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Anti-Melanogenic Effect of Cannabis sativa Stem Extracts Fermented with Weissella paramesenteroides
Kim Taehyun,Kim Jin-Woo,Min Huitae,Park Jisu,Kim Taejung,Kim Geun-Hyeong,Park Byung-Joon,Kim Jeong Kook,Park Young-Tae,Kim Jin-Chul,Ham Jungyeob 한국미생물·생명공학회 2023 한국미생물·생명공학회지 Vol.51 No.3
Cannabis sativa (CS) has been in the spotlight not only for its medical uses but also as a raw material for cosmetics. As fermented cosmetics are known to have various health benefits, they have been extensively researched. Here, we investigated the characteristics of CS stems fermented using various gut microbes. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay and melanin content analysis revealed that melan-a cells containing CS stems fermented with Weissella paramesenteroides (CSWP) showed considerably reduced melanin content. Additionally, CSWP downregulated the expression of several melanogenesis factors, tyrosinase-related protein-1, and tyrosinase-related protein-2. This study suggests that the anti-melanogenic effect of CSWP could provide a new basis for the development of skinlightening agents.
The Changes in Respiratory and Enteric Adenovirus Epidemiology in Korea From 2017 to June 2022
Kim Kyung-Ran,Won Jisu,Kim Hyungjun,Kim Bryan Inho,Kim Mi Jin,Kim Jae Young,Gwack Jin,Kim Yae-Jean 대한의학회 2023 Journal of Korean medical science Vol.38 No.9
Since October 2021, severe acute hepatitis of unknown etiology in pediatric patients has been observed in many countries around the world. Adenovirus (mainly enteric adenovirus) was detected in more than 50% of the cases. Nationwide surveillance on acute hepatitis of unknown etiology in pediatric patients was started in May 2022 in Korea. Taking into account the severity of the illness and the urgency of the epidemiological situation worldwide, we report a summary of changes in adenovirus epidemiology during the past five years and six months in Korea.
( Jisu Kim ),( Kang Pa Lee ),( Myoung-ryu Kim ),( Bom Sahn Kim ),( Byung Seok Moon ),( Chul Ho Shin ),( Suji Baek ),( Bok Sil Hong ) 한국운동영양학회 2021 Physical Activity and Nutrition (Phys Act Nutr) Vol.25 No.3
[Purpose] As Panax ginseng C. A. Meyer (ginseng) exhibits various physiological activities and is associated with exercise, we investigated the potential active components of ginseng and related target genes through network pharmacological analysis. Additionally, we analyzed the association between ginseng-related genes, such as the G-protein-coupled receptors (GPCRs), and improved exercise capacity. [Methods] Active compounds in ginseng and the related target genes were searched in the Traditional Chinese Medicine Database and Analysis Platform (TCMSP). Gene ontology functional analysis was performed to identify biological processes related to the collected genes, and a compound-target network was visualized using Cytoscape 3.7.2. [Results] A total of 21 ginseng active compounds were detected, and 110 targets regulated by 17 active substances were identified. We found that the active compound protein was involved in the biological process of adrenergic receptor activity in 80%, G-protein-coupled neurotransmitter in 10%, and leucocyte adhesion to arteries in 10%. Additionally, the biological response centered on adrenergic receptor activity showed a close relationship with G protein through the beta-1 adrenergic receptor gene reactivity. [Conclusion] According to bioavailability analysis, ginseng comprises 21 active compounds. Furthermore, we investigated the ginseng-stimulated gene activation using ontology analysis. GPCR, a gene upregulated by ginseng, is positively correlated to exercise. Therefore, if a study on this factor is conducted, it will provide useful basic data for improving exercise performance and health.
Jisu Kim,Seyeop Jeong,Donghyeon Lee,Taekhyeon Lee,Suhyeok An,Kab-Jin Kim,Ki-Seung Lee,Chun-Yeol You,Sanghoon Kim 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.1
Ferrimagnet is a material whose magnetic moments are aligned in opposite directions like antiferromagnets with non-zero net moment. In a class of ferrimagnets composed of rare earth (RE)-transition metal (TM), the magnitude of each magnetic moment can be adjusted by changing the ratio of the RE-TM or the measurement temperature. Since the temperature dependence of the magnetization of each element is different, the magnetic moments cancel each other at the magnetization compensation temperature T<sub>M</sub>. In this study, He<sup>+</sup> ions were accelerated with 20 keV energy to a 15-nm-thick Gd<sub>36</sub>Co<sub>64</sub> film with perpendicular magnetic anisotropy. We observe that the T<sub>M</sub> decreases after He<sup>+</sup> irradiation. We also succeed in a local modulation of T<sub>M</sub> using He<sup>+</sup> ion beam. In addition, we will present that magnetic switching properties by current or external field can be modulated by the He<sup>+</sup> irradiation.
Field free switching of ferrimagnetic GdCo with artificially broken symmetry
Jisu Kim,Seyeop Jeong,Taekhyeon Lee,Suhyeok An,Kab-Jin Kim,Ki-Seung Lee,Chun-Yeol You,Soogil Lee,Byong-Guk Park,Sanghoon Kim 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.2
During the last decade, current-induced magnetization switching by spin-orbit torque (SOT) is of great importance to nanoelectronics due to energy-efficient control of spintronic memory and logic devices. However, it has a problem that an external magnetic field is required to switch magnetization of a device when magnetic layers are perpendicularly magnetized. This implies that there should be limitation of scalability and low energy efficiency because of necessity to use the external magnetic field. Therefore, field-free switching of a magnetization should be achieved for realization of the energy efficient and ultra-fast SOT-driven devices. Here, we report field-free SOT switching of ferrimagnetic GdCo thin films with a He ion microscope (HIM) technique. The Pt(5)/Gd36Co64(5)/Ta(3) structure is irradiated by He ions with the dose range from 5 to 50 ions/nm². We find that magnetic properties of the GdCo layer such as coercivity (HC) and magnetization compensation temperature (TM) strongly depend on ion dose of a He irradiation. Based on the idea that ferrimagnetic properties can be controlled using He ion irradiation method, we introduced a lateral gradient of magnetization by the HIM to form a broken mirror symmetry in the device. The mirror symmetry breaking was observed after the local modulation; TM and perpendicular magnetic anisotropy (PMA) properties were locally modulated by He ion irradiation. As the magnetic mirror symmetry is broken, we observed the field-free SOT switching behavior. The Sz component of the spin current generated by the broken mirror symmetry was also observed. We will discuss details about structural change in the ferrimagnetic GdCo by the He ion irradiation.