5세 남아의 Influenza 종격동기종 및 대엽성 폐렴 1례

오희성,한유진,연은경,선동신,송준환,박경배,박준수,김영통,남해선,최영진,김용배 순천향의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.14 No.3S

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스테로이드 여드름과 여드름양 발진에서 Malassezia (Pityrosporum) 효모균의 출현 빈도

이수근,김재홍,양홍윤,김윤석,유희준,손숙자 대한의진균학회 1998 대한의진균학회지 Vol.3 No.1

Background: Steroid acne is a folliculitis that can result from a systemic or topical administration of steroid and has been described as showing similar clinical pictures to Malassezia folliculitis, but there have been few reports about the incidence of Malassezia in steroid acne and other acneiform eruptions. Objective: Our purpose was to describe the incidences of Malassezia in acneiform eruptions and to discuss about the relationship between clinical steroid acne and Malassezia folliculitis. Methods: The history, clinical features, direct microscopy, histopathological analysis, and therapeutic results of 125 cases with steroid acne or other acneiform eruptions were described and compared. Results: Over 80% of patients with acneiform eruption receiving systemic steroid revealed significant numbers of Malassezia in the lesional follicle. Conclusion: Steroid acne and other acniform eruptions showing discrete follicular papules and/or pustules localized to the upper trunk or acneiform facial skin lesions associated with multiple acneiform lesions on the body in the summer period should be suspected as Malassezia folliculitis. [Kor J Med Mycol 3(1): 24∼32]

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

여성 복압성요실금에서 술 전 발살바요누출압에 따른 Suprapubic Arch 술식의 결과

박준명,유지형,성락희,정재용,노충희 인제대학교 2008 仁濟醫學 Vol.29 No.-

Objective : There were variant results for correlation between the postoperative cure rate and valsalva leak point pressure (VLPP) for female stress urinary incontinence (SUI). Therefore the aim of this study was to assess the influence of VLPP on the outcome of suprapubic arch (SPARC) procedure. Materials and Methods : A retrospective analysis was made of 246 women who underwent SPARC procedure for SUI. Based on VLPP, the patients were divided into 2 groups: group A (VLPP<60cmH2O) and group B (VLPP≥60cmH2O). The objective success rate and subjective success rate were assessed. Before surgery, the patients were evaluated with history taking, physical examination, urinalysis and urodynamic studies. The objective success rate was evaluated by clinical examination and the 1-hour pad test postoperatively and the subjective satisfaction rate was assessed using questionnaires for the patients' satisfaction and evaluated by recommendation rates of SPARC procedure to other patients. The objective success rate included cure and improvement, the subjective success rate included satisfaction and fair. Results : The number of patients in each group was 145 patients (group A) and 101 patients (group B). The objective success rate was 99.3% (group A) vs 98.0% (group B) (p=0.285). The subjective success rate was 98.6% (groupA) vs 98.0% (group B) (p=0.500). Recommendation rates of SPARC procedure was 94.5% (group A) vs 95.0% (group B) (p=0.422). Conclusion : It is our belief that SPARC procedure for female SUI is efficacious and safe regardless of preoperative VLPP.

Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구

장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.

GT rotary file을 이용한 근관성형법과 충전방법의 비교

강유미,진정희,유미경,이세준,이광원 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.5

The purpose of this study was to compare the shaping time of two shaping methods and the leakage of three different obturation techniques. Ninty three canaled human molar teeth were used. which were randomly divided into two groups of forty teeth each and ten control teeth. After working length determination. the one group was prepared crowndown technique using rotary root canal instruments of GT rotary files .12/20, .10/20, .08/20 and .06/20 taper(Maillefer Instrument SA. Switzerland). The other group was instrumented with Gates Gildden burs(#1, #2 and #3) to coronal preparation and GT rotary files .08/20 and .06/20 taper to apical preparation. Shaping time was measured. After root canals were instrumented, they were divided to three subgroups and obturated as follows: Subgroup 1, obturated with single cone method : Subgroup 2, obturated with lateral condensation : Subgroup 3, obturated with continuous wave technique. Three subgroups were obturated using non-standardized gutta-percha cone(Diadent, Korea, 06 or .08 taper) and AH-26(Dentsply DeTrey, Germany) as a root canal cement. Ten unobturated teeth served as positive and negative controls. After immersion in 2% methylene blue solution for 1 month, the teeth were washed during 24h. The teeth were determineralized in 10% nitric aciid and dehydrated by immersion in 80, 90 and 100% ethyl alcohol. The teeth were finally cleared and stored in 100% methylsalicylate, and apical dye penetration was evaluated under stereomicroscope(Leica M420, LC, U.S.A) at (×) 8.75 magnification. Liner measurement of dye penetration was assessed with the use of digitalized image analysing system (analySIS, GmbH, Germany), The data were analysed statistically using independent T-test and Two-way ANOVA and Tukey test. The result were as follows: 1. In canal prepared with GT^Trotary file, shaphing time taked more than the group of using Gates Gildden drill to coronal preparation without statistical significant (p>0.05). 2. The group of single cone obturation using canal preparation of GT^TM rotary files showed significantly more apical leakage than those of lateral condensation and continuous wave technique regardless of shaping method (p<0.05). 3. The group of single cone obturation using canal preparation of GT^TM rotary files and Gates Gildden drill showed significantly more apical leakage than those of continuous wave technique regardless of shaping method (p<0.05). 4. Regardless of shaping method. The group of continuous wave obturation showed less apical leakage than those of lateral condensation without statistical significance (p>0.05). 5. The group of single cone obturation using canal preparation of GT^TM rotary files and Gates Gildden drill showed more apical leakage than the group of lateral condensation using sane shaping method without statistical significance (p>0.05).

Impedance를 이용한 전도성고분자 센서의 가스감응특성

이경문,유준부,이병수,전희권,이상태,이덕동,허증수 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

구리 인근 경기 동북 지역에서의 피부질환의 통계적 관찰

이창우,유희준,양홍윤,전재홍 한양대학교 의과대학 1996 한양의대 학술지 Vol.16 No.2

We reviewed 4,173 new out-patients visited dermatology clinic of Hanyan University Kuri Hospital (from November 1995 to October 1996) to study the prevalence of common dermatoses occurring in this region (northeastern area of Kyounggi province) and compared to those of other Korean data. Among 4,173 new out-patient, 1,866(44.7%) were male, and 2,307(55.3%) were female. Fifteen common dermatoses were found to be contact dermatitis(13.0%), dermatophytosis(9.1%), atopic dermatitis(8.4%), seborrheic dermatitis(8.1%), other eczemas(7.8%), urticaria(6.4%), acne vulgaris(4.9%), herpes zoster(3.4%), drug eruption(2.5%), bacterial infection(2.1%), psoriasis(1.9%), verruca(1.8%), vitiligo(1.4%), syphilis(0.5%), and scabies(0.5%) in order of frequency. The most frequently visited age group was those between the age 21 to 30 years old constituting 20.4% of total patients. On monthly visited number of patients, the highest was in January, and the lowest was November. The results suggest that age, sex and monthly distribution patterns in northeastern area of Kyounggi province are similar to those of other epidemiological reports in Korea except for the higher prevalences of contact dermatitis, seborrheic dermatitis and herpes zoster.

단순 남성 임균성 요도염에서의 levofloxacin과 ofloxacin의 치료 효과 비교

김재홍,권상진,유희준,노영석 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.4

Ofloxacin의 광학적 L-isomer 활성체로서 광범위한 항균 파장을 가지며 항균 활성이 약 2배로 알려져 있는 levofloxacin의 단순 남성 임균성 요도염에 대한 유용성을 평가하고자 단순 남성 임균성 요도염의 치료 약제로 그 효과가 입증된 ofloxacin을 대조약으로 하여 그 치료 효과를 비교 분석하였다. 1995년 8월부터 1996년 6월까지 요도 배농을 주소로 서울 중구 보건소 성병질료실에 내원한 환자중 요도 분비물의 그람염색이나 임균 배양 검사로 단순 임균성 요도염으로 진단된 환자중 치료 효과를 추적 관찰 할 수 있었던 남자 환자 79명을 대상으로 하여, 이들 환자를 levofloxacin 200㎎ 1회 경구 복용 환자군과 ofloxacin 400㎎ 1회 경구 복용 환자군으로 나누어 치료 효과에 대한 연구를 시행한 결과 이미 알려져 있던 ofloxacin의 임균성 요도염에 대한 효과와 마찬가지로 levofloxacin 200㎎ 1회 경구 복용 치료의 경우에도 단순 남성 임균성 요도염에 우수한 치료 효과를 보였으며, 부작용도 발견되지 않았다. PPNG가 높은 빈도로 발생하고 있는 국내의 현상황에서 levofloxacin은 임균성 요도염의 치료시 1회 복용의 간편함뿐만 아니라 적은 용량 투여로도 우수한 치료 효과를 보이고, 부작용의 발현도 없는 안전하게 추천할 만한 우수한 경구용약제라고 생각된다. Background : The gonococcal urethritis is one of the most widely distributed sexually transmitted disease in the world. Recently, there are needs of new effective antibiotics for the development of the resistant strains of gonococcus. So we evaluated the effect of levofloxacin on uncomplicated male gonococcal urethritis. Methods : According to the random number sheet, we divided the patients into the group A and group B. The group A were treated with a single 200mg oral dose of levofloxacin and the group B with a single 400mg oral dose of ofloxacin. Results : 38 out of 39 patients(97.4%) treated with levofloxacin were successful in the treatment and 39 out of 40 patients(97.5%) treated with ofloxacin. Postgonococcal Urethritis noted in 9 patients(23.1%) from group A, and 10 patients(25.0%) from group B. Conclusion : As a results of this, it is considered that a single dose of 200mg levofloxacin has an excellent effect like a single dose of 400mg ofloxacin for the treatment of the uncomplicated male gonococcal urethritis.

Case Report : A Case of Systemic Candidiasis with Skin Manifestations Simulating Varicella

( Hee Joon Yu ),( Young Gon Baik ),( Hee Ok Kim ),( Sook Ja Son ) 대한피부과학회 1994 Annals of Dermatology Vol.6 No.2