Eosinophilic annular erythema: A case report

( Jungyoon Ohn ),( Kwang Hyun Cho ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

A 45-year-old female patient presented with multiple erythematous annular indurated patches on trunk, arm, and leg, which had slowly developed within 3 months. No specific medical history of medication or travel history was reported. The skin lesion accompanied mild itching sensation. Lyme disease was ruled out by negative in serologic evaluation. Histological findings showed dense lymphohistiocytic perivascular infiltration in the dermis with eosinophils without “flame figure”. Based on the clinical and histopathologic manifestation, she was diagnosed with eosionophilic annular erythema, and treated by hydroxychloroquine 200mg twice a day for 16 weeks. Skin lesion improved slowly without complete remission. Eosinophilic annular erythema is a rare eosinophil-rich disease of unknown etiology. Clinically, it is characterized by recurrent non-scaly arcuate or annular configured erythematous papules and plaques. Histologically, dense perivascular and interstitial infiltration of cell infiltration, especially eosinophils. There is no standard treatment, but some effective modalities have been reported: prednisolone, hydroxychloroquine, dapsone, and narrowband ultraviolet B.

Acne conglobata induced by anabolic androgenic steroids: A case report

( Jungyoon Moon ),( Jungyoon Ohn ),( Seon Yong Park ),( Dae Hun Suh ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

A 29-year-old man visited to our department with complaint of sudden onset multiple inflammatory papules and nodules on the face, chest, and back which appeared three months ago. There was no specific trigger without fact that he had been injected with testosterone enanthate (one of the anabolic androgenic steroids) 250mg intramuscularly 16 times every week to gain muscular strength. Based upon the clinical manifestation and history, we diagnosed him as acne conglobata induced by anabolic androgenic steroids. Anabolic androgenic steroids are well known for exerting direct and indirect influence on sebaceous gland and Propionibacterium acnes, consequently resulting in acne. They now have very limited medical indications, such as endocrinopathy, due to their systemic side effect like libido change, mood swings, and testicular atrophy, as well as dermatologic complication-acne.

[P134] Linear cutaneous lupus erythematosus along the Blaschko line in a child improved by topical tacrolimus ointment

( Jungyoon Ohn ),( Kyu Han Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

A 35-month-old female patient presented with erythematous a little scaly and slightly elevated plaques arranged linearly on the right infraorbital, perioral, and pre- and post-auricular areas for 7 months. The associated symptom was negative. Her past medical and familial history was nonspecific. After 12 weeks, the skin lesion progressed slowly to the chin, nasolabial fold, and retro-auricular area along the Blaschko line. Histological findings showed mild papillomatosis and superficial perivascular and periadnexal lymphocytic infiltration. The anti-dsDNA level in the laboratory examination was very low. Based on the clinical and histopathologic manifestation, she was diagnosed as having linear cutaneous lupus erythematosus (LCLE). After applying 0.03% topical tacrolimus ointment for 4 months, the lesions much improved. LCLE is a rare variant of lupus erythematosus in children without systemic involvement. It usually presents as an erythematous, atrophic, and dyschromic macule or patch linearly arranged in the head and neck area associated with Blaschko line. Treatment modality includes oral hydroxychloroquine, dapsone, and topical corticosteroids. Our case was very well responded to topical tacrolimus ointment.

[P229] Incontinentia pigmenti in male: two cases report

( Jungyoon Ohn ),( Kyu Han Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

First, an 18-day-old male patient presented with erythema followed by vesicles and crusts on the right leg posterior aspect along the Blaschko’s line from birth. His pastmedical and familial history was nonspecific. Second, a 1-month-old male patient presented with linearly distributed vesicles and scales on the left leg along the Blaschko’s line from birth. Histological findings showed superficial perivascular lymphocyte and eosinophil infiltration with dyskeratotic cells. No mutation in the inhibitor of nuclear factor kappa B kinase subunit gamma (IKBKG) gene was observed in the leukocyte in peripheral blood samples of both cases. The ophthalmologic and neurologic examination failed to reveal any abnormal finding. Based on the clinical and histopathologic manifestation, they were diagnosed as having incontinentia pigmenti (IP). IP is a chromosome X-linked dominant genetic disorder. The mutated gene in IP patients is located in Xq28 and encodes a protein, IKBKG. It is characterized by typical 4 staged cutaneous findings: vesicular, verrucous, hyperpigmented, and atrophic. Abnormalities of ectodermal and mesodermal organ could be associated. Although it is mostly considered to be fatal in utero in male, postzygotic mutation or somatic mosaicism has been suggested as a pathogenesis of IP in males born alive.

Acral Lentiginous Melanoma, Indolent Subtype Diagnosed by En Bloc Excision: A Case Report

( Jungyoon Ohn ),( Jeong Mo Bae ),( Ji Soo Lim ),( Jong Seo Park ),( Hyun-sun Yoon ),( Soyun Cho ),( Hyun-sun Park ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.3

Nail unit melanoma is a type of acral lentiginous melanoma and requires histopathologic examination for a confirmed diagnosis. However, inadequate biopsy techniques make definitive diagnosis difficult. A 61-year-old man presented with progressive nail pigmentation for 15 years, which was clinically highly suspicious for malignancy. Acral lentiginous melanoma was not detected in punch and longitudinal biopsy specimens, but en bloc excision tissue revealed melanoma. Acral lentiginous melanoma is known to have a heterogeneous pathologic manifestation depending on the pigmented region and the time it takes to progress. In this regard, en bloc excision can be considered as a first-line biopsy technique to diagnose acral lentiginous melanoma, indolent subtype. (Ann Dermatol 29(3) 327∼330, 2017)

Morgellons Disease

( Jungyoon Ohn ),( Seon Yong Park ),( Jungyoon Moon ),( Yun Seon Choe ),( Kyu Han Kim ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.2

Morgellons disease is a rare disease with unknown etiology. Herein, we report the first case of Morgellons disease in Korea. A 30-year-old woman presented with a 2-month his-tory of pruritic erythematous patches and erosions on the arms, hands, and chin. She insisted that she had fiber-like ma-terials under her skin, which she had observed through a magnifying device. We performed skin biopsy, and observed a fiber extruding from the dermal side of the specimen. Histopathological examination showed only mild lympho-cytic infiltration, and failed to reveal evidence of any microorganism. The polymerase chain reaction for Borrelia burgdorferi was negative in her serum. (Ann Dermatol 29(2) 223∼225, 2017)

A window technique for nail matrix biopsy of longitudinal melanonychia

( Jungyoon Moon ),( Jungyoon Ohn ),( Gwanghyun Jo ),( Je Byeong Chae ),( Je-ho Mun ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Histopathologic examination of nail matrix is essential for diagnosing longitudinal melanonychia (LM). There are various methods for nail matrix biopsy. However, majority of clinicians have difficulty in performing nail biopsy due to technical challenges and post-biopsy complication. Objectives: The present study was conducted to present a novel window technique as a minimally invasive and accurate method for nail matrix biopsy. Methods: Patients with LM who underwent nail matrix biopsy by the window technique at our institution were analyzed from September 2015 to August 2017. Results: Seventeen LM samples from 15 patients were evaluated using our tailored window technique assisted by carbon dioxide (CO₂) laser and dermoscopy. Biopsy site was carefully selected using nail plate dermoscopy. After determining the biopsy site, we created a window using CO₂ laser in the proximal nail plate. Intraoperative dermoscopy was also performed to examine nail matrix pigmentation. This technique enables accurate diagnosis of all LM cases, without significant complications: melanoma in situ (6 cases) and nail matrix activation (11 cases). Conclusion: We propose a novel window technique which can be a useful alternative method for nail matrix biopsy with less invasiveness and high accuracy.

Human sample handling

( Jungyoon Ohn ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Allergen Sensitization Pattern by Sex: A Cluster Analysis in Korea

( Jungyoon Ohn ),( Seung Hwan Paik ),( Eun Jin Doh ),( Hyun-sun Park ),( Hyun-sun Yoon ),( Soyun Cho ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.6

Background: Allergens tend to sensitize simultaneously. Etiology of this phenomenon has been suggested to be allergen cross-reactivity or concurrent exposure. However, little is known about specific allergen sensitization patterns. Objective: To investigate the allergen sensitization characteristics according to gender. Methods: Multiple allergen simultaneous test (MAST) is widely used as a screening tool for detecting allergen sensitization in dermatologic clinics. We retrospectively reviewed the medical records of patients with MAST results between 2008 and 2014 in our Department of Dermatology. A cluster analysis was performed to elucidate the allergen-specific immunoglobulin (Ig)E cluster pattern. Results: The results of MAST (39 allergen-specific IgEs) from 4,360 cases were analyzed. By cluster analysis, 39 items were grouped into 8 clusters. Each cluster had characteristic features. When compared with female, the male group tended to be sensitized more frequently to all tested allergens, except for fungus allergens cluster. Conclusion: The cluster and comparative analysis results demonstrate that the allergen sensitization is clustered, manifesting allergen similarity or co-exposure. Only the fungus cluster allergens tend to sensitize female group more frequently than male group. (Ann Dermatol 29(6) 735∼741, 2017)

CASE REPORT : Venous Leg Ulcer in a Sarcoidosis Patient: A Case Report

( Jungyoon Ohn ),( Sang Young Byun ),( In Su Kim ),( Kyoung Chan Park ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.6

Venous leg ulcers, the most common form of leg ulcers, are relevant to the pathogenicity of pericapillary fibrin cuff. Sarcoidosis, a multiorgan granulomatous disease, causes fibrin deposition in tissues. We report a case of a 50-year-old man with venous leg ulcers coexisting with sarcoidosis. On the basis of the histologic findings, we propose the hypothesis that sarcoidosis patients are prone to the development of venous leg ulcers. (Ann Dermatol 27(6) 744∼747, 2015)