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Comparative proteomic analysis of plant responses to sound waves in Arabidopsis
권영상,Mi-Jeong Jeong,Jaeyul Cha1,Sung Woo Jeong,박수철,신성철,정우식,배한홍,Dong-Won Bae 한국식물생명공학회 2012 식물생명공학회지 Vol.39 No.4
Environmental factors greatly influence the growth,development, and even genetic characteristics of plants. The mechanisms by which sound influences plant growth,however, remain obscure. Previously, our group reported that several genes were differentially regulated by specific frequenciesof sound treatmentusing a sound-treated subtractive library. In this study, we used a proteomic approach to investigate plant responses to sound waves in Arabidopsis. The plants were exposed to 250-Hz or 500-Hz sound waves,and total proteins were extracted from leaves 8 h and 24 h after treatment. Proteins extracted from leaves were subjected to 2-DE analysis. Thirty-eight spots were found to be differentially regulated in response to sound waves and were identified using MALDI-TOF MS and MALDI-TOF/TOF MS. The functions of the identified proteins were classified into photosynthesis, stress and defense, nitrogen metabolism,and carbohydrate metabolism. To the best of our knowledge,this is the first report on the analysis of protein changes in response to sound waves in Arabidopsis leaves. These findings provide a better understanding of the molecular basis of responses to sound waves in Arabidopsis.
Cha, Gi Wook,Hong, Won Hwa,Shin, Sung Woo Trans Tech Publications, Ltd. 2013 Applied mechanics and materials Vol.357 No.-
<P>In recent year, Korea relies on imports for most of the iron ore, the main raw material of rebar, resulting in CO2 pollution with lots of energy consumption. Hereupon, this study carried out the research on the energy consumption and CO2 emissions of the recycled rebar using the wasted steel from building demolition. For that, this study worked out the energy consumption and CO2 emissions in the process of generation, transportation and production of wasted steel and, on the basis of which, it conducted the comparative study with virgin materials. The major research results are as follows: First, the energy consumption and CO2 emissions of the recycled rebar were found to be highest in the process of its production at 89.2% and 85%, respectively. In addition, in the comparison between recycled rebar and virgin material, the former was found to be most advantageous in energy consumption. On the contrary, as for CO2 emissions, the recycled rebar showed a 88.3% reduction possibility of greenhouse gas (GHG) emissions comparing to statistics of input-output analysis based on competition inducement coefficient, but it was found to be more disadvantageous from the perspective of GHG reduction than the statistics of input-output analysis based on non-competition inducement coefficient.</P>
Cha, Jin Soon,Seo, Jeong Beob,Lee, Jae Cheol,Kim, Jong Mi,Lee, Hyung Soo,Park, Young Bae,Uhm, Jae Kook,Shim, Sang Chul,Kim, Hong Seok,Kim, Tae Jeong,Kwak, Young Woo,Lee, Dong Ho 대구효성가톨릭대학교 자연과학연구소 1991 基礎科學硏究論集 Vol.1991 No.1
2,2'-Biphenoxyborane (1,3,2-biphenyldioxaborepin, 1), readily available from the reaction of 2,2'-biphenol with borane in THF, reacts with alkenes readily at 25℃, or rapidly at 68℃, and with alkynes rapidly at 25℃, to give the corresponding alkyl-and alkenylbiphenoxyboranes in high yields. These hydroboration reactions proceed stereospecifically in a cis manner. A similar regioselectivity to catecholborane is realized with a greater reactivity.
Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation
Cha, Pu-Hyeon,Cho, Yong-Hee,Lee, Sang-Kyu,Lee, JaeHeon,Jeong, Woo-Jeong,Moon, Byoung-San,Yun, Ji-Hye,Yang, Jee Sun,Choi, Sooho,Yoon, Juyong,Kim, Hyun-Yi,Kim, Mi-Yeon,Kaduwal, Saluja,Lee, Weontae,Min, Nature Publishing Group, a division of Macmillan P 2016 Nature chemical biology Vol.12 No.8
Both the Wnt/β-catenin and Ras pathways are aberrantly activated in most human colorectal cancers (CRCs) and interact cooperatively in tumor promotion. Inhibition of these signaling may therefore be an ideal strategy for treating CRC. We identified KY1220, a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway, and synthesized its derivative KYA1797K. KYA1797K bound directly to the regulators of G-protein signaling domain of axin, initiating β-catenin and Ras degradation through enhancement of the β-catenin destruction complex activating GSK3β. KYA1797K effectively suppressed the growth of CRCs harboring APC and KRAS mutations, as shown by various in vitro studies and by in vivo studies using xenograft and transgenic mouse models of tumors induced by APC and KRAS mutations. Destabilization of both β-catenin and Ras via targeting axin is a potential therapeutic strategy for treatment of CRC and other type cancers activated Wnt/β-catenin and Ras pathways.
Cha, Jae-Eun,Lee, Tae-Ho,Eoh, Jae-Hyuk,Seong, Sung-Hwan,Kim, Seong-O,Kim, Dong-Eok,Kim, Moo-Hwan,Kim, Tae-Woo,Suh, Kyun-Yul Korean Nuclear Society 2009 Nuclear Engineering and Technology Vol.41 No.8
Systematic research has been conducted by KAERI to develop a supercritical carbon dioxide Brayton cycle energy conversion system coupled with a sodium cooled fast reactor. For the development of the supercritical $CO_2$ Brayton cycle ECS, KAERI researched four major fields, separately. For the system development, computer codes were developed to design and analyze the supercritical $CO_2$ Brayton cycle ECS coupled with the KALIMER-600. Computer codes were developed to design and analyze the performance of the major components such as the turbomachinery and the high compactness PCHE heat exchanger. Three dimensional flow analysis was conducted to evaluate their performance. A new configuration for a PCHE heat exchanger was developed by using flow analysis, which showed a very small pressure loss compared with a previous PCHE while maintaining its heat transfer rate. Transient characteristics for the supercritical $CO_2$ Brayton cycle coupled with KALIMER-600 were also analyzed using the developed computer codes. A Na-$CO_2$ pressure boundary failure accident was analyzed with a computer code that included a developed model for the Na-$CO_2$ chemical reaction phenomena. The MMS-LMR code was developed to analyze the system transient and control logic. On the basis of the code, the system behavior was analyzed when a turbine load was changed. This paper contains the current research overview of the supercritical $CO_2$ Brayton cycle coupled to the KALIMER-600 as an alternative energy conversion system.
Cha, Jang Gyu,Kim, Dong Hun,Kim, Dae Ho,Paik, Sang Hyun,Park, Jai Soung,Park, Seong Jin,Lee, Hae Kyung,Hong, Hyun Sook,Choi, Duek Lin,Yang, Kyung Moo,Chung, Nak Eun,Lee, Bong Woo,Seo, Joong Seok The Korean Society of Radiology 2010 KOREAN JOURNAL OF RADIOLOGY Vol.11 No.4
<P><B>Objective</B></P><P>We prospectively compared whole-body multidetector computed tomography (MDCT) and 3.0T magnetic resonance (MR) images with autopsy findings.</P><P><B>Materials and Methods</B></P><P>Five cadavers were subjected to whole-body, 16-channel MDCT and 3.0T MR imaging within two hours before an autopsy. A radiologist classified the MDCT and 3.0T MRI findings into major and minor findings, which were compared with autopsy findings.</P><P><B>Results</B></P><P>Most of the imaging findings, pertaining to head and neck, heart and vascular, chest, abdomen, spine, and musculoskeletal lesions, corresponded to autopsy findings. The causes of death that were determined on the bases of MDCT and 3.0T MRI findings were consistent with the autopsy findings in four of five cases. CT was useful in diagnosing fatal hemorrhage and pneumothorax, as well as determining the shapes and characteristics of the fractures and the direction of external force. MRI was effective in evaluating and tracing the route of a metallic object, soft tissue lesions, chronicity of hemorrhage, and bone bruises.</P><P><B>Conclusion</B></P><P>A postmortem MDCT combined with MRI is a potentially powerful tool, providing noninvasive and objective measurements for forensic investigations.</P>
Role of corticosterone in ethyl carbamate-induced immunosuppression in female BALB/c mice
Cha, Shin Woo,Lee, Hu Jang,Cho, Myung Haing,Lee, Mun Han,Koh, Woo Suk,Han, Sang-Seop,Kim, Jung-Ae,Lee, Eung-Seok,Nam, Doo-Hyun,Jeong, Tae Cheon 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
We have recently demonstrated that the antibody response to the T-cell-dependent antigen, sheep red blood cells(SRBCs), was suppressed by ethyl carbamate in female BALB/c mice. At the same doses, ethyl carbamate decreased in the numbers of splenic macrophages. B cells, total T cells, CD4^(+) T cells and CD8^(+) T cells. In addition, the serum level of corticosterone was increased dose-dependently. To investigate the possible role of corticosterone in ethylcarbamate-induced immunosuppression, the antibody response to SRBCs and the subpopulation changes of splenocytes and thymocytes were determined in naive, sham-operated and adrenalectomized (ADX) female BALB/c mice. When the mice were treated intraperitoneally with 400 mg/kg ethyl carbamate, the antibody response was significantly suppressed by ethyl carbamated in naive and sham-operated mice in accompanying the decrease in spleen and thymus weights and/or the increase in the level of serum corticosterone. Meanwhile, the antibody response was not suppressed by ethyl carbamate in the ADX mice. The splenic numbers of total cells, macrophages B and T cells, and CD4^(+) cells were decreased by ethyl carbamate in naive and sham-operated mice. Meanwhile, each cell number was comparable with control in the ADX mice. The flow cytometric analyses on thymocytes did not show obvious differences as seen in the spleen. Finally, when the ADX mice were treated intraperitoneally with 25 mg/kg corticosterone, the antibody response was significantly suppressed. Taken together, our present results suggested that corticosterone might be, at least partially, responsible for ethy; carbamate-induced immunosuppression in female BALB/c mice. ⓒ 2001 Elsevier Science Ireland Ltd. All rights reserved.
Sang Hoon Lee,Chun Geon Park,Jeong Hoon Lee,Yeon Bok Kim,Young Guk Kim,Seon Woo Cha,Gwan Hou Kim,Hyo Jin Kim,Chang Suk Huh,Sang Won Lee 한국약용작물학회 2016 한국약용작물학술대회 발표집 Vol.2016 No.05
Background : This study was development of moisture tolerance and high-yielding Rehmannia glutinosa cultivar. Methods and Results : Segang is developed by the medicinal crop breeding team of National Institute of Horticulture and Herbal Science(NIHHS), Rural Development Administration(RDA), during the period from 2005 to 2015. The reproduction of Rehmannia glutinosa has been accomplished mainly by vegetative propagation with its seedlings have many variants. The cultivar was selected from seedling of Jihwang 1(check variety). The plant type of Segang is some rising from ground. Regional yield trials conducted at three site from 2014 to 2015. The root yield of Segang was 21.1ton per hectare, which was increased 12% compared with Jihwang 1. Also, Segang has higher catalpol content and dried root ratio compared with Jihwang 1. Conclusion : Segang is a moisture tolerance and high-yielding Rehmannia glutinosa cultivar.