전해산성수를 이용한 새로운 내시경 소독 시스템(Cleantop WM-1??)의 소독효율

이준행,이풍렬,송재훈,이남용,임윤정,장재권,김영호,김재준,백승운,이종철,최규완 대한감염학회 2001 감염 Vol.33 No.2

Background : Electrolyzed acid water (EAW) is a new liquid chemical germicide containing a mixture of oxidizing species and prepared by mixing a small amount of salt with tap water in an electrolyzer. We attempted an in-use evaluation of the high-level disinfection capability of Cleantop WM-1□, a new endoscope reprocessing system using EAW. Methods : Forty-seven flexible endoscopes were randomly collected just after upper endoscopic examinations and were disinfected using Cleantop WM-1□. Parts of the endoscopes without contact to EAW were disinfected with 75% ethyl alcohol. Immediately after the disinfection procedure, samples were taken from the biopsy channel (S-1), tip of the insertion tube (S-2), the umbilical cord (S-3), and the angulation knob (S-4). Results : In EAW-disinfected parts of the endoscopes, the culture-positive rates were 4.3% (2/47) in S-1 samples and 12.8% (6/47) in S-2 samples. In ethyl alcohol-disinfected area, the culture-positive rates were 2.1% (1/47) in S-3 samples and 25.5% (12/47) in S-4 samples. The colony counts of culture-positive samples ranged from 1 to 144. Pseudomonas aerugi-nasa was recovered from the angulation knob of an endoscope, but other contaminating organisms were mostly : normal flora or opportunistic pathogens. Conclusion : Although part of the endoscopes disinfected with 75% ethyl alcohol were contaminated with more organisms than EAW-disinfected areas, Cleantop WM-1□ showed a relatively good disinfection efficacy in reprocessing patient-used endoscopes. (Korean J Infect Dis 33:133∼138, 2001)

수도권 내륙화물기지 신설에 따른 효과 분석

장준석(Jun-Seok Jang),이준(Jun Lee),박재현(Jae-Hyun Park),송민호(Min-Ho Song),권용장(Yong-Jang Kwon) 한국철도학회 2011 한국철도학회 학술발표대회논문집 Vol.2011 No.10

내륙물류기지는 도로 철도 항만 공항 간의 연계운송 및 복합운송을 할 수 있는 규모와 시설을 갖춘 대규모 물류처리 시설을 지칭하며 화물의 대량수송으로 인한 물류비절감을 위하여 전국의 주요 물류 거점에 구축하여 운영을 하고 있다. 하지만 수도권 물류를 처리하는 유일한 화물거점시설인 의왕ICD의 경우 2015년 이전에 물류시설의 용량이 한계치에 도달할 것으로 예상되어 추가적인 시설개량이나 다른 수도권 물류처리시설 신설이 필요한 실정이다. 특히 입지적으로 부지 확장에 대하여 주변 여건상 한계가 있으므로 물류처리시설 신설로 인한 용량 및 처리능력 향상이 요구된다. 또한 현재 남북 간 화물철도운송에 대한 관심이 증대됨에 따라 향후 화물운송은 도로와 선박에서 철도로 물량전환이 가능할 것으로 판단되나 이들 살화물의 주요 수요지인 수도권(서북부 지역)에는 이 물동량을 처리 및 보관 할 수 있는 화물역과 물류기지가 부재하여 이들 확보할 필요가 있다. 따라서 본 연구는 서해안축 신규 물류기지(송산역 안중역)와 서북부 신규 물류기지(대곡역) 신설을 통하여 수도권 물동량 급증에 따른 철도 선로용량 부족 문제 해소방안과 남북 간의 효율적인 철도수송 수도권 철도화물의 분산효과 등을 검토함으로써 원활한 철도수송서비스를 제공하여 물류비를 절감하는 데 그 목적이 있다. The inland logistics center is a large scale of logistics facility that enables roads rails ports and airports to carry out chained-transports and combined-transports and the logistics center are established at the main logistics posts in order to reduce the cost of transport by mass transportation. However it is expected that the capacity of Euiwang ICD the only inland logistics centers in the capital area will reach its limit before 2015 so it is required to establish another stations or to improve the existing facility. Especially in case of Euiwang ICD the expansion of the center is not possible because of its position so it is required to establish new logistics centers in other places in order to raise the capacity of transport. Therefore this study suggests to establish new metropolitan logistics centers on the western coast line in order to solve the problem of shortage of tract capacity that is brought on by the newly established inland logistics centers on the axis of the western coastline (Song-san Station and An-jung Station) and analyzes how the new logistics center will distribute railroad cargoes. By these this study contributes to reduce the cost of transport by providing smooth railroad transport service.

기저질환이 없는 사람에서 발생한 Campylobacter fetus에 의한 재발성 심내막염 1예

전재범,정진원,김성혜,송문희,오형철,안성기,최상호,김남중,김양수,우준희,류지소 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

C. fetus 심내막염은 드물게 발생하는 질환으로 주로 면역능이 저하된 환자에서 발병하고 대동맥판을 침범하는 경우가 많으며 적절한 치료가 되지 않을 경우 치사율이 높다. 저자들은 기저질환이 없던 69세 남자에서 C. fetus 심내막염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 발열로 내원하여 시행한 혈액배양 검사상 C. fetus가 동정되었고 경식도 초음파 검사상 삼첨판에 증식증이 발견되어 심내막염 진단하에 ceftriaxone에 이어 meropenem으로 총 4주간 항생제를 투여받고 호전되었다가 한달 후 다시 재발하였고 판막부전 소견 진행하여 삼첨판 치환술을 시행받고 전신상태 호전되어 퇴원하였다. Campylobacter fetus is a rare cause of endocarditis. To date, only about 30 cases of C. fetus endocarditis have been reported mainly in the elderly with chronic underlying illnesses. Most cases showed tendency to involve aortic valve. This report describes a case of native tricuspid valve infective endocarditis in a 69-year-old man without any underlying disease. Despite adequate antibiotic therapy for 4-weeks, endocarditis recurred and leading to surgical valve replacement.

Baculovirus를 이용한 Aujeszky's Disease Virus gⅢ 단백질 발현

송재영,이중복,현방훈,박종현,김병한,권창희,전무형,안수환 충남대학교 생물공학연구소 1993 생물공학연구지 Vol.3 No.-

The g Ⅲ gene located in U_L region of Yangsan strain, a field isolate of Aujeszky's disease virus (ADV) in Korea, was cloned into pTZ18R and sequenced. The gⅢ gene consisting of 1,437 nucleotides showed 98% sequence homology with that of Becker strain, a reference strain of ADV. The gene encoding gⅢ of Yangsan strain was placed under the control of Autographa californica nucleopolyhedrosis virus (AcNPV) polyhedrin promoter, and expressed by the derived recombinant baculovirus using Spodoptera frugiperda 9 (Sf9) cells. The expressed gⅢ was a protein with molecular weight of 72kd determined by immunoprecipitation and Western blotting assay using anti-ADV polyclonal antibodies and anti-gⅢ monoclonal antibody. The partially purified gⅢ protein was utilized as antigen in the radial immunodiffusion enzyme assay (RIDEA) to detect to specific antibody against ADV in pig sera. The results indicated that the sensitivity of RIDEA with the recombinant gⅢ protein antigen (98%) was as high as that with the conventional glycoprotein antigen extracted from the ADV infected cells. In addition, the false positive and false nagative reactions in gⅢ RIDEA were significantly reduced than the conventional glycoprotein RIDEA as judged from the results of standard serum neutralization test.

안내염과 대장암이 동반된 재발성 간농양

전승정,김태헌,류민선,오다연,송명은,이신아,류재인,김혜인,문일환,유권 이화여자대학교 의과학연구소 2011 EMJ (Ewha medical journal) Vol.34 No.2

The causes of pyogenic liver abscess has been known as biliary tract disease or intrabadominal infection but the large proportions of the patients has no apparent underlying disorders. Recently colonic mucosal lesions were reported in patients with cryptogenic liver abscess and it has been suggested that colonic mucosal break may play a role in developing liver abscess in otherwise healthy patients. We experienced a patient of severe recurrent liver abscess complicated with endophthalmitis only 3 months after successful treatment of initial cryptogenic liver abscess and a polypoid colon cancer was discovered by chance. It seems prudent to proceed colonoscopic examination in patients with cryptogenic liver abscess especially when it is recurrent.

북한강 상류 천연자원의 종합관리 시스템 개발

송화선,김남호,김동욱,장재형,정영준,임길재 강원대학교 석재복합신소재제품연구센터 1998 석재연 논문집 Vol.3 No.-

강원도 춘천시를 중심으로하는 북한강 상류는 수도권에 청정 상수원류를 제공하는 생활의 핏줄이다. 또한 수도권 지역 건설에 필수적인 석재 자원의 주요 공급 지역으로 알려져 있다. 본 연구에서는 이 지역의 보존과 체계적 개발을 위한 지리정보처리 기술을 이용한 천연자원 종합관리 시스템을 개발하였다. 이 시스템은 자원관리를 위한 막강한 도구와 기능 예를 들면 정보수집, 편집, 처리, 모델링, 분석 및 가시화기능을 제공한다. 결과적으로 이 시스템은 지하자원 분석, 천연자원의 기획 및 개발, 자연보호 등 자원관리와 연계된 문제를 효율적으로 해결할 수 있는 능력을 제공하고 있다. The upper stream area of the north Han river, which is located around the Chunchon city of the Kangwon province, is out essential resources, which supply clear drinking water to the capital city of out conutry, Seoul. This area has also produced stone and aggregate resources required for building and road constructions in the capital area For preservation and planned-development of this area, in this study, we have developed an integrated management system for natural resources, based upon geological information technologies. This system includes powerful tools and functions for resource management such as information collection, edition, processing, modeling, analysis, and visualization. As a result, this system may give us capabilities to efficiently handle a variety of resource management issues such as the analysis of underground resources, the planning and development of natural resources, the protection of environment and their related projects.

수평/수직 보간법을 이용한 계층적 영상 부호화에 관한 연구

송영준,안재형 충북대학교 컴퓨터 정보통신 연구소 1999 컴퓨터정보통신연구 Vol.7 No.1

본 연구에서는 보간법을 사용한 계층적 부호화의 성능을 개선시키기 위하여 기존의 보간법인 선형 보간법 대신에 수평/수직 보간법을 제안하고 그 성능을 분석하였다. 수평/수직 보간법은 윤곽선을 정확히 예측하기 위하여 Zschunke에 의해 제안된 비선형 예측 방법을 응용한 것으로 윤관선의 방향에 따라 보간 방법을 수평 또는 수직 방향으로 선택하여 행하는 방법이다. 제안된 방법이 선형 보간법보다 MOS(Mean Option Score)로 0 레벨에서 0.5의 화질 개선치를 보였다. This paper proposed a nonlinear interpolation method to improve the quality of reconstructed images for the hierarchical interpolation (HINT) coding. Its method is horizontal or vertical interpolation according to boundary direction. The proposed interpolation method gives better image quality than the linear interpolation. The results by subjective tests show that the MOS value for the reconstructed image using the horizontal/vertical interpolation is about 0.5 higher than using the linear interpolation at the level-zero hierarchy.

Baculovirus Vector System에 의해 발현된 재조합 Pseudorabies Virus Major Capsid Protein의 면역원성

전무형,안동준,장경수,조용성,박종현,송재영,현방훈,안수환 충남대학교 생물공학연구소 1997 생물공학연구지 Vol.5 No.-

The recombinant pseudorabies virus major capsid protein (rMCP) was produced by expression of the MCP gene in Sf-9 cell using baculovirus transfer vector system. Following evaluation of the immunochemical properties of the rMCP, the immunogenicity of the recombinant subunit protiens were investigated in guinea pig and swine to obtain the preliminary guide line for the subunit vaccine using rMCP and gP50. It was proved that ultrasonication and 30% ammonium sulfate was most efficient to concentrate and purify the protein. The rMCP was safe in mice, guinea pigs and piglets. In guinea pigs, rMCP mixed with various adjuvants induced substantial degree of serum neutralizing antibody titers, but revealed incomplete protecivity against challenge. In swine, the combination of rMCP and gP50 showed the higher serum neutralizing antibody titers and cellular immune responses than rMCP alone. However, the protectivity was lower in comparison with the commercial gI-deleted inactivated vaccine. We expect these results to contribute to characterization of MCP gene of Korean isolate of PRV and to ultilize as preliminary information for prodution and evaluation of PRV recombinant subunit vaccines.

역위 매복된 상악 중절치의 외과적 재위치 후 치근 발육 정지

송제선,최병재,최형준,김성오,손흥규,이제호 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.1

상악 중절치의 매복은 소아 환자의 심미적 사회적 기능적 문제를 일으킬 수 있어 적절한 치료를 통해 바로잡아 주어야 한다. 상악 중절치 매복의 치료로 외과적 노출 후 교정적 견인이 어려울 경우 발치하기에 앞서 외과적 재위치(surgical repositioning) 혹은 치조 내 자가치아이식(intra-alveolar autotransplantation)을 고려해 볼 수 있다. 본 증례는 5세 9개월 된 남아의 역위 매복된 상악 우측 중절치를 치근 발육 초기인 Nolla's stage 6.5에 부분 맹출된 위치로 외과적 재위치를 시행하여 자발적 맹출을 기대하였으나 21개월 간의 추적 검사 결과 치관 발육 및 맹출이 정지된 증례이다. 그 원인으로서 수술 시 치배를 발거하고 치조와를 적합하는 과정에서 Hertwig's epithelial root sheath(HERS)가 손상 받았기 때문으로 생각된다. 매복 치아의 외과적 재위치 시에는 본 증례와 같이 합병증 발생 가능성이 있으므로 신중한 적응증의 선택, 치근 발달 정도를 고려한 적절한 치료 시기의 결정, 최소한의 손상을 주는 외과적 술식 등의 노력이 필요할 것이다. Impaction of the maxillary central incisor may cause social, esthetic, and functional problems in children. There are various means of treatment for the inverted maxillary central incisor, such as extraction, surgical opening followed by orthodontic traction, surgical repositioning or intra-alveolar autotransplantation prior to extraction. In this case, we surgically repositioned the inverted maxillary central incisor to normal semi-erupted position in a 5-year-old boy. The developmental stage of the inverted tooth was Nolla’ s 6.5, which indicates formation of less than one third of the root. After surgical reposition, we did follow-up for 21 months, expecting spontaneous growth. Unfortunately, poor prognosis was noted : further root was not observed. Such failure seems to originate from possible injury on Hertwig’ s epithelial root sheath by surgical trauma. We performed surgical repositioning to retain the tooth instead of extraction. However, arrest of root development occurred, which is one of the critical complications. In order to increase the success rate of the surgical reposition procedure, minimal surgical trauma is required as well as selection of adequate indication and decision of proper time of treatment considering the stage of root development.

지역사회획득 폐렴의 치료지침 권고안

송재훈,정기석,강문원,김도진,배현주,서지영,심태선,안중현,안철민,우준희,이남용,이동건,이미숙,이상무,이영선,이혁민,정두련,지역사회획득 폐렴 치료지침 제정위원회 대한감염학회 2009 감염과 화학요법 Vol.41 No.3

A successful therapy of community-acquired pneumonia requires appropriate empirical antimicrobial therapy. Etiology and antimicrobial susceptibility of major pathogens of pneumonia can differ by country. Therefore, an ideal treatment guideline of community-acquired pneumonia should be based on the studies performed in each country. We developed a treatment guideline for community-acquired pneumonia in immunocompetent adults in Korea. This guideline was developed by the joint committee of the Korean Society for Chemotherapy, the Korean Society of Infectious Diseases, and the Korean Academy of Tuberculosis and Respiratory diseases.