A Case of Urethral Stent for Recurrent Urethral Stricture and Penile Prosthesis for Erectile Dysfunction

Jung, Gyung-Woo,Song, Young-Jin,Park, Young-Ho,Kwon, Heon-Young,Yoon, Jin-Han 동아대학교의과대학 1992 동아의대학술지 Vol.4 No.1

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

정지궤도 위성과 지구국간 광통신 링크의 전송속도 해석

한종석,정진호,김영권,Han, Jong-Seok,Jung, Jin-Ho,Kim, Yung-Kwon 한국전기전자학회 1997 전기전자학회논문지 Vol.1 No.1

정지궤도 위성과 지구국간 광통신을 대기상태와 앙각의 함수로써 해석할 수 있는 한모델(Han's model)을 제시하였다. 한모델에서는 대기상태를 맑은날, 구름낀 날, 안개, 헤이즈, 비, 눈의 여섯가지 전형적인 상태로 구분한다. 비트오류을 $10^{-7}$을 만족하는 데이터 전송속도를 한모델을 이용하여 상향링크와 하향링크에 대해 해석하였다. 상향링크시의 포인팅손실이 하향링크시의 대기에 의한 공간 가간섭 저하보다 크기 때문에 데이터 전송속도는 하향링크 보다 오히려 상향링크시에 제한됨을 알 수 있었다. Han's model, which is able to analyze optical communication between earth station and geo-satellite as a function of atmospheric conditions and elevation angles. is presented. In Han's model, atmospheric conditions are roughly classified into six basic types; clear sky, cloud, haze, fog, rain and snow. Data rate satisfying for the BER below $10^{-7}$ is analyzed by Han's model in case of up-link and down-link, respectively. Data rate is more limited by up-link than by down-link because the pointing loss caused by atmosphere on the up-link is greater than the spatial coherence degradation caused by atmosphere on the down-link.

전기자극 스트레스 또는 심리갈등 스트레스가 흰쥐 비장 임파구 증식과 Interleukin-2 생산능에 미치는 영향

한상진,김정목,양병환 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.2

The purpose of this study was to examine the relastionship between stress and immunologic function as a possible mechanism of stress and disease process. The authors investigated how the psychological stress induced by avoidance-avoidance conflict model or physical stress of electric shock do impact the immune function, measuring proliferation and interleukin-2(IL-2) production of rat splenic lymphocytes stimulated with various mitogens such as concanavalin-A(Con-A). phytohemagglutinin-M(PHA) and phorbol 12-myristate l?-acetate+calcium inophore A23187(PMA+A23187). In this experiment, female Sprag-Dawley rats were used an subjects. Animals were separated into 4 group according to different stress conditions. Conflict group received psychological conflict stress with electric shock depending on the coping behaviour and Yoked group was not in psychological conflict situation but received as same amount of electric shock as conflict group. Skinner-Box control group was immobilized without electric shock and Home-cage control group had no stress condition. The results are as follows : 1) There is significant difference in lymphocyte proliferation in case of Con-A and PMA+A 23187 between Skinner-Box control group and Yoked group at the high current condition. 2) There is significant difference in IL-2 production in case of PHA and PMA+A23187 between Skinner-Box control group and Yoked group. 3) There is more significant difference in lymphocyte proliferation in case of all of mitogens, Con-A. PHA and PMA+A23187 between Yoked group and Conflict group regardless of high or low current condition. 4) There is significant difference in IL-2 production in case of PMA+A23187 between Yoked group and Conflict group. This results suggest that psychological stress could reduce the immue function more profoundly than physical stress and also means the importance of coping and appraisal in the stress-immunology relationship.

하시모토 갑상선염과 동반된 갑상선 유두암에서 BRAFV600E의 발현과 임상적 특징

남성진,최영식,박요한,김정훈 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Background: An association between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) is still controversial. Studies to date established the coexistence of HT in 11% to 36% of PTC patients. BRAFV600E mutation was presented 90% with no HT, 64% with HT in PTC patients. Therefore, BRAFV600E mutation is associated with the pathogenesis of PTC arising in HT. The purpose of this study was to identify predictive factors for the coexistence of PTC and HT and to evaluate the association of the BRAFV600E mutation with the clinicopathological features of coexistence of PTC and HT. Methods: A total of 247 patients underwent surgery for thyroid disorders between January 2007 and April 2009. In all, 212 patients was diagnosed as thyroid papillary carcinoma only (PTC group), 33 had coexistence of PTC and HT (PTC+HT group), and 2 had been diagnosed with HT. DNA was extracted from paraffin embedded thyroid tumor specimens taken from 99 patients with PTC, 13 coexistence of PTC and HT, and 2 was HT. The presence of the BRAFV600E mutation was determined by polymerase chain reaction amplification of exon 15 followed by direct sequencing. Results: Among clinicopathological features sex, age, tumor size and capsule invasion was not significant between PTC group and PTC+HT group. Lymph node metastasis and stage was significantly lower in PTC+HT group than PTC group (p=0.044). BRAFV600E mutation was found in 34 of the 99 PTC group (34.3%), 1 of the 13 PTC+HT group and 2 HT show no BRAFV600E mutation. Conclusion: These data demonstrated that the coexistence of PTC and HT was less aggressive than PTC only.

요추부의 Transpedicular Screw를 이용한 수술의 합병증

정진명,한종우 대한신경외과학회 1991 Journal of Korean neurosurgical society Vol.20 No.12

46 consecutive patients underwent application of transpedicular screw since June 1988, and had follow-up at least for 6 months. 15 cases(32.6%) of them had one or two complications. There were 5 wound infections, which seemed to be caused by long operation time, wide metal implant area and personal predisposing factors. There were 5 patients with screw breakage. The exact screw alignment and avoidance of vigorous distraction are considered to by important in minimizing screw breakage. 2 patients had screw loosening, which could be reduced by proper placing of screw and methy1 metacrylate enforcement. Nerve root irritation and adjacent disc space degenerative change were developed in 5 cases. Discspace changes were induced by stress transfer after rigid fixation. Finally, postoperative severe wound pain which persisted for a long time was another troublesome problem.

초정밀 마이크로 물성평가를 위한 비전변형률 측정모듈 개발

한아름,이혜진,이낙규,이근안,송정한 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

Researches about micro technology travel lively in these days. Such many researches are concentrated in the field of micro materials and a process field. But properties of micro materials should be known to give results of research developed into still more. In these various material properties, reliability data such as mechanical, optical, thermal property, etc is the basic property. In this paper, it is developed that is Strain measurement module for micro material property system.

江原道內 造景植物의 利用과 有用自生植物에 관한 硏究

정진형,이기의,한재오 강원대학교 조형예술연구소 2005 조형예술논문집 Vol.6 No.-

This study was executed to find out how to improve the planting and use of landscaping plants in Kangwon-Do by surveying the planting, gardens, parks, schools, etc. and the main mountains in this province to select available native plants. The result are as follows: 1. Forty-four tree species and 41 flower species were counted at 703 schools in Kangwon-Do. The major species of school trees were Juniperus chinensis, Pinus densiflora, Abies holophylla, Ginkgo biloba, Pinus koraiensis, Taxus cuspidata, Zelkova serrata, and Pinus thunbergii. The ratio of native species to exotic was 35:9. The major species of school flowers were Rosa centifolia, Forsythia koreana, Zinnia elegans, Rhododendron mucronulatum, Chrysanthemum morifolium, and Rosa rugosa. The ratio of native species to exotic was 21:20. 2. Twelve flower species and 7 tree species were designated in 18 City and Keun. The species of flowers that ,presented high designation frequency were Rhododendron schlippenbachii, Forsythia koreana, Magnolia sieboldii, and Prunus armeniaca var. ansu, the trees that presented high designation frequency were Ginkgo biloba, Pinus koraiensis, and Taxus cuspidata. 3. Eighty-seven woody plants species were planted in 2003 and 2004 in the Young Seo district (the southern area of Kangwon-Do), the ratio of native species to exotic was 56:31. The major species of woody plants were Pinus densiflora, Prunus yedoensis, Prunus sargentii, Cornus officinalis, Pyrus pyrifolia, Rhododendron yedoense var. poukhanense, Pinus koraiensis, Taxus cuspidata, Hibiscus syriacus, Forsythia koreana, Zelkova serrata, Acer triflorum, Rhododendron obutusum, and Ligustrum obtusifolium. A total of 620,000 plants were planted. 3. Eighty-seven woody plants species were planted in 2003 and 2004 in the Young Seo district (the southern area of Kangwon-Do), the ratio of native species to exotic was 56:31. The major species of woody plants were Pinus densiflora, Prunus yedoensis, Prunus sargentii, Cornus officinalis, Pyrus pyrifolia, Rhododendron yedoense var. poukhanense, Pinus koraiensis, Taxus cuspidata, Hibiscus syriacus, Forsythia koreana, Zelkova serrata, Acer triflorum, Rhododendron obutusum, and Ligustrum obtusifolium. A total of 620,000 plants were planted. 4. Eighty-three woody plants species were planted recently in Youngdong district (the eastern area of Kangwon-Do), the ratio of native species to exotic was 53:30. The major species were Pinus thunbergii, Rhododendron lateritium, Rhododendron schlippenenbachii, Hibiscus syriacus, Prunus yedoensis, Pinus densiflora, Syringa dilatata, Rhododendron yedoense var., Poukhanense, Rosa rugosa, Prunus sargentii, Rosa centifolia, Juniperus chinensis, Euonymus japonica, Forsythia koreana, Chionanthus retusus, Acer palmatum, and Chaenomeles sinensis. 5. Through these results, it was thought that a diversification of plant species, including a selection of plants suitable to each space and the general use of native species were needed. So 254 plants native to Kangwon-Do were presented to correspond to these requirements. The especially valuable wild plants were Chionanthus retusus, Acer mandshuricum, Acer tegmentosum, Celtis sinensis, Malus baccata, Syringa wolfi, Cornus controversa, Styrax japonica, Styrax obassia, Sorbus commixta, Deutzia coreana, Viburnum carlesii, Sambucus williamsii var. coreana, Philadelphus schrenckii, Echinosophora koreensis, Exochorda serratifolia, Spiraea trichocarpa, Symplocos chinensis for. Pilosa, Rhododendron brachycarpum, Rhododendron micranthum, Rosa davurica, Rhododendron mucronulatum for. albiflorum, Actinidia spp., Akebia quinata, Vitis amurensis, Aster koraiensis, Chrysanthemum boreale, Chrysanthemum zawadskii var. latilobum, Dianthus sinensis, Heloniopsis orientalis, Hosta lancifolia, Hylomecon vernale, Leontopodium coreanum, Lilium spp., Aceriphyllum rossii, Paeonia obovata, Patrinia saniculaefolia, Primula sieboldi, Convallaria keiskei, Sedum kamtschaticum, and Saxifraga fortunei var. incisolobata.

Heavily T2-weighted Fast Spin Echo 기법을 이용한 자기공명 요로조영술의 임상적 고찰

한재진,김정삼 광주보건대학 1997 論文集 Vol.22 No.-

The purpose of this study was to evaluate the utility of the MR urography in patient with ureterohydronephrosis. Twenty-five patients with ureterohydronephrosis were researched by 1.5T superconducting unit with body coil. The causes of dilation were the follows: Ureteral benign stricture (n=10), ureteral stone (n=7), ureteral malignant stricture (n=6), and uretero-vesical reflux. (n=2). Coronal images were obtained by using a fat suppressed, respiratory-triggered, heavily T2-weighted fast spin echo sequences, and the images were processed by using a maximum intensity projection algorithm, We evaluated the technical success rate, the level and the cause of the obstruction. In 100%(25/25): of cases, MRU could be obtained successfully. The accuracy of MRU in the determining the level of the obstruction was 100%(25/25). The accuracy of the chagnosis of obstruction was 92%(23/25). MRU may be an effective chagnosis method for evaluating the ureterohydronephrosis without exposure of radiation or risks associated with lodinated contrast material. MRU may be alternative to IVU in patient with hydronephrosis.

범가자미, Verasper variegatus의 난황단백질 분리 및 면역학적 특성

백혜자,한창희,김우진,박중연,김진한,김윤 동의대학교 기초과학연구소 1998 基礎科學硏究論文集 Vol.8 No.1

The yolk protein of spotted flounder, Verasper variegatus was purified by precipitation with cold distilled water, followed by Sepharose CL-6B column chromatography. The purified protein was identified as vitellin by Ouchterlony's immunodiffusion test and immunoelectrophoresis. The purified vitellin from ovarian crude extracts has same antigenic determinants with the female specific serum protein, vitellogenin. The molecular weight of purified vitellin was estimated about 550kD by gel filtration. The vitellin was composed of three major subunits with molecular weight of about 108, 85 and 31 kD, and two minor subunits. The vitellin was identified by western blot analysis using anti-vitellin antibody.