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( Woo Haing Shim ),( Hyun Je Park ),( Hoon Soo Kim ),( Su Han Kim ),( Do Sang Jung ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Kyung Sool Kwon ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.4
We report the case of a 23-year-old woman who developed bowenoid papulosis of the vulva and subsequent periungual Bowen`s disease. She had a history of a long standing periungual wart on her right thumb before the outbreak of periungual Bowen`s disease. By HPV DNA chip, human papillomavirus (HPV) 11, 18 and 31 were identified from the periungual lesions, and HPV 11, 18 and 33 from the vulvar lesion. This case supports the theory of anogenital-digital spread of HPV, and proposes that the periungual wart may change into Bowen`s disease by mucosal HPVs. To the best of our knowledge, this case is important as the first Korean case of periungual Bowen`s disease concurrent with bowenoid papulosis of the vulva. (Ann Dermatol 23(4) 493 ~496, 2011)
Three zone of purple, red and white patch, A characteristic dermoscopic sign for glomus tumor
( Woo-haing Shim ),( Geun-hwi Park ),( Sung-min Park ),( Hyun-joo Lee ),( Tae-wook Kim ),( Hyunju Jin ),( Hyang-suk You ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-b 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Despite characteristic clinical features of glomus tumor, dermatologists can meet diagnostic difficulty in some cases with glomus tumor. Objectives: To investigate clinical features and dermoscopic findings of glomus tumors. Methods: For 22 cases of glomus tumors, sex, age of initial visit, disease duration, site of lesion, size, associated symptoms and nail deformities and dermoscopic findings were investigated. Results: Mean age of initial visit and disease duration was 43.4±13.4 years old and 5.6±5.1 years, respectively(19 female, 3 male). Both 1st Fingers(9, 40.9%) were most common involved site. Nail lunula(12,54.5%) was more frequently involved than proximal nail fold(6,27.3%) or nail bed(4,18.2%). 15 cases were identifiable for size, and mean size was 6.0±1.9mm. There was associated symptoms such as pain(16,72.7%), tenderness(7,31.8%) and cold intolerance(2,9.1%). Onychoschizia(13,59.1%), longitudinal ridging(12,54.5%) and distal nail notching(8,36.4%) were commonly associated nail changes. On dermoscopic examination, whitish patch(16, 72.7%), purplish patch(15, 68.2%), erythematous patch(13, 59.1%) and irregular linear vessel(1, 4.5%) were observed. In 9 cases(40.9%), characteristic three zone consisting of central purplish patch, middle erythematous patch and peripheral whitish patch were observed. Conclusion: Characteristic dermoscopic findings of this study can help making more accurate diagnosis and performing appropriated treatment in glomus tumors
[P171] Congenital melanocytic nevus with mucin deposition
( Woo-il Kim ),( Seong-min Park ),( Hyun-ju Lee ),( Hyunju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun-chang Ko ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Congenital melanocytic nevus is defined as a lesion present at birth and containing nevus cells. It is characterized by a diffuse infiltration of nevus cells in the deepest reticular dermis to subcutaneous layer and presence of nevus cells around skin appendages. Cutaneous mucin deposition can be observed in variety of cutaneous disorders. However, it is rare in association with congenital melanocytic nevus. A 9-year-old girl presented with a black colored nodule on the right areolar area. The lesion existed from birth and the size of the lesion increased proportionally as the patient grows up. No subjective symptom such as itching or pain was noted. There was no trauma or medication for nevus lesion on her past history. Skin biopsy was done from the black colored nodule on the right areolar area showed diffuse infiltrated cell nests composed of nevus cells with abundant mucin deposit in papillary and reticular dermis. Mucin deposition in congenital melanocytic nevus has been rarely reported. Aging process, trauma and medication have been suspected as trigger factors. Furthermore, the interaction between melanocytes and the extracellular matrix via various cytokines might be a possible mechanism, but the exact pathway remains to be identified. We report a rare case of congenital melanocytic nevus with mucin deposition, which is especially scarce in children.
A plaque-type variant of acquired rhabdomyomatous mesenchymal hamartoma on the chin
( Woo Il Kim ),( Hyun Ju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Gun Wook Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Rhabdomyomatous mesenchymal hamartoma (RMH) is a rare congenital skin disease. The lesion commonly presents as a solitary sessile papule or nodule on the head and neck in childhood. Its pathologic finding is characterized by aberrant existence of striated muscle fibers in the dermis and subcutaneous tissue. The treatment of typical RMH usually can be a simple excision. However, certain variant of acquired RMH presenting as a plaque on the chin tends to be difficult to be simply excised. To the best of our knowledge, there have been only two reported cases of plaque-type variant of acquired RMH in pubmed searching. A 22-year-old man presented with an asymptomatic erythematous indurated plaque on the chin. The lesion appeared 18 months ago and has shown recent increase of size. Incisional biopsy was performed on the chin and histopathologic finding showed mature striated muscle fibers interspersed haphazardly with collagen fibers and adipocytes in the dermis and subcutaneous tissue. The diagnosis of plaque-type RMH was made based on clinicopathologic finding. We recommended observation with regular follow-up because the lesion was too wide to be excised. We report an extremely rare case of plaque. type variant of acquired RMH and discuss its peculiar clinicopathologic features with the review of literatures.
Ha, Hye-Yeong,Cho, Ik-Hyun,Lee, Kang-Woo,Lee, Ko-Woon,Song, Ji-Young,Kim, Kyoung-Shim,Yu, Young-Mi,Lee, Ja-Kyeong,Song, Jin-Sook,Yang, Sung-Don,Shin, Hee-Sup,Han, Pyung-Lim Elsevier 2005 Developmental Biology Vol.277 No.1
<P><B>Abstract</B></P><P>The JNK interacting protein, JSAP1, has been identified as a scaffold protein for mitogen-activated protein kinase (MAPK) signaling pathways and as a linker protein for the cargo transport along the axons. To investigate the physiological function of JSAP1 in vivo, we generated mice lacking JSAP1. The JSAP1 null mutation produced various developmental deficits in the brain, including an axon guidance defect of the corpus callosum, in which phospho-FAK and phospho-JNK were distributed at reduced levels. The axon guidance defect of the corpus callosum in the <I>jsap1</I><SUP><I>−/−</I></SUP> brain was correlated with the misplacement of glial sling cells, which reverted to their normal position after the transgenic expression of JNK interacting protein 1(JIP1). The transgenic JIP1 partially rescued the axon guidance defect of the corpus callosum and the anterior commissure of the <I>jsap1</I><SUP><I>−/−</I></SUP> brain. The JSAP1 null mutation impaired the normal distribution of the Ca<SUP>+2</SUP> regulating protein, calretinin, but not the synaptic vesicle marker, SNAP-25, along the axons of the thalamocortical tract. These results suggest that JSAP1 is required for the axon guidance of the telencephalic commissures and the distribution of cellular protein(s) along axons in vivo, and that the signaling network organized commonly by JIP1 and JSAP1 regulates the axon guidance in the developing brain.</P>
( Woo-il Kim ),( Seong-min Park ),( Hyun-ju Lee ),( Hyun Ju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Gun-wook Kim ),( Hoon-soo Kiim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun-chang Ko ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Drug-induced acneiform eruption is characterized by occurring on non-seborrheic location and spontaneous resolution after discontinuation of offending drug. Valproate, oxcarbazepine and topiramate are well-known antiepileptic drugs (AEDs) and various skin diseases including acneiform eruption have been reported as their adverse skin reaction. A 16-year-old boy presented with multiple erythematous monomorphic papules and pustules on trunk and both extremities. The lesion was first recognized several weeks after he was prescribed valproate to treat epilepsy 4 months ago. After one month, AED was changed to oxcarbazepine and then, eruption aggravated. His medication was additionally changed to topiramate, but the skin lesion became even worse. Skin biopsy performed from erythematous papule on trunk was consistent with acneiform eruption. In adverse skin reactions due to AED, AED with different chemical structure is usually recommended as an alternative therapy, since cross reactivity between aromatic AEDs (oxcarbazepine) and non-aromatic AEDs (valproate and topiramate) is extremely rare. This case could be informative for physicians to prescribe alternative drugs in case of hypersensitivity reaction to AEDs. They should keep in mind the possibility of cross reactivity among structurally different AEDs like aromatic and non-aromatic drugs.
Germanium p-i-n avalanche photodetector fabricated by point defect healing process.
Shim, Jaewoo,Kang, Dong-Ho,Yoo, Gwangwe,Hong, Seong-Taek,Jung, Woo-Shik,Kuh, Bong Jin,Lee, Beomsuk,Shin, Dongjae,Ha, Kyoungho,Kim, Gwang Sik,Yu, Hyun-Yong,Baek, Jungwoo,Park, Jin-Hong Optical Society of America 2014 Optics letters Vol.39 No.14
<P>In this Letter, we report Ge p-i-n avalanche photodetectors (APD) with low dark current (sub 1 μA below V(R)=5??V), low operating voltage (avalanche breakdown voltage=8-13??V), and high multiplication gain (440-680) by exploiting a point defect healing method (between 600C and 650C) and optimizing the doping concentration of the intrinsic region (p-type ~101? cm?3). In addition, Raman spectroscopy and electrochemical capacitance voltage analyses were performed to investigate the junction interfaces in more detail. This successful demonstration of Ge p-i-n APD with low dark current, low operating voltage, and high gain is promising for low-power and high-sensitivity Ge PD applications.</P>