Association of 20 potential ATP2B1‐interacting genes with blood pressure in Koreans

Kyung‐Won Hong,Hyun‐Seok Jin,Ji‐Eun Lim,Bermseok Oh 한국유전학회 2011 Genes & Genomics Vol.33 No.3

Plasma membrane calcium‐transporting ATPase 1 (ATP2B1)is associated significantly with blood pressure in Caucasians and Asians. ATP2B1 regulates calcium homeostasis and belongs to the P‐type calcium pump family; several studies have identified diverse proteins that bind to ATP2B1. We hypothesized that ATP2B1 regulates blood pressure through ATP2B1‐interacting genes. To this end, 20 potential ATP2B1‐interacting genes were selected, 197 SNPs of which were analyzed for their association of systolic and diastolic blood pressure. These 20 genes were categorized into 2 groups: ATP2B1‐binding genes and ATP2B1‐cleaving calpain family members. Three ATP2B1‐binding genes (CALM1, NOS1, and PDLIM1)were associated with blood pressure, and a SNP in CALM1(rs2401887) generated the strongest association signal (beta=‐3.60±0.92, p=8.9×10^(‐5) for systolic blood pressure and beta=‐1.40±0.62, p=0.02 for diastolic blood pressure). Of the calpain family members, 3 genes (CAPN6, CAPN9, and CAPN10)were associated with blood pressure, and the CAPN10 SNP rs4676348 yielded the strongest association signal (beta=‐0.88±0.27, p=0.001 for systolic blood pressure and beta=‐0.58±0.18, p=0.015 for diastolic blood pressure). Further, the interaction of CALM1 to ATP2B1 was examined using the blood pressure of individuals who carried both variants of CALM1and ATP2B1 genes. Similarly the interaction of CAPN10 to ATP2B1 was also examined. The CALM1 variant (rs2401887)and CAPN10 variants (rs4676348) appear to decrease blood pressure further in addition to the decrease by the variant (rs17249754) of ATP2B1, which suggests that ATP2B1 might regulate blood pressure through the ATP2B1‐interacting genes CALM1 and CAPN10.

장애학생 관련 변인에 따른 비장애 학생의 통합태도 연구

오원석 ( Won Seok Oh ),남경숙 ( Kyung Sook Nam ),허명진 ( Myung Jin Huh ) 한국특수교육문제연구소 2006 특수교육저널 : 이론과 실천 Vol.7 No.3

장애학생 관련 변인에 따른 비장애 학생의 통합교육에 대한 태도 및 장애학생에 대한 친근감을 알아보기 위하여 본 연구를 수행하였으며, 연구 대상은 대구광역시 초등학교 5개교15학급 477명을 선정하였다. 연구 결과 장애학생의 통합에 대한 비장애 학생의 태도에 영향을 미치는 변인은 장애유형, 장애학생 성별, 장애학생의 청결상태이며, 영향을 미치지 않는 변인으로는 장애학생 부모의 관심도, 장애아 가정의 경제적 수준 그리고 장애학생의 학습 능력인 것으로 나타났다. The purpose of this study is to determine the attitudes for integration education and the intimacy with disabled students of Nondisabled students influenced by disabled students. For such purpose, 477 students of 15 classes from 5 elementary schools located in Daegu Metropolitan City were selected as the object of this study. Integrated Attitudes was measured through an investigation equipment by Oh Won-Seok and Seo-Yeong Ran which adapted and modified a testing document called Inclusion of Students who are Deaf or Hard of Hearing Inventory (ISDHH) invented by Hsin-Ling Hung(2005). The result indicated that the factors which influence the Attitudes of nondisabled students regarding integration with disabled students are the type of injury, the gender and the cleanness of the disabled student. The factors which do not influence the above are interests of the disabled student``s parents, economic level of the family and the learning ability of the disabled student.

비장경색이 동반된 쯔쯔가무시병 1예

오종찬,이범주,장재현,원경준,박경희,김동민,박치영,정춘해 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Tsutsugamushi disease is an acute febrile illness caused by Orientie. tsutsugsmushi. It is characterized by fever, myalgia, lymphadenopathy, and rash. And it can be easily diagnosed by characteristic eschar and serologic testing. Nearly all of the patients with tsutsugamushi disease improve with antibiotics such as doxycycline. However, the fatality rate of untreated cases is seven to ten percent. Splenic infarction is not common disease which is caused by occlusion of the main splenic artery or any of its branches. It is mainly caused by emboli that arise from cardiovascular disease, but sometimes by regional thrombosis associated with leukemia, myeloproliferative disorder, sickle cell anemia, pancreatitis, splenic torsion and septicemia. We experienced one case of tsutsugamushi disease with splenic infarction, which was improved after doxycycline treatment finished.

난소 및 난소 종양 염전의 초음파 소견

오연희,이현경,이원재,이성우,박수성,윤혜원,임문환,심재철,김용탁,김성숙,김정란 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

Acute torsion of the ovary and ovarian mass is a recognized surgical emergency, but rarely has the diagnosis been made preoperatively on the basis of imaging studies. The sonographic findings in 14 cases of surgically proven torsion of the ovary and ovarian mass are described. Mostly cystic ovarian mass, engorged vessel, dilated uterine tube, beak-like echo(torsion site), smooth mass wall thickening an free-fluid collection in cul-de-sac are described. More significant in terms of specificity were the demonstration in 6 cases(42.9%) of the smooth mass wall thickening and in 8 cases(57.1%) of a free fluid in the cul-de-sac. We report the sonographic findings of ovary and ovarian mass torsion that may suggest the preoperative diagnosis of this condition.

재구성 가능한 구조를 위한 HW/SW 분할 및 스케쥴링 알고리즘

오세준,김남섭,김진상,조원경 경희-다반 ASIC 설계교육센터 2002 경희-다반 ASIC센터 논문집 Vol.3 No.-

동적 재구성 가능한 하드웨어 구조를 포함하는 시스템은 실시간으로 알고리즘을 처리할 수 있도록 하드웨어 자원을 효과적으로 이용할 수 있어야 한다. 이런 시스템의 수행 성능은 기본적으로 HW/SW 분할 문제에 의존한다. 이 논문은 동적 재구성 가능한 하드웨어를 위한 새로운 HW/SW 분할 알고리즘을 제안했다. 알고리즘은 초기해 얻기 후 그 해를 다시 최적화하는 단계적인 접근방법이다. 알고리즘은 분할 과정에서 FPGA를 재구성하는 과정을 고려했고 이를 최적화하기 위해서 부분적인 재구성(partial reconfiguration) 방법과 prefetching 재구성 방법을 사용했다. 이 휴리스틱(heuristic) 알고리즘을 통하여 JPEG 부호화기가 다른 접근 방법에 비하여 최적의 수행 성능을 얻음을 보였다.

HRTF(머리저달함수)의 샘플링률 변환에 따른 입체음향 플레이어

오재경,이동재,임철수,최범석,이원돈 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

본 논문에서는 3D사운드 생성 기술 중 대표적인 방법인 원음에 HRTF(머리전달함수)를 콘볼루션(convolution하는 방식으로 음상정위 모듈을 구현하였으며 음장감을 부여하기 위하여 잔향(reverberation)효과를 추가하고 크로스토크 현상을 제거하기 위하여 트랜스오럴 필터를 추가하였다.본 논문에서는 sampling rate conversion을 사용하여 decimation과 interpolation을 수행하여 44.1KHz의 sampling rate로된 coefficient를 downsample하거나 upsample한 HRTR(머리전달함수)를 사용하여 콘볼루션(convolution)을 수행했다.본 논문에서는 3D사운드 생성과정에서 필요한 연산과정을 최소화하여 일반 PC의 computing power로도 sampling rate conversion된 데이터를 처리하여 줄 수 있는 알고리즘을 제시하고 구현하였다.

IMT-2000 위성통신 시스템에서 폐쇄루프 전송 다이버시티 기법의 성능 분석

오관명,김학성,김산해,이경규,이원철,신요안 崇實大學校 2000 論文集 Vol.30 No.1

In this paper, we apply a close loop transmit diversity scheme to IMT-2000 satellite systems, and investigate the performance of the scheme in both ideal and more realistic situations. We verify that the performance of the closed loop transmit diversity scheme is quite sensitive to errors in feedback information. However, we also show that the number of quantization bits for feedback information does not significantly affect the system performance when considering the feedback of phase information only. In addition, 2-bit quantized system achieves the better performance than 4-bit quantized system in terms of slot error rate.

한국인 성장기 아동에서 Angle씨 2급 1류 부정교합자의 골격 특징

경희문,권오원,김유경,성재현 대한치과교정학회 1989 대한치과교정학회지 Vol.19 No.3

This study was designed to investigate the difference of teeth and craniofacial complex between normal occlusion and Angle's Class II, div. 1 malocclusion in korean childern. The sample was divided into 2 groups, the 66 subjects with normal occlusion and 96 subjects with Angle's Class II, div.1 malocclusion in both sexes. The results obtained were as follows: 1. No significant differences were observed in ant. cranial base length & flexure(saddle angle) between normal occlusion & cranial Angle's Class II, div. 1 malocclusion group, but posterior cranial base length of Class II, div. 1 malocclusion group was larger than that of normal occlusion group. 2. No significant difference was observed in the anteroposterior position of Maxilla to cranial base between two groups, but mandibular position in Class II. div. 1 malocclusion was posterior and interior to that of normal occlusion. 3. The length of maxilla (ANS-PSN) was larger in Class II, div. 1 malocclusion than normal occlusion. The length of mandibular body(Go-Me) was nor differnet between Class II, div. 1 malocclusion and normal occlusion. 4. Maxillary incisor position of Class II, div. 1 malocclusion to cranial base was more protrusive than that of normal occlusion, but there was no difference in mandibular incisor position between two groups.

저빈도 반복성 경두개 자기자극이 정상인의 시각적 단기 기억에 미치는 영향

오해정,김원,이경욱,박원명,전태연,한진희,채정호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : Repetitive transcranial magnetic stimulation (rTMS) is a novel, noninvasive method of brain stimulation. Since conventional rTMS does not cause seizure, marked advantage over electroconvulsive therapy (ECT), rTMS can be used easily and widely. Once the effects of rTMS on cognitive function are elucidated, its application will be further extended. However, the effects of rTMS on cognitive function have not been well examined. This study aimed to evaluate the effect of low frequencyr TMS on visual short term memory. Methods : Forty normal healthy volunteers were randomly assigned to rTMS (n=20) or sham (n=20) groups. The rTMS group were again randomly divided into left prefrontal (n=10) and right prefrontal (n=10) groups. For each group rTMS was given at 1 Hz for 20 minutes with 100% of motor threshold. As a cognitive task, Corsi Block Tapping Test (CORSI) in the computerized Vienna Test System, which can assess visual short term memory, was performed before, during, and after the rTMS. Results : No significant difference was found in the visual short term memories between the rTMS and the sham groups before, during, or after 1 Hz rTMS, nor between the left and right prefrontal rTMS groups. Conclusion : This study demonstrates that rTMS, contrary to ECT, has no adverse visual short term memory effect when used as the standard treatment paradigm. Therefore, rTMS could be a new and safe treatment method in various neuropsychiathc fields without any interference of cognitive function.

연령에 따른 흰쥐 망막 속얼기층의 미세구조 변화

오원영,고정식,양남길,안의태,박경호 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

이 실험은 연령에 따른 흰쥐 망막 속얼기층의 미세구조적 변화를 관찰하기 위하여 시행하였다. 실험동물로는 생후 3개월(어린 흰쥐), 12개월(젊은 흰쥐) 및 30개월(늙은 흰쥐)된 Fisher계통 344흰쥐를 사용하였다. 각 동물은 4% chloral hydrate로 마취한 후 2.5% glutaradehyde-1.5% paraformaldehyde로 관류 고정한 다음, 안구를 적출하여 톱니둘레를 다라 절단한 후 시신경원반외측의 일정부위에서 망막조직을 떼어내었다. 떼어낸 조직은 2.5% glutaradehyde- 1.5% paraformaldehyde 고정액에 다시 고정한 후, 1% osmium tetroxide액에 또 다시 고정하였다. 고정된 조직은 ethyl alcohol과 acetone으로 탈수한 후 araldite혼합액에 포매하였다. 포매된 조직은 LKB-V ultratome으로 얇은 절편을 작성하여 uranyl acetate와 lead citrate로 염색한 후 JEM 100CX-Ⅱ 전자현미경으로 관찰하여 다음과 같은 결론을 얻었다. 1. 무축삭신경원의 세포질돌기는 세포질의 전자밀도, 연접소포의 종류 및 양에 따라 4종류 구분되었다. 2. 속얼기층에서 관찰되는 신경연접의 형태는 연접리본복합체외에 4종류의 일반신경연접을 관찰할 수 있었으나, 연령증가에 따른 연접형태의 미세구조적 변화는 관찰할 수 없었다. 3. 연령이 증가함에 따라 부챗살아교세포의 상대적 영역이 넓어졌다. 4. 연령이 증가함에 따라 무착삭신경원과 신경절세포의 가지돌기안에 수초구조, 용해소체, 잔여소체가 자주 관찰되었다. 이상의 결과를 종합해 보면 흰쥐의 망막속얼기층은 연령이 증가하면 무축삭신경원과 신경절세포는 기능이 점점 약해지므로 부챗살아교세포의 영역이 상대적으로 더 넓어진다고 생각된다. Morphological differences among the inner plexiform layers at different age groups have been studied in young(three months old), adult(twelve months old) and old(thirty months old) Fisher stain 344 rats. Under anethesia, 2.5% glutaraldehyde- 1.5% paraformaldehyde solution was perfused through the heart. Pieces of the tissue taken from the posterior region of the retina were fixed in 2.5% glutaraldehyde- 1.5% paraformaldehyde, and in 1% osmium tetroxide followed by fixation embedded in aralditse mixture. Ultrathin seciton were statined with uranyl acetate and lead citrate solution and were observed with JEM 100CX-II electron microscope. The results were as follows: 1. Four types of amacrine cells were found according to their electron densities, and kind and amount of the synaptic vesicles, were found, i.e., dark amacrine cell with clear vesicles(Al cell), light amacrine cell with clear vesicles(A2 cell), dark amacrine cell with clear and granular vesicles(A3 cell) and light amacrine cell with clear and granular vesicles(A4 cell) 2. In the inner plexiform layer, there appear two types of synapses : 1) synaptic ribbon complex and 2) conventional synapses. Conventional ones exhibited four different types, showing, i.e., prominent presynaptic density(type 1), prominent postsnaptic density(type 2), prominent pre-and postsynaptic densities(type 3), and lesser prominent pre-and postsynaptic densites. 3. Territories of the Muller cells were expanded during aging. 4. Myelin figures, lysosomes, lipofuscin granules and lipid droplets were frequently observed in the amacrine and ganglion cells of the adult and old rats. From the above results, it was suggested that functions of the bipolar, amacrine and ganglion cells were diminished gradually, whereas territories of the Muller cells were expanded during aging.