Pb□Ge□O□ 단결정의 유전적 성질

김재형,이광세,김정배 인제대학교 1992 仁濟論叢 Vol.8 No.2

Ferroelectric Pb5Ge3011 single crystal was grown from the melt by the Czochra1ski method. From the complex dielectric measurements and the pyroelectric measurements, it was confirmed that Pb5Ge3011 undergoes a displacive second order phase transition at 177 ℃. Arrehnius' activation energy was estimated as 1.2eV from the measurements of electric conductivities. Refractive indices obtained by using the Brewster's law are no=2.111, ne=2.140for λ=6328Å at room temperature and thermo-optical coefficients are 4.26×10-5/℃ in the ferroelectric phase and 2.71×10-5/℃in the paraelectric phase. An impedance relaxation was observed over a wide temperature range, including the Curie temperature. The relaxation was composed of two mechanisms, the one due to a charge carrier hopping Process and the other one resulting from the intrinsic polarization of the ferroelectric material.

확률적 페트리네트 기반의 워크플로우 최적화 모델링

임경택,박세권,명광식,김도일 중앙대학교 산업경영연구소 2000 산업경영연구 Vol.9 No.1

워크플로우에서는 기업이 정한 목표를 달성하고, 기업의 현재의 불확실성과 불안정성을 제거하고, 현재의 치열한 경쟁을 극복하고, 장래에 보다 나은 기업이 되기 위해서, 기업의 모든 재 구성원과 자원들 사이에 존재하는 이질적 요소를 조정·조화시킨 후, 유기적으로 결합하여, 조직의 목적을 이루는 것이 중요하다. 본 논문은 크게 두 가지에 초점을 두고 있다. 첫 번째, 프로세스를 최적화시키기 위한 조정 기준을 제시한다. 이 전의 연구들에서는 프로세스를 조정 할때, 대부분 분석가의 직관과 경험에 의존했었다. 그러나, 본 연구에서는 이러한 분석가의 직관과 경험에 의존한 프로세스 조정을 최대한 줄일 수 있는 몇가지 간단하면서도, 강력한, 정량화 된 기준을 제시한다. 두 번째, 워크플로우에, 시간을 소요하는 처리와 하지 않는 처리로 구분 할 수 있으며, 처리 시간을 확률 함수로 파악함으로써 현실세계에 가까운 모델링을 할 수 있는, GSPN(Generalized Stochastic Petri-net)을 적용한 프로세스 모델링 방법을 제시한다. This paper proposes a method to analyze and design for workflow systems called GSWN(Generalized Stochastic Workflow Net), which is based on stochastic Petri-net, and an algorithm for workflow process optimization based on simulation analysis. The proposed modeling method was developed by adding workflow characteristics to stochastic petri-net. The proposed algorithm is consist of 4 major steps such as GSWN step, GSWN to matrix step, block establishing step, and process optimizing step.

Clinical Experience of Rigid Bronchoscopy in Single Center

Kim, Hyun-Jin,Kim, Sei-Won,Lee, Hye-Yeon,Kang, Hyeon-Hui,Kang, Ji-Young,Kim, Ju-Sang,Kim, Myung-Sook,Kim, Seung-Soo,Kim, Jin-Woo,Yun, Hyeong-Gyu,Kim, Chi-Hong,Kim, Kwan-Hyoung,Moon, Hwa-Sik,Cho, Kwang The Korean Academy of Tuberculosis and Respiratory 2012 Tuberculosis and Respiratory Diseases Vol.72 No.6

Background: The aim of this study was to analyze clinical situations requiring rigid bronchoscopy and evaluate usefulness of rigid bronchoscopic intervention in benign or malignant airway disorders. Methods: We retrospectively reviewed 29 patients who underwent rigid bronchoscopy from November 2007 to February 2011 at St. Paul's Hospital, The Catholic University of Korea School of Medicine. Results: Of the 29 patients, the most frequent underlying etiology was benign stenosis of trachea (n=20). Of those 20 patients, 16 had post-intubation tracheal stenosis (PITS), 2 had tracheal stenosis due to inhalation burn (IBTS) and other 2 had obstructive fibrinous tracheal pseudomembrane (OFTP). Other etiologies were airway malignancy (n=6), endobronchial stenosis due to tuberculosis (n=2), and foreign body (n=1). For treatment, silicone stent insertion was done in 16 cases of PITS and IBTS and mechanical removal was performed in 2 cases of OFTP. In 6 cases of malignant airway obstruction mechanical debulking was performed and silicone stents were inserted additionally in 2 cases. Balloon dilatation and electrocautery were used in 2 cases of endobronchial stenosis due to tuberculosis. In all cases of stent, airway obstructive symptom improved immediately. Granulation tissue formation was the most common complication. Conclusion: Tracheal stenosis was most common indication and silicone stenting was most common procedure of rigid bronchoscopy in our center. Rigid bronchoscopic procedures, at least tracheal silicone stenting, should be included in pulmonary medicine fellowship programs because it is a very effective and indispensable method to relieve critical airway obstruction which needs training to learn.

45,X / 47,XYY 모자이크 터너증후군

김세광(Sei Kwang Kim),김재욱(Jae Wook Kim),양영호(Young Ho Yang),김현주(Hyun Joo Kim),모형진(Hyoung Jin Mo),배상욱(Sang Wook Bai),김인규(In Kyu Kim) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.1

45,X/47,XYY mosaicism is a rare sex chromosomal disorder with clinical information limited to 25 cases in the literature. We report an unusual mosaic Turner syndrome case in a 35-year old Korean woman with a phenotypic female, primary amenorrhea, short stature, immature secondary sexual characteristics. Cytogenetic analysis including G- and Q-banding revealed 45,X/47,XYY mosaicism, and SRY gene was demonstrated by polymerase chain reaction(PCR). Prophylactic bilateral gonadectomy was performed because the presence of Y-chromosomal sequences in Turner stigmata may predispose this patient to gonadoblastoma formation.

자궁내막암 환자에서 혈청 CA 125 의 예후인자로서의 가치

김세광(Sei Kwang Kim),정재은(Jae Eun Chung),김재욱(Jae Wook Kim),김영태(Young Tae Kim),김동규(Dong Kyu Kim),노성일(Sung Il Roh),조정현(Jung Hyun Cho) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.10

N/A Objective : The prognostic value of serum CA 125 sampled before the staging operation and the right CA 125 cut-off level in endometrial cancer was evaluated. Methods : Medical charts of 119 endometrial cancer patients diagnosed and surgically treated at the Department of Obstetrics and Gynecology, Yonsei University College of Medicine from March 1995 to March 2001 were reviewed. The prognostic value of CA 125 was evaluated by comparing it to other established prognostic factors of endometrial cancer such as myometrial invasion, cervix extension, tumor size, and grossly invasive disease. Enzyme immunoassay (Elecsys 2010; Roche Ltd., Basel, Switzerland) was used for the measurement of serum CA 125. Results : The level of presurgically taken serum CA 125 level correlated well with the established prognostic factors of endometrial cancer. CA 125 was one of the information that could be obtained prior to the surgical staging for predicting extensive endometrial cancer, and it could be correlated with the 5 year survival. CA 125≥20 U/ml had a higher sensitivity and lower false negative rate in predicting extensive endometrial cancer compared to the conventionally used level of CA 125≥35 U/ml. Conclusion : CA 125 has a prognostic value in predicting the extensive endometrial cancer needing lymphadenectomy, therefore it might be included in the baseline study of endometrial cancer for predicting the prognosis and individualizing the treatment modality. CA 125≥20 U/ml might be considered as the cut-off level in endometrial cancer for a better sensitivity and false negative rate.

자궁경부암에서 Cdc25A, Cdc25B 및 Cdc25C의 발현

김혜연 ( Hye Yeon Kim ),김재욱 ( Jae Wook Kim ),김세광 ( Sei Kwang Kim ),김영태 ( Young Tae Kim ),김재훈 ( Jae Hoon Kim ),김성훈 ( Sung Hoon Kim ),김상운 ( Sang Wun Kim ),윤보성 ( Bo Sung Yoon ),남은지 ( Eun Ji Nam ),조혜진 ( Hye 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.10

목적: 본 연구는 자궁경부암에서 세포주기 조절인자인 cell division cycle (Cdc) 25A, Cdc25B 및 Cdc25C 발현 양상을 정량적으로 측정하여 이들이 자궁경부암의 발암과정에서 어떠한 역할을 하는지를 규명하며 아울러, 자궁경부암의 여러 다른 임상적 및 병리학적 예후 인자와 상관관계가 있는지를 연구하고자 하였다. 연구 방법: 본원 산부인과에서 2000년 2월부터 2005년 3월까지 수술적 치료를 받은 환자를 대상으로 하여 신선 자궁경부 조직을 얻었다. 역전사 중합요소 연쇄 반응과 Western blot analysis를 이용하여 각각 Cdc25A, Cdc25B 및 Cdc25C의 mRNA와 단백질 발현 양상을 확인하였다. 결과: 자궁경부암 조직에서의 Cdc25A, Cdc25B 및 Cdc25C의 mRNA 발현은 정상 자궁경부 조직보다 모두 통계학적으로 유의하게 높았으며 (p=0.02, 0.01, 0.02), Cdc25A, Cdc25B 및 Cdc25C의 단백질 발현 양상도 자궁경부암 조직에서 정상 자궁경부 조직에 비해 모두 통계학적으로 유의하게 높은 결과를 보였다 (p=0.01, 0.02, 0.01). 또한 자궁경부암에서의 Cdc25A, Cdc25B 및 Cdc25C의 mRNA 발현과 단백질 발현을 임상적 및 병리학적 예후 인자들에 따라 비교한 결과 환자의 연령과 Cdc25B mRNA 발현 (p=0.03), 세포 형태와 Cdc25C mRNA 발현 (p=0.04) 사이에서는 통계학적으로 유의한 상관관계를 보였으나 그 외의 인자들인 세포아형태, 혈청내 squamous cell carcinoma antigen (SCC Ag) 수치, 유세포 분석법을 통한 DNA flow cytometry 결과, 림프절 전이, 림프혈관 침범, 인유두종 바이러스 감염 등과는 통계학적으로 유의한 상관 관계를 보이지 않았다. 결론: 본 연구 결과에 따르면 Cdc25A, Cdc25B 및 Cdc25C가 대조군인 정상 자궁경부 조직에 비해 자궁경부암 조직에서 통계학적으로 유의하게 높게 발현됨을 확인할 수 있었다. 따라서, 자궁경부암의 발생기전에 Cdc25A, Cdc25B 및 Cdc25C가 중요한 역할을 할 가능성을 제시하였다. 또한 Cdc25A, Cdc25B 및 Cdc25C의 mRNA와 단백질 발현은 환자의 연령이 50세 이상인 경우에 Cdc25B mRNA 발현이 유의하게 높았으며 (p=0.03), 세포형태에 따라 분류하였을 때 편평상피세포암에서 Cdc25C mRNA 발현이 통계학적으로 유의하게 높았다 (p=0.04). 그러나, 다른 예후 인자들과는 통계학적으로 유의한 상관관계를 보이지 않았다. 향후 Cdc25A, Cdc25B 및 Cdc25C가 자궁경부암의 유용한 예후 인자로 사용되기 위해서는 향후 생존율과 연관된 연구가 추가로 뒷받침되어야 할 것으로 생각된다. Objective: This study was undertaken to quantitatively detect Cdc25A, Cdc25B and Cdc25C in cervical carcinoma and determine the relationship between the expression of mRNA and protein of cell division cycle (Cdc)25 phosphatase and various clinicopathologic prognostic factors of cervical carcinoma. Methods: 39 patients diagnosed with cervical carcinoma between February 2000 to March 2005 and 10 patients with benign gynecologic disease were enrolled in this study. A reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analysis were used to analyze the expression of Cdc25 phosphatase mRNA and protein in fresh invasive cervical cancer tissue and normal cervix tissue. Results: The mRNA expressions of Cdc25A, Cdc25B and Cdc25C in the cancer tissues were significantly greater than in the control (p=0.02, 0.01, 0.02), respectively. A Western blot analysis yielded same results (p=0.01, 0.02, 0.01). There were also significant relationships between the age and the Cdc25B mRNA expression (p=0.03), between the cell type and the Cdc25C mRNA expression (p=0.04). However, other clinicopathologic prognostic factors including stage, subtype, SCC Ag level, DNA flow cytometry, lymph node metastasis, lymphovascular space invasion and HPV positivity were not statistically significant. Conclusion: Our results show that Cdc25A, Cdc25B and Cdc25C expression levels were significantly greater in cervical cancer patient group than in those of control group. Thus Cdc25 phosphatase might play an important role in carcinogenesis of cervical carcinoma. Further studies based on the correlation between Cdc25 phosphatase and survival rate would be need to support Cdc25 phosphatase as a prognostic factor of cervical carcinoma.

( Poster Session ) ; Perinatal Outcomes in Women with Unexplained Midtrimester Elevations of Maternal Serum Alpha - Fetoprotein Levels

(Sei Kwang Kim),(Chan Ho Song) 대한산부인과학회 1994 춘계학술대회 Vol.- No.-

Survey of Yogurt Powder Storage in Ambient Export Countries A Safety Evaluation Standard Compliance and Comparative Analysis

Kim, Na-Kyeong,Park, Jung-Min,Lee, Jung-Hoon,Kim, Ha-Jung,Oh, Sejong,Imm, Jee-Young,Lim, Kwang-Sei,Kim, Jin-Man Korean Society for Food Science of Animal Resource 2015 한국축산식품학회지 Vol.35 No.1

Yogurt powder is fermented milk processed in the form of dry yogurt, and has advantages such as stability, storability, convenience, and portability. China and Vietnam are important export target countries because of the increased demand for dairy products. Therefore, we surveyed dairy product standardization in order to establish an export strategy. Lactic acid bacteria counts are unregulated in Korea and Vietnam. In China, lactic acid bacteria counts are regulated at $1{\times}10^6$ colonyforming units (CFU)/mL and detected at $6.24{\pm}0.33\;Log\;CFU/mL$. All three countries have regulated standards for total bacterial counts. In China, total bacterial counts of milk powder are regulated to n=5, c=2, m=50,000, M=200,000 and detected at $6.02{\pm}0.12\;Log\;CFU/mL$, exceeding the acceptable level. Lactic acid bacterial counts appeared to exceed total bacterial counts. Coliform group counts, Staphylococcus aureus, Listeria monocytogenes, and Salmonella species were not detected. Acidity is not regulated in Korea and Vietnam. In China, acidity was regulated to over $70^{\circ}T$ and detected $352.38{\pm}10.24^{\circ}T$. pH is unregulated in all three countries. pH was compared to that of general fermented milk, which is 4.2, and that of the sample was $4.28{\pm}0.01$. Aflatoxin levels are not regulated in Korea and China. In Vietnam, aflatoxin level is regulated at 0.05 ppb. Therefore, all ingredients of the yogurt powder met the safety standards. This data obtained in this study can be used as the basic data in assessing the export quality of yogurt powder.

Outcome of Pregnancy in Patients with Unexplained Elevated Midtrimester Maternal Serum Alpha-Fetoprotein

( Sei Kwang Kim ),( Chan Ho Song ) 대한산부인과학회 1994 대한산부인과학회 학술대회 Vol.73 No.-

Smart Transdermal Vaccine Delivery Systems Using Hyaluronic Acid Derivatives

Sei Kwang HAHN,Hyemin KIM,Ki Su KIM,Seok Hyun YUN 한국생물공학회 2013 한국생물공학회 학술대회 Vol.2013 No.10