공간지각 능력수준에 따른 활성화 뇌 영역의 차이 : fMRI 연구 An fMRI study

손진훈,김연희,이경화,박세훈 한국뇌학회 2001 한국뇌학회지 Vol.1 No.2

본 연구는 공간지각 능력이 높거나 낮은 사람들이 공간지각 과제를 수행하는 동안 활성화되는 뇌 영역을 확인하기 위해 수행하였다. 428명의 대학생을 대상으로 집단심리실험을 수행하여, fMRI 연구를 위한 실험참여자로 30명의 오른손잡이 여대생을 선정하였다. fMRI 실험을 위한 패러다임은 block디자인으로, 한 block 내에 공간지각과제 세 문항이 포함되어 있는 네 block으로 구성되었다. fMRI imaging은 1.5T Siemens Vision Scanner로 수집되었으며, single-shot EPI 기법으로(TR/TE: 3840/40ms, flip angle: 90, FOV: 220, 64×64 matrix) 이미지를 스캔하였다. 자료분석은 SPM-99 소프트웨어를 사용하였다. 감산(subtraction)분석결과, 공간지각 능력이 우수한 집단은 양측 대상회(bilateral cingulate gyri)와 우측 상두정엽(right superior parietal lobe)에서 뇌 활성화가 더 많이 나타났고, 우측 시상(right thalamus)과 좌측 측-후두엽(left temporooccipital)은 공간지각능력이 떨어지는 집단에서 더 많이 활성화되었다. 이는 공간지각능력의 차이가 뇌의 활성화에 기인한다는 것을 나타낸다. The purpose of study was to identify brain areas that become activated while subjects performing visuospatial tasks(VST) with different performance levels. 428 college students were evaluated for VST, then 30 females were selected for fMRI study. Subjects were selected through psychometric test and were right-handed with no history of brain injury. The fMRI paradigm was designed to have 4 blocks of each task and each block has 3 items. Imaging was performed on a 1.5T Siemens Vision Scanner. Single-shot EPI fMRI scans(TR/TE 3840/40ms, flip angle 90, FOV 220, 64x64 matrix) were acquired. Imaging data were motion-corrected, coregistered, normalized, and then analyzed using SPM-99. There was greater activation in the bilateral cingulate gyri and the right superior parietal lobe for better VST performance group, whereas the right thalamus and left temporooccipital area for poor VST performance group.

역행적 골수정 삽입술을 이용한 대퇴골 과상부 골절의 치료

권진우,신승호,조원호,성기호,김기환,손경태,이상훈,박세원,배종문,권태우 대한골절학회 2003 대한골절학회지 Vol.16 No.4

Poster Session : PS 0980 ; Study of an Elevated Carbohydrate Antigen 19-9 in Asymptomatic Patients

( Se Hoon Sohn ),( Kyeong Ok Kim ),( Kook Hyun Kim ),( Si Hyung Lee ),( Byung Ik Jang ),( Tae Nyeun Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: CA19-9 has been established as a useful tumor marker for gastrointestinal cancer. However interpretation of elevated CA19-9 is diffi cult because it could be also noted in many benign diseases. We aimed to evaluate the etiology and clinical outcome of elevated CA19-9 levels in asymptomatic subjects. Methods: From January 2004 to December 2013, total 734 subjects with elevated CA19-9 level (>37 U/mL) from 63867 subjects, who underwent an examination at the health promotion center in our institution were analyzed retrospectively. Results: Mean age of the patients was 50.62 (±13.27) years and male to female ratio was 1:1.3. Mean level of CA 19-9 was 155.33 (±1624.54) U/ml. Malignancy was detected in 36 cases (4.9%). There were 9 cases of pancreatic cancer, 9 cases of hapatobiliary cancer and 13 cases of other gastrointestinal cancer. Benign diseases included 56 cases of gallbladder or biliary stone, 32 cases of GB polyp and 17 cases of hypothyroidism. The mean CA19-9 level of patients with cancer was 717 (±1449) U/mL and 126.3 (±1629) U/ml for other cases. Factors related to cancer were age above 65 and increased ALP level above 270 IU/L. In 455 subjects (60.6%), the etiology could not be confi rmed and among them, 128 subjects could be followed up. Among subjects who were followed up, 55.5% subjects showed increased CA 19-9 level continuously while the other 44.5% subjects showed normalization. Conclusions: Our result showed that 698 (95.1%) asymptomatic subjects with increase CA 19-9 were not associated with malignancy and 455 (65.2%) of them were with unknown cause. Normalization was noted in 44.5% of the unknown cause. Increased ALP level and older age were related to malignancy and we need to evaluate more meticulously to fi nd out hidden malignancy in subjects with these factors.

한국의 화농성 간농양 환자들의 예후 인자: 단일기관 후향 연구

손세훈 ( Se Hoon Sohn ),김국현 ( Kook Hyun Kim ),박재현 ( Jae Hyun Park ),김태년 ( Tae Nyeun Kim ) 대한소화기학회 2016 대한소화기학회지 Vol.67 No.5

Background/Aims: The mortality rate of pyogenic liver abscess (PLA) has decreased dramatically, but it remains a potentially life threatening disease. Most cases are cryptogenic or occur in elderly men with underlying biliary tract disease. Although several studies have addressed the characteristics and etiology of PLA, research on factors affecting PLA-associated mortality is lacking. This study intended to identify the clinical and radiological features, pathogens, complications, and predictors of mortality in Korean PLA patients. Methods: The medical records of 231 PLA patients diagnosed at Yeungnam University Medical Center between January 2010 and January 2014 were analyzed. A diagnosis of PLA was made based on imaging studies and blood and abscess cultures. The clinical, radiological, and laboratory findings of patients were analyzed. Results: The mean patient age was 64.0±12.9 years and the male to female ratio was 1.5:1. Klebsiella pneumoniae was the predominant organism isolated from hepatic abscesses (69.9%) and blood (74.2%). The most common complication was pleural effusion (35.8%) and most common co-infection was cholangitis (8.2%). The overall mortality rate of PLA was 6.9% (16/231), and was significantly higher in patients with a history of liver abscess (OR 5.970, 95% CI 1.207-29.529; p=0.028), bilirubinemia (>2 mg/dL) (OR 9.541, 95% CI 2.382-38.216; p=0.001), thrombocytopenia (<140×103/μL) (OR 4.396, 95% CI 1.130-17.106; p=0.033), or anemia (<12 g/dL) (OR 13.277, 95% CI 1.476-119.423; p=0.021). Conclusions: The prognosis of PLA appears to be dependent on underlying pathologies and severity of condition. More aggressive treatment should be considered if a poor prognosis is expected. (Korean J Gastroenterol 2016;67:238-244)

고대 이스라엘의 자녀교육 이해

손세훈(Se-Hoon Sohn) 한국기독교교육정보학회 2012 기독교교육정보 Vol.34 No.-

본 연구는 고대 이스라엘의 자녀교육을 이해하기 위하여 구약성서와 외경을 중심으로 그들의 교육기관과 교과과정, 그리고 교육의 핵심 사상을 다루고 있다. 고대 유대인 부모들은 가정에서 자녀들에게 자연스럽게 종교교육과 함께 말과 글을 가르쳤고, 6-7세부터 학교에서 의무교육을 실시했으며, 회당에서 종교생활과 더불어 자녀교육을 시행하였다. 그들은 오경을 통하여 종교성뿐만 아니라 사회성, 법규, 삶의 지혜 등을 배웠으며, 솔로몬의 지혜서와 시락의 지혜서를 중심으로 예절과 습관, 처신 등 다양한 것을 익혔다. 특별히 고대 이스라엘 사람들은 자녀교육의 핵심 주제로 지혜를 강조하였다. 그들에게 있어서 지혜는 하나님을 경외하는 근본이며 동시에 세속의 삶에서 현명하게 살아가는 처세이기도 하였다. 본 연구의 바탕으로 한국교회가 자녀교육에 있어서, 기독교 신앙위에서 공동체 관계를 중시하는, 소위 전인격적인 기독교 교육으로 한 걸음 더 나아가기를 기대한다. The purpose of this study is to understand the educational systems of ancient Israel in terms of their educational institutions and curriculum. The scope of the study is limited to the Old Testament and the Apocrypha. Ancient Jewish parents often taught language and religious education to their children in the home. At 6-7 of age, the compulsory education from the school was carried out. The synagogue provided varied aspect of this education, which included religiosity, social, standards, laws and wisdom of life through Torah. In addition, children a variety of manners, habits and behavior through the Wisdom of Solomon and Wisdom of Sirach. Ancient Israel stressed wisdom as a subject of their children"s education. To them, wisdom is how to deal with life and the world in general. The fear of God was fundamental to this learning. In addition to its historical description, this study hopes to provide insight and application for modern church educational systems, with special attention given to community relations, faith restoration.

고대 유대인들의 아동교육에 관한 연구 -구약성서와 외경을 중심으로-

손세훈 ( Se Hoon Sohn ) 대한아동복지학회 2006 아동복지연구 Vol.4 No.1

본 연구는 고대 유대인들의 아동교육에 대한 이해를 도모하기 위하여 구약성서와 외경을 중심으로 다음과 같이 그들의 교육기관과 교과과정, 그리고 교육의 핵심사상을 살펴보았다. 고대 유대인들은 가정에서 자연스럽게 종교교육과 함께 말과 글을 가르쳤고 배웠고, 6-7세부터 학교에서 의무교육을 실시했으며, 회당에서 종교생활과 더불어 아동교육을 실시하였다. 그들은 오경을 통하여 종교성뿐만 아니라 사회성, 법규, 삶의 지혜 등을 배웠으며, 솔로몬의 지혜서와 시락의 지혜서를 중심으로 예절과 습관, 처신 등 다양한 것을 익혔다. 이를 통하여 다음과 같은 결론을 얻을 수 있었다. 첫째, 오경은 종교 중심적 교과과정이었다. 고대 유대인들에게 있어서 종교성은 공동체 결속을 유지시키는 근간이었다. 이 때 종교성은 오경이 중심이었다. 따라서 오경 읽기와 묵상 그리고 실천의 강조가 교육적으로 시행되었다. 여기서 아동교육도 예외가 아니었음을 추정할 수 있었다. 둘째, 솔로몬의 지혜서와 시락의 지혜서는 고대 유대인들의 교육의 진수라고 말할 수 있다. 비록 두책에서 종교성이 나타나고 있지만, 처신, 효, 친구관계, 교양 등 삶의 지혜가 곳곳에 배어있다. 이런 내용들을 통하여 당시 아동들의 교육을 추정해보게 되었다. 셋째, 고대 유대인들의 아동교육의 핵심은 지혜주제였다. 이들에게 있어서 지혜는 하나님을 경외하는 근본이며 동시에 세속의 삶에서 현명하게 살아가는 처세였기도 하였다. 지혜주제를 통하여 그들의 이동교육 사상을 추론할 수 있었다. This study focuses on ancient jewish child education. My approach was to try to understand their educational institutions, curriculum and educational philosophy in the Old Testament and in the Apocrypha. Parents taught their children a religion and language in the home. In practice, this was a form of compulsory education for children aged 6 or 7 years old, Child education was also given from the synagogue, where students studied the Torah, Wisdom of Solomon and Wisdom of Ben-Sira. It will reach and to lead with afterwards the possibility of getting a same conclusion it was. First, the Torah was a religious-center curriculum. Among the Ancient Jews, religion was the foundation on which was maintained binding together. Consequently, the community revolved around Torah emphasized meditation and religious practice. From here we able to speculate about child education. Second, We can say, the Wisdom of Solomon and the Wisdom of Ben-Sira were the soul of Jewish education. From these, We can understand find behavior, piety, the friendship, relationships, and culture. Third, the focus of the ancient Jewish child education was wisdom. Wisdom characterized God and the lives of the jewish people were guided by the wisdom revealed in the Torah and the Wisdom of Solomon and the Wisdom of Ben-Sira. Like wisdom subject, we can see the contents of child education.

The metabolic syndrome and body composition in childhood cancer survivors

Sohn, Young-Bae,Kim, Su-Jin,Park, Sung-Won,Kim, Se-Hwa,Cho, Sung-Yoon,Lee, Soo-Hyun,Yoo, Keon-Hee,Sung, Ki-Woong,Chung, Jae-Hoon,Koo, Hong-Hoe,Jin, Dong-Kyu The Korean Pediatric Society 2011 Clinical and Experimental Pediatrics (CEP) Vol.54 No.6

Purpose: Long-term survivors of childhood cancer appear to have an increased risk for the metabolic syndrome, subsequent type 2 diabetes and cardiovascular disease in adulthood compared to healthy children. The purpose of this study was to investigate the frequency of the metabolic syndrome and associated factors in childhood cancer survivors at a single center in Korea. Methods: We performed a retrospective review of medical records of 98 childhood cancer survivors who were diagnosed and completed anticancer treatment at Samsung Medical Center, Seoul, Korea between Jan. 1996 and Dec. 2007. Parameters of metabolic syndrome were evaluated between Jan. 2008 and Dec. 2009. Clinical and biochemical findings including body fat percentage were analyzed. Results: A total of 19 (19.4%) patients had the metabolic syndrome. The median body fat percentage was 31.5%. The body mass index and waist circumference were positively correlated with the cranial irradiation dose (r=0.38, P<0.001 and r=0.44, P<0.00, respectively). Sixty-one (62.2%) patients had at least one abnormal lipid value. The triglyceride showed significant positive correlation with the body fat percentage (r=0.26, P=0.03). The high density lipoprotein cholesterol showed significant negative correlation with the percent body fat (r=- 0.26, P=0.03). Conclusion: Childhood cancer survivors should have thorough metabolic evaluation including measurement of body fat percentage even if they are not obese. A better understanding of the determinants of the metabolic syndrome during adolescence might provide preventive interventions for improving health outcomes in adulthood.

Effect of ECQ on Iodoacetamide-Induced Chronic Gastritis in Rats

Se Eun Lee,Hyun Ju Song,Sun Young Park,Yoonjin Nam,Chang Ho Min,Do Yeon Lee,Jun Yeong Jeong,Hyun Su Ha,Hyun-Jung Kim,Wan Kyun Whang,Ji Hoon Jeong,In Kyeom Kim,Hak Rim Kim,Young Sil Min,Uy Dong Sohn 대한생리학회-대한약리학회 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.5

This study investigated effect of extract containing quercetin-3-O-Ղ-D-glucuronopyranoside from Rumex Aquaticus Herba (ECQ) against chronic gastritis in rats. To produce chronic gastritis, the animals received a daily intra-gastric administration of 0.1 ml of 0.15% iodoacetamide (IA) solution for 7 days. Daily exposure of the gastric mucosa to IA induced both gastric lesions and significant reductions of body weight and food and water intake. These reductions recovered with treatment with ECQ for 7 days. ECQ significantly inhibited the elevation of the malondialdehyde levels and myeloperoxidase activity, which were used as indices of lipid peroxidation and neutrophil infiltration. ECQ recovered the level of glutathione, activity of superoxide dismutase (SOD), and expression of SOD-2. The increased levels of total NO concentration and iNOS expression in the IA-induced chronic gastritis were significantly reduced by treatment with ECQ. These results suggest that the ECQ has a therapeutic effect on chronic gastritis in rats by inhibitory actions on neutrophil infiltration, lipid peroxidation and various steps of reactive oxygen species (ROS) generation.

Preparation of hEGF-chitosan conjugates for prolongment of biological half-life of EGF activity

( Se-hoon Park ),( Tae-ll Sohn ),( Chun Ho Kim ) 한국공업화학회 2002 한국공업화학회 연구논문 초록집 Vol.2002 No.1

Effects of Korean Red Ginseng Extract for the Treatment of Atopic Dermatitis-Like Skin Lesions in Mice

Sohn, Eun-Hwa,Jang, Seon-A,Lee, Chul-Hoon,Jang, Ki-Hyo,Kang, Se-Chan,Park, Hye-Jin,Pyo, Suhk-Neung The Korean Society of Ginseng 2011 Journal of Ginseng Research Vol.35 No.4

Atopic dermatitis (AD) is an allergic, inflammatory skin disease characterized by chronic eczema and mechanical injury to the skin, caused by scratching. Korean red ginseng (RG) has diverse biological activities, but the molecular effects of RG on allergic diseases, like AD, are unclear. The present study was designed to investigate whether RG inhibits 1-chloro-2,4-dinitrobenzene (DNCB)-induced AD in a mouse model. DNCB was applied topically on the dorsal surface of Balb/c mice to induce AD-like skin lesions. We observed the scratching behavior and examined the serum IgE level and interleukin (IL)-4 and IL-10 in splenocytes compared with dexamethasone. We also evaluated the DNCB-induced mitogen-activated protein kinases (MAPKs), NF-${\kappa}B$, and Ikaros activities after RG treatment using reverse transcriptase-polymerase chain reaction, Western blotting, and ELISA. Our data showed that the topical application of RG significantly improved the AD-like skin lesions and scratching behavior. RG decreased not only the mRNA expression of IL-4 and IL-10, but also the secretion of IL-4 protein and serum IgE in mice. Additionally, RG treatment decreased the DNCB-induced MAPKs activity and subsequent Ikaros translocation irrespective of NF-${\kappa}B$. We suggest that RG may be useful as a therapeutic nutrition for the treatment of AD.