mortality risk of benzene is about 50 million Won in Ulsan metropolitan city. But, it is very important that this cost is not for all health damage cost of cancer mortality in some area. We just recommended a model for evaluating a cancer risk reduction, so we must re-evaluate all integrated application of total VOCs damage cost including benzene.

Poster Session : PS 1489 ; Allergy : A Case of Eosinophilic Gastroenteritis Which Led to Malabsorption and Iron Defl ciency Anemia Associated with Multiple Food Allergies

( Young Soo Lee ),( Ga Young Ban ),( Ji Hye Kim ),( Dae Hong Seo ),( Young Min Ye ),( Yoo Seob Shin ),( Dong Ho Nahm ),( Hae Sim Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Eosinophilic gastroenteritis (EG) is a rare disease characterized by massive eosinophilic infiltration of gastrointestinal tissue, increased peripheral eosinophilia and nonspecific gastrointestinal symptoms. EG have no known causes for eosinophilia such as drug, parasite, or malignancy. About 50% of EG patients have allergic diseases suggesting EG may be associated with allergic status since some EG patients exhibit elevated serum immunoglobulin E (IgE) levels. We report a case of EG which led to severe malabsorption and iron deficiency anemia associated with multiple food allergies. A 28-yearold Caucasian male patient visited emergency room complaining general weakness and leg swelling for 2 months. He had allergic rhinitis and vomiting whenever eating eggs, steaks, and salmons. He looked chronically-ill and conjunctivae were pale. In laboratory findings, hemoglobin level and WBC count were 6.4g/dL and 7,400/uL with 24.4% of eosinophil fraction as well as serum total protein and albumin levels were 3.9g/dL and 2.8g/dL, respectively. Serum iron level (12μg/dL), total iron binding capacity (247μg/ dL), and ferritin level (2.2μg/L) were all decreased. Serum eosinophil cationic protein level was increased (30.0μg/L) whereas serum total IgE level was within normal reference value (77KU/L). Serologic tests for parasite were all negative. Endoscopic studies were performed to exclude gastrointestinal bleeding and multiple nodular lesions were seen on gastric antrum with increased eosinophil in. ltration in lamina propria. High serum specific IgE levels to offending foods (beef: 0.82kU/L, pork: 0.83kU/L, egg white: 0.40kU/L, egg yolk: 0.54kU/L, and milk: 0.81kU/L) were noted. He was recommended avoiding offending foods with oral prednisolone therapy. Six months after food restriction, eosinophil count was 400/uL and hemoglobin level was restored to 11.5g/dL with 4.1g/dL of serum albumin level. We report a rare case of eosinophilic gastroenteritis associated with multiple food allergies.

Prognostic Factors for Chronic Spontaneous Urticaria: A 6-Month Prospective Observational Study

Ye, Young-Min,Park, Jung-Won,Kim, Sang-Ha,Ban, Ga-Young,Kim, Ji-Hye,Shin, Yoo-Seob,Lee, Hyun-Young,Park, Hae-Sim The Korean Academy of Asthma, Allergy and Clinical 2016 Allergy, Asthma & Immunology Research Vol.8 No.2

<P><B>Purpose</B></P><P>Chronic urticaria (CU) has a substantial impact on the quality of life. Little clinical data on the prognosis of CU has been reported. This study aimed to investigate the control status and remission rate of CU and to explore potential predictors of good responses to the treatment during a 6-month treatment period.</P><P><B>Methods</B></P><P>A total of 75 patients with chronic spontaneous urticaria (CSU) were enrolled from 3 university hospitals in Korea. Urticaria control state was classified into 2 groups: group I (remission and well-controlled) and group II (partly and uncontrolled). CU-specific quality of life (CU-QoL) and the urticaria activity score (UAS) were measured before and after the treatment. Autologous serum skin test (ASST), and anti-nuclear and anti-thyroid antibodies were measured at the enrollment into the study. Aspirin intolerance was confirmed by an oral provocation test.</P><P><B>Results</B></P><P>Of 59 patients completing the study, 21 (35.6%) arrived at well-controlled status and only 2 (3.4%) achieved remission, whereas 26 (44.1%) remained at partly controlled status and 10 (16.9%) were at uncontrolled status. Mean changes in CU-QoL (36.5±2.7 vs 20.6±4.3, <I>P</I>=0.017) and UAS (-7.9±0.8 vs -3.0±1.0, <I>P</I>=0.001) were significantly different between groups I and II. The presence of serum autoantibodies and aspirin intolerance had no influence on the control of urticaria in this study. However, ASST positivity was identified as a significant predictor of CU control in multivariate analysis (OR=6.106, <I>P</I>=0.017).</P><P><B>Conclusions</B></P><P>The proportion of CSU patients that achieved remission or a well-controlled state was 39% for the 6 months of stepwise treatment. Longer observations are necessary to assess the exact prognosis of CSU. ASST results may be a useful parameter for predicting a better response to treatment and both UAS and CU-QoL are helpful to monitor therapeutic response.</P>

Establishment of organoid-based xerostomia modeling platform

Ye Young Shin,Su-Jeong Oh,Yoojin Seo,Ji-Su Ahn,Min-Jung Kang,Hyung-Sik Kim 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.1

Antigen-binding Characteristics of Circulating IgG Autoantibodies to Cytokeratin 18 Protein in Patients with Nonallergic Asthma

Young Min Ye,Dong Ho Nahm,Jeong Eun Kim,Hyunee Yim,Jee Young Shin,Hae Sim Park 대한의학회 2006 Journal of Korean medical science Vol.21 No.4

Iris Nertschinskia Ethanol Extract Differentially Induces Cytotoxicity in Human Breast Cancer Cells Depending on AKT1/2 Activity

Shin, Jae-Sik,Maeng, Hyung-Gun,Hong, Seung-Woo,Moon, Jai-Hee,Kim, Jin-Sun,Suh, Young-Ah,Kim, Eun-Sung,Lee, Young-Min,Kim, Ye-Seul,Choi, Eun-Kyung,Kim, Inki,Lee, Sok-Young,Cho, Dong-Hyung,Hong, Nam-Joo Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Recently, we reported that an ethanol extract of Iris nertschinskia induces p53-dependent apoptosis in the MCF7 human breast cancer cell line. However, the detailed mechanisms were not fully explored. Here, we demonstrate another aspect of the activity of I. nertschinskia in breast cancer cells. We compared the response to an ethanol extract of I. nertschinskia in two different human breast cancer cell lines, Hs578Tand MDA-MB231, respectively with relatively low and high AKT1/2 activity by trypan blue exclusion assay and FACS analysis. Knockdown of endogenous AKT1 or AKT2 in breast cancer cells by RNA interference determined the sensitivity to I. nertschinskia ethanol extract compared to control cells. The I. nertschinskia ethanol extract induced cell death in a manner that depended on the level of phosphorylated AKT1/2 protein and was associated with a significant increase in the sub-G1 cell population, indicative of apoptosis. Our results indicate that an ethanol extract of I. nertschinskia differentially induces cell death in breast cancer cells depending on their level of phosphorylated AKT1/2.