실험적 진폐증에서 투여약제에 따른 면역학적 병리학적 조직변화

윤임중,임현우,노영만,오상용,정장영,임영,김경아 가톨릭 대학 산업의학 쎈타 산업의학연구소 1993 韓國의 産業醫學 Vol.32 No.2

To access the effects of some drugs such as piperazine phosphare, azathioprine and allopurinol in the experimental pneumoconiosis, 263 rats weighted 240-320 gm was divided into the control and eight experimental groups. To each group, the turbid solution mixed free silica, talc and natural coal dust of 50 mg in 0.8 ml saline were instilled intratracheally. At the begining and 5th week of experiment, piperazine phosphate(8mg/week orally), aspirin(1.5mg/day intramuscularly), azathioprine(25mg/day orally) and allopurinol(1.5mg/day orally) were administered simultaneously, while the dust turbid solution was only given to the control group. For each group the change of body weight. dry right lung weight, cellularity including total cell, macrophage, lymphocyte and neurtrophil in bronchoalveolar lavage fluid, superoxide ion, hydroxyproline, leukotriene B₄, tumor necrotsis factor, prostaglandin E₂were examined, and observed the pathological chages in lung tissue. The results were as follow : 1. The larger amount of their instilled dust and the longer observation period, the severer pathological findings were found in the lung tissue of each experimental group. 2. The body and dry right lung wight was not significantly changed in the experimental groups compared with the control group. 3. The number of total cell in bronchoalveolar lavage fluid was markedly less in the experimental group than the control one, while no significant difference was found in the percent alveolar macrophages and lymphocytes in both groups. However, the percent of neutrophiles was usually lower than in the control group. 4. The amount of superoxide ion was frequently less in the experimental group compared with the control one. 5. The amount of hydroxyproline was significantly lower in the experimental group than in the control one. 6. The amount of leukotriene B₄was usually less in the drug administered group than in the control one. 7. The amount of tumor necrotic factor was also frequently lower in each experimental group than in the control one. 8. The amount of prostaglandin E₂was usually higher in each experimental group than in the control one.

공간구문론을 이용한 루이스 칸 건축의 공간구조 분석에 관한 연구

노재원,김영욱,이상호 대한건축학회 2003 대한건축학회논문집 Vol.19 No.5

This study is the quantitative analysis which doesn't only focus on Kahn's statement but also the architectural space itself. The purpose of this study is to understand Kahn's architecture with an actual proof with the use of Space Syntax. The results of this study were as follows; Firstly, in the spatial configuration like concentric circle centering around a huge space, the characteristics are, - forming the rank of syntactic value and determining building user's flow - clarifing building user's spatial cognition - representing Kahn's architectural concept from the beginning Secondly, in the spatial configuration with centrality by putting specific spatial unit to the universal spaces without especially integrated or segregated spaces, - spatial configuration would rather be settled by Kahn's architectural concept which has priority to building's function than satisfy the functional demand following building type. Thirdly, Kahn's void space doesn't mean empty space but his point of architectural concept ; 'Room'

Plasma arc light를 이용한 금속 브라켓의 부착시 광조사 방향과 중합시간이 전단결합강도에 미치는 영향

노상정,이현정,전영미,김정기 대한치과교정학회 2004 대한치과교정학회지 Vol.34 No.5

본 연구는 Plasma arc light를 이용하여 금속 브라켓의 부착시 광조사 방향, 중합시간 그리고 경화시간이 전단결합강도에 미치는 영향을 평가하기 위해서 시행되었다. 240개의 발거된 소구치를 15군으로 나눈 후, 광중합기(Plasma arc light와 Halogen light), 중합시간(Plasma arc light 2, 4, 6초와 Halogen light 20초), 그리고 광조사 방향(Vertical 방향과 Oblique 방향)을 다르게 하여 브라켓을 부착하였다. 광중합 접착제는 Transbond XT를 이용하였으며 브라켓 부착 후 5분과 24시간 후에 만능물성시험기를 이용하여 전단결합강도를 측정하였다. 결과는 다음과 같다 광중합기의 종류와 중합시간에 관계없이 Vertical군과 Oblique군 간의 전단결합강도는 유의한 차이가 없었다 (p>0.05). Plasma arc light를 이용하여 2초 동안 광중합한 군들의 전단결합강도는 다른 중합시간의 군들보다 현저히 낮았다 (p<0.05). 부착 5분 후의 전단결합강도는 24시간 후보다 현저히 낮았다 (p<0.05). ARI 점수는 군들 간에 통계적으로 유의한 차이가 없었다. 이상의 결과는 plasma arc light를 사용한 금속 브라켓의 부착시 광조사 방향은 전단결합강도에 영향을 끼치지 않으며, Halogen light와 유사한 결합강도를 얻기 위해서는 4초 이상의 중합시간이 필요함을 시사한다. The purpose of this study was to compare the effects of different light direction. exposure times and setting times when using plasma arc light on shear bond strength of metal brackets. 240 extracted human premolars were randomly assigned to one of 16 groups. Standardized brackets were bonded to enamel using different light curing units (Plasma arc light and Halogen light), exposure times (Plasma arc light 2, 4, 6 seconds and Halogen light 20 seconds), and light directions (Vertical direction [V] and Oblique direction [O]). 8 groups were tested after 5 minutes and the remaining 8 groups after 24 hours. The metal brackets were bonded with Transbond XT. Shear bond strength was measured by a universal testing machine. The results were as follows: There were no differences between the shear bond strengths of the Vertical groups (V) and Oblique groups (O), regardless of exposure times and types of light curing units (p>0.05), The shear bond strength of the group with 2 seconds of plasma light were significantly lower than other exposure time groups (p<0.05). The shear bond strength tested after 5 minutes was lower than after 24 hours (p<0.05). The Adhesive Remment Index (ARI) score showed no statistically significant difference among the different groups. The results of this study suggested that the light direction of plasma arc light had no influence on the shear bond strength of metal brackets to enamel, and exposure times more than 4 seconds produced shear bond strengths similar to those produced with a conventional halogen curing light.

광중합형 레진에서 초기 저광도 광중합 및 연마 시기가 변연부 미세 누출에 미치는 영향

노병덕,정일영,이상훈 大韓齒科保存學會 2000 Restorative Dentistry & Endodontics Vol.25 No.1

호알칼리성 Bacillus sp.F204와 Bacillus sp.K17의 원형질체 융합

성낙계,노종수,박석규,정영철 순천대학교 기초과학연구소 1990 基礎科學硏究誌 Vol.1 No.-

To develop cellulase and xylanase-producing strain by protoplast fusion, alkalophilic Bacillus sp. F204 and K17 were treated with NTG(N-methyl-N'-nitro-N-nitrosoguanidine) and isolated antibiotics resistant strains of S20 (Km', Cm') and G70(Str'). The frequency of protoplast formation was about 95% when cells of mid-log phase were treated with 200㎍/㎖ lysozyme at 37℃ for 30-45 minutes. Under addition of 0.4-0.5M sodium succinate, 0.5% casamino acid, 1.5% polyvinylpyrrolidone, 25mM MgCl_2 and 50mM CaCl_2 to the regeneration medium, the regeneration frequency of Bacillus sp. F204 and K17 was 24.9% and 26.2%, respectively. the fusion frequency was 6.6×10^-6 in the presence of 30% polyethylene glycol 6000 containing 50mM Ca^++ at 45℃ for 5 minutes. Cellulase complex and xylanase activities of fusant were compared with parental strains.

요로조영상에서 요관폐색 및 음영결손을 보인 환자에서의 요관경검사

염규영,하용원,노안식,손성용,김진겸,설종구 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2

Purpose: To evaluate the clinical value of ureteroscopy for the ureteral filling defect or obstruction on the excretory or retrograde pyelogram(RGP). Materials and Methods: The 72 patients with filling defect or intrinsic obstruction ureteral lesion on the excretory urogram or RGP underwent ureteroscopy to examine and treat the lesions. We used the 9.5Fr. or 11.5Fr. rigid ureteroscope with 5Fr. working channel. Results: The results were as follows; I. Among the 72 patients, 39 were male and 33were female. The mean age of patient was 45.7 years. 2. Ureteroscopy was successfully performed in 70 cases(97%) out of 72. In 2 cases, the advance of ureteroscope was failed. 3. Among 70 successful cases, ureteroscopy revealed 45 radiolucent stones, 9 ureteral stricture, 2 ureteral TCC. I metastatic tumor, 3 blood clot, each case of ureteral polyp, epithelial hyperplasia and Von-Brunn's nest. In 7 cases, no causative lesions were identified. 4. 41 out of 45 radiolucent stones were successfully removed by ureteroscopic procedure and 9 ureteral strictures were dilated. 6 cases of ureteral mass were successfully biopsied for pathological diagnosis. 5. 23 cases of post-operative or fever were treated conservatively and 10 cases of mucosal tearing and 1 case of ureteral perforation were treated with double-J stent indwelling. Conclusions: The ureteroscopy is effective modality to evaluate and treat in the ureteral filling defect or obstruction on the excretory urogram.

조선업 도장작업자의 유사노출군과 노출변이; 크실렌 노출을 중심으로

고상백,노영만,임현우,신용철,김수근,최홍열,김재용,장성훈 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4

목적 : 조선업 도장 작업자의 크실렌 노출을 평가하기 위하여, 수행직무 및 밀폐특성에 따라 유사노출군으로 구분하여 노출 변이 및 동질성을 파악하고자 하였다. 방법 : 3회 이상 반복측정이 이루어진 근로자 중동일공정에서 직무상 변동이 없는 근로자 총 28명을 대상으로 하였다. 노출농도 값을 대수전환(lOgtransformation)하여 근로자간, 근로자내 노출 분산요소을 추정하기 위하여, nested randomeffects ANOVA model을 활용하였다. 선정된 유사노출군 내 구성원의 측정 평균이 동일하다고 할수 있는지를 검정하기 위하여 분산요인(9f)을 산출하였고, 쿨즈0.031일 경우 동일하다고 생각하였다.또한 노출 값을 대수전환하여 95 %의 근로자(b-R9s)가 2배수 범위 내에 측정값을 가질 경우 동일하다고 생각하였다. bwRSS의 값을 유사노출군내의 근로자들간(between worker)의 기하표준편차(bwsy)를 구한 후 exp(3.92 bwsy)로 계산하여 산출하였고, 그 값이 2이하이면 동일하다고 생각하였다. 결과 : 일반적으로 유사노출군은 노출농도가 비슷한 것이라는 생각과는 달리, 직무에 근거한 유사노출군은 동질성 검정상 이질적이었다. 분무도장과 붓도장 모두 bwRss은 2를 초과하였고, 룰 또한 0.031를 초과하여 변이 폭이 컸다. 그러나 밀폐특성에 따른 노출 분포의 변이성은 직무만으로 구분했을 때의 변이지표 보다 그 수치가 낮아 밀폐특성으로 직무의 변이성을 설명 할 수 있었다. 결론 : 직무에 근거한 유사노출군이 동질적이지알다는 결과는 유사노출군으로 구분된 근로자의 업무특성이 하나의 유사노출군으로 설정할 수 없다는 점을 시사한다. 따라서 향후 작업환경 측정 시 직무뿐만 아니라 특정 업무(specific task) 또는 세부작업현황까지 파악할 필요성을 제시하고 있다. Objectives : This study was conducted to assess the concentration of xylene exposure and exposure variability of a similar exposure group (SEG) in accordance with job title and confined space. Method : The study subjects included 28 workers working in the painting process in the ship-building industry. Measurement of subjects were repeated three times. Within and between-worker exposure valiance components were estimated from log-transformed exposure concentrations employing a one-way nested random effects analysis of variance model. A uniformly exposed group was defined as one where the between-worker variance(σB2) was less than or equal to 0.031 or bwR95 ≤2, where bwR95 =exp(3.92 bwSy) , representing the radio of the mean exposures of the 97.5th and 2.5th percentile groups of the workers sampled. Result : The results indicated that, contrary to popular belief, similar exposed groups based on job title were heterogeneous. The between-worker variance(σB2) is large(≥0.031) and the ratios of the 97.5th and 2.5th percentile workers of the log normally distributed exposures of each group of worriers was more than 2. However dividing job title into confined space (in-block, out-block, in/out-block) decreased the between-worker exposure variability. Conclusion : This study focused on the quantitative aspects of exposure in painters in the ship-building industry. We cannot accept the assumption that SEG are uniformly exposed, as a major component of variation in exposure relates to differences in tacks or other factors. Therefore, the observational schemes can be improved by investigating Job-specific task and practice.

생산전략에 의한 기업성과에 관한 실증적 연구

이성호,오영진,박노국 尙志大學校 生産技術硏究所 1997 生産技術論叢 Vol.- No.1

The growth and survival of a business depend upon its proper strategic capability against the rapid change in environment. The business that well accommodates the changing environment and properly uses the resources will continue its growth. The problems in accommodating business environment are how to focus the limited corporate strategy on certain point. This study analyzed the performance of corporate and lower level functional strategy to produce the competitiveness of manufacturing company and to recommend the corporate strategic directions from the results. Consequently, business competitiveness depends upon how a business consistently precedes the alternatives of corporate strategy and the focused factory strategy. Therefore, top management should pay attention to the focused factory in product manufacture.

줄넘기 운동강도에 따른 혈액화학성분 및 체력요인의 변화 : focused High School Boys

노영옥,노성규 강원대학교 체육과학연구소 2000 江原大學校附設體育科學硏究所論文集 Vol.- No.23

This study analyzes the influence of the rope skipping intensities on the blood chemical components and physical fitness of high school male students. The subjects of this study are the 45 male high school students. In the experiment the two groups did the rope skipping with 60% and 80% intensity of their maximal capacity respectively for 60 minutes. Three times a week for 12 weeks. The change of the blood chemical components and physical fitness are analyzed. The results of study are as following 1.The blood chemical component 1) The exercise groups of 60% and 80% intensity of their maximal capacity have shown the increase in the following areas; HDL-C. 2) The exercise groups of 60% and 80% intensity of their maximal capacity have shown the decrease in the following areas; LDL-C. 2.The physical fitness 1) The exercise group of 60% and 80% intensity of their maximal capacity have shown the increase in the following areas; back-strength, leg strength, cardirespiratory endurance. Since as this study result shows the blood chemical components and physical fitness has changed positively through rope skipping, it is expected that the rope skipping will be an effective exercise for obese students.

스포츠 마케팅의 커뮤니케이션 요소

이상봉,노영태 釜山大學校 師範大學 1996 교사교육연구 Vol.32 No.-

The theoretical investigation of the sports marketing communication by examining literatures. Conclusion from the results as follows. Marketing communication is process of stimulus translate. It is change receiver's attitude that role as promoters or translators by firm's significant message. Various promotion can be controlled by maketer. But generally using promotions are sales promotion, advertising, personal selling and publicity. Publicity is able to growing recognition with low cost and which can disapper advertising disbelief as overflowing with advertising. Recently many firms are participating in sports and culture activities, had an effect on opening professional baseball. Sports consumers are must classification according to type of light, medium and heavy user with promotion programs. Product giveaways, quasi-price promotion, or special attractions is offer to the light user. Medium user may outlined under light user strategies. The heavy user is ensuring that the consumer does not drop off lower frequency of consumption as antidefection strategies. Antidefection strategies is two categories:preventive strategies and come back to the fold, it's need new computer system.