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      • KCI등재

        Metabolomics approach to serum biomarker for loperamide-induced constipation in SD rats

        Ji-Eun,Kim,Young-Ju,Lee,Moon-Hwa,Kwak,Go,Jun,Eun-Kyoung,Koh,Sung-Hwa,Song,Ji-Eun,Seong,Ji,Won,Kim,Kyu-Bong,Kim,Suhkmann,Kim,Dae-Youn,Hwang 한국실험동물학회 2014 Laboratory Animal Research Vol.30 No.1

        Loperamide has long been known as an opioid-receptor agonist useful as a drug for treatment of diarrhea resulting from gastroenteritis or inflammatory bowel disease as well as to induce constipation. To determine and characterize putative biomarkers that can predict constipation induced by loperamide treatment, alteration of endogenous metabolites was measured in the serum of Sprague Dawley (SD) rats treated with loperamide for 3 days using ¹H nuclear magnetic resonance (¹H NMR) spectral data. The amounts and weights of stool and urine excretion were significantly lower in the loperamide-treated group than the Notreated group, while the thickness of the villus, crypt layer, and muscle layer was decreased in the transverse colon of the same group. The concentrations of aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatinine (Cr) were also slightly changed in the loperamide-treated group, although most of the serum components were maintained at a constant level. Furthermore, pattern recognition of endogenous metabolites showed completely separate clustering of the serum analysis parameters between the Notreated group and loperamide-treated group. Among 35 endogenous metabolites, four amino acids (alanine, glutamate, glutamine and glycine) and six endogenous metabolites (acetate, glucose, glycerol, lactate, succinate and taurine) were dramatically decreased in loperamide-treated SD rats. These results provide the first data pertaining to metabolic changes in SD rats with loperamide-induced constipation. Additionally, these findings correlate the changes in 10 metabolites with constipation.

      • Anti-cancer Effect of Cordyceps Bassiana derived KTH-13

        Ji,Hye,Kim,Woo,Seok,Yang,Han,Gyung,Kim,Eun,ji,Kim,Sung,youl,Hong,Jae,Youl,Cho 한국버섯학회 2014 버섯 Vol.18 No.2

        In this study, we aimed to examine the cellular and molecular mechanisms of KTH-13 (4-isopropyl-2,6-bis(1-phenylethyl)phenol) which is derived from Cordyceps staphylindaecola in the cancer cells survival. The apoptotic effect of KTH-13 on various cancer cells, such as C6 glioma, MDA-MB-231 breast cancer, and A549 cells, was determined by MTT assay, and result showed that KTH-13 (0-100mM) dramatically inhibited the cancer cell survival. IC50 of KTH13 were 60.549, 53.512, >100, in C6, MDA-MB-231, and A549, respectively. DNA fragmentation result revealed that MDA-MB-231 cells treated with KTH-13 100mM undergoes apoptosis. To understand the action mechanism of KTH-13, the effect of KTH-13 on caspase which is key regulator of apoptosis was verified. The amount of cleaved capspase-3 and 7, executioner caspases, was increased by KTH-13 treatment, at time dependent (capspase-3 case) and dose dependent manner (caspase-7 case). And the cleavage of caspase-9 which is initiator caspase was also elevated in KTH-13 treated MDA-MB-231 cells showing time dependent manner. However, caspase-8 was not regulated by KTH-13, indicating KTH-13 specifically targets caspase-9 signal. As caspase-9 is closely associated with intrinsic pathway, the involvement of bcl-2 family was identified. Bax, pro-apoptotic molecule, was up-regulated whereas Bcl-2, anti-apoptotic protein, was down-regulated. And the Bax/Bcl-2 ratio was increased about 10 times. Then, the survival signal was also observed. The phosphorylation of Akt and p85 was diminished by KTH-13 treatment at 2,4,6 and 8 hour. Collectively, results suggest that KTH-13 induces cancer cells apoptosis via caspase3, 7, 8 and Bcl-2 family signaling pathway. And the Akt and p85 is also involved in KTH-13 action mechanism.

      • KCI등재

        원저 : 성인의 부정구강진료 경험 관련 요인: 국민건강영양조사제4기(2007-2009년) 자료를 중심으로

        김지은 ( Ji Eun Kim ), 정지인 ( Ji In Jung ), 김한나 ( Han Na Kim ), 김세연 ( Se Yeon Kim ), 전은주 ( Eun Joo Jun ), 김민지 ( Min Ji Kim ), 정승화 ( Seung Hwa Joeng ), 김진범 ( Jin Bom Kim ) 대한구강보건학회 2014 大韓口腔保健學會誌 Vol.38 No.4

        Objectives: The aim of the study was to analyze the factors related to the illegal dental treatment experience(IDTX) among Korean adults. Methods: The raw data for the analysis of IDTX among Korean adults were obtained from the datasetof the Fourth Korea National Health and Nutrition Examination Survey conducted in 2007-2009. Stratifiedweighted subjects aged ≥45 years were selected according to region by using clustered samplingmethods. In total, the data of 9,254 subjects, who participated in the interview and dental examinationsrelated to the experience of illegal dental treatments, were analyzed using chi-square test, general linearmodel, and logistic regression analysis with complex sampling design by considering demographicand socioeconomic variables (age, gender, region, educational level, household income, and medicaland dental delivery system) as well as oral status variables (prosthesis and number of natural remainingteeth). Results: IDTX rate was <10% among adults aged 35-44 years or below. However, it increased to 15%among adults aged 45-54 years and was >30% among adults aged ≥65 years. The age group with ahigh IDTX rate coincided with the age group with a high number of lost teeth. Most of the IDTX caseswere presumed to be prosthetic treatments. The model comprising demographic, socioeconomic, andoral status variables had the highest explanation power. Significant variables were educational level,household income, prosthesis status, and number of remaining teeth. Women and persons under themedicaid system were more likely to undergo illegal dental treatments. Conclusions: Comprehensive prosthetic treatments are suggested to be included in the care servicesof the national health insurance and medicaid system to reduce the number of illegal dental treatments.

      • KCI등재후보

        감비수 향 흡입이 절식을 유도한 쥐의 시상하부에서 섭식관련 신경전달물질의 발현과 인지력에 미치는 영향

        김동현(Dong-Hyun Kim), 고일규(Il-Gyu Ko), 김성은(Sung-Eun Kim), 김지은(Ji-Eun Kim), 강연호(Yeon-Ho Kang), 김태운(Tae-Woon Kim), 지은상(Eun-Sang Ji), 김용민(Yong-Min Kim), 김이화(Ee-Hwa Kim), 김정범(Jeong-Beum Kim), 김동희(Dong-Hee Kim), 김창주(Cha) 대한스트레스학회 2010 스트레스硏究 Vol.18 No.3

        본 연구는 절식을 유도한 ICR계 생쥐에서 감비수 향 흡입이 시상하부에서 leptin과 neuropeptide Y (NPY)의 발현에 미치는 영향과 단기 기억력에 미치는 효과를 알아보고자 하였다. ICR 계열 수컷 쥐 24마리를 무작위 추출법에 의해 대조군, 절식군, 절식과 감비수 향 흡입군(각 군 n=8)의 3군으로 분류하였다. 실험결과, 절식은 시상하부에서 leptin의 발현을 감소시켰고 NPY의 발현은 증가시켰다. 또한, 절식에 의하여 단기 기억력과 해마에서의 신경성장인자인 BDNF의 발현이 감소되었다. 반면에, 절식 중 감비수 향을 흡입 시 시상하부에서 leptin의 발현은 증가되었고 NPY의 발현은 감소되었다. 그리고 감비수 향의 흡입에 의하여 단기 기억력이 향상 되었고 해마에서의 신경성장인자인 BDNF의 발현이 증가되었다. 본 실험 결과, 감비수 향 흡입은 절식 시 증가된 음식섭취에 대한 욕구를 억제할 수 있으며 절식에 의하여 감소된 단기 기억력을 향상시키는 효과가 있음을 알 수 있었다. In the present study, we investigated the effects of Gambisu inhalation on the expressions of neurotransmitters implicated in the food intake in the hypothalamus and cognition using starved mice. For this, the effects of Gambisu inhalation on the expressions of leptin and neuropeptide Y (NPY) in the paraventricular nucleus (PVN) of hypothalamus of starved mice were evaluated by immunohistochemistry. Short-term memory of the mice was also assessed using a passive avoidance task and brain-derived neurothrophic factor (BDNF) expression in the hippocampus was determined by Western blot analysis. ICR mice were divided into three groups: control group, starvation group, and starvation with Gambisu inhalation group. The mice in the food-deprivation group were restricted food for 48 h. The mice in the Gambisu inhalation group were exposed to inhale Gambisu for 60 min twice a day for 2 consecutive days. The present results showed that food-deprivation decreased leptin expression and increased NPY expression in the PVN of the hypothalamus. Food-deprivation decreased short-term memory ability and also suppressed BDNF expression in the hippocampus. However, Gambisu inhalation increased leptin expression and decreased NPY expression in the PVN of hypothalamus under the starvation conditions. Gambisu inhalation alleviated starvation-induced short-term memory impairment and enhanced BDNF expression in the hippocampus under the starvation conditions. The present study revealed that Gambisu inhalation might suppress desire for food intake and exert beneficial effect on cognition by enhancing BDNF expression in the hippocampus under the starvation conditions. (Korean J Str Res 2010;18:209∼217)

      • KCI등재

        Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats

        Kim,,Ji,Eun,Kang,,Mi,Ju,Choi,,Jun,Young,Park,,Jin,Ju,Lee,,Mi,Rim,Song,,Bo,Ram,Kim,,Hye,Ryeong,Park,,Ji,Won,Choi,,Hyeon,Jun,Bae,,Su,Ji,Hwang,,Dae,Youn Korean Association for Laboratory Animal Science 2018 Laboratory Animal Research Vol.34 No.4

        <P>Regulation of gastrointestinal hormones have been reported in animal models for constipation undergoing laxative therapy when administered herbal products. We undertook to investigate whether the laxative activity of gallotannin-enriched extracts isolated from Galla Rhois (GEGR) affects the regulation of gastrointestinal hormones, by examining the concentration of four hormones and the activation of their receptors in the loperamide (Lop)-induced constipation model. Stool parameters, including number, weight and water content, were significantly recovered in the Lop+GEGR treated group, relative to the Lop+vehicle treated group; however, food intake and water consumption were maintained at a constant level. Also, a similar recovery was detected for thickness of mucosa, muscle and flat luminal surface in the Lop+GEGR treated group. Furthermore, concentration of the four gastrointestinal hormones evaluated, namely, cholecystokinin (CCK), gastrin (GAS), somatostatin (SS) and motilin (MTL), were lower in the Lop+vehicle treated group than the No treated group, but were remarkably enhanced in the Lop+GEGR treated group. Moreover, the downstream signaling pathway of MTL and SS receptors were recovered after GEGR administration. Results of the present study therefore indicate that the laxative effects of GEGR treatment may be tightly related with the regulation of gastrointestinal hormones in the Lop-induced constipation model.</P>

      • SCIESCOPUSKCI등재

        Generation of Fibroblasts Lacking the Sal-like 1 Gene by Using Transcription Activator-like Effector Nuclease-mediated Homologous Recombination

        Kim,,Se,Eun,Kim,,Ji,Woo,Kim,,Yeong,Ji,Kwon,,Deug-Nam,Kim,,Jin-Hoi,Kang,,Man-Jong Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.4

        The Sal-like 1 gene (Sall1) is essential for kidney development, and mutations in this gene result in abnormalities in the kidneys. Mice lacking Sall1 show agenesis or severe dysgenesis of the kidneys. In a recent study, blastocyst complementation was used to develop mice and pigs with exogenic organs. In the present study, transcription activator-like effector nuclease (TALEN)-mediated homologous recombination was used to produce Sall1-knockout porcine fibroblasts for developing knockout pigs. The vector targeting the Sall1 locus included a 5.5-kb 5' arm, 1.8-kb 3' arm, and a neomycin resistance gene as a positive selection marker. The knockout vector and TALEN were introduced into porcine fibroblasts by electroporation. Antibiotic selection was performed over 11 days by using $300{\mu}g/mL$ G418. DNA of cells from G418-resistant colonies was amplified using polymerase chain reaction (PCR) to confirm the presence of fragments corresponding to the 3' and 5' arms of Sall1. Further, mono- and bi-allelic knockout cells were isolated and analyzed using PCR-restriction fragment length polymorphism. The results of our study indicated that TALEN-mediated homologous recombination induced bi-allelic knockout of the endogenous gene.

      • PE-057 : Environmental risk factors for lung cancer in female never-smokers

        ( Ji-eun Kim ), ( In-jae Oh ), ( Min-seok Kim ), ( Ha- Young Park ), ( Tae-ok Kim ), ( Hong-joon Shin ), ( Bo- Gun Kho ), ( Cheol-kyu Park ), ( Yong-soo Kwon ), ( Yu- Il Kim ), ( Sung-chul Lim ), ( Young-chul Ki) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

        Introduction: Lung cancer in never-smokers is regarded as a distinct disease entity with female predominance. We compared the environmental factors of female patients who never smoked cigarettes between non-small cell (NSCLC) and small cell lung cancer (SCLC). Methods: The observational study was conducted from August 2017 to May 2019 at Chonnam National University Hwasun Hospital. After inform consented, a simplified questionnaire based on demographic data, second-hand smoking, residential environment, kitchen environment, disease state and life style. Never-smokers are defined as those patients who report having smoked £ 100 cigarettes in their lifetime. Results: Among 178 patients of female never-smoker, 162 (91%) cases were NSCLC (156 adenocarcinoma and 6 squamous cell carcinoma) and only 16 (9%) cases were SCLC. There was no significant difference between NSCLC and SCLC groups according to demographics, second-hand smoking, residential and kitchen environment. There was no difference in comorbidity, family cancer history or life style. Conclusion: Nine percent of female never-smokers had SCLC. Because we did not find significant risk factors that could distinguish SCLC from NSCLC, further study is warranted for environmental air pollutants and genetic mutation analysis.

      • SCOPUSKCI등재

        Alcohol exposure induces depression-like behavior by decreasing hippocampal neuronal proliferation through inhibition of the BDNF-ERK pathway in gerbils

        Kim,,Ji-Eun,Ji,,Eun-Sang,Seo,,Jin-Hee,Lee,,Moon-Hyoung,Cho,,Se-Hyung,KimPak,,Young-Mi,Seo,,Tae-Beom,Kim,,Chang-Ju The Korean Society for Integrative Biology 2012 Animal cells and systems Vol.16 No.3

        Depression is one of the most prevalent diseases of alcohol abuse. Brain-derived neurotrophic factor (BDNF) plays a critical role in cell survival in the hippocampus. Phosphorylation of extracellular signal-regulated kinase 1/2 (p-ERK1/2) is induced by BDNF, and it regulates cell proliferation and differentiation in the brain. We investigated the effects of alcohol intake on depression-like behavior, cell proliferation, expressions of BDNF and its downstream molecules in the hippocampus using Mongolian gerbils. The gerbils were divided into four groups: control group, 0.5 g/kg alcohol-treated group, 1 g/kg alcohol-treated group, 2 g/kg alcohol-treated group. Each dose of alcohol was orally administered for 3 weeks. The present results demonstrated that alcohol intake induced depression-like behavior. Both 5-hydroxytryptamine synthesis and its synthesizing enzyme tryptophan hydroxylase expression in the dorsal raphe and cell proliferation in the hippocampal dentate gyrus were decreased by alcohol intake. Alcohol intake suppressed BDNF expression, and resulted in the decrease of its downstream molecules, pERK1/2 and Bcl-2, in the hippocampus. We showed that alcohol intake may lead to a depressed-like state with reduced hippocampal cell proliferation through inhibition of the BDNF-ERK signaling pathway.

      • PE-117 : A contact investigation of the transmission of Mycobacterium tuberculosis in a psychiatric hospital

        ( Eun-young Kim ), ( Ae-jung Lee ), ( Jin-a Park ), ( Ji Eun Kim ), ( Sung Eun Kim ), ( Ju Young Park ), ( Shin-young Park ), ( Misun Park ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

        Objective: Residents in a long-term care (LTC) facility are at risk of TB infection because of frequent disease transmission, and they also may have comorbidities that are associated with an increased risk of TB reactivation. In addition, people with a mental illness recognized as an important risk factor for TB. The objective of this study was to describe outcomes of TB contact investigations in a psychiatric hospital. Methods: A psychiatric hospital inpatients were reported as tuberculosis in August 2017, and a contact investigations in psychiatric hospital have been conducted according to the National Tuberculosis Control Programme. From August 2017 to May 2019, the contact investigation included 102 patients and 15 healthcare workers. Chest X-ray (CXR) and interferon- gamma releasing assay (IGRAs) were performed in contacts. Molecular typing was performed with 24- loci MIRU-VNTR and Spoligotyping. Results: There were 6 cases of pulmonary TB were diagnosed among contacts. All additional cases used the same layer as the index patient, one of whom used the same room with the index patient. Among the contacts, 74.4% (87/117) were tested for LTBI; 52.8% were identified as having LTBI. There were 43 inpatients (49.4%) and 3 healthcare workers (3.4%) with LTBI. According to the analysis of the genetic type of tuberculosis bacteria, all three confirmed cultured strains were identified with the same genetic type as the index patient. Conclusion: It is important to detect and treat tuberculosis patients and latent TB infections early through contact investigation. Also routine CXR screening at admission and maintaining a high alert for TB in daily practice are essential in psychiatric hospital.

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