홍삼류의 섭취가 비만과 혈중 지질의 상호관계에 미치는 영향

박화진,이정희,이소진,함혜선,조현정,임창률,유영빈,박기현 대한의생명과학회 2000 Journal of biomedical laboratory sciences Vol.6 No.4

비만은 동맥경화의 위험인자로서 혈중에 triglyceride의 농도를 종가시키고, 상대적으로 HDL-Cholesterol의 농도를 감소시킴과 동시에 수축기 혈압을 상승시킨다. 본 연구에서 홍삼제품류를 4년 또는 5년 동안 복용해 온 건강한 사람 (ginseng군)과 홍삼제품을 복용하지 않은 건강한 사람 (control군)을 대상으로 하여 신체 계측치로부터 비만지수를 구하고 이것과 혈중의 triglyceride (TG)농도, TG/HDL-Cholesterol ratio 및 수축기 혈압과의 상호관계를 연구한 바, ginseng군에서는 대조군에 비해 혈중의 TG 농도가 일정하게 유지되었고, TG/HDL-Cholesterol ratio 및 수축기 혈압도 일정하게 유지되었다. 이러한 현상은 ginseng군에서 기호품으로 alcohol을 섭취하거나, 흡연을 한 경우에도 상관없이 일정하게 유지 되었다. 이 결과는 홍삼제품류를 장기 복용하면 비만의 저하 및 고혈압 또는 동맥경화의 위험인자가 억제될 수 있고, 결론적으로 비만, 고혈압 및 동맥경화를 예방할 수 있을 것으로 추정한다. Obesity is the risk fcactor of atherosclerosis and not only increases triglyceride concentration in blood but also decreases relatively the ratio of TG to HDL-Cholesterol in blood. In case of obesity, systolic blood pressure is also increased in responding the increase of TG in blood. Index of obesity in red ginseng-taking group (ginseng group) was lower as compared with non-red ginseng-taking group (control group). The TG concentration, the ratio of triglyceride to HDL-cholesterol in blood and systolic blood pressure were decreased in the subjects of ginseng group compared with that in control group. It is inferred that long-term intake of ginseng products may help to prevent the risk of atherosclerosis and obesity.

Caving Disaster and Oil Spill Removal Adsorbent Mag-Sorbent

Soh, Dea-Wha,Soh, Hyun-Jin,Soh, Hyun-Jun,Soh, Hyun-Jae The Speleological Society 2008 동굴 Vol.85 No.-

For trying to frontal attack of new solution by fusion of technical tasks and conditions with it's solving methods of the essential tasks of marine resource development and environmental conservation in addition with elements of electronic high-technologies, the magnetic oil spill adsorbent of Mag-Sorbent* has been prepared and proposed to dispose oil spill from the marine disaster for preventing oil pollution by using them and their system with sequentially circular collection of oil spill mag-sorbent powder and fabrics on the electronic equipment like as barge robot for the scheme of sustainable development of environment-friendly technology. Because of recent marine accident occurred at Tae-An cost and earthquake in Sichuan province were very large scale accident of disaster to prevent and manage of them. So, it was verified from the experiment of electronic demonstrator that the skimmer system of oil spill mag-sorbent powder and fabrics prepared was very effective and useful technique to collect oil spill samples on the water surface specially at the closed space of underground cave. At this point, the barge-based electronic remote control was very useful system operating easily on the marine fields but also water level at the small pool to skim it with the environment-friendly system of the disposing marine disaster and preventing oil pollution using magnetic adsorbents of Mag-Sorbent*.

Caving Disaster and Oil Spill Removal Adsorbent Mag-Sorbent

( Dea Wha Soh ),( Hyun Jin Soh ),( Hyun Jun Soh ),( Hyun Jae Soh ) 한국동굴학회 2008 동굴 Vol.85 No.-

For trying to frontal attack of new solution by fusion of technical tasks and conditions with it`s solving methods of the essential tasks of marine resource development and environmental conservation in addition with elements of electronic high-technologies, the magnetic oil spill adsorbent of Mag-Sorbent* has been prepared and proposed to dispose oil spill from the marine disaster for preventing oil pollution by using them and their system with sequentially circular collection of oil spill mag-sorbent powder and fabrics on the electronic equipment like as barge robot for the scheme of sustainable development of environment-friendly technology. Because of recent marine accident occurred at Tae-An cost and earthquake in Sichuan province were very large scale accident of disaster to prevent and manage of them. So, it was verified from the experiment of electronic demonstrator that the skimmer system of oil spill mag-sorbent powder and fabrics prepared was very effective and useful technique to collect oil spill samples on the water surface specially at the closed space of underground cave. At this point, the barge-based electronic remote control was very useful system operating easily on the marine fields but also water level at the small pool to skim it with the environment-friendly system of the disposing marine disaster and preventing oil pollution using magnetic adsorbents of Mag-Sorbent.

전통식품과 동굴과학 -전통(傳統) 숙성식품(熟成食品)과 인공토굴(人工土窟) 응용기술 중심-

소현진 ( Hyun Jin Soh ),홍영자 ( Yong Ja Hong ) 한국동굴학회 2007 동굴 Vol.79 No.-

인공토굴(人工土窟) 숙성식품의 장기가공보관 수단의 원조로 자리 잡아, 광천옹암리 토굴이 전통식품 산업의 지혜와 관광산업의 역동으로 변신하고, 인공 굴은 폐광토굴에서 농산물저장을 위한 인공제작 굴의 활용기술로 이어져 산업화사회에 기여하고 있다. 대표적인 인공토굴중의 하나는 광천토굴이며, 마을뒤편 야산에 활석암으로 된 암반을 굴착한 토굴이다. 폭과 높이가 각각 2m 정도, 200여 m의 토굴 속에 수많은 젓갈을 담은 드럼통을 저장하여 숙성, 발효시킨다. 젓갈은 우리나라의 대표적인 수산발효식품이며, 어패류 등에 비교적 다량의 식염을 가해 자가소화효소 및 미생물분해 작용으로 알맞게 숙성되는 원리를 이용한다. 젓갈은 일종의 균 식품으로 식품을 발효시킴으로써 독특한 맛과 향 영양을 갖게 되며, 빵, 요구르트, 장류(간장 된장 등), 김치, 막걸리, 동동주, 식혜뿐 아니라 심지어는 버섯조차도 균 식품에 해당한다. 특히 어패류를 염장 발효시켜서 독특한 감칠맛이 나도록 한 우리나라 특유의 저장식품으로 예로부터 기호식품, 조미료 및 김치의 재료로서 널리 식용되어 왔던 양질의 단백질인 동시에 칼슘과 지방질 공급원이기도 하다. 최근에는 상품화된 자연친화적 농산물저장 굴로 사용되는 인공토굴도 등장하였다. 그것은 타공판과 흙을 이용한 생태환경지중건축물(生態環境地中建築物)로서 우리조상들이 오래전부터 지열을 이용하여 주거와 농산물을 저장하였던 재래식 토굴을 현대화시킨 구조물의 지중저장토굴 공간이다.

홍삼류의 섭취가 비만과 혈중 지질의 상호관계에 미치는 영향

박화진(Hwa-Jin Park),이정희(Jung-Hee Lee),이소진(Soh-Jin Lee),함혜선(Hye-Seon Ham),조현정(Hyun-Jeong Cho),임창률(Chang-Ryul Lim),유영빈(Young-Bin Yoo),박기현(Ki-Hyun Park) 대한의생명과학회 2000 Biomedical Science Letters Vol.6 No.4

비만은 동맥경화의 위험인자로서 혈중에 triglyceride의 농도를 증가시키고, 상대적으로 HDL-Cholesterol의 농도를 감소시킴과 동시에 수축기 혈압을 상승시킨다. 본 연구에서 홍삼제품류를 4년 또는 5년 동안 복용해 온 건강한 사람 (ginseng군)과 홍삼제품을 복용하지 않은 건강한 사람 (control군)을 대상으로 하여 신체 계측치로부터 비만지수를 구하고 이것과 혈중의 triglyceride (TG) 농도, TG/HDL-Cholesterol ratio 및 수축기 혈압과의 상호관계를 연구한 바, ginseng군에서는 대조군에 비해 혈중의 TG 농도가 일정하게 유지되었고, TG/HDL-Cholesterol ratio 및 수축기 혈압도 일정하게 유지되었다. 이러한 현상은 ginseng군에서 기호품으로 alcohol을 섭취하거나, 흡연을 한 경우에도 상관없이 일정하게 유지되었다. 이 결과는 홍삼제품류를 장기 복용하면 비만의 저하 및 고혈압 또는 동맥경화의 위험인자가 억제될 수 있고, 결론적으로 비만, 고혈압 및 동맥경화를 예방할 수 있을 것으로 추정한다. Obesity is the risk factor of atherosclerosis and not only increases triglyceride concentration in blood but also decreases relatively the ratio of TG to HDL-Cholesterol in blood. In case of obesity, systolic blood pressure is also increased in responding the increase of TG in blood. Index of obesity in red ginseng-taking group (ginseng group) was lower as compared with non-red ginseng-taking group (control group). The TG concentration, the ratio of triglyceride to HDL-cholesterol in blood and systolic blood pressure were decreased in the subjects of ginseng group compared with that in control group. It is inferred that long-term intake of ginseng products may help to prevent the risk of atherosclerosis and obesity.

Upregulation of Cytosolic NADP+-Dependent Isocitrate Dehydrogenase by Hyperglycemia Protects Renal Cells Against Oxidative Stress

Soh-Hyun Lee,Sun-Ok Ha,Ho-Jin Koh,김길수,Seon-Min Jeon,최명숙,권오신,허태린 한국분자세포생물학회 2010 Molecules and cells Vol.29 No.2

Hyperglycemia-induced oxidative stress is widely recog-nized as a key mediator in the pathogenesis of diabetic nephropathy, a complication of diabetes. We found that both expression and enzymatic activity of cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) were upregu-lated in the renal cortexes of diabetic rats and mice. Simi-larly, IDPc was induced in murine renal proximal tubular OK cells by high hyperglycemia, while it was abrogated by co-treatment with the antioxidant N-Acetyl-Cysteine (NAC). In OK cells, increased expression of IDPc by stable transfec-tion prevented hyperglycemia-mediated reactive oxygen species (ROS) production, subsequent cellular oxidative stress and extracellular matrix accumulation, whereas these processes were all stimulated by decreased IDPc expres-sion. In addition, production of NADPH and GSH in the cy-tosol was positively correlated with the expression level of IDPc in OK cells. These results together indicate that upregulation of IDPc in response to hyperglycemia might play an essential role in preventing the progression of dia-betic nephropathy, which is accompanied by ROS-induced cellular damage and fibrosis, by providing NADPH, the re-ducing equivalent needed for recycling reduced glutathione and low molecular weight antioxidant thiol proteins.

Poster Session : NO/ROS in Cell Signaling ; Regulation of cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) in diabetic nephropathy

( Soh Hyun Lee ),( Ha Na Kim ),( Dong Kyu Choi ),( Ho Jin Koh ),( Seung Hee Jo ),( Tae Lin Huh ) 한국생화학분자생물학회 (구 한국생화학회) 2007 생화학분자생물학회 춘계학술발표논문집 Vol.2007 No.-

上顎洞 根治手術時 篩骨洞 手術의 必要性에 對하여(第1報)

蘇鎭明,金吉原,金杜炫 대한이비인후과학회 1966 대한이비인후과학회지 두경부외과학 Vol.9 No.2

Celecoxib 유도체인 PCX-계열 화합물의 항염증 및 혈관신생 억제 작용

소지현,안은경,전혜진,임은주,박은희 숙명여자대학교 약학연구소 2005 약학논문집-숙명여자대학교 Vol.22 No.-

This study aimed to evaluate the pharmacological efficacies of PCX-series compounds, which were synthesized as prodrugs of celecoxib, a COX-2 selective inhibitor. Celecoxib, PCX-1, PCX-2, PCX-3, PCX-7, PCX-15 and PCX-16 provide potent anti-angiogenic activity in chorioallantoic membrane (CAM) assay. In addition, celecoxib, PCX-2, and PCX-16 showed anti-angiogenic activity in a dose-dependent manner. PCX-2 inhibited swelling in the carrageenan-induced rat paw edema test 24 hours after the administration. In the acetic acid-induced writhing test, PCX-7 and PCX-15 were verified to provide more potent analgesic effect than celecoxib 12 hours after the administration, and PCX-2 showed potent analgesic effect 24 hours after the administration. In the carrageenan-induced rat air pouch model, PCX-2 significantly decreased exudate volume, number of leukocyte and NO level. In the ulcerogenic activity test, PCX-2, PCX-7, PCX-15, and PCX-16 showed significantly less ulcer formation than indomethacin. Especially, PCX-7 showed the highest safety in the GI safety test. These findings provide novel pharmacological knowledge on pharmacological actions of celecoxib and its PCX-series compouds.

舌에 생긴 Neurilemmoma(Schwannoma)의 1例 : A Case Report

蘇鎭明,金吉原,金杜炫 대한이비인후과학회 1966 대한이비인후과학회지 두경부외과학 Vol.9 No.2