확대 영상의 해상도 향상에 관한 연구

강길봉,김장형,김정효 제주대학교 공과대학 첨단기술연구소 2004 尖端技術硏究所論文集 Vol.15 No.1

Generally, the still image magnification uses image growing, interpolation and restoration in order to get magnificated image. Still image Magnification does not get high-resolution image because, amount of information is not sufficient. In this thesis, we proposed the hybrid method of high resolution image magnification. that is, to get high resolution image, the image processed by both lowpass filtering and highboost filtering. Result of apply proposed method to Lena image, we gained result of enhancement more better than formerly simple technique.

셀레콕시브 및 그 합성유도체들의 항암활성 스크리닝

박정란,강진형,구효정,노지영,류형철,박상욱,고동현,조일환,이주영,황다니엘,김인경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

Selective COX (cyclooxygenase)-2 inhibitors including celecoxib have been shown to induce apoptosis and cell cycle changes in various tumor cells. New inhibitors are recently being developed as chemomodulating agents. We evaluated celecoxib and screened 150 synthetic compounds for anti-proliferative activities in vitro. Effects of celecoxib on COX activity, cell growth, cell cycle distribution, and apoptosis induction were determined in A549 COX-2 overexpressing human non-small cell lung cancer (NSCLC) cells. The COX inhibition of celecoxib increased with concentration up to 82% at 1μM after 24 hr exposure. Forty μM and 50μM of celecoxib induce G_1 arrest, and TUNEL-positive apoptotic cells, respectively. Among 150 compounds, several compounds were selected for having greater COX-2 inhibitory activity and higher selectivity than celecoxib with growth inhibitory activity. Celecoxib showed concentration-dependent COX inhibitory activity, and ability to induce cell cycle arrest and apoptosis in human NSCLC cells in vitro. Among synthetic analogues screened, several compounds showed promising in vitro activity as COX-2 inhibitory anticancer agents, which warrant further evaluation in vitro and in vivo.

전북지방 젖소의 유방염 검색

조정곤,김종면,최민순,채효석,강명대,송희종 全北大學校 附設 畜産開發硏究所 1987 畜産開發硏究報告 Vol.1 No.-

A total of 444 quarters milk samples of 111 dairy cattle in Chonbuk area were examined for infection rete and causative agents of mastitis by "the laboratory procedures used in the Connecticut Mastitis Control Program (CMCP) and California mastitis Test (CMT)". The results obtained were as follows: 1. Of 444 samples, 39.2% had positive CMCP value and 24.4% positive CMT reaction. 2. One hendred and seventy four (39.2%) from 82 cattle (73.9%) were found to infected with mastitis. It was found that 8(1.8%0 of the infected quarters were clinical mastitis and all of the rest were subclinical mastitis. 3. The main causative agents were found to Staphylococcus aureus (63 quarters), Streptococcus agalactiae (56 quarters), non-Str. agalactiae streptococci (54 querters), Escherichia coli (19 quaters), the actual total number of quarters detected as mastitis would be 174, as 18 of these quarters showed multiple infection with two different organisms. 4. Having examined the number of infection quarter per head of mastitis in dairy cattle sampling, major finding were that the average number of infection quarters to total dairy cattle exemined was 1.57 quarters, and that of the infected cattle was 2.1 quarters. Infected quarters in cattle with 1, 2, 3 and 4 were noted 27(32.9%), 28(34.1%), 17(20.7%), and 10(12.3%), respectively.

수영장 소비자들의 사회성 수용과 생활만족의 관계

임효택,정명수,김철주,이강욱,유충완 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.4

The purpose of the present study is to investigate and analyze effects of aerobic dance training on housewives' life satisfaction. 270 subjects were selected from members at aerobic dance clubs in Kwangju. A questionnaire was used to collect the data. The data were analyzed with SAS 6.12 statistics package. The findings of the study were : 1. 65% of the subjects participated in the aerobic dance activities 4~5 days a week while 18.3% of the subjects participated every day. 2. 67.4% of the subjects participated in the aerobic dance activities for 30~50 minutes and monthly mean expenses were 30,000~50,000 won(56.1%). 3. In comparison of the housewives' general characteristics with the motive of participation in the aerobic dance activities, there were no significant differences. 4. According to the subjects's jobs, there were significant differences in the motive of participation. Especially, employees for management and administration had higher motive of participation(3.644). 5. In comparison of life satisfaction with the aerobic dance activities, all parameters(duration, periods, degree and existence of the activities) were related with the life satisfaction. 6. In case of participation for more than 5 years, more life satisfaction was observed.

간세포암의 크기와 알파 피토프로틴의 연관성

임효순,정용연,김재규,윤웅,강형근,박진균 全南大醫大 2001 전남의대학술지 Vol.37 No.4

플라보노이드의 세포 신호전달 조절

이응룡,강근호,강용진,김우열,최혜연,김봉우,정효순,조쌍구 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

Many studies revealed the neuroprotective, cardioprotective, and chemopreventive actions of dietary flavonoids. The plausible mechanistic interpretation of the various effects of flavonoids was concentrated on the anti-oxidant or free radical-scavenging properties of these phytochernicals, both in model systems and under in vivo conditions. While there has been a major focus on the anti-oxidant properties. there is an emerging view that flavonoids and their in vivo metabolites. do not act as conventional hydrogen-donating anti-oxidants. but they may exert regulatory functions in cells through actions at protein kinase or lipid kinase signaling pathways. Flavonoids and more recently their metabolites. have been reported to act at phosphoinositide 3-kinase(PI 3-kinase). Akt/protein kinase B(Akt/PKB), protein kinase C (PKC), mitogen activated protein kinase(MAP kinase), and various tyrosine kinases signaling cascades. Inhibitory or stimulatory actions at these pathways are likely to affect cellular function profoundly by altering the phosphorylation state of target molecules and by modulating gene expression. A clear understanding of the mechanisms of action of flavonoids, either as anti-oxidants or modulators of cellular signaling pathways, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anti-cancer agents, cardio-protectants, and inhibitors of neurodegeneration.

소아에서 Fogarty 카테터를 이용한 일측폐 환기 마취 경험

유수봉,강효석,임지훈,김두식,류시정 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Thoracic surgery may be greatly facilitated by causing selective atelectasis of the lung being operated on (one-lung ventilation anesthesia). But the tube used for one-lung ventilation is greater outer diameter than conventional endotracheal tube when compare to each other with same inner diameter, so in some young children it is impossible to one-lung ventilation using double lumen tube or bronchial blocker tube because of narrow vocal cord. We performed one lung ventilation anesthesia using conventional endotracheal tube and Fogarty catheter as a bronchial blocker in 11-year old women who received lung biopsy surgery and left lower lobectomy.

흰쥐 생체시료 중 5-플루오로우라실 및 테가푸르의 안정성

장지현,박종국,강진형,정석재,심창구,구효정 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.3

5-Fluorouracil (5-FU) is an antimetabolite anticancer agent active against many types of solid tumors. Tegafur (TF), a prodrug of 5-FU, is frequently used in combination with uracil as dihydropyrimidine dehydrogenase (DPD) inhibitory fluoropyrimidine. We studied the stability of 5-FU and TF in biological fluids of rats and determined their bioavailability (BA) and excretion into bile, and urine. The drug concentrations were analyzed by an HPLC method. At room temperature, there was a 14-30% decrease in the concentration of 5-FU and TF in bile, urine, and plasma specimen at 10 and 100 μg/ml over 240 min. No significant difference was noted among the sample types or between two different concentrations of 10 and 100 μg/ml. The decrease in drug concentration was significantly less in samples kept on ice (6-12%) for both drugs. These data indicate that biological fluid samples containing 5-FU or TF in plasma, urine, or bile should be placed on ice during the sample collection. Following these storage guidelines, samples were collected after administration 50 ㎎/㎏ of each drug via i.v. or oral route. BA was 1.5 folds greater for TF (60%) than that of 5-FU (42%). Approximately 0.52 and 3.3% of the i.v. doses of 5-FU and TF was excreted into bile, respectively. Renal clearance of 5-FU was about 16% of its total body clearance. These results suggest that instability of 5-FU and TF in biological fluids should be considered in pharmacokinetic or pharmacogenomic studies.

마이크로 그루브 가공의 특성 평가

권동희,박진효,김정석,김병민,정융호,강명창 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

As demands for micro parts are on the increase in recent industries such as aerospace, biomedical, electronics, environment, information technology and display, the need for manufacturing such parts is also increasing. Major methods of manufacturing micro parts are based on semiconductor process technology such as lithography and etching and non-traditional machining using lasers, ultrasonic, ion-beams or electrical discharge. However, these methods require lots of time, workpiece materials are limited, and such methods are only applicable to the machining of two-dimensional shapes. Therefore, mechanical machining methods are required for the manufacturing of micro parts with complex shapes. This paper presents an investigation on the characteristics for micro groove machining by using the ultrahigh-speed air turbine spindle, and verifies the properties of mechanical method in fabricating molds for micro barrier ribs. As a result, the optimal machining condition could be found from the investigation of surface roughness according to the kinds of burr shapes in the fabricating of iron mold by using micro endmill.

Inhibitory Effect of Cordycepin on Human Platelet Aggregation

박화진,--,--,--,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.1

Cordycepin separated from Cordyceps militaris is a major physiologic active component in Cordyceps militaris. The platelet aggregation is stimulated by Ca^(2+), which is either mobilized from intracellular endoplasmic reticulum or transported from extracellular space. cGMP antagonizes the actions of Ca^(2+). Based on these facts, we have investigated the effects of cordycepin on the mobilization of Ca^(2+) and the production of cGMP on collagen (10 ㎍/ml)-induced human platelet aggregation. Cordycepin potently stimulated the human platelet aggregation induced by collagen (10 ㎍/ml) in a dose-dependent manner. Cordycepin (500 μM) inhibited also the collagen-induced human platelet aggregation in the presence both 1 mM and 2 mM of CaCl_(2). These are in accord with the results that cordycepin inhibited the Ca^(2+)-influx on collagen-induced human platelet aggregation. These results suggest that cordycepin decrease the intracellular Ca^(2+) concentration to inhibit collagen-induced human platelet aggregation. Besides, cordycepin increased the level of cGMP on collagen-induced human platelet aggregation. This result is related with the decrease of intracellular Ca^(2+) concentration, because cGMP inhibits the mobilization of Ca^(2+). In addition, cordycepin inhibited the human platelet aggregation induced by LY-83583, inhibitor of guanylate cyclase. This result suggested that cordycepin inhibit the platelet aggregation by stimulating the activity of guanylate cyclase. In conclusion, we demonstrated that cordycepin might have the antiplatelet function by inhibiting Ca^(2+)-mobilization via the stimulation of the production of cGMP.