신이식에서 이식신의 생존분석

오선미,김종학,황평주,구영선,강민규,나기량,김종섭,김성숙,이강욱,신영태,설종구,배진선,손기섭 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

To investigate the prognostic factors for the survival of transplanted kidney in patients with end-stage renal failure, 59 cases of renal transplantation from September 1986 to Feburary 1997 in Chungnam National University Hospital were analyzed retrospectively. The results were as follows: 1)The mean age of recipients was 33.8 years and that of doners was 38.9 years. The male to female ratio of recipients was 2.5:1, and that of donors was 1.03:1 2) Living related donore(LRD) were 79.6% and living non-related donors were 20.3%. The HLA-identical donors(ID) in LRD were 18.7% and HLA-haploidentical donors(HID) were 61.0%. In living non-related donors(LNRD), mean matched HLA-AB antigens were 1.56 and mean matched HLA-DR antigens were 0.56. 3) The average 5-year patient survival fate was 94%, and average 5-year graft survival rate was 70%. The 5-year graft survival fate of HLA-ID was 100%, and those HLA-HID and LNR were 70% and 36% respectively. 4) Total 33 episodes of acute rejection were found in 45.8% of transplanted patients. The number of acute rejection episode did not show significant difference between LRD and LNRD(P > 0.05). There was no significant difference in MLC between two groups(p > 0.05). 5) In comparison between the 18 patients who lost their graft function in 5 years and 17 patients who are maintaining graft function for more than 5 years, MLC was significantly lower in patients with functioning graft than of patients with non-functioning graft (p < 0.05). The number of rejection episode was also lower in patients with functioning graft than that of the patients with non-functioning graft(p < 0.05). However, there were no significant difference in recepient and donor age and history of pre-transplantation donor specific transfusion between two groups. With the results above, we can speculate that adequate donor selection according to good matched HLA typing and low MLC is very important for graft survival in renal transplantation. Prevention and treatment of acute rejection in renal transplantation is also na important factor for graft survival.

B형 간염 바이러스 단백질에 있어서 HLA-A2에 의해 표현되는 Epitope 펩타이드 들의 분석

이희구,임종석,김승목,이기영,김희수,김승호,권태종,최인성,정태화,김길현 이화여자대학교 생명과학연구소 1995 생명과학연구논문집 Vol.6 No.-

The cytotoxic T lymphocyte(CTL) are an important component in host defense mechanism against viral infection. They can recongnize virus-derived peptides presented by the ClassⅠ MHC molecule at the cell surface of the infected cells. On searching for effective CTL epitopes of hepatitis B virus(HBV), we synthesized a distinct set of 9-10 mer peptide containing amino acid sequence of hepatitis B virus surface proteion that are selected on the basis of a computer modeling and the previously described HLA-A2 specific motifs. Binding assay of the synthetic peptides to HLA-A2 molecules using human antigen processing defectantn T2 cells showed what 3 out of 4 synthetic peptides enhaced the expression of HLA-A2 molemule on T2 cell surface. Two anchor positions, namely P2 and P9(or P10) appeared to play a decisive role for binding. Structural chacteristics of the peptides addressed by molecular dynamics simulation was analysed and compared. These peptides also parially triggerd CTL isolatied frmo human peripheral blood mononuclear cells of HBV positive patients, and the response was peptide-specific. These results showed that negatively-charged amino acid residue at P2 hampered binding affinity of the peptides to HLA-A2 molecules, and that binding affinity of the peptides are not always reflected by thier immunogenicity among natural T cell repertoire.

B형 간염 바이러스 단백질에 있어서 HLA-A2에 의해 표현되는 Epitope 펩타이드 들의 분석

이희구,임종석,김승목,이기영,김희수,김승호,권태종,최인성,정태화,김길현 梨花女子大學校 藥學硏究所 1995 藥學硏究論文集 Vol.- No.5

The cytotoxic T lymphocyte (CTL) are an important component in host defense mechanism against viral infection. They can recongnize virus-derived peptides presented by the Class I MHC molecule at the cell surface of the infected cells. On searching for effective CTL epitopes of hepatitis B virus(HBV), we synthesized a distinct set of 9-10 mer peptide containing amino acid sequence of hepatitis B virus surface protein that are selected on the basis of a computer modeling and the previously described HLA-A2 specific motifs.Binding assay of the synthetic peptides to HLA-A2 molecules using human antigen processing defectant T2 cells showed that 3 out of 4 synthetic peptides enhanced the expression of HLA-A2 molecule on T2 cell surface.Two anchor positions, namely P2 and P9(or P10) appeared to play a decisive role for binding.Structural. characteristics of the peptides addressed by molecular dynamics simulation was analysed and compared.These peptides also partially triggered CTL isolated from human peripheral blood mononuclear cells of HBV positive patients, and the response was peptide-spcific.These results showed that negatively-charged amino acid residue at P2 hampered binding affinity of the peptides to HLA-A2 molecules, and that binding affinity of the peptides are not always reflected by their immunogenicity among natural T cell repertoire.

인라인스케이터의 인라인스케이트 의복흥미 (Ⅰ)

김영란,유태순,조기여 한국의류산업학회 2004 한국의류산업학회지 Vol.6 No.4

The purpose of this study was to classify the In-line skate clothing interest of in-line skaters according to in-line skate involvement. The questionnaire was administrated to 124 male, 96 female in-line skaters aged over 20 living in Daegu. Data were analyzed by using Frequency, Factor analysis, One-way analysis of variance, Duncan test, T-test, Correlation analysis. The results of this study can be summarized as follows ; The factor of in-line skate clothing interest of in-line skater were classified into 5 factor, expression orientation, performance enhancement, information dependence, anti deviation, individual assertion. The in-line skate clothing interest, men have interests in performance enhancement, women have interest in individual assertion. The more experience of in-line skate they have. the more interest in performance enhancement they want. High involvement in-line skater have high cloth interesting of sub-factors which are expression orientation, performance enhancement and individual assertion etc. As a result, we need more deliberate marketing strategies for the experience degree, involvement degree and women in-line skater then men.

남자 고등학생의 흡연실태 및 학교생활 태도

김기남,이순상,현태선 충북대학교 교육 ·생활연구소 생활과학연구센터 2002 생활과학연구논총 Vol.6 No.1

The purpose of this study was to investigate smoking status of high school students, and the effect of smoking on school life attitudes. A total of 370 male students in Jinchun-kun were asked to complete a self-administered questionnaire, and the data of 355 students were analyzed. Thirty-seven percents of the respondents smoked. Among the smokers, 34% started smoking from the first year of high school and 26% from the third year of middle school. Fifty eight percents of the smokers started smoking due to curiosity, and 21% for relaxing from stress. Smokers spent more money than non-smokers. More smokers were dissatisfied with school life, made poor academic achievements, and had girl friends compared to non-smokers. These results indicate that a smoking student had several undesirable characteristics as a student. Therefore, education for the effects of smoking should be offered to high school students and even to middle school students in order not to start smoking as well as to abstain from smoking.

근대문학작품의 도시풍경구도에 나타난 시·공간의 체험적 인식에 관한 연구 : 소설 "소설가 구보씨의 일일"을 중심으로 Focused on the novel entitled "a novelist Gubo's day"

김기범,김태영 淸州大學校 都市·地域開發硏究所 2000 都市·地域開發硏究 Vol.8 No.2

The purpose of this study aims to understanding a common mental image between architecture and literature work in the modem ages, and especially the experiential recognition of time·space described on townscape. Following the result, Kyong-song have been represented to compound emotion with modem architecture established in 1930s of Modem Ages. First of all, the experiential recognition have been connected to the conflict structure between past and present townscape in the novel entitled "a novelist Gubo's day" by Park Tai-Won. And so on, such townscape consciousness was one of the immediate causes of the reminiscence.

부분 신절제 백서모델에서 Angiotensin Converting Enzyme Inhibitor 및 Angiotensin II ATI 수용체 길항제가 Plasma Renin Activity 및 Angiotensin II level에 미치는 영향

김종학,구영선,강민규,황평주,나기량,이강욱,서광선,신영태 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

Renin-angiotensin-system(RAS) has been thought to have a pivotal role in renal injury mechanism. Many reports state that the inhibition of RAS prevents the progression of renal disease in 5/6 nephrectomized rats as a typical chronic renal failure model. Angiotensin converting enzyme inhibitor blocks the conversion from Angiotensin I to Angiotensin Ⅱ (A-Ⅱ ), and ATI RA inhibits the action of A-Ⅱ at the level of AT1 receptor. Therefore the PRA and A-Ⅱ level may be influenced independently by each treatment modality with these drugs. In this study, the influence of long term treatment with ACEI or AT1RA in these models on systolic blood pressure, PRA, and A-Ⅱ level was evaluated. Male Sprague-Dawley rats weighing 270-300 grams were anesthesized with thiopental sodium(50 mg/kg) and underwent right nephrectomy and partial(approximately two thirds) infarction of the left kidney by ligation of two-three segmental arterial branches. The rats were divided into four groups : sham group, control group, 5/6 subtotal nephrectomized and ACEI treated group (enalapril 100 mg/L in drinking water), 5/6 subtotal nephrectomized and ATIRA treated group (losartan, 200 mg/L in drinking water). They were treated for twelve weeks. In the twelve weeks, both groups treated with ACEI and AT1RA ingestion demonstrated a significant decrease in systolic blood pressure(165±23 vs. 132±9, mmHg, control vs. ACEI, M±SEM, p<0.05, 165±23 vs. 124±7 mmHg, control vs. ATIRA, M±SEM, p<0.01) compare to the control group. In both group treated with ACEI and AT1RA showed a significant increase in PRA(ACEI ; 7.2±2.9, AT1RA ; 4.7±0.4, control ; 2.7±1.1, sham ; 2.7±1.4, ng/ml/hr, ACEI vs. control and sham, M±SEM, p<0.05). However no significant differences were found in the sham vs. control(p>0.05), and in ACEI vs. control. The plasma A-II level was significantly increased in AT1RA treated group compared to sham and ACEI treated group(2,753±543 vs. 484±169.3, ng/ ml, AT1RA vs. Sham, p<0.01). In conclusion, treatment with ACEI and AT1RA for twelve weeks normalized systolic blood pressure, proteinuria and increased PRA compared to the control group; whereas plasma A-II level was increased only by AT1RA treatment.

개에서 심실 조율부위 및 조율주기에 따른 혈역학적 변화

김희열,김재형,노태호,김종진,진승원,유기동,이만영,채장성,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.9

「한」사상의 역사적 정통성에 관한 연구

김기태 인천교육대학교 초등교육연구소 2001 교육논총 Vol.18 No.-

유구한 문화민족은 그 민족전통의 사상이 있기 마련이다. 우리는 반만년 문화민족임을 자랑하고 있다. 우리의 역사를 크게 보아 4,000년으로 볼 때 문헌기록이 불확실하고 실증적으로 역사적 사상기록이 뒷받침하기 힘든 전반 2,000년의 상고시대와 문헌기록이 비교적 확실시되는 후반 2,000년의 역사로 나누어진다면 외래사상(유, 불, 도)의 유입사는 지금으로부터 1,600년전의 것으로 되어 있어 4,000년의 문화전통의 바탕 위에 1,600년의 외래문화란 결국 고유전통사상이 완숙된 이후에 덧붙여 흘러오고 있던 것이 외래사상인 것이다. 그렇다면 이 시점에서 우리의 전통사상의 정맥을 찾기 위해서는 외래사상이 흘러 들어오기 이전 즉 고유사상을 찾아야 할 것이다. 이것이 바로 우리 고유 사상인 「한」사상이다. 우리의 고유사상인 「한」사상은 외래사상(유, 불, 선)에 밀려 그 모습을 내지 못한 점도 있었으나 그 사상은 면면히 이어 오고 있으니 삼국시대에는 화랑도정신으로, 고려시대에는 묘청사상으로, 조선시대에는 동학사상과 삼일정신으로 이어오고 있는 것이다. 그러함에도 불구하고 혹자들은 우리의 전통사상을 유교, 불교, 도교에서 찾으려고 하고있는데 그것은 외국에서 온 어머니지 우리의 어머니가 아닌 것과 같다. 본 연구에서는 우리의 고유사상인 「한」사상에서 연원을 밝히고 한사상이 우리 민족 사상에 어떻게 이어왔는가를 알아보고자 하였다. It is said that a long historical cultural nation has had its own national tradition, like the spirit of Chinese In 「仁」 or Do「道」, the spirit of Indians Jabisim [merciful heart], Japanese Shintoism, and Israeli Sionism. We Koreans are also called a traditional cultural nation by Koreans and various people over the world. Koreans also has a strong long thought in our traditional culture from long ago. We are proud of our half million long cultural nation. They say Korea has 4000 year long history. We can divide this period by two, the former 2000 years when its historical record is not so correct, and the latter 2000 years when the record is somewhat correct compared to the former period. Foreign thoughts like Yu[儒], Bool [佛] and Do[道] are introduced about 1600 years long foreign thoughts can be said to be introduced upon our concrete traditional thoughts of 4000 year long. That is the reason why I maintain that we have to seek our traditional thoughts in the period that the foreign thoughts began to be introduced into Korea. And thus the former thoughts is the very thoughts of Han [한]. Our Han thoughts has been called by various names like Hongik[弘益], Gwanfmyong[光明], Poongyou[風流], Gumtap[金塔], Gumchok[金尺] according to the dynasties. Even if it has different names, it meant the same contents connecting its main ideas from period to period. Our traditional thoughts, Han thoughts, was one time couldn't show itself under the foreign thoughts Yu, Bool, Seon[儒, 佛, 仙], but its main thoughts has been flowing connected dynasty by dynasty, by various names like Hwarangdo spirit, Myochong thoughts, Donghak thoughts, and Samil spirit. Without thinking of this situation, some scholars are trying to seek our traditional from Confusianism, Budism, and Doism. But I think it is not our true 'mother'.

경희대학교 수원캠퍼스 교문광장 시계탑 디자인

김동찬,이윤수,정덕용,민창기,김태현 경희대학교 부설 디자인연구원 2002 예술· 디자인학연구 Vol.5 No.1

The purpose of this study was to suggest a design proposal for a clock tower on the gate plaza of Hyunghee univ., Suwon campus. The basic ideas of design were harmony in the form and contrast in the quality of material. Therefore the clock tower was designed a sphere form by stainless steel with a glossy surface and to has a clock per four orientation.