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Risk of Osteoporotic Fracture in Patients with Breast Cancer: Meta-Analysis
Seeyoun Lee,유준일,이영균,Jung-Wee Park,Seokhyung Won,Jiung Yeom,Jin Woo Im,Seok Min Lim,Yong-Chan Ha,Kyung-Hoi Koo 대한골대사학회 2020 대한골대사학회지 Vol.27 No.1
Background: The fracture risk induced by anti-estrogen therapy in patients with breast cancer remains controversial. The aim of this study was to perform a meta-analysis and systematic review to evaluate the risk of osteoporotic fracture in patients with breast cancer. Methods: A systematic search was performed to identify studies that included any osteoporotic fracture (hip fracture and vertebral fracture) in patients breast cancer. Main outcome measures were occurrence and risk of osteoporotic fractures including hip and vertebral fractures in patients and controls. Results: A systematic search yielded a total of 4 studies that included osteoporotic fracture outcomes in patients with breast cancer. Meta-analysis showed a higher risk of osteoporotic fracture in patients with breast cancer. Analysis of these 4 studies involving a total of 127,722 (23,821 cases and 103,901 controls) patients showed that the incidence of osteoporotic fractures was higher in the breast cancer group than in the control group. The pooled estimate of crude relative risk for osteoporotic fracture was 1.35 (95% confidence interval, 1.29–1.42; P<0.001). Conclusions: Although studies were limited by a small number, results suggested a possible association between anti-estrogen therapy and increased risk of osteoporotic fractures in patients with breast cancer.
Lee, Hyo Sang,Kim, Seok Won,Kim, Byoung-Hee,Jung, So-Youn,Lee, Seeyoun,Kim, Tae-Sung,Kwon, Youngmi,Lee, Eun Sook,Kang, Han-Sung,Kim, Seok-ki Society of Nuclear Medicine 2012 The Journal of nuclear medicine Vol.53 No.11
<P>Several models for predicting the likelihood of nonsentinel lymph node (NSLN) metastasis using histopathologic parameters in sentinel-positive breast cancer patients have been proposed. In this study, we established a new model that uses sentinel lymphoscintigraphic findings and histopathologic parameters as covariates and assessed its predictive performance.</P>
Lee, Youjin,Yoon, Byung-Ho,Lee, Seeyoun,Chung, Youn Kyung,Lee, Young-Kyun The Korean Society for Bone and Mineral Research 2019 대한골대사학회지 Vol.26 No.1
<P><B>Background</B></P><P>The effects of subclinical hyperthyroidism on fracture risk induced by thyroid-stimulating hormone (TSH) suppression therapy in patients with thyroid cancer still remains controversial. We performed a meta-analysis and systematic review to evaluate the effects of TSH suppression therapy on osteoporotic fracture in patients with thyroid cancer.</P><P><B>Methods</B></P><P>We performed a systematic search to identify studies which included osteoporotic fractures (hip fracture and vertebral fracture) in patients on TSH suppression therapy for thyroid cancer. Main outcome measures were occurrence and risk of osteoporotic fractures including hip and vertebral fractures between patients and controls.</P><P><B>Results</B></P><P>A systematic search yielded a total of 8 studies appropriate for review which included osteoporotic fracture outcome in patients on TSH suppression therapy for thyroid cancer. Studies with larger number of subjects showed the higher risk of osteoporotic fracture in group with TSH suppression therapy, although studies with smaller sample size presented a similar risk of fracture with control group.</P><P><B>Conclusions</B></P><P>Although studies were limited by small numbers, results suggested possible association between chronic TSH suppression therapy and the increased risk of osteoporotic fractures in patients with thyroid cancer.</P>
Kim, Yunju,Sim, Sung Hoon,Park, Boram,Lee, Keun Seok,Chae, In Hye,Park, In Hae,Kwon, Youngmi,Jung, So-Youn,Lee, Seeyoun,Ko, Kyounglan,Kang, Han-Sung,Lee, Chan Wha,Lee, Eun Sook Elsevier 2018 Clinical breast cancer Vol.18 No.6
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>To investigate the diagnostic performance of magnetic resonance imaging (MRI) for predicting pathologic complete response after neoadjuvant chemotherapy (NAC) depending on subtypes of breast cancer using different interpretation thresholds of MRI negativity.</P> <P><B>Patients and Methods</B></P> <P>A total of 353 women with breast cancer who had undergone NAC were included. Pathologic examination after complete surgical excision was the reference standard. Tumors were divided into 4 subtypes on the basis of expression of hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2). Tumor enhancement was assessed on early and late phases of MRI. MRI negativity was divided into radiologic complete response (rCR, complete absence of enhancement on both early and late phases) and near-rCR (no discernible early enhancement but observed late enhancement).</P> <P><B>Results</B></P> <P>Ninety (25.5%) of 353 patients experienced pathologic complete response. When analyzing the data of all patients, sensitivity of MRI was higher for rCR versus near-rCR (97.72% vs. 90.49%, <I>P</I> < .0001), whereas specificity was lower for rCR versus near-rCR (44.44% vs. 72.22%, <I>P</I> < .0001). Accuracy was equivalent (84.14% vs. 85.84%). In HR−HER2<SUP>+</SUP> tumors, 100% sensitivity and negative predictive value were achieved by assessing early enhancement only. In HR<SUP>+</SUP>HER2− tumors, sensitivity of MRI was higher for rCR versus near-rCR (96.12% vs. 86.82%, <I>P</I> = .0005).</P> <P><B>Conclusion</B></P> <P>Diagnostic performance of MRI after NAC differs in accordance with the subtypes and threshold of MRI negativity. MRI assessment with consideration of tumor subtypes is required, along with standardization of MRI interpretation criteria in the NAC setting.</P>
Prognostic Impact of [18F] FDG-PET in Operable Breast Cancer Treated with Neoadjuvant Chemotherapy
Jung, So-Youn,Kim, Seok-Ki,Nam, Byung-Ho,Min, Sun Young,Lee, Seung Joo,Park, Chansung,Kwon, Youngmee,Kim, Eun-A,Ko, Kyoung Lan,Park, In Hae,Lee, Keun Seok,Shin, Kyung Hwan,Lee, Seeyoun,Kim, Seok Won,K Springer - Society of Surgical Oncology 2010 Annals of Surgical Oncology Vol.17 No.1