C -11 및 F - 18 표지 콜린의 합성과 체내동태에 관한 연구

전권수,유국현,김상욱,임상무,홍성운,서용섭,양승대,안순혁,허민구 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.3

Objectives: Recently, [methyl-(11)^C]-(β-Hydroxyethyl)trimethylammonium ([(11)^C]choline) has been discovered to be a very effective tracer in imaging various human tumors using positron emission tomography. Because of the short half-life of C-11, it is very difficult to use in a routine imaging procedure and needs a frequent synthesis of [(11)^]choline. This can be supplemented by the substitution of [(11)^Ccholine with [methyS-18]fluorocholine. Here, we would like to report cell uptake and biodistribution of [(11)^Ccholine and [(18)^F]fluorocholine as a basic study. Methods [(11)^C]Choline was prepared by the treatment of [(11)^C]CHzI with N,N-dimethylaminoethanol and [18F]fluorocholine was synthesized from reaction of CHzBr[18F]F with N,N-dimethylaminoethanol. The radiochemical purity was checked by high performance liquid chromatography (HPLC). The biodistribution of [(11)^C]choline and [(18)^F]fluorocholine was determined in balb/c mouse at 5 min, 20 min, 40 min and 80 min. The cell uptake wa measured using glioma (9L) and colon adeocarcinoma (SW620). Results: The radiochemical purity was more than 98% after purification. In the liver, uptake did not change over time the uptake was 20/ID/g for [C]choline and 13%ID/g for [(18)^F]fluorocholine. In the kidney, radioactivity decreased over tirne the uptake was 15%1D/g for [(11)^Ccholine and 20%ID/g for [(18)^F]fluorocholine, 80 min post-injection. The cell uptake of [(11)^Ccholine was 4.93% for glioma (9L) and 18.69F for colon adenocarcinoma (SW620). For [(18)^F]fluorocholine, 1.77% for glioma (9L) and 2.77% for colon adenocarcinoma (SW620). Conclusion: [(11)^CCholine and [(18)^F]fluorocholine showed a different cell uptake tendency, depending on cancer cell line. (Korean J Nucl Med 200135:185-191)

지속성 외래복막투석 환자들의 예후에 영향을 미치는 요인들에 관한 고찰

권혁만,김찬덕,조지형,장민화,최혁준,이현철,박자용,박선희,김용림 대한신장학회 2004 대한신장학회잡지 Vol.23 No.2

중족골 단축증 일단계 신연술 : 증례 보고 A Case Report

민경대,권혁룡 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Congenital shortening of the matatarsal bone has both functional and cosmetic problems. The most widely used surgical correction techniques are either one-stage lengthening with intercalary bone graft or gradual lengthening by callotasis using external fixator. Authors present the case of 21-year-old female patient with brachymetatarsia who treated by one stage lengthening without bone graft or external fixator.

원광의대 부속 제 2병원 신경정신과 환자에 대한 통계적 고찰

박민철,김종주,박남진,오상우,권혁일,권영숙,박종호 圓光大學校 醫科學硏究所 1986 圓光醫科學 Vol.2 No.2

We examined 1,856 patients who visited Won Kwang Neuropsychiatric hospital since July 11 of 1984(since the hospital opened) until June 11 of 1986. We researched diagnostic and other distributions of inpatients and outpatients. The study revealed as follows : 1. Of total patients males visited this hospital more than females as 52.7%. Most of them(67.1 %) resided in Iri, Iksan and Kimje. In the point of insurance, insured patients and uninsured patients except medicaids were 73 %. Males(60%) were more insured medically than females (55.4%). While insured patients relatively resided in urban area, but uninsured patients except medicaids did in rural area. 2. Of outpatients neurotic disorder was the most as 35.1%, secondly schizophrenic disorder and thirdly affective disorder, but of inpatients schizophrenic disorder was the most as 41.4%, secondly neurotic disorder thirdly affective disorder. 3. Alcohol abuse (98.2 %), paranoid disorder, convulsive disorder and child mental disorder were mostly found in males, but neurotic disorder (59 .6 %), affective disorder and other psychotic disorder were mostly found in females. 4. In unmarried ones schizophrenic disorder ( 43 .6 %), neurotic disorder, other psychotic disorder were common, but in married ones neurotic disorder (55.1 %), schizophrenic disorder, affective disorder were common. 5. On the distribution of age schizophrenic disorder was found the most in the twenties (28.4 %), next in the thirties and in the forties, but neurotic disorder was found the most in the thirties, next in the twenties and in the forties. 6. On the distribution of age at onset schizophrenic disorder develops mostly during the twenties (45.5 %), secondly during the teens and thirdly during the thirties, but neurotic disorder develops mostly during the thirties and the twenties (53.1 %). 7. On the duration of hospitalization 34.4% of the patients was hospitalized during less than 15 days, 22.0% during 60-90 days and 80.4% during less than 3 months. 8. In the result of treatment 41.2% of the patients was improved and 31.7% a little improved. In total 72.9% of the patients got helped therapeutically.

Tacrolimus의 LC/MS 분석과 지원자에 대한 약물동태 연구

윤민혁,이서판,남진경,권광일 忠南大學校 生命科學硏究院 醫藥品開發硏究所 2006 藥學論文集 Vol.21 No.-

The purpose of this study was to confirm the analysis method and also to estimate the pharmacokinetic parameters of tacrolimus in human volunteers. The pharmacokinetics of tacrolimus tablet was examined on 24 healthy volunteers who received a single oral dose(4mg) of each preparation in the fasting state. After an oral dosing, blood samples were collected for a period of 72 hours. Blood concentrations of tacrolimus were determined using a liquid chromatographic electrospray mass spectrometric (LC-MS) method. The pharmacokinetic parameters were calculated with non-compartmental(AUC, C_(max), T_(max), Cl_(t), V/F) and compartmental(K_(el), K_(a), K_(12), K_(21), t_(1/2)) pharmacokinetic analysis using WinNonlin program. The estimated means of AUC_(0-72hours), C_(max) and T_(max) were 425.54 ± 197.49 ng·hr/ml, 76.14 ± 29.18 ng/ml and 1.40 ± 0.44 hr, respectively. The means of other pharmacokinetic parameters(V/F, CL_(t), K_(el), K_(a), K_(23), K_(32) and t_(1/2)) were 35.12 ± 34.28 L, 10.45 ± 5.32 L/hr, 0.39 ± 0.21 hr^(-1), 1.91 ± 4.17 hr^(-1), 0.32 ± 0.33 hr^(-1), 0.07 ± 0.09 hr^(-1), 26.94 ± 10.19 hr^(-1), respectively.

산도변화와 침지시간이 광중합 복합레진의 잔류단량체 유출에 미치는 영향

전철민,유현미,권혁춘 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.3

Objectives : The purpose of this study was to determine whether pH and time has any influence on the degradation behavior of composite restoration by analyzing the leached monomers of dental composites qualitatively and quantitatively after storage in acetate buffer solution as a function of time using high performance liquid chromatography (HPLC) / mass spectrometer. Materials and Methods : Three commercial composite restorative resin materials (Z-250, Heliomolar and Aeliteflo) with different matrix structure and filler composition were studied. Thirty specimens (7 ㎜ diameter × 2 ㎜ thick) of each material were prepared. The cured materials were stored in acetate buffer solution at different pH (4, 7) for 1, 7 and 45days. As a reference, samples of unpolymerized composite materials of each product were treated with methanol (10 mg/ml). Identification of the various compounds was achieved by comparison of their mass spectra with those of reference compound, with literature data, and by their fragmentation patterns. Data were analysed statistically using ANOVA and Duncan's test. Results : 1. Amounts of leached TEGDMA in Aeliteflo were significantly larger than those of UDMA in Z-250 and Heliomolar at experimental conditions of different storage time and pH variation (p<0.001). 2. As to comparison of the amounts of leached monomers per sorage time, amounts of leached TEGDMA in Aeliteflo and UDMA in 2-250 and Heliomolar were increased in the pH 4 solution more significantly than in the pH 7 solution after 1day, 7days and 45days. respectively (p<0.001). 3. In total amounts of all the leached monomers with storage times, the overall amounts of pH 4 extracts were larger than those of pH 7 extracts for all resin groups, but there was no significant difference (p >0.05).

정신질환자 수용시설환자의 정신과적 입원치료 경험 유무에 따른 비교연구

박민철,오상우,권혁일,박남진,김종주 圓光大學校 醫科學硏究所 1986 圓光醫科學 Vol.2 No.2

We have visited the asylums in Chollapukdo for two months since March of 1985. We conducted a comparative study between the patients who has been previously hospitalized and who has not been hospitalized for psychiatric problems. We individually interviewed 489 patients using the interview schedule. The results are shown as follows: 1. The group who were young, single and highly educated have been more hospitalized than the groups who were old, married and little educated. However, no significant difference was made by sex and districts. 2. The group who lived alone or were deserted from the family has been rarely hospitalized. 3. The group, who has been entered the asylum by the family or who explained the reason as treatment, has been more hospitalized previously than the group entered by the others or who said that they came due to alcohol. 4. While the group who has been hospitalized showed tendency to accept having their psychiatric disorders, but the group who has not been hospitalized showed tendency to deny having their disorders. 5. The group who named their disorders psychoses or schizophrenia has been more hospitalized than the group who named them alcoholics. 6. The group hospitalized previously has been also treated in other ways besides psychiatric treatment, and chronic patients with the duration of more than three years has been relatively hospitalized previously. 7. While the group who has been previously hospitalized was relatively indicated for hospitalization, but the other group was not relatively indicated.

한국과 프랑스 음식문화에서 마늘 이용에 관한 문헌적 고찰

신민자,권혁련 동아시아식생활학회 2001 동아시아식생활학회지 Vol.11 No.5

This treatise deals mainly with the culinary cultures of garlics, a very important condiment in Korea and France. Classified specifically as a condiment in the category of spices, garlic(A, sativum L.) is typically used to season a wide variety of foods, to give the dishes to add a pungent and pleasant flavor, highly characteristic of the delicate seasoning styles of Korean and French cuisine. Garlic is also known to be used as an invigorant, used for medicinal and mystical purposes. In both Korea and France, garlic is used in fresh state, sliced, diced, or crushed. Some examples of traditional Korean dishes using garlic is Tongmaneul Jangachi(garlic in a whole bulb, seasoned in soy sauce). alcoholic liquor of garlic, and red pepper paste with garlic. French cuisine includes garlic in sauces such as Aillade, Vinairette a l'alil, Sauce Pailloti, and in a variety of salads and Cruton, mixed with the local vegetables of every province of the country.

자세변화에 대한 뇌성마비아동(경직성 양마비)의 손 기능 차이 비교와 제변수와의 상관관계의 연구

정민예,구애련,권혁철 한국전문물리치료학회 1996 한국전문물리치료학회지 Vol.3 No.3

수정된 강제유도 운동치료가 뇌졸중 환자의 일상생활활동과 삶의 질에 미치는 영향

이종민,김환,조영남,권혁철 대구대학교 특수교육재활과학연구소 2012 再活科學硏究 Vol.30 No.1

본 연구는 수정된 강제유도 운동치료가 뇌졸중 환자의 일상생활활동 및 삶의 질에 미치는 영향을 알아보고자 하였다. 방법 : 뇌졸중 진단을 받은 환자 30명을 대상으로 실험군 15명과 대조군 15명으로 나누어, 치료 중재 전․후 일상생활활동 수행능력과 삶 의 질을 비교하였다. 결과 : 실험군과 대조군의 치료 중재 전․후 뇌졸중 환자의 일상 생활활동 수행능력과 삶의 질은 통계학적으로 유의한 차이를 보였고, 실험군이 대조군에 비해 통계학적으로 유의하게 일상생활활동 수행능력과 삶의 질이 향상되었다. 그리고 일상생활활동 수행능력과 삶의 질은 통계학적으로 유의한 상관관계를 보였다. 결론 : 작업치료와 더불어 수정된 강제유도 운동치료를 적용할 때 뇌졸중 환자의 일상생활 활동 수행능력과 삶의 질을 향상시키고, 일상생활활동 수행능력이 삶의 질에 영향을 미친다는 것을 알 수 있었다. The purpose of this study was to investigate the effect of modified constraint induced movement therapy(mCIMT) on activities of daily living(ADL) and quality of life(QOL) for patients with stroke. Methods : Thirty subjects were randomly allocated into two groups: mCIMT, an experimental group(n=15) and traditional occupational therapy group, a control group(n=15). Both groups also received the usual occupational therapy after the first intervention. The ADL performance ability of both groups was assessed using Motor Activity Log(MAL) and QOL was assessed by Stroke Specific Quality of Life(SS-QOL). Results : ADL performance ability had a meaningful increase statistically for both groups. QOL also had a meaningful increase statistically for both groups. ADL performance ability showed statistically significant correlations with QOL. Conclusion : It was found that carrying out mCIMT with occupational therapy has an effect on ADL performance ability and QOL of patients with stroke. It was also found that ADL performance ability influences QOL.