고혈압 환자에서 경동맥 신전성의 변화

허영선,김학진,송영빈,안지현,임성훈,이왕수,김상욱,김태호,김치정,류왕성,유언호 중앙대학교 의과대학 의과학연구소 2000 中央醫大誌 Vol.25 No.3

국내 다기관에서 조사한 지역사회획득 메티실린내성 황색포도알균의 빈도와 임상적 특성

송진수,최평균,송경호,조재현,김성한,방지환,이창섭,박경화,박경운,신수,최희정,김의석,김동민,이미숙,박완범,김남중,오명돈,김의종,김홍빈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

목적 : 최근 전세계적으로 지역사회획득 메티실린내성 황색포도알균(community-associated methicillin-resistant Staphylococcus aureus, CA-MRSA)의 보고가 증가하고 있다. 하지만, 우리나라에서는 CA-MRSA 감염증에 대한 증례보고만 있을 뿐 아직까지 체계적인 연구결과가 없는 실정이다. 저자들은 국내에서 CA-MRSA의 빈도, 감염증의 임상적 양상, 분리된 균주의 항균제내성 양상을 조사하였다. 재료 및 방법 : 2005년 1월부터 2005년 6월까지 7개 병원에서 MRSA가 분리된 환자의 명단을 파악한 후 의무기록지와 건강보험심사평가원의 자료를 검토하였다. 외래나 응급실에서 혹은 입원 후 72시간 이내에 균주가 분리되고 MRSA 획득과 관련된 위험인자가 없는 경우 CA-MRSA로 정의하였으며, 분리된 균주의 임상적 의미에 따라 원인병원체(pathogen), 집락화(colonizer), 미결정(undetermined)으로 분류하였다. Penicillin과 oxacillin을 제외하고 3개 이상의 다른 계열 항균제에 내성이면 다제내성으로 정의하였다. 결과 : 연구기간동안 총 3,251주의 황색포도알균이 분리되었으며, 이 중 MRSA는 1,900주(58.4%)였다. MRSA 가운데 CA-MRSA는 114주(6.0%) 였으며, 이들이 분리된 부위는 귀(62주), 비뇨기계(14주), 피부 및 연부조직(11주), 호흡기계(10주), 혈액(3주) 등이었다. CA-MRSA 균주 가운데 집락균은 22주, 원인병원체는 22주였으며, 나머지 균주에 대해서는 그 임상적 의미를 결정할 수 없었다. 항균제 감수성 검사를 시행한 73균주 중 47주(64.4%)는 다제내성이었다. CA-MRSA 감염증 22예 중 피부 및 연부조직 감염(9예)과 중이염/외이도염(9예)이 가장 흔하였다. 침습적 감염증(invasive infection)은 4명(원발성 균혈증 3예, 감염성 관절염 1예)에서 확인되었지만, CA-MRSA 감염증으로 사망한 환자는 없었다. 결론 : 병원내 감염증에서는 MRSA가 심각한 문제이지만, 아직까지 지역사회 감염증에서 CA-MRSA는 흔하지 않았다. Background : Methicillin-resistant Staphylococcus aureus (MRSA) infection has emerged in patients who do not have the established risk factors. In Korea, little is known about the epidemiology and clinical features of community-associated MRSA (CA-MRSA). Material and Methods : Clinical microbiology laboratory databases of 7 hospitals were reviewed to identify the patients from whom MRSA was isolated during the period of January to July 2005. Only one isolate per patient was enrolled. In order to identify the risk factors of MRSA acquisition, the medical records and the Health Insurance Review Agency databases were reviewed. CA-MRSA was defined as MRSA isolated from patient without established risk factors. We analyzed patient demographics, underlying medical conditions, characteristics of infection, and antimicrobial susceptibility profiles. Results : Of total 3,251 S. aureus isolates, 1900 (58.4%) were MRSAs. Of the MRSA isolates, 114 (6.0%) were CA-MRSA. Of 114 CA-MRSA isolates, 22 (19.3%) were colonizers, 22 (19.3%) were pathogens, and the clinical significance of remaining 70 (61.4%) could not be determined. Median age of the 22 patients with CA-MRSA disease was 47 years. Nine patients had skin and soft tissue infections, 9 ear infections, 3 bacteremia, 1 septic arthritis. Seven patients had underlying medical disease. None died of the CA-MRSA infections. Of the 73 isolates of CA-MRSA, 47 (64.4%) were resistant to more than 3 classes of antibiotics besides β-lactams. Conclusion : Although MRSA is highly prevalent among hospital-associated S. aureus infection, CA-MRSA infections are not common.

男性不姙症의 治療에 對한 文獻的 考察

김길섭,서운교,鄭智天 東國大學校韓醫學硏究所 1994 東國韓醫學硏究所論文集 Vol.3 No.-

Studying documents & papers on the cure of mate sterility to conclusion as follows. 1. The methodes of cure were applied Onbosinyang, Jaeumbosin, Soganheul, Joseubhwadam, Boickgihyul, Hwalhyeolhwaua, Boickbisn, etc. And the causes of disease were applied Sinyanghue, Sineumhue, Ganulgihe, Damseubneon, Gihwelyanghue, Gichehyeolul, Bisinyanghue, etc. 2. Prescription were applied Chanyukdan Ojayuenjonghwan on Sinyanghue, Yukmijihwan Jibekjihwanghwan on Sinuemhue, Sihosogansan Soyosan on Ganulgiche, Changchuldodamtang Bihebunchungeum on Damseubneon, Sibjyundaebotang Paljintang on Gihyeolyanghue, Sobokchu-kuatang Gueasengjungtang on Gichehyeolul, Sibjayukguntang Bisinssangbohwan on Bisinyanghue, etc. and Ojayunjonghwan being added in the base to cure another causes of disease as well as Sinhue. 3. The cause of disease were presonted to be Sinhue mostly ; Sinvanghue particulatly. And there were usually 25∼42years old, married lives of 3~8years, cure periods of 2∼5mon-ths, general effectiveness(approximately 76%), pregnancies(approximately 47%). 4, The methodes of cure in oriental medical prepared with the causes of disease in western one are showed in blow ; The cause of semen formation disorder is considered the methodes of cure in Onbosinyang, Jaeumbosin, Boickbin and the cause of functional ejaculation disorder in mind is considered the method of cure in Sogangegwu on the base in Bosin.

2-deoxy-D-glucose와 quercetin이 방사선조사 MC3T3-E1 골모세포주의 분화시 bone sialoprotein과 osteocalcin 유전자의 발현에 미치는 영향

이지운,김경아,고광준 대한구강악안면방사선학회 2009 Imaging Science in Dentistry Vol.39 No.3

Purpose : To investigate the effects of 2-deoxy-D-glucose (2-DG) and quercetin (QCT) on gene expression of bone sialoprotein (BSP) and osteocalcin (OC) during the differentiation in irradiated MC3T3-E1 osteoblastic cells. Materials and Methods : When MC3T3-E1 osteoblastic cells had reached 70-80% confluence, cultures were transferred to a differentiating medium supplemented with 5 mM 2-DG or 10 μM QCT, and then irradiated with 2, 4, 6, and 8 Gy. At various times after irradiation, the cells were analyzed for the synthesis of type I collagen, and expression of BSP and OC. Results : The synthesis of type I collagen in cells exposed to 2 Gy of radiation in the presence of 2-DG or QCT showed no significant difference compared with the control group within 15 days post-irradiation. When the cells were irradiated with 8 Gy, 2-DG facilitated the irradiation mediated decrease of type I collagen synthesis, whereas such decrease was inhibited by treating with QCT. During MC3T3-E1 osteoblastic cell differentiation, the mRNA expression of BSP and OC showed the peak value at 14 days and 21 days, respectively. 2-DG or QCT treatment alone decreased the level of BSP mRNA, but increased the OC mRNA level only at early time of differentiation (day 7). In the cells irradiated with 2, 4, 8 Gy, the mRNA expression of BSP and OC decreased at 7 days after the irradiation. The cells were treated with various dose of radiation in the presence of 2-DG or QCT, the mRNA level of both BSP and OC increased although this increase was observed at low dose of radiation (2 Gy) and at the early stage of differentiation. However, when the cells were exposed to 4, 6, or 8 Gy, the increase of BSP and OC mRNAs was detected only in cells co-incubated with QCT. Conclusion : This study demonstrates that 2-DG and QCT affect differently the expression of bone formation related factors, type I collagen, BSP, and OC in the irradiated MC3T3-E1 osteoblasic cells, according to the dose of radiation and the times of differentiation. Overall, the present findings suggest that 2-DG and QCT could have the regulatory roles as radiation-sensitizer and -protector, respectively. (Korean J Oral Maxillofac Radiol 2009; 39 : 121-32)

집단미술치료가 정신지체인의 정서 및 행동에 미치는 효과

임지향,김은경 한국특수아동학회 2003 특수아동교육연구 Vol.5 No.2

본 연구에서는 집단미술치료가 정신지체인의 정서 및 행동에 미치는 효과를 살펴보기 위해 장애3등급으로 복지관에서 생활적응훈련을 받고 있는 정신지체장애인 3명을 선정하여 미술치료 프로그램을 시행하였으며 첫째, 집단미술치료가 정신지체인의 정서에 미치는 영향은 미미하게 나타났다. 일상생활에서의 문제해결능력에 대한 변화는 크게 나타나지 않았지만 어떤 상황에서도 항상 생각하려는 모습을 보였고, 둘째, 행동에서는 많은 변화가 나타났다. 과제에 대한 집중이 높아졌으며, 끈기 있고 성실한 자세로 미술활동에 임했으며 열심히 하면서 인정받기위해 노력하였으며 몸도 청결해 지고 상스러운 표현을 많이 하던 언어습관도 많이 성숙하였으며 자신의 실수에 대해 미안해하며 사과도 하게 되었다. The purpose of this study is to measure the effect of group art therapy program on mild retardation's emotion and behavior. The design of this study is pretest-post test control group design. The independent variable was group art therapy and the dependent variable was emotion and behavior. The subjects were 3 females retardation of from special institution in D city. All of subjects, 3 females were placed in the experimental group participate in group art therapy. To perform this study the group art therapy program is carried out 1 session for a week and the whole sessions are 19. Each session being allocated 50 minutes. The instruments of measurement used in this study is behavior measurement and LMT. The conclusions of this study were as follows: 1) The experimental group's emotion was increased than did after the group art therapy sessions. 2) The experimental group's behavior was significantly increased than did after the group art therapy sessions. From these conclusions, it is suggested that group art therapy is effective in improving mild retardation's emotion and behavior. I'd like to suggest the following points based on this study. First, the group art therapy program was made for the one institution with mental retardation, so we have to study many students from many institution's and to settle the program because of fitting for mental retardation in Korea. Second, The practice of the group art therapy program needs administration and financial conducts because of the positive participation of parents, pertinent, and companies.

Monocyte Chemoattractant Protein-1[MCP1] -2518 유전자 다형성과 주요 우울장애

배치운,이지현,신윤경,김태석,김정진,이창욱,이수정,전태연,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Object : This study was designed to examine the association between monocyte chemoattractant protein-l (MCPl) -2518poly morphism and major depressive disorder (MDD). Methods : Ninety patients with MDD and 114 healthy controls participated in this study. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method. Results : Genotype and allele distributions in patients with MDD were significantly different from those of the controls, In particular, subjects with the allele A were found to have an increased risk of MDD. Conclusion : The present study suggests that the MCPl -2518 polymorphism may have a potential role for susceptibility to MDD in the Korean population and thus calls for consecutive studies in order to pile up the data with larger different ethnic background.

Cone beam형 전산화단층촬영법을 이용한 하악과두의 골변화에 관한 연구

이지운,김형섭,송주섭,김경아,고광준 대한구강악안면방사선학회 2007 Imaging Science in Dentistry Vol.37 No.3

Purpose : To assess bone changes of mandibular condyle using cone beam computed tomography (CBCT) in temporomandibular disorder (TMD) Patients. Materials and Methods : 314 temporomandibular joints (TMJs) images of 163 TMD patients were examined at the Department of Oral and Maxillofacial Radiology, Chonbuk National University. The images were obtained by PSR9000N (Asahi Roentgen Co., Japan) and reconstructed by using Asahivision software (Asahi Roentgen Co.,Japan). The CBCT images were examined three times with four weeks interval by three radiologists. Bone changes of mandibular condyle such as flattening, sclerosis, erosion and osteophyte formation were observed in sagittal, axial, coronal and 3 dimensional images of the mandibular condyle. The statistical analysis was performed using SPSS 12.0. Intra-and interobserver agreement were performed by 3 radiologists without the knowledge of clinical information. Results : Osteophyte (2.9%) was found more frequently on anterior surface of the mandibular condyle. Erosion (31.8%) was found more frequently on anterior and medial surfaces of the mandibular condyle. The intraobserver agreement was good to excellent(k=0.78-0.84), but interobserver agreement was fair(k=0.45). Conclusion : CBCT can provide high qualified images of bone changes of the TMJ with axial, coronal and 3 dimensional images.

법랑아세포종에서의 p53 및 MIB-1 발현 : 임상 및 병리학적 요인들간의 연관성 Correlation Between Clincopathologic Parameters

이수운,한지용,권창석,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Thirty five patinets' paraffin embedded biops block , which was previously diagnosed ameloblastoma and obtained from oral and maxillofacial surgery dept. of pusan paik hospital and OMS dept of collage dentistry, pusan national university hospital, from January 1994 to march 1999, were performed immunohistochemistry with p-53 and MIB-1. On investigating the expression, correlation between clinical and histologic factor and correlation between prognosis and moleculopathologic property were examined. And we obtained the following results; 1. Age over forty, recurrence rate was 58.5%. 91.4% of the tumor was developed on mandibule, recurrence rate of maxilla area tumor was 66.7% On radiologic and histologic feature, multilocular and follicular type has high recurrence rate but no significance statistical difference was found 2. Expression of p-53 was 25.7%, When underage of forty. location on mandibule, multilocular and plexiform type, the expression of p-53 was somewhat higher and recurred cases of tumor, expression rate was 12.5%. 3. MIB-1 expression rate was 77.1%. When location on mandibule, unilocular, plexiform type tumor and previously recurred case, MIB-1 expression was 87.5% which was somewhat higher than no recurrence case of 74.1%. 4. 33.3.% of positive on MIB-1 have expression of p-53 and all p-53 positive case express MIB-1 positive. All p-53 positive case have high cell proliferation rate. From this result, age and location have closely related with the prognosis of tumor, histologic feature and MIB-1 expression has related with the prognosis of tumor. But p-53 has highly expressed on cell proliferation area, not closely related with the prognosis of tumor.

고혈압 환자에서 운동부하 심폐기능 검사로 측정한 Anaerobic Threshold와 VO₂max의 변화

허영선,송영빈,안지현,이상엽,김상욱,이광제,김태호,김치정,류왕성,유언호 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.1

소득작물 전후작지 적응 극단기성 벼 ‘중모 1032’

손영보,이종희,조준현,이지윤,오성환,송유천,박동수,박노봉,김상열,여운상,남민희,권영업 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2