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이온 교환체로서 Quinine-금속thiocyanate착물을 이용한 Quinine의 정량
허문희,백광진,최현영,안문규 경성대학교 1997 論文集 Vol.18 No.1
The fabrication and performance characteristics of quinine sensitive poly(vinyl chloride) membrane electrodes based on the ion-association complex of quinine with an anionic counter ion, metal thiocyanates (Co(SCN)??, Cd(SCN)??, Fe((SCN)??, Hg(SCN)??, Mn(SCN)??, Ni(SCN)??, zn(SCN)??) was described. The sensing membrane was based on the quinine complex of cobalt thiocyanate plasticized with 65.3% (w/w) tris(2-ethylhexyl) phosphate (TEHP), ferric thiocyanate with 65.3% (w/w) TEHP, nickel thiocyanate with 65.3% (w/w) TEHP and zinc thiocyanate with 49% (w/w) TEHP. These electrodes show a linear response down to 1.2×10?, 1.0×10?, 9.6×10?, 2.0×10?M with Nernstian slope of 55.69, 54.96, 56.63, 55.80 mV/dec. for quinine with relative standard deviation of 3.1, .51, 2.26, 3.16% at pH 5.5∼7.6, respectively. Response time was 10∼20s. The quinine-nickel complex with 65.3% (w/w) TEHP was the optimal ion-exchanger for quinine selective electrode. The electrode exhibits good selectivity for the quinine in the presence of some inorganic cation and organic cations. The quinindine-nickel complex instead of quinine-nickel complex as an ion-exchanger was successfully applied to the direct potentiometric determination of quinidine pharmaceutical preparation giving an average recovery of 101.5% and relative standard deviation of 2.5%.
방울토마토중 Dichlofluanid 및 Iprodione의 생산단계별 잔류농약 경시변화
최규일,성기용,정태균,이주환,허장현,고광용,이규승 한국환경농학회 2002 한국환경농학회지 Vol.21 No.4
방울토마토의 생산단계에서의 잔류허용기준 설정과 수확후 저장기간중 경시변화 및 세척에 의한 잔류농약의 감소양상을 파악하였다. 해당약제를 안전사용기준의 기준량 및 배량을 각각 시설재배 포장에서 살포후 10일간 잔류양상을 조사하였고, 실온 및 냉장조건 하에서의 저장실험 및 세척에 따른 전류농약의 잔소량을 파악하여 생산단계부터, 출하, 저장, 소비단계까지의 잔류량을 예측할 수 있는 모델개발을 위한 자료로 이용하고자 연구를 수행하였다. Dichlofluanid와 iprodione은 포장조건에서 반감일수가 기준량 2.2, 3.3일 이었으며, 배량은 3.5, 5.4일로 나타났다. 저장조건하에서의 약제별 반감기는 포장조건보다 잔류량의 감소속도가 느린 것으로 나타나 반감일수가 증가하였고, 세척방법에 의한 잔류농약의 감소량을 조사한 결과 세제 사용시의 평균제거율은 dichlofluanid는 73.7%, iprodione은 64.3%로 나타났고, tap-water 사용시에는 dichlofluanid 73.5%, iprodione 63.5%로 나타났다. 이러한 결과는 작물의 생산단계에서 구한 합리적인 희귀식을 이용하여 잔류농약의 경시변화를 파악하고, 저장 및 세척과정을 거쳐 최종 소비단계에서의 잔류농약의 수준을 평가할 수 있었다. We studied the residual patterns of two fungicides, dichlofluanid and iprodione, in cherry tomato greenhouse after applying with the recommended and double dose. Also, the degradation patterns during storage periods of up to ten days were compared between at room temperature (20℃) and at cold temperature (4℃). Removal rates of fungicides by washing with tap-water and detergent solution (0.1%, 0.2%) were measured. Half-lives of dichlofluanid and iprodione in greenhouse cherrytomato were 2.2~3.5 and 3.3~5.4 days, respectively. During the storage period, the residues were dissipated more slow. Removal rates were 62.8~80.3% by tap-water, 60.4~83.1% by 0.1% detergent solution, and 65.3~77.6% by 0.2% detergent solution. So, we can predict of terminal residues from cultivation period to marketing, storage and consuming.
Abuse Potential of Synthetic Cannabinoids: AM-1248, CB-13, and PB-22
( Kwang-hyun Hur ),( Shi-xun Ma ),( Bo-ram Lee ),( Yong-hyun Ko ),( Jee-yeon Seo ),( Hye Won Ryu ),( Hye Jin Kim ),( Seolmin Yoon ),( Yong-sup Lee ),( Seok-yong Lee ),( Choon-gon Jang ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.4
Currently, the expanding recreational use of synthetic cannabinoids (SCBs) threatens public health. SCBs produce psychoactive effects similar to those of tetrahydrocannabinol, the main component of cannabis, and additionally induce unexpected pharmacological side effects. SCBs are falsely advertised as legal and safe, but in reality, SCB abuse has been reported to cause acute intoxication and addictive disorders. However, because of the lack of scientific evidence to elucidate their dangerous pharmacological effects, SCBs are weakly regulated and continue to circulate in illegal drug markets. In the present study, the intravenous self-administration (IVSA) paradigm was used to evaluate the abuse potential of three SCBs (AM-1248, CB-13, and PB-22) in rats. All three SCBs maintained IVSA with a large number of infusions and active lever presses, demonstrating their reinforcing effects. The increase of active lever presses was particularly significant during the early IVSA sessions, indicating the reinforcementenhancing effects of the SCBs (AM-1248 and CB-13). The number of inactive lever presses was significantly higher in the SCB groups (AM-1248 and CB-13) than that in the vehicle group, indicating their impulsive effects. In summary, these results demonstrated that SCBs have distinct pharmacological properties and abuse potential.
The Dairy Calves Mortality : the Causes of Death during Ten Yearsin a Large Dairy Farm
Tai Young Hur,Young–,Hun Jung,Seog–,Jin Kang,Chang yong Choe,Ui Hyung Kim,Il Sun Ryu,Dong Soo Son,Kwang Soo Baek,Kwang Seok Ki,Hyun June Lee,Eung Gi Kwon,Guk Hyun Suh,Young Il Cho 대한수의학회 2012 대한수의학회 학술대회발표집 Vol.2012 No.-
국내 유통 소금 중의 포타슘시아니이드와 페로시아나이드염의 분석에 관한 연구
허숙진,소유섭,최장덕,이화정,최선희,성준현,임무혁,김광수,최용훈,오해성,최정희,최정실,허옥순,이진하,신동우,신현수,문병우 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-
본 연구는 국내 유통 소금중의 안전성을 규명하기 위하여 천일염 54건, 재제염 보건, 가공염 33건 등 총 143건에 대하여 숲행하였다. HPLC, ICP, Mercury Analyzer 등을 이용하여 KCN, 페로시아나이드 염, 납 등 6개 성분의 항량을 측정하였으며 그 결과는 다음과 같다. [rdn-max(mean) ; m곱3 ; f(CN : ND-ND(ND), 페로시아나이드염 : ND-ND(ND), Pb . ND-1.30 (0.331), Cd :ND-0.23(0.070), Hg ND-0.35(0,035), As :ND-1.52fo.062). 또한, 신속하고도 효율적이 면서 기존의 환경부 시안분석법의 단점을 보완할 수 있는 KCN과 페로시아나이드염의 분석 조건을 계시하였으며, 천일염, 재제염, 가공염 뿐만아니라 소금이 첨가된 식품까지도 적용하기 위한 기초 자료로 활용이 가능할 것으로 사료된다. This study was conducted to confirm the safety in a total of 143 samples of salts. The contents of potassium cyanide(KCN), potassium ferrocyanide(K_(4)Fe(CN)_(6)), lead(Pb), cadmium(Cd), mercury(Hg), and arsenic(As) were determined using a high performance liquid chromatograph(HPLC), inductively coupled plasma spectrometer(ICP), and mercury analyzer. The values of cyanide complexes and metal elements in salts were as follow [min-max(mean);mg/kg] ; KCN : ND-ND(ND), Ferrocyanide salt : ND-ND(ND), Pb : ND-1.30(0.331), Cd: ND-0.23(0.070), Hg : ND-0.35(0.035), As : ND-1.52(0.062). In this study, we established efficient
Quantitative Profiling of Dual Phosphorylation of Fus3 MAP Kinase in Saccharomyces cerevisiae
Hur, Jae-Young,Kang, Gum-Yong,Choi, Min-Yeon,Jung, Jin Woo,Kim, Kwang-Pyo,Park, Sang-Hyun Korean Society for Molecular Biology 2008 Molecules and cells Vol.26 No.1
Mitogen-activated protein kinase (MAPK) signaling is a crucial component of eukaryotic cells; it plays an important role in responses to extracelluar stimuli and in the regulation of various cellular activities. The signaling cascade is evolutionarily conserved in the eukaryotic kingdom from yeast to human. In response to a variety of extracellular signals, MAPK activity is known to be regulated via phosphorylation of a conserved TxY motif at the activation loop in which both threonine and tyrosine residues are phosphorylated by the upstream kinase. However, the mechanism by which both residues are phosphorylated continues to remain elusive. In the budding yeast, Saccharomyces cerevisiae, Fus3 MAPK is involved in the mating signaling pathway. In order to elucidate the functional mechanism of MAPK activation, we quantitatively profiled phosphorylation of the TxY motif in Fus3 using mass spectrometry (MS). We used synthetic heavy stable isotope-labeled phosphopeptides and nonphosphopeptides corresponding to the proteolytic TxY motif of Fus3 and accompanying data-dependent tandem MS to quantitatively monitor dynamic changes in the phosphorylation events of MAPK. Phosphospecific immunoblotting and the MS data suggested that the tyrosine residue is dynamically phosphorylated upon stimulation and that this leads to dual phosphorylation. In contrast, the magnitude of threonine phosphorylation did not change significantly. However, the absence of a threonine residue leads to hyperphosphorylation of the tyrosine residue in the unstimulated condition, suggesting that the threonine residue contributes to the control of signaling noise.