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위선종과 조기위암에서 내시경 점막절제술의 연구 -완전절제율에 영향을 미치는 인자와 점막 절제술 전후의 조직학적 차이-
고강훈 ( Kang Hun Koh ),정혜진 ( Hey Jin Jung ),김상욱 ( Sang Wook Kim ) 전북대학교 의과학연구소 2007 全北醫大論文集 Vol.31 No.1
Objectives: The endoscopic mucosal resection of gastric adenomas or early gastric cancers is now widely accepted as a useful radical treatment method. We studied that the rate of successful treatment by the endoscopic mucosal resection of gastric adenomas or early gastric cancers and the factors related to the rate of the complete resection. Methods: We analysed, retrospectively, 118 lesions in 114 patients diagnosed early gastric cancer or gastric adenoma at the Chonbuk National University Hospital from January, 2005 to June, 2006. Of the 118 lesions, there were 107 adenomas and 11 early gastric cancers. We tried to follow up the lesions of resection by the endoscopic biopsy later. Results: The lesions were diagnosed 107 adenomas, 6 early gastric cancers type IIa, 5 type IIb, and the rate of complete resection was 85%(91), 84%(5), 80%(4), each. The sites of the lesions were divided antrum, angle, body, pylorus and each 60 cases, 14 cases, 42 cases, 2cases was reported. The rate of complete resection for the site was each 83%(50), 85%(12), 81%(34), 100%(2). The size of the lesions was divided ≤10 mm, 11~15 mm, 16~20 mm, 21~25 mm, 26~30 mm, ≥31 mm and each 14 cases, 21 cases, 41 cases, 6 cases, 31 cases, 5 cases were reported. The rate of complete resection for the size was each 86%, 86%, 90%, 100%, 71%, 60%. Of the 14 cases which were diagnosed as high grade dysplastic adenoma, early gastric cancer was diagnosed in 4 cases after the biopsy by endoscopic mucosal resection. Conclusion : We concluded that the site, size and the other factors of the lesions were related to the rate of complete resection after endoscopic mucosal resection, and the abnormal gastric mucosal lesions should be diagnosed with the biopsy by endoscopic mucosal resection.
고강훈 ( Kang Hun Koh ),백경현 ( Kyung Hyun Paeck ),이석 ( Seuk Lee ),오호준 ( Ho Jun Oh ),박승용 ( Seung Yong Park ),문희 ( Hee Moon ),강선미 ( Seon Mi Kang ),김인희 ( In Hee Kim ),김상욱 ( Sang Wook Kim ),김성훈 ( Seong Hun Ki 전북대학교 의과학연구소 2006 全北醫大論文集 Vol.30 No.1
악성 종양의 자연 치유는 어떠한 치료도 받지 않거나 일반적으로 확립되지 않은 치료법으로 악성 질환의 소실을 야기하는 것을 말하는 것으로 매우 드문 현상으로 알려져 있다. 대개 이러한 현상은 모든 암종에 걸쳐 일어날 수는 있지만 소화기계 관련된 암종의 자연 치유의 예는 극히 드물며 본 저자들은 내사경적, 조직학적 진단으로 위암을 진단받은 뒤 약 1년 반 동안 별다른 증상 없이 지냈으며 추적 관찰하여 시행한 내시경적, 조직학적 검사상 악성 소견을 발견할 수 없어서 위암의 자연 치유로 결론 짓고 잦은 외래 추적관찰을 결정한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Spontaneous regression is shown to occur in malignancies such as neuroblastoma, Wilms` tumor, leukemias, melanoma and retinoblastoma and is extremely rare in carcinoma of the stomach. Many theories exist regarding the possible factors such as genetic, hormonal, immunological and psychological factors. Some reports of spontaneous regression have implicated surgery or operative trauma as an element that can increase immunological resistance to tumor growth. We here report one case of spontaneous regression of carcinoma of the stomach with review of the literature.
Ixodes species 에 의한 Tick bite 1예
고창조,전수일,강원형,장경훈 대한피부과학회 1982 大韓皮膚科學會誌 Vol.20 No.5
The importance of the ticks in medical field has been emphasized because of their association with and transmission of various diseases. We report herein a case of tick bite in a 55-year-old male farmer, who visited our hospital on July 2, 1981 with a parasite attached on right lower flank and rice to small pea sized, pruritic erythematous papular skin eruptions on chest and right lower flank. The skin lesions disappeared completely with.in five days after removal of the parasite, which was identified with an adult female tick which belongs to Genus Ixodes.
Koh, Hun-Yeong,Kang, Han-Young,Choi, Kyung-Il,Chang, Moon-Ho Korean Chemical Society 1990 Bulletin of the Korean Chemical Society Vol.11 No.6
New aminothiazolyl cephalosporins with alkoxyiminomethyl(2-aminothiazol-4-yl)acetyl substituents at 7-position of cephems were synthesized starting from (2-aminothiazol-4-yl)acetate via one carbon homologation followed by acylation with 7-aminoceph-3-em-4-carboxylic acid derivatives. These new aminothiazolyl cephalosporins exhibit promising in vitro activities against various strains including Gram positive bacteria.
Kang, Han-Young,Pae, Ae-Nim,Koh, Hun-Yeong,Chang, Moon-Ho Korean Chemical Society 1991 Bulletin of the Korean Chemical Society Vol.12 No.1
A series of compounds, N-(2-substituted-1-carboxy)vinylazetidinones were successfully synthesized in order to test the hypothesis that biological activities of ${\beta}$-lactam antibiotics could be attributed to the smooth flow of electrons after a nucleophilic attack at the carbonyl carbon in the ${\beta}$-lactam ring. After introduction of aminothiazolylacetamido group at 3-position of the azetidinones, their biological activities were evaluated. Their low activities led to the conclusion that the smooth electron flow in ${\beta}$-lactams in not the sufficient source for the biological activities.
Synthesis and Biological Evaluation of New Aminothiazolyl Cephalosporins with Elongated Side Chains
Kang, Han-Young,Koh, Hun-Yeong,Kim, Mi-Young,Kim, Hyun-Mi,Yoon, Du-Weon,Chang, Moon-Ho Korean Chemical Society 1991 Bulletin of the Korean Chemical Society Vol.12 No.6
The elongation of the chain length at 2'position of aminothiazolylacetamido group of cephalosporin antibiotics was achieved. The derivatives with elongated side chain at 2'position were successfully synthesis and their in vitro activities were evaluated. It is indicated that there is an optimum range of the chain length in order to exhibit higher biological activities. This result could open a possibility for the development of the cephalosporin antibiotics with higher activities by further variation of the substituents at other positions. The cephalosporin derivatives with a simple (relatively non-functionalized) side chain as well as with a linear extended side chain were also prepared. Low activities of these derivatives led to a conclusion that either simple (non-functionalized) change or linear elongation of the side chain does not enhance the antibacterial activities.
N-Substitution Reactions of 1-Substituted Tetrazoline-5-thiones
Kang, Han-Young,Cho, Yong-Seo,Lee, Won-Jae,Koh, Hun-Yeong,Chang, Moon-Ho Korean Chemical Society 1990 Bulletin of the Korean Chemical Society Vol.11 No.6
N- vs. S-Substitution reactions of 1-substituted tetrazoline-5-thiones with various allyl or benzyl halides were studied in order to find effective conditions for N-substitution reactions. When allyl or benzyl halides were reacted with 1-substituted tetrazoline-5-thiones in the presence of TMSI or $BF_3{\cdot}OEt_2$ (or other Lewis acids), N-substitution at 4-position in addition to S-substitution occurred. Reactions were performed either with or without a solvent such as dioxane or propionitrile in the presence of potassium iodide.
Kang, Ben,Kim, Jung Eun,Jung, Jae Hun,Choe, Jae Young,Kim, Mi Jin,Choe, Yon Ho,Kim, Seung,Koh, Hong,Lee, Yoo Min,Lee, Jee Hyun,Lee, Yoon,Lee, Ji-Hyuk,Lee, Hae Jeong,Jang, Hyo-Jeong,Choi, Youjin,Choi, The Korean Society of Pediatric Gastroenterology 2020 Pediatric gastroenterology, hepatology & nutrition Vol.23 No.1
Purpose: We aimed to investigate the disease phenotype of Korean pediatric Crohn's disease (CD) patients at diagnosis according to the Paris classification by comparison with patients from the European multicenter 5-years recruitment of children with newly developed IBD (EUROKIDS registry). Methods: Korean children and adolescents who had been newly diagnosed with CD at the age of <18 years during 2013-2016 were included in this multicenter retrospective study. Disease phenotype at diagnosis was classified according to the Paris classification, and compared with the published data from the EUROKIDS study. Results: A total of 255 patients were included. The median diagnosis age was 14.7 years (range, 0.8-17.9 years). No significant difference was observed in male-to-female ratio with EUROKIDS (1.9:1 vs. 1.45:1, p=0.062). The proportion of children aged <10 years was significantly lower in Koreans (7.1% vs. 19.6%, p<0.001). Colonic disease was less prominent (10.0% vs. 27.3%, p<0.001), while upper GI involvement was more prominent in Korean children (59.3% vs. 46.2%, p<0.001). The proportion with perianal fistulizing disease at diagnosis was significantly higher in Korean patients (44.8% vs. 8.2%, p<0.001). A separate analysis of Korean patients revealed that perianal fistulizing disease at diagnosis was positively associated with male sex and body mass index z-score (odds ratio [OR]=2.12, 95% confidence interval [CI]=1.20-3.76, p=0.010; and OR=1.29, 95% CI=1.05-1.58, p=0.015, respectively). Conclusion: Approximately half of pediatric CD patients in Korea present with perianal fistulas and/or abscesses at diagnosis, which is a distinct feature of CD in Korean children and adolescents compared to their European counterparts. An underlying genetic difference between ethnicities may play a role in this expression of different phenotypes in pediatric CD.
인슐린의존성 당뇨병 환자에 합병된 Sino-orbital Aspergillosis 1 예
최강원,고창순,민헌기,서교일,민양기,한대희 대한내과학회 1986 대한내과학회지 Vol.31 No.4
Sino-orbital aspergillosis is defined as invasive aspergillosis of the paranasal sinuses involving orbit. 1ts prognosis has been reported to to be disastrous when complicated by neurologic signs. We herein report a patient with insulin-dependent diabetes mellitus with bilateral ophthalmoplegia, who was finally diagnosed as sino-orbital aspergillosis. Marked improvement was achieved with strict glycemic control, long term amphotericin H therapy and surgical removal of granulation and necrotic tissues. Our experience suggests that in case of bilateral opthalmoplegia in patients with diabetes mellitus, the possbility of sino-orbital aspergillosis should be kept in mind and strict glycemic control and amphotericin-B therapy may play some role in the treatment of the disease.