축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.

발열을 동반한 호중구감소증에서 Cefepime 단독투여와 Ceftazidime 및 Tobramycin 병합투여의 효능비교

정현욱,채제욱,강미라,양정채,문치숙,기현균,장현하,오원섭,김기현,백경란,이남용,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

목적 : 국내에서 발열을 동반한 호중구감소증이 있는 악성 종양환자에게 경험적 항생제로 베타락탐계 항생제와 아미노배당체의 병합요법의 사용이 일반적이다. Cefepime은 광범위 항균 작용을 가지고 있어, 그람 음성균 뿐만 아니라 그람 양성균에 대해서도 우수한 효과를 나타낸다. 재료 및 방법: 발열을 동반한 호중구감소증이 있는 악성 종양환자를 대상으로 무작위, 공개, 비교 연구를 시행하였다. 대상 환자를 무작위로 cefepime 단독요법군과 ceftazidime 및 tobramycin 병합요법군으로 나누어 투여하고 각각의 임상적 효능과 안전성을 비교하였다. 구강및 인후 점막염이 있는 환자에서 분리된 녹색 연쇄알 구균에 대한 항생제 내성 정도를 조사하였다. 결과 : 대상환자 89명 중 CA 투여군이 48예(53.9%), CT 투여군이 41예(46.1%)이었다. 발열의 유형별로 MDI는 18예(20.2%), CDI는 9예(10.1%), UF는 62예(69.7%)로 두 군 간에 차이가 없었다. CA 투여군과 CT 투여군의 임상적 호전률은 시험약 투여 후 2-4일째 각각 91.7%, 85.4% (P=0.31), 치료 종료 시 각각 91.7%, 100% (P=0.15)로 두 군간에 유의한 차이가 없었다. 치료 종료 시 CA 투여군과 CT 투여군의 세균학적 소실률은 모두 100%로 두 군간의 유의한 차이가 없었다(P=0.78). 점막염이 있는 환자로부터 녹색 연쇄알 구균이 분리된 경우는 25예(28.1%)이었으며, 분리된 녹색 연쇄알 구균은 penicillin, ceftriaxone, cefepime, vancomycin에 모두 감수성을 보였다. 약제 관련 이상 반응의 발생 빈도도 두 군간에 유의한 차이가 없었다. 결론 : 발열을 동반한 호중구감소증이 있는 악성 종양환자의 경험적 항생제로서 cefepime 단독요법은 ceftazidime 및 아미노배당체의 병합요법만큼 효과적이고 안전하였다. Background : Broad-spectrum antibiotic therapy has been recommended as an empirical regimen in cancer patients with febrile neutropenia. Cefepime is a fourth generation cephalosporin with good activity against both gram-positive cocci and gram-negative bacilli. Materials and Methods : To compare the efficacy and safety of cefepime alone with ceftazidime plus tobramycin as empirical regimen for adult cancer patients with febrile neutropenia, a randomized, open label, comparative trial was performed. If the patient showed clinical improvent 72 hours, antibiotic could be changed to oral ciprofloxacin. Clinical and microbiological responses were determined at 72 hours and at the end of therapy. To investigate the antimicrobial resistance of viridans streptococci, swab cultures were obtained from throat in all enrolled patients and antimicrobial susceptibility tests were performed by using microdilution method according to the NCCLS. Results : A total of 89 patients were enrolled. Forty-eight patients received cefepime alone (CA), and 41 patients received ceftazidime plus tobramycin (CT). Demographic and baseline clinical characteristics were similar in both groups (P>0.05). The initial clinical success rate at day 2-4 in group CA (91.7%) was similar with that in CT group (85.4%) (P=0.31). At the end of therapy, the final clinical success rate in CA group (91.7%) was similar to that in CT group (100%) (P=0.15). In 18 patients, with microbiologically defined infections, the eradication rate was 100% in both groups. Adverse events including liver dysfunction (21.3%) and renal dysfunction (2.2%), were similar in both groups (P=0.87). Viridans streptococci were isolated from the throat cultures in 25 cases, and all of these strains were susceptible to penicillin (MIC_(90) 0.12 ㎍/mL), cefepime (1 ㎍/mL), and vancomycin (0.12 ㎍/mL). Conclusion : Efficacy and safety of cefepime monotherapy was comparable to the combination of ceftazidime and tobramycin. It could be used as an alternative empirical regimen for treating cancer patients with febrile neutropenia.

원위 대퇴골의 고립성 골연골종에서 발생한 속발성 연골 육종 1례 보고

정필현,황장수,강석,김용민,오형호,채동주,김종필 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

연골육종은 비교적 서서히 자라며 늦게 전이하는 악성 연골 종양으로 알려져 있다. 골 연골종에서 발생한 속발성 연골육종은 발생빈도는 드물며 타부위로의 전이가 적고 악성도가 낮은 경우가 많아 적합한 수술적 치료로서 좋은 예후를 보이는 것으로 보고되고 있다. 본 동국대학교 정형외과학 교실에서는 우측 대퇴골 원위부 골간단부에 생긴 고립성 골 연골종에서 이차적으로 발생한 연골육종을 치험한 바 문헌고찰과 함께 보고하는 바이다. A case of Secondary Chondrosarcoma Arising from Solitary Osteochondroma of the Distal Femur Department of Orthopaedic Surgery, College of Medicine, DongGuk University Phil Hyun Chung M.D., Jung Su Hwang M.D., Suk Kang M.D., Yang Mln Kim M.D., Hyung Ho Oh M.D., Dong Ju Chae M.D., Jong Pil Kim M.D. Chondrpsarcoma is a malignant cartilage-forming tumor that grows slowly and metastasis of this tumor occurs in late stage. Secondary chondrosarcomas arising from a solitary osteocartilaginous exostosis are rare and those have a better prognosis than other chondrosarcomas, and they rarely metastasize. We present our experience with a case of secondary chondrpsarcoma arising in solitary osteochondroma of distal metaphysis of right femur with clinical details.

췌장염에 의한 가성낭종내에 생긴 가성동맥류 : 1례 보고

오연희,이채경,김승현,이성우,양창현,이정호,이영현 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

만성 췌장염의 합병증으로 생긴 가성동맥류는 드문질환으로, 반복적으로 다량의 출혈을 일으킬 수 있으며, 치료를 하지 않을 경우 사망율이 높기 때문에, 조기 진단과 치료가 필수적이다. 저자들은 38세 남자 환자에서 췌장염의 합병증으로 생긴 가성낭종내에서 발생한 가성동맥류 1예를 경험하였기에 보고하는 바이다. 가성 동맥류의 색혈류도플러상 낭종내에 양방향 흐름의 와류를 볼 수 있었다. Pancreatic Pseudoaneurysm within Pseudocyst from Pancreatitis: 1 Case Department of Diagnostic Radiology and Internal Medicine, College of Medicine,DongGuk University Yeon Hee OH M.D., Chae Kyeong Lee M.D., Seoung Hyeon Kim M.D., Sung Woo Lee M.D., Chang Heon Yang M.D., Jung Ho Lee M.D., Young Hyun Lee M.D. Pseudoaneurysm from pancreatitis is uncommon, but it can cause recurrent and massive hemorrhage. Because of high morbidity and mortality, early detection and treatment of the pseudoaneurysm is needed. We report a case of pseudoaneurysm within pseudocyst from pancreatitis. Color-flow Doppler sonography shows bidirectional flow and turbulent arterial flow, within anechoic mass.

실천적 추론 가정과 수업이 중학생의 도덕성에 미치는 효과

채정현,유태명,박미정,이지연 대한가정학회 2003 Human Ecology Research(HER) Vol.41 No.12

The purpose of thii study was to develop lesson plans and teaching materials applying practical reasoning instruction for the 7th home economics cuniculum content, and to test the effects of practical reasoning instruction on morality of middle school students. This study is a quasiaperimental research with a pretest-postkt &qn. Practical reasoning instruction for experimental group and traditionally lecture oriented insbuction for comparison group were input, and tested the statistical differences between two groups before and after the treatment. The subjects for this study were 8th grade students of a mi& school located in Kwangiu city. Two classes of 76 students homogeneous in characteristics and academic record for each experimental and comparison group were assigned. lnstnunent used for this study was a revised moral indicator, that was developed by KEDI(2001). Spss/wi for 10.0 statistics program was used for analysis of data. ANCOVA was done for testing statistical difference been pretest and posttest of experiment group and comparison group. Result of study which showed statistically significant difference between groups were: 1. V i e of responsibility for words and deeds (from 3.22 to 3.61 for experimental group and from 3.27 to 3.26 for comparison group) in domain of responsibility and cooperation, and virtue of punduality (from 3.59 to 3.76 for experimental group and from 3.41 to 3.28 for comparison group) in domain of trustworthiness, 2. V i e of conversation etiquette (from 3.47 to 3.67 for experimental group and from 3.28 to 3.31 for comparison group) in domain of caring for others, 3. Virtue of forgiveness other s mistakes (from 3.32 to 3.65 for experimental group and from 3.33 to 3.25 for comparison group) in domain of kindness, concession, forgiveness, and virtue of volunteering activity from 2.89 to 3.71 for experimental group and from 3.36 to 3.45 for comparison group) in domain of compassion and service, 4. Virtue of equip the convenient facility for handicapped (from 4.19 to 4.29 for experimental group and from 4.17 to 3.91 for comparison group) in domain of equality and human rights, virtue of recovering selfness for own community (from 2.34 to 2.79 for experimental group and from 2.14 to 2.29 for comparison group), virtue of opposing way of accomplishing purpose by all means (from 3.27 to 3.31 for experimental group and from 3.47 to 3.05 for comparison group), virtue of opposing election of considering aquaintance (from 3.35 to 3.56 for experimental group and from 3.12 to 3.14 for comparison group) in domain of fairness, and virtue of eradication of military force or violence among countries (from 3.49 to 3.57 for experimental group and from 3.38 to 3.05 for comparison group) in domain of love for humanity. The morality of experimental group was improved more than that of comparison group in all of above items. From the results of thii study, following conclusion was drawn. Practical reasoning insbudion in home economics is effective in raising students virtue and value of responsibility in words and deeds, trustworthiness in punctuality, courtesy of not intempting conversation, forgiveness of other s mistakes, volunteering activity, equity for handicapped, fairness opposing selfness for own community, fairness opposing way of accomplishing purpose by all means, fairness opposing election of considering acquaintance, and love for humanity opposing war.

CBAM 모형에 근거한 가정과 교사의 ICT 활용수업 평가 : 관심도와 실행 수준을 중심으로 on Concerns and Implementation

채정현,황선경 한국 가정과 교육 학회 2002 한국가정과교육학회지 Vol.14 No.2

This study was made on the concerns and implementation of the ICT(Inormation and Communication Technology)-utilized lesson by home economics teacher. The objective of this study is to investigate the stages of concern and the level of use of the ICT-utilized lesson by home economics teachers in Kyunggi Province through the concerns based adoption model(CBAM) and to provide assistance for ICT-utilizing lesson to be efficiently adopted to home economics. This study made selected 200 schools by random sampling among 23 middle schools which have two or more home economic teachers and 21 or more classes in Kyunggi Province which has a total of 395 middle schools and mail-surveyed on 400 home economics teachers by means of questionnaire. The stages of concern, the levels of use and the types of implementation were used as instruments in this survey. The results of this study on the stages of concern, the levels of use and the type of implementation of the ICT-utilized lesson by home economics teachers in Kyunggi Province were as following: First, the highest point of the concern of home economics teachers of ICT-utilized lesson was the stage of awareness, the second highest point was the stage of management, the 3rd stage, and the stage of information, the 1st stage. Second, the highest level of implementation of ICT-utilized lesson by home economics teachers was the level of mechanical use, the 3rd stage(30.4%), which followed by the level orientation, the 1st stage(22.5%), and the level of nonuse(16.7%), the level of rountine use, the 4th stage(13.7%), the level of integration, the 5th stage(11.8%), the level of preparation 2(3.9%), and the level of renewal, the 6th stage(1.0%). Third, information search was the most in the type of ICT-use and in the course of lesson CD-ROM was used the most.. During ICT-utilized lesson, most of teachers used computer one to two hours a week mainly in the lessons of clothing life and eating lift. Home economics teachers took the most training of how to use word-processor(68.6%) during computer education, and 60 teachers(66.0%) gave positive response about the effect of computer education on teacher's learning. Finally, the biggest problem with ICT-use in the teacher's learning was the long preparation time for lesson, and problem with ICT-utilized lesson was the burden of time and effort spent to buy needed materials and to recompose the existing materials for the lesson. Therefore, so as to adopt ICT-utilized lesson efficiently into school it is needed that active promotion for the lesson should be made to teachers, training teachers to raise their ability to use computer and various kinds of software should be expanded, ad school authorities' financial and administrative assistance should be given for the smooth proceeding of the lesson.

7차 교육과정에 의한 중학교 과학교과서간 비교 분석 : 1학년 생물단원을 중심으로 With Reference to Biology Part

채현정,조현욱,김종홍 順天大學校 師範大學 附屬 科學敎育硏究所 2002 科學과 敎育 Vol.10 No.-

The aim of this study was to compare and analyze seven textbooks of science scheduled to be used for the first graders of middle school according to the 7th curriculum. In the frequency of the organization of biological contents between 6th and 7th textbooks, average number of page was changed from 79 pages to 65 pages. In the analysis of the inquiry content, the total number of themes in seven kinds of textbook was 152 contents. The number of inquiry content in seven kinds of textbook was diverse. For the analysis of inquiry process dimension, observation (54%) and interpreting data (22%) were generally emphasized. Concerning the analysis of the inquiry activities, the percentage of inquiry activities presented experiment (55%). discussion (28%), and survey (0%), respectively. The experiment showed the largest percentage of inquiry activities.

영양사 유무에 따른 재가노인 급식서비스 제공기관의 실태 분석

정현영,양일선,채인숙,이해영 대한영양사협회 2004 대한영양사협회 학술지 Vol.10 No.2

The purposes of this study was to analyze the operational difference of foodservice center for homebound elderly by the presence of the dietitian. The questionnaire was developed to measure all variables for menu management and distributed to 103 meal service centers in charge of congregate meal service program and 57 centers for home-delivered meal service program. The data of 160 centers in charge of congregate meal service and home-delivered service centers were usable for analysis. Statistical data analysis was completed using the SAS 8.1 package program for descriptive analysis and chi-square test. Only 2 1.9% meal service centers had dietitians, what is more, they were not professionals who did menu management but foodservice managers, volunteers, cook or social workers. The current foodservice programs for the homebound elderly were operated without professional. In the part of menu management, dietitians were more actively involved in menu planning in the elderly foodservice center in the presence of the dietitians. The performance level of healthcare service was not significantly different, but the nutrition education in the elderly foodservice center with the dietitians was more frequently performed than that without the dietitians(p<0.05). In the food purchasing and food production management, the significant differences were shown that in the elderly foodservice centers in the presence of the dietitians, the proportion of the contract purchasing was significantly higher than that of direct purchasing(p<0.01). In food sanitaq management, the significant differences were not shown in the part of management of keeping meal for identifying the cause of food-borne illness and left-over, but the sanitation education for the foodservice employees was performed more frequently by the presence of the dietitians(p<0.01). In conclusion, the foodservice management was more systematically conducted in the elderly foodservice centers in the presence of the dietitians than that without dietitians. The elderly foodservice program has offered the health-related support for homebound elderly. Although there were several problems in elderly foodservice management, the program delivered well-targeted, effective, and efficient nutrition services and wide range of supportive service to the at-risk older population. It needs to be managed by professional for the improvement in the elderly foodservice.

과학고 및 영재고 Research and Education (R&E) 운영실태 분석 및 활성화방안 제안 : R&E 운영담당자 면담사례를 중심으로

정현철,류춘렬,채유정 韓國英才學會 2012 영재교육연구 Vol.22 No.2

The purpose of this study was to investigate the current status of R&E programs in gifted high schools/science high schools and to provide suggestions for the better program. The sample included 21 R&E coordinators in the gifted high schools and science high schools. They filled out the survey, asking about the R&E program; then, the researchers interviewed the coordinators based on the answers of the survey. The results are as follows: 1) The R&E guidelines and related materials were not enough to use. 2) At the planning step, students and the mentors received were provided a little information, such as ethical issues, students' information, the roles of mentors/ students, mentor's research interest areas and products, etc. 3) At the research step, 80% of the schools had the monitoring process but the details were not written and saved. 4) At the evaluation step, the rubric of the product evaluation existed; the rubric of performance process were established by half of the schools. 5) At the closing step, 100% of the schools had the final product materials; the results of the evaluation and the information of the mentors were saved by 2/3 and 1/3 of the schools, respectively. Discussions and suggestions were included for the better R&E programs. 본 연구에서는 R&E 프로그램의 운영지원현황 및 실태를 알아보기 위하여 R&E 운영단계를 준비-계획-실행-평가-종료 5단계로 구분하여 조사 및 분석이 이루어졌다. 총 18개 과학고와 3개 영재학교 R&E 운영담당자들이 본 연구에 참여하였다. 2010년 12월, 전수조사를 목적으로 각 학교에 설문지를 배포하였으며, R&E 운영담당자 21명(100%)이 설문에 응답하였다. 주요 결과는 다음과 같다. 첫 번째, 준비단계에서 학생의 R&E 수행지침은 적절히 이루어지지 않고 있었으며, 운영을 위해 참고할 수 있는 자료도 매우 부족한 것으로 나타났다. 두 번째, 계획 단계에서 지도자를 대상으로 윤리적인 문제, 참고자료, 학생배경 특성 등에 관한 안내가 적절히 이루어지지 않고 있었으며, 학생들에게 지도자의 의무와 역할, 연구정보 및 업적 등에 대한 정보제공이 충분히 이루어지지 않고 있었다. 세 번째, R&E 실행단계에서는 80%의 학교가 수행 점검을 실시하고 있었으나 세부적인 점검내용에 대한 기록은 이루어지지 않고 있었다. 네 번째, 평가단계에서 산출결과의 평가기준은 모든 학교가 갖추고 있었으나, 수행 과정에 대한 평가기준은 약 절반의 학교만 가지고 있었고, 평가비율에 발표내용과 결과보고서 비율이 높게 나타나 평가가 ‘결과’에 많은 비중을 두고 있는 것으로 나타났다. 마지막으로, 종료단계에 결과자료집은 100% 보관되고 있었으나 평가결과는 2/3 학교가, 그리고 지도교수 정보는 약 1/3의 학교만이 보관하고 있는 것으로 나타났으며, 학생관찰 내용 및 면담자료도 비교적 잘 보관되지 않는 것으로 나타났다. 이와 같은 결과를 바탕으로, 효과적인 R&E 프로그램 운영을 위한 운영개선 지원방안을 제시하였다.

흰 쥐에서 Olanzapine의 장간 재순환을 설명하기 위한 약동학적 모델

백현문,채정우,권광일 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

Abstract - Olanzapine is an atypical antipsychotic drug that is widely used for the treatment of schizophrenia and acute bipolar disorder. It had been reported that olanzapine was shown enterohepatic recirculation in rat and human. But pharmacokinetic model for enterohepatic recirculation of olanzapine had not been developed yet. In this study, we developed pharmacokinetic model for enterohepatic recirculation of olanzapine. 30mg/kg of olanzapine was administered to rats (n=7) by oral and plasma concentration of olanzapine was determined by HPLC-MS/MS(API2000). Noncompartmental analysis was done by WinNonlin and pharamcokinetic model was developed by NONMEM ver 7.2. Enterohepatic recirculation model was developed with two compartment including gall bladder compartment with mtime option and evaluation was done by visual predictive check(VPC) and bootstrap. As a result of VPC and bootstrap, our model was robust and parameter values were reliable. In conclusion, pharmacokinetic model for enterohepatic recirculation of olanzapine was successfully developed and evaluated. The model was appropriate to predict the plasma concentration of olanzapine in rat and may be useful to develop human model in further study.