유방의 양성 및 악성질환에서 bcl-2의 표출

황호현,김대중,김의한,양승하 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

Breast carcinoma is common malignant tumor in korea and many oncogens have been found in tumor cells. bcl-2 prevent apoptosis and located in mitochondria, endoplasmic reticulum, and nuclear membrane. To evaluate the expression of bcl-2 according to histopathologic features and the relation between bcl-2 and prognosis in breast carcinoma, we have performed immunohistochemical staining, using mouse anti-bcl-2, for 27 cases of benign disease and 49 cases of breast carcinoma. The results were as follows; 1) The expression rates were 77.9% in benign disease and 55.1% in breast carcinoma. 2) In benign disease, expression rate of fibroadenoma, atypical ductal hyperplasia, and intraductal papilloma were 85.7%, respectively, and adenosis 50%, tubular adenoma 0%, and lactating adenosis 100%. But there were no significant difference. 3) In breast carcinoma, expression rate of ductal carcinoma in situ was 100%(3/3) and infiltrating carcinoma 52.2%(24/46), but there were no significant difference. 4) Expression rate of bcl-2 according to histologic grade on breast carcinoma was 68.8% of grade Ⅰ, 54.2% of grade Ⅱ, and 33.3% of grade without significant difference. Expression rate of lymph node metastatic cases was 43.8% and non-metastatic cases 66.8% without significant differnece. Above results showed that bcl-2 expression in breast carcinoma may be related to good prognosis of patients. But further continued study should be followed with more cases.

밀턴의 한계 : 그의 사상과 신학을 중심으로

黃晧順 서울市立大學校 1994 論文集 Vol.28 No.-

After surveying the doctrine of accommondation, the Platonic theory of Ideas (dualism), and Christian humanism which can be traced in his imagery of light, they are of some help to conclude that Milton's theoretic philosophy and theology have had much to do with his poetic techniques and imagery in describing his invisible worlds and background, fulfilling his planned hopes along with his reader's expectations. As some critics thought of Milton's hopes as impossible, Milton himself agreed to their ideas to some extent that the heavenly characters or events are very unrealistic and nearly impossible to describe and therefore it is better to leave them alone, unexpressed but Milton didn't succumb himself to the difficulties nearly all human beings would like to avoid or deny. He managed to overcome those impossible difficulties through the aids of various strands of philosophy and literary theory, which correspond and reinforce one another to a remarkable extent in practising his poetic techniques. All of the theoretic aspects provide a foundation for a portrayal of transcendental or supernatural characters, events, and even the heavenly wars in physical, human terms. At the same time, they do not minimize the very real differnece between the visible and invisible worlds, and they show that the transcendental vision or otherness is, in important ways, not directly accessible to human experience. An awareness of the theoretic background is helpful not only in establishing theoretic ideas with which Milton composed his Paradise Lost and with which the reader of his generation interpreted the poem, but also in suggesting profitable critical approaches to Paradise Lost for modern readers. The theoretic background broadens expectations or possibility and fruits of his success which the poem accomplishes.

John Milton: Paradise Regain'd의 등장인물 고찰

황호순 서울市立大學校 1988 論文集 Vol.22 No.-

Milton's Satan in Faradise Regan'd in not a man of flesh and blood ; he is a fallen angel and captain of devils. On the other hand Christ is, in every respect, a human being of common sense to those who are reading Paradise Regain'd. In Milton's Paradise Lost Adam as a representative human being was defeated by Satan's subtle guile and lost paradise while in Paradise Regain's Christ as our second Adam defeating Satan in all the temptations Christ recovers paradise. Both characters, Satan and Christ, are well versed in the Bible. They are fighting not with swords but with words from the Bible but in every encounters, the three temptation, Christ defeats Satan. Many critics say Christ's power has grown gradually through meeting with Satan but Milton seems to remind us, the readers, that Christ's power is from God the Father and was given at His baptism at which a voice from heaven proclaims "This my heloved Son in whom I am well pleased " and the Holy Spirt like adove eame like a dove came upon Christ. Milton's Satan is described as self-centered ;that is the world, the flesh, the devil while Christ is doing nothing with His own decision or resolution. He is alway's 'awaiting for God's words and his whole victory over Satan is ascribed to His total dependence upon God, the Father and upon the guidance of the Holy Spirit. Some critics trace evidences that Milton's ideas about the Holy Spirit and flesh, the devil have been framed through the influences from the Reformers, Calvin and Luther but the writer of this thesis insists rather that Milton's ideas about the Holy spirit promptings are from the Bible and his own Spirit. Since Milton invokes the Holy Spirit 8 times in the beginning 100 lines of paradise Regain'd, the same poem seems to charge our dependence upon the Holy Spirit in reading his poem, In other words Milton not only kept his consistency in grasping the power of Christ is from God but Milton himself is making it clear that any reader who hopes to understand and appreciate his poem must be led and prompted every moment by the Holy Spirit.

한국산 호박의 Carotenoid 색소

황혜정,박용곤,석호문 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.5

우리나라 늙은 호박의 carotenoid함량을 확인하기 위하여 silica gel column chromatography, HPLC 및 분광광도법을 행하였다. 부위 별 호박의 총카로테노이드 함량은 내부섬유상 물질이 65.33㎎%로 호박 총카로테노이드의 87%를 차지하였고, 과육, 껍질은 6.61, 3.31㎎%였다. Sllica gel column chromatography 결과 2개 의 피크로 분리되었고 이 중 피크 Ⅱ는 염산반응시 청색을 나타내어 epoxide 기를 함유하는 그룹으로 나타났으며 피크 Ⅰ은 hydrocarbon 그룹으로 판명되었다. 호박 색소액을 HPLC로 분리, 정량한 결과 β-carotene과 α-carotene이 주된 성분으로서 껍질과 과육부위는 유사한 조성비를 나타내었으나 섬유상은 β-carotene이 64.5%로 이들 부위보다 1.6배나 높았고, 또한 섬유상 부위는 다른 부위에서 다량(27.3∼32.8%)존재하는 미확인 성분의 함량이 극히 낮았다. In order to qualify and quantify carotenoid pigment of pumpukin were analyzed by HPLC, column chromatography and spectrophotometry. Eightyseven percent of total carotenoids in the pumpkin was in the fiber amounting 65.33㎎%, however flesh and skin contained 6.61 and 3.3l㎎%, respectively. A silica gel column chromatography of the carotenoids produced 2 different peaks. The components eluted in peak Ⅱ showed blue color when treated with hydrochloric acid. The fact suggested it contained epoxide and the component in peak Ⅱ was a monol. By the separation with HPLC, α and β -carotene were the major compounds in the carotenoids. In fiber the total β-carotene content was 1.6 times higher than in the flesh and skin. The fiber contained less unidentified compounds than other part which contained 27.3∼32.8%

영역기반 이미지 검색 시스템 설계 및 구현

정호영,황환규 강원대학교 정보통신연구소 2001 정보통신논문지 Vol.5 No.-

In the real world, natural scenes are rich in color and texture. It is known to be difficult to identify image regions containing the same color-texture pattern in natural scenes. In this paper, we propos a new approach to designing a region-based image retrieval. First, colors in the image are quantized to serveral representing classes that can be used to differentiate edge in the image. We get an gray level edge image with Fisher's multi-class linear discriminant, make a binary image using a local threshold value, find a snapped edge, and then link to the nearest edge. Finally, we can get the last segmentation image by merging similar regions. In addition, we implement the region-based image retrieval system using that algorithm.

방향성 특징을 이용한 이미지 검색

정호영,황환규 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.B

For efficient massive image retrieval, an image retrieval requires that several important objectives are satisfied, namely: automated extraction of features, efficient indexing and effective retrieval. In this work, we present a technique for extracting the 4-dimension directional feature. By directional detail, we imply strong directional activity in the horizontal, vertical and diagonal direction present in region of the image texture. This directional information also present smoothness of region. The 4-dimension feature is only indexed in the 4-D space so that complex high-dimensional indexing can be avoided.

Growth Characteristics and Productivity of Italian Ryegrass (Lolium multiflorum Lam.) New Variety, 'Green Call 2ho'

Ji, Hee Chung,Whang, Tae Young,Lee, Ki-Won,Kim, Won Ho,Woo, Jae Hoon,Hong, Ki Hung,Choe, Kuh Wann The Korean Society of Grassland and Forage Science 2019 한국초지조사료학회지 Vol.39 No.3

This experiment was conducted to breed a very early maturing variety of Italian ryegrass (Lolium multiflorum Lam.) in Grassland and Forage Crops Division, National Institute of Animal Science, RDA, Cheonan 2015-2017. The new variety of Italian ryegrass, 'Green call 2ho' is a diploid variety with green in leaf color and has semi-erect growth habit in late autumn and erect growth habit in early spring, 'Green call 2ho' was in heading date as a early-maturing variety April 24. Also 'Green call 2ho' was narrower by 2 mm in flag leaf width, longer by 2.5 cm in flag leaf length and shorter by 3 cm in plant height than those of the control variety, 'Florida 80', respectively. 'Green call 2ho' was also thicker by 0.33 mm in stem thickness and strong in winter hardness. Dry matter (DM) yield (11,688 kg/ha) of 'Green call 2ho' was 7% higher than that of 'Florida 80'. Total digestible nutrient (TDN), crude protein (CP) and relative feed value (RFV) of 'Green call 2ho' were 61.3 %, 9.8 % and 98.2, respectively which are 2.6, 0.6, and 8.4 % higher, respectively than those of 'Florida 80', respectively. Acid detergent fiber (ADF) and neutral detergent fiber (NDF) of 'Green call 2ho' were 34.9 and 58.5 % which are 3.3 and 2.7 % lower than those of 'Florida 80', respectively.

A Study on Caliration of Neutron Moisture Gauge Using MCNP4A

Whang, Joo-Ho,Lim, Chun-Il,Song, Jung-Ho 대한방사선 방어학회 1997 방사선방어학회지 Vol.22 No.4

중성자 수분함량 측정기의 개발에 있어서 중성자 계측값과 흙속의 수분함량에 대한 관계식을 유도하기 위해서는 공시체 제작등의 많은 실험을 통해 유도한 교정식이 필요하다. 또한 공시체 제작 및 측정실험의 통계적 오차를 줄이기 위해서는 많은 시간과 노력이 필요하다. 하지만 몬테카를로방법을 사용한 전산코드를 이용하여 수행할 경우 시간과 노력을 줄일 수 있을 뿐만아니라, 보다 일반적인 흙에 대한 교정식을 얻을 수 있다. 본 연구에서는 중성자의 수송문제를 계산하는데 유용한 MCNP4A 전산코드를 이용하여 실제 실험을 모사하였다. 또한 모사결과를 공시체를 제작하여 실험한 결과와 비교하였다. 비교결과 실제실험의 결과와 모사 범위내에서 일치함을 알 수 있었다. 중성자 수분함량 측정기의 교정식 도출 및 교정상수를 결정하기 위해 적용할 수 있음을 알 수 있었다. 또한 수분함량 측정기의 계측값에 영향을 미치는 인자중의 하나인 흙의 건조밀도 변화에 대한 영향을 살펴 보았다. Time-consuming experiments have been required in the development of neutron moisture gauge to induce a relation between the water content in soil and the neutron counts. Applying a monte carlo computer code to simulate the experiments of neutron moisture gauging may contribute to redue time and efforts for experiments and produce a calibration equation which is more applicable to soil in general. In this study MCNP4A, a monte carlo computer code, was employed to simulate soil experiments and the simulated results were compared with experimental ones. The comparative study showed that MCNP4A is applicable to simulate the experiments and calibration equation can be obtained through simulations. Effects of dry density changes were also studied.

Study on the Improvement of Indirect Intra-Oral Dental Digital X-ray Image Sensor with Optical Coupling

Whang, Joo-Ho,Chung, Jin-Bum,Kim, Tae-Woo Korean Nuclear Society 2001 Nuclear Engineering and Technology Vol.33 No.5

Optimum characteristics of digital X-ray sensor components were analyzed to develop intra- oral dental digital X-ray image sensor using indirect method. Parametric analysis was carried out to optimize the phosphor thickness and the fiber optic plate (FOP) coupling to charge coupled device (CCD). X-ray absorption and light diffusion in the phosphor layer were analyzed by the Monte Carlo method. Real time X-ray image was obtained with prototype X- ray image sensor using general CCD camera with 1∼10 Ip/mm resolution. It has been previously shown that large resolution degradation in X-ray images was caused by miss alignment of FOP to CCD and optical adhesive selection. In this study, we reported that X-ray image quality was greatly improved by using optimized characteristics of alignment device and phosphor thickness.

Source Intensity Analysis of DUPIC Fuel

Whang,Ju-ho,Park,Kwang-heon,Lim,Jae-yong,Park,Bhum-Lak,Kim,Yun-Goo 대한방사선 방어학회 1996 방사선방어학회지 Vol.21 No.2

사용전 그리고 사용후 DUPIC핵연료의 선원분석들 연료다발에서 1m 떨어진 지점의 조사선량률을 기준으로 분석하였다. DUPIC핵연료 제조에 사용된 PWR 핵연로는 표준 연소도와 장주기 연소도를 갖는 것으로 설정하였고, 건식가공에서 제거되는 핵분열생성물의 양을 고려하여 두 가지의 경우를 고려하였다. 조사선량률은 균일 혼합체 모형을 사용하여 구하였다. 조사선량률 값은 매우 크게 나왔으며, 건식가공중의 Cs 제거율에 민감하게 변화하는 것으로 나타났다. 10년 이상 냉각된 PWR 핵연로를 사용한 DUPIC핵연료의 경우 핵연료 내 모든 Cs를 제거하면 약 90% 이상의 조사선량률을 감소시킬수 있다. 조사선량률에 주된 영향을 미치는 주요 방사선원은 Cs-137이다. Cs 제거에 관련된 연구는 DUPIC핵연료의 조사선량 뿐만 아니라, 건식 처리시설의 방사성 물질 관리에도 중요하다. Source intensities in terms of the exposure rates at 1 m from the fresh and spent DUPLC fuels, made from standard and extended burnup PWR fuels, were analyzed. Two cases were studied based on the degree of elimination of removable elements. Homogeneous mixture model was applied to get the exposure rate. The exposure rate turned out ot be very high and sensitive to Cs elimination during the dry process. About 90% of exposure can be reduced in the case of fresh DUPIC fuel made from 10-year cooled spent PWR fuels if Cs is fully removed during the dry process. The main radiation source in spkent fuels is Cs-137. The dry storage of spent DUPIC fuel may need a longer wet stor-age period and require a further review.