개의 아토피 피부염에 대한 Leflunomide의 임상적 적용 1례

홍은지,윤기영,서경원,최호정,정성목,송근호,조종기,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2012 動物醫科學硏究誌 Vol.19 No.1

A Shih-tzu(8-year-old, castrated male) was referred to the Veterinary Medical Teaching Hospital of Chungnam National University with the history of relapsing pruritus, recurrent dermatitis. On the physical examination, generalized erythema, otitis externa, alopecia and lichenification were observed. Using Favrot's criteria for diagnishing atopic dermatitis, 7 criteria were satisfied out of 8 criteria. After treatment for infection, intradermal skin test was performed(positive allergen : Df, Dp). And then immunotherapy was performed, but clinical signs were not getting better. Next treatment of glucocorticoid shown little improvement of clinical signs, and adverse effect(diarrhea) was shown after cyclosporine application. So application of leflunomide which is used for human atopic dermatitis treatment in some case was planned. After 6 months of application of leflunomide, clinical signs were decreased gradually.

Peroxide와 자간전증 환자의 혈청 관류에 따른 제대정맥의 prostaglandin 생성의 변화

목정은,김암,이필량,한지수,이인식 울산대학교 의과대학 1996 울산의대학술지 Vol.5 No.1

Objective This study was performed to evaluate the prostaglandin secretion rates in human umbilical vein with preeclamptic sera and peroxide perfusion. Study design Isolated human umbilical cords(n=10) were perfused for 30-minute intervals with cord buffer, 15% normal pregnant sera and preeclamptic patient sera, 100 mol/L t-butyl hydroperoxide alone, and after perfusion with low-dose aspirin(5×10( )mol/L). Cord buffer gassed with 95% oxygen and 5% carbon dioxide and warmed to 37℃ was used for the perfusion buffer. Effluent flow rates were measured during each experimental treatment. Effluent samples were measured for 6-keto prostaglandin Flα and thromboxane B( ) by enzyme immunoassays. Results The concentrations of 6-keto prostaglandin F( )α in preeclamptic sera were significantly higher than those in normal pregnant sera.(989.3849 ± 1602.927 vs. 1.3116 ± 1.22085 ng/ml, mean ± SD, p<0.01). However, the concentrations of thromboxane B( ) were not different between normal pregnant sera and preeclamptic sera. The secretion rate of 6-keto-prostaglandin F( )α in human umbilical endothelial cells was not significantly different(p=0.77) between two groups. Comparing to normal pregnant sera, the secretion rate of thromboxane B( ) was significantly increased(p<0.01) after preeclamptic sera perfusion. The secretion rate of 6-keto-prostaglandin F( ) was significantly increased(p<0.01) following peroxide perfusion and that was significantly decreased by aspirin. The secretion rate of thromboxane B( ) was not significantly different between preeclamptic sera and peroxide alone or subsequent perfusion with aspirin. Conclusions (1) Preeclamptic sera stimulate thromboxane production rather than prostacyclin production by endothelial cells of human umbilical vein in vitro. (2) Peroxide stimulates the secretion of both prostacyclin and thromboxane, and low dose aspirin mitigates hydroperoxide-induced prostacyclin secretion. We confirmed that thromboxane secretion is stimulated by preeclamptic sera and the role of peroxide in prostaglandin secretion. We established the perfusion system using human umbilical vein through this study. This perfusion system may be useful to understand the pathophysiology of preeclampsia.

체외수정시술을 위한 과배란유도시 Nafarelin 과 Triptorelin 사용에 따른 임상성적의 비교

목정은,김낙연,김정훈,강병문,장윤석 울산대학교 의과대학 1996 울산의대학술지 Vol.5 No.1

Gonadotropin-releasing hormone agonists(GnRH-a) vary in structure and route of administration. We performed this study to compare patient response to intranasal nafarelin acetate versus subcutaneous triptorelin as adjuncts to ovulation induction for in vitro fertilization(IVF). From October 1995 to May 1996, sixty-four patients with tubal factor infertility entering their 79 cycles of IVF were randomized to receive either intranasal nafarelin acetate(Group Ⅰ, 38 cycles) or subcutaneous triptorelin(Group Ⅱ, 41 cycles). Controlled ovarian hyperstimulation(COH) using luteal long protocol of GnRH-a was used in all patients. Patient characteristics in the two groups did not differ significantly, nor did sperm parameters or endocrine profiles. There was no significant difference in ovarian response as indicated by duration of GnRH-a administration before ovarian stimulation, number of ampules of gonadotropin used and duration of gonadotropin administration in ovarian stimulation, and serum E( ) level and number of follicles(≥14mm) on the day of hCG administration between the two groups. There were no significant differences in clinical results of oocyte and embryo obtained such as number of oocytes retrieved, oocytes fertilized, embryos cleaved, embryos frozen, and embryos transfered between the two groups. There were also no significant differences between group Ⅰ and group Ⅱ in clinical pregnancy rate(31.6% versus 34.1%) and abortion rate per clinical pregnancy(8.3% versus 14.3%). This study suggests that intranasal nafarelin acetate as well as subcutaneous triptorelin can be used successfully in ovulation induction using luteal long protocol of GnRH-a.

자궁내막암의 진단과 치료

목정은 한국의학사 1985 診斷과治療 Vol.5 No.2

光 多變色 迷路裝置에 의한 초파리의 光鮮好性 差異에 관한 遺傳學的 硏究

金明仲,朴殷圭,崔五木 圓光大學校 基礎自然科學硏究所 1989 基礎科學硏究誌 Vol.8 No.2

The present experiments for positive and negative walking behavior were carried out with the popula-tions of Drosophila melanogaster, collected from eight localities of the Korean peninsula. The behavior was examined by means of photo-varicolored ladyrinth apparatus. The realized heritabi-lity for males on difference in photo-preference was estimated to the about 3.4∼9.4% for the positivewalking behavior, and that for negative behavior was about 4.2~8.6% . The heritability for femaleswas estimated to be about 1.0∼12.6% for the positive walking behavior, and that for negative behaviorwas about 2.4∼9.5%. Walking score for males and females in inland was estimated to be about 2,00~3,00 for the positivewalking behavior, and that for negative behavior was about 1,00∼1.25. Walking score for males and females on the coast was estimated to be about 2.25~2.90 for the positivewalking behavior, and that for negative behavior was about 1.16∼1.50. In conclusion, the walking behavior of photo-varicolored preference showed that it prefered bluelight color best, second; yellow, third; red, and last; dark. It seems resonable to assume that thewalking behavior is possibly controlled by a major gene.

난소암의 조기진단

남주현,목정은 울산대학교 의과대학 1993 울산의대학술지 Vol.2 No.2

Ovarian cancer is the leading cause of death from gynecologic malignancies. In 1992, it has been reported that the incidence of ovarian cancer was 3% of all female malignancies in Korea. During the last decade, the incidence of cervical cancer which is the most common one of female malignancies was gradually declining, however that of ovarian cancer tended to be slightly increasing probably because of changes in socioeconomic status of this country. Despite of aggressive debulking operation and intensive platinum-based combination chemotherapy, the overall survival rate for ovarian cancer has not changed appreciably over the last twenty years. One of the reasons for poor prognosis of ovarian cancer is that greater than 70% of patients with ovarian cancer is unfortunately detected after the disease has already spreaded beyond the pelvis because of the lack of early symptoms. The cure rate for these patients with advanced ovarian cancer is only 15-20%, This low survival rate is in marked contrast to that of as high as 90% with stage I disease. Therefore, development of early detection method for ovarian cancer would be the best way to reduce the mortality rate of this disease. Ultrasonography and serum tumor marker, CA 125 have been extensively studied for early detection of ovarian cancer. Recently, combined use of transvaginal color Doppler technique is studied to increase the specificity of the screening test. However, the value of these methods as a screening test is still debating. So far, unfortunately there is no conclusive method which has cost-effectiveness and perfect sensitivity and specificity for ovarian cancer screening. Moreover, the optimal population and interval for ovarian cancer screening are not currently defined. In this review, recent data of studies using ultrasound and serum marker, CA 125 and debating issues for ovarian cancer screening are discussed.

자궁경부암의 조기진단

김영탁,목정은 울산대학교 의과대학 1993 울산의대학술지 Vol.2 No.2

Incidence and mortality rates for cervical cancer have decreased steadily in developed Western countries since the 1950s largely as the result of widespread cervical screening. It is now accepted dogma that premalignant disease can be detected by conscientious screening and that cervical cancer can be forestalled by therapeutic modalities that preserve reproductive capacity. However cytologic cervical screening alone has not totally eradicated cervical carcinoma nor has it reduced the incidence of cervical intraepithelial neoplasia. We reviewed methodologies most widely used for early detection of cervical cancer in detail with introduction of a new method which should in-crease the effectiveness of the former methods when used additionally.

만삭아에 있어서 중증 호흡기 합병증에 대한 분석

이인식,김암,목정은 울산대학교 의과대학 1992 울산의대학술지 Vol.1 No.1

A group of 33 term infants with significant respiratory complications were compared with 3,194 term infants delivered during the same time period and without respiratory morbidity. Compared with controls, the study group had a higher incidence of antepartum risk factors such as intrautirne growth retardation(12.1% versus 0.41%), postdatism(18.2% versus 2.79%) and intrapartum risk factors such as abnormal FHR(42.$% verse 3.2%), meconium-stained amniotic fluid(72.7% versus 6.9%). The odds ratio of intrauterine growth retardation for significant respiratory complications is 33.75 and that of postdatism is 7.753. The odds ratio of abnormal FHR for significant respiratory complications is 22.12 and ,that of meconium-stained amniotic fluid is 36.23. Even in the presence of normal intrapartum FHR and 5-minute Apgar scores, infants with meconium-staines amniotic fluid had an indicidence of respiratory complications 7∼8 times higher than those with clear amniotic fluid. Anterpartum risk factors, meconium-stained amniotic fluid, and abnormal FHR identified the fetus at high risk for significant respiratory complications.

모 제약회사 근로자들의 직업성 천식 유병률과 약제 분말 노출수준

오성수,최용휴,김은아,이영목,장재길,유장진,박승현,김태균,정수영,김규상,강성규 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 제약회사에서 직업상 천식의 유병 규모를 파악하고 작업공정에 대한 작업환경 측정을 통해 제약회사의 약제 분말에 대한 노출수준을 평가하고자 하였다. 방법: 제약회사에서 약제 분말에 노출되는 근로자를 대상으로 천식을 선별하기 위하여 설문조사 및 진찰, 혈액검사, 폐기능 검사 그리고 피부단자시험을 실시하였고, 각 부서별 공정에 따라서 총분진과 항생제 또는 효소제 분말에 대한 작업환경 측정을 실시하였다. 직업상 천식이 의심되는 근로자에 대하여 기관지과민성에 대한 검사(메타콜린을 이용한 비특이 기관지유발시험)와 약제 분말 기관지유발시험을 실시하여 확진하였다. 결과: 설문조사 및 진찰에서 작업 관련 천식 증상이 있는 근로자는 11명(34.4%)이었고, 약제 분말을 이용한 피부단자시험에서 1+ 이상 반응을 보인 근로자 10명(31.2%)이었다. 비특이 기관지유발시험 결과 8명(25.0%)이 양성(PC20 ≤16 mg/ml)이었다. 약제 분말 기관지유발시험을 통해 직업상 천식으로 확진된 근로자는 5명(15.6%)이었다. 작업환경 측정에서 원료를 충진하거나 투입하는 작업 그리고 정립작업에서 약제 분말에 대한 노출이 많았다. 결론: 제약회사에서 직업상 천식은 주로 제조공정 중 약제 분말에 노출된 근로자에서 발생하여, 증상 및 직업성 천식의 유병률이 높았다. 따라서 원료를 충진 또는 투입하는 작업과 정립작업 등 제조과적에서 약제 분말 노출을 줄이기 위한 세심한 주의가 필요하여, 약제 분말을 취급하는 근로자에 대해서는 천식 증상 조사뿐 아니라 정기적으로 피부단자시험, 비특이 기관지유발시험 등을 실시하여야 할 것이다. Objectives: After the investigation of one worker with occupational asthma, we surveyed the preva- lence of occupational asthma and the exposure level of pharmaceutical dust of 32 workers in a pharmaceutical company. Methods: Thirty-two of the 90 employees participated in the survey which consisted of questionnaire, blood sampling, spirometry and skin prick tests with 8 common allergens as well as 9 antibiotics and 2 enzymes. Various indices of the working environment were also measured. Subjects who had a symptom suggestive of work-related asthma or positive skin prick test were further investigated by PC20 methacholine. Nine subjects who had a PC20 result of 16 mg/ml or less (n=7) or had work-related symptoms and positive skin prick test (n=2) were referred to undergo a specific bronchial provocation test to phar- maceutical dust in an academic allergic disease center. Results: Eleven of 32 workers (34.4%) had a work-related symptom suggestive of occupational asthma. Ten (31.2%) showed positive skin prick test. 8 (25.0%) had a PC20 result of 16 mg/ml or less (indicative of significant bronchial hyperresponsiveness), and 5 (15.6%) had a positive result on the specific bronchial provocation test. Exposure levels of stuffing, input of raw materials and screening process were relatively high. Conclusions: This survey showed that pharmaceutical workers have an increased risk of occupational asthma. Although pharmaceutical factories maintain a relatively good working environment, careful control of respiratory tract exposures, especially during stuffing, input or raw materials and screening process, is important to prevent occupational asthma. Pharmaceutical workers need to undergo regular skin prick and methacholine bronchial provocation tests, as well as asthmatic symptom survey, to ensure the early detection and prevention of occupational asthma.

개에 있어서 耳根部의 Lidocaine 水針에 의한 全身 無痛覺의 誘發

권현주,유건주,이상은,이정연,송근호,김명철,정성목,박성준,김덕환 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Twelve clinically healthy mongrel dogs were used to clarify the possibility of general analgesia induction by lidocaine aquapuncture to auricular root area in the present study. The experimental animals were devided into control (6 heads) and experimental groups (6 heads), respectively. Physiological salines (3 ml/kg) were injected into both auricular root areas in control group. Lidocaine hydrochlorides (3 ml/kg) were injected into both auricular root areas in experimental group. Superficial pain, the changes of vital signs and blood leukocytes, and PCV were examined on pre, 5 min., 15 min., 30 min, and 60 min. after injection in control and experimental groups, respectively. Analgesia was not detected at all in control group, however, all experimental animals were recumbent and analgesia was generally detected in the auricles, noses, dorsal parts, ventral areas, limbs and tails from 5 to 30 minutes after injection with lidocaine hydrochloride into auricular root areas in experimental group. As for the change of vital signs, body temperature showed decreasing tendency from 5 minutes after lidocaine injection in experimental group. Heart rates and respiration rates were increased on 5 minutes after lidocaine injection and then they showed decreasing tendency in experimental group. No significant difference were found among groups. As for the changes of hematological findings, the numbers of blood leukocytes were increased till 15 minutes after lidocaine injection and then they showed decreasing tendency. PCV values were increased on 5 minutes after lidocaine injection, and then they showed decreasing tendency. However, no significant differences were observed among groups. Considering the above findings, it was thought that general analgesia was possible by aquapuncture with lidocaine hydrochloride into auricular root areas and lidocaine aquapuncture didn’t affect so much to the changes of vital signs and blood.