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<P>A large scale sodium test facility of ‘CPTL’(Component Performance Test Loop) for simulating thermal hydraulic behavior of the Korean demonstration fast reactor components such as IHX(Intermediate Heat Exchanger), DHX(Decay Heat Removal Heat Exchanger) and sodium pump under development by KAERI is to be constructed. The design temperature of this test loop is 600°C and design pressure is 1MPa. The three heat exchangers are made of Grade 91 steel. Another sodium test facility of the ‘STEF’(Sodium Thermal-Hydraulic Experimental Facility) will be constructed next to the CPTL facility to simulate the passive decay heat removal behavior in the sodium cooled fast reactor. In this paper, the overall facility features of the CPTL and STEF are introduced and preliminary conceptual design of the facilities are carried out.</P>
On the basis of Busan University of foreign studies, a methodical experiment was planned, during which a group of Korean students under the guidance of Professor Jae Hyuk Lee was offered the Russian by tandem method for a four-day trip to Sakhalin, as a supplement to the basic course of studying at the Busan University of foreign studies. For this experiment with the help of a survey were selected students of the second-third year undergraduate, studying Russian language and culture. Three groups were formed and their subjects of research projects were announced like these (“History and culture of the Sakhalin region”, “A. P. Chekhov on Sakhalin”, “the Fate of Sakhalin Koreans”). The level of knowledge of the Russian language in the three groups is about the same–about two years of learning a foreign language, and none of the participants of the experiment had previously had experience in tandem method. Before the trip to Russia (Sakhalin region, Yuzhno-sakhalinsk), it was decided to form 5 tandem pairs. The experiment was held in February 2018. The aim of this experiment was to test the hypothesis that the tandem method has an impact on the process of learning the Russian language and contributes to the most effective and complete formation of communicative competence. The results of the experiment confirmed the hypothesis about the effectiveness of the tandem method in the study of teaching Russian as a foreign language. The use of this method in the experiment included the following steps: 1) The teacher divided the students into groups of 3-4 people and gave each group one common task; 2) Each student performed a specific task facing him, then brought it to the discussion group; 3) The group formed a general plan for solving the research task, based on the results achieved by each individual; 4) The teacher determines the degree of correctness of the task and assesses the work done not individually, but by the whole group. The purpose of the project activity is the formation and development of intellectual skills related to creative and critical thinking. The learning process using this technology is characterized by the following features: 1) the new role of the teacher (in the collective form of tandem method): it defines the framework of the educational process and creates an appropriate learning environment, thus motivating further cognitive activity of a foreign language and culture; monitors the parity of both languages; activates communication; makes recommendations; monitors the process of communication; 2) Heterogeneity of groups: participants of the tandem proceed from the individual, real level of the partner; communication in tandem always occurs between two partners, but not between the teacher and the group. As an auxiliary method in the study of a foreign language at the University tandem method also has a huge impact on the learning process, because this method fills the gaps in the components of communicative competence. There is also a process of applying the acquired knowledge in practice. At any stage of the study of Russian as a foreign language tandem method is an effective way of forming socio-cultural competence -knowledge of cultural and historical characteristics of the native speaker, his habits and traditions, norms of behavior and etiquette and the ability to understand and use them in the communication process, as well as sociolinguistic competence -the ability to choose and use appropriate language tools depending on the situation and purpose of communication.
The 2-chlorophenol (2-CP) was oxidized in a continuous anti-corrosive supercritical water system. The variation of decomposition efficiency by the corrosion of zirconium 702 was also studied at the variation of feed concentration and reaction time. According to AES depth profile, the oxygen penetration depth to zirconium was not proportional to the exposure time. It might stem from the formation of zirconium oxide layer on the surface delaying the corrosion. However, the increase in feed concentration accelerated the corrosion of zirconium. The corrosion of zirconium at low feed concentration led to the improvement of decomposition efficiency due to the catalytic effect of formed zirconium oxides, while that at high feed concentration deteriorated the decomposition efficiency owing to large consumption of oxidant in corrosion.
( Jae Yik Lee ), ( Sang Joon Park ), ( Jae Hyuk Lee ), ( Mi Kyung Kwak ), ( Hye Jeong Kim ), ( Dong Won Byun ), ( Kyo Il Suh ), ( Myung Hi Yoo ), ( Hyun Sook Kim ), ( Hyeong Kyu Park ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Introduction: Several capillary changes detected by finger nailfold capillaroscopy have been shown to correlate with microvascular complications in type 1 diabetes. However, there are few reports on the relationship between nailfold capillary abnormalities and microvascular complications in type 2 diabetes (T2DM). Herein, we investigated whether nailfold capillary microscopic changes are associated with diabetic nephropathy in patients with T2DM. Methods: We conducted a cross-sectional study in patients with T2DM diagnosed within 20 years (duration of diabetes: 6.4±6.0 years). The nailfold capillaroscopy can visualize the capillary network in fingers and is a non-invasive test. The presence of morphological abnormalities, including avascular areas, giant capillaries, dilated, tortuous, or ramified capillaries, hemorrhages and capillary architectural derangements, in finger nailfold capillaroscopy image was assessed by a single rheumatology specialist. The severity of nailfold capillary change (0 : no change, 1 : capillary change/mm <33%, 2 : capillary change/mm between 33-66%, 3 : capillary change/mm >66%) was scored. Statistical analyses were performed using Pearson correlation or Spearman rank correlation as appropriate Results: A total of 63 patients with T2DM were enrolled. Both capillary architectural derangements and avascular areas in nailfold capillaroscopy showed significant correlations with albuminuria measured by spot urine or 24-hour urine collection after adjusting for sex, age, body mass index, duration of diabetes, hemoglobin, and HbA1C. Moreover, architectural derangements and avascular areas in nailfold capillaries were significantly associated with urinary albumin excretion rate in T2DM patients diagnosed within 10 years. Conclusions: These findings have shown that nailfold capillary abnormalities are independently associated with albuminuria in patients with T2DM of moderate duration, suggesting a role of capillary changes in the pathogenesis of diabetic nephropthy.
<P>We report a new and simple design of a fully automated dual-online ultra-high pressure liquid chromatography system. The system employs only two nano-volume switching valves (a two-position four port valve and a two-position ten port valve) that direct solvent flows from two binary nano-pumps for parallel operation of two analytical columns and two solid phase extraction (SPE) columns. Despite the simple design, the sDO-UHPLC offers many advantageous features that include high duty cycle, back flushing sample injection for fast and narrow zone sample injection, online desalting, high separation resolution and high intra/inter-column reproducibility. This system was applied to analyze proteome samples not only in high throughput deep proteome profiling experiments but also in high throughput MRM experiments.</P> <P>Graphic Abstract</P><P>A new and simple design of a fully automated dual-online ultra-high pressure liquid chromatography system for high throughput deep proteome profiling and high throughput MRM experiments. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c5an00639b'> </P>
The objective of this study was to demonstrate the effectiveness of the Sool`s method of anterior shoulder dislocations. This was a retrospective study conducted in a university affiliated emergency department (ED). Sequence of the Sool`s method: (1) the patient is placed in a sitting position. (2) The patient to raise the affected arm and hand with forward flexion until the angle of the arm and trunk reaches 90 degree, and put the patient`s hand on the operator`s shoulder of same side. (3) The operator grabs the muscles of anterior part of deltoid and pectoralis of affected side with a hand of the patient`s hand putted on and grabs the elbow of affected side with an opposite hand and pulls the elbow slowly with slight lateral rotating and massages the muscles of anterior part of deltoid and pectoralis. 59 eligible patients presented to the ED were recruited. 35 patients were recruited to TSRT and 24 patients were recruited to the Sool`s method. The rate of successful reduction in ED was 80% (26/35) in TSRT group and 75% (18/24) in the Sool`s method group (P=0.75). The length of (LOS) in the ED was 72.3 minutes in the Sool`s method group and 98.4 minutes TSRT group (P=0.037). No significant difference in neurovascular deficit before and after reduction between both groups was reported. In the Sool`s method group, procedural time of successfully reduced cases was shorter than failed cases (P=0.015). The Sool`s method was as successful as other methods in reducing shoulder dislocations. Sool`s method has shown encouraging results including significant reduction in LOS in ED, and unnecessary use of sedation. Sool`s method is technically easy and requires only a chair or a bed to sit on and a single operator, which reduces the use of valuable ED resources.
We constructed a cooling system for solar cells using convection phenomena and investigated its cooling performance. The cooling system didn't need any driving power or water resources. The convection cooler manufactured with a right-triangle shape of an air duct was attached to the rear of the solar cell to confirm that cooling was performed using convection phenomena. When the ratio of duct width to attachment surface width was 3:7, and the ratio of entrance height and exit height of duct was 5:1, it showed the best cooling performance. Comparative experiments with solar cells without convection cooler showed that cooling effects from 16.5°C to 20.9°C occurred after 40 minutes exposed to the 1300W Xenon lamp condition.
Lee,,Ji,Hee,Bae,,Jeong,A,Lee,,Jae,Hyuk,Seo,,Young-Woo,Kho,,Dhong,Hyo,Sun,,Eun,Gene,Lee,,Song,Eun,Cho,,Sang,Hee,Joo,,Young,Eun,Ahn,,Kyu,Youn,Chung,,Ik,Joo,Kim,,Kyung,Keun British Medical Association 2010 Gut Vol.59 No.7
<P>BACKGROUND AND AIMS: 90K, a tumour-associated glycoprotein, interacts with galectins and has roles in host defence by augmenting the immune response, but the serum 90K level was suggested to indicate poor prognosis in several cancers. The cellular mechanisms of 90K action on colorectal cancer (CRC) cell motility and its effect on CRC progression were investigated. METHODS: The impact of 90K was analysed by combining cell cultures, in vitro assays, and immunohistochemistry. RESULTS: Secreted 90K suppresses CRC cell invasion, but this action of 90K is masked through binding with extracellular galectins. A novel pathway is identified comprising a secretory 90K and a CD9/CD82 tetraspanin web; in this pathway, 90K interacts with CD9/CD82, suppresses the Wnt/beta-catenin signal via a novel proteasomal-ubiquitination mechanism of beta-catenin that is dependent on ISG15 (interferon-stimulated gene-15) modification (ISGylation) but not on glycogen synthase kinase 3beta (GSK-3beta) and Siah/Adenomatous polyposis coli (APC). In a syngeneic mouse colon tumour model, tumour growth and lung metastasis were increased with 90K knockdown. In colon tissues from stage IV human CRC and invading cancer cells of corresponding metastatic liver tissues, in which beta-catenin and galectin expression was higher, immunostained 90K and CD9/CD82 were lower than in adjacent hepatic tissues or colon tissues from stage I. CONCLUSIONS: 90K itself has antitumour activity in CRC cells via suppression of Wnt signalling with a novel mechanism of ISGylation-dependent ubiquitination of beta-catenin when it interacts with CD9/CD82, but is downregulated in advanced CRC tissues. The data suggest a strategy of strengthening this novel pathway with concomitant knockdown of galectins as a potential therapeutic approach to CRC progression.</P>